array:19 [ "pii" => "S0025775320303213" "issn" => "00257753" "doi" => "10.1016/j.medcli.2020.03.013" "estado" => "S300" "fechaPublicacion" => "2020-08-28" "aid" => "5213" "copyright" => "Elsevier España, S.L.U." "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Med Clin. 2020;155:165-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => "Efficacy of ursodeoxycholic acid combined with prednisolone and immunosuppressant triple therapy in the treatment of refractory primary biliary cholangitis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "165" "paginaFinal" => "170" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Eficacia del ácido ursodesoxicólico combinado con prednisolona y triple terapia inmunosupresora en el tratamiento de la colangitis biliar primaria refractaria" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3742 "Ancho" => 2500 "Tamanyo" => 621319 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A. The improvement of chemical parameters after 18-month triple therapy. A1-A6: The dynamic paired data of ALT, AST, ALP, GGT, TBIL and ALB were compared used Friedman test. *<span class="elsevierStyleItalic">P</span>< 0.05, ** <span class="elsevierStyleItalic">P</span>< 0.01, and *** <span class="elsevierStyleItalic">P</span>< 0.001 is shown for comparisons between each follow-up values and baseline values.° <span class="elsevierStyleItalic">P</span>< 0.05,°° <span class="elsevierStyleItalic">P</span>< 0.01, and°°° <span class="elsevierStyleItalic">P</span>< 0.001 is shown for comparisons between values and the last follow-up values. B. The improvement of IgG, IgM and non-invasive fibrosis assessments after 18-month triple therapy. The dynamic data were compared used Kruskal-Wallis test. *<span class="elsevierStyleItalic">P</span>< 0.05, ** <span class="elsevierStyleItalic">P</span>< 0.01, and *** <span class="elsevierStyleItalic">P</span>< 0.001 is shown for comparisons between each follow-up values and baseline values.° <span class="elsevierStyleItalic">P</span>< 0.05,°° <span class="elsevierStyleItalic">P</span>< 0.01, and°°° <span class="elsevierStyleItalic">P</span>< 0.001 is shown for comparisons between values and the last follow-up values. C. Cumulative incidence of ALP, ALT, AST and GGT normalization. Censored data represent patients who achieved biochemical parameters normalization. Grey area represents 95% confidence interval. The follow time were shown as months.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Tian-Tian Yao, Jian-Dan Qian, Gui-Qiang Wang" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Tian-Tian" "apellidos" => "Yao" ] 1 => array:2 [ "nombre" => "Jian-Dan" "apellidos" => "Qian" ] 2 => array:2 [ "nombre" => "Gui-Qiang" "apellidos" => "Wang" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2387020620302965" "doi" => "10.1016/j.medcle.2020.03.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2387020620302965?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775320303213?idApp=UINPBA00004N" "url" => "/00257753/0000015500000004/v1_202008110620/S0025775320303213/v1_202008110620/en/main.assets" ]
Información de la revista
Vol. 155. Núm. 4.
Páginas 165-170 (agosto 2020)
Vol. 155. Núm. 4.
Páginas 165-170 (agosto 2020)
Review
Efficacy of ursodeoxycholic acid combined with prednisolone and immunosuppressant triple therapy in the treatment of refractory primary biliary cholangitis
Eficacia del ácido ursodesoxicólico combinado con prednisolona y triple terapia inmunosupresora en el tratamiento de la colangitis biliar primaria refractaria
Tian-Tian Yao, Jian-Dan Qian, Gui-Qiang Wang
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