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Vol. 46. Núm. 2.
Páginas 75-90 (enero 2003)
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Vol. 46. Núm. 2.
Páginas 75-90 (enero 2003)
Acceso a texto completo
Posibilidades y limitaciones de una ecografía en la semana 12–13 de gestación: la translucencia nucal en el cribado del síndrome de Down
Possibilities and limitations of ultrasonography in weeks 12–13 of gestation: nucal translucency in screening for Down syndrome
Visitas
8274
F. Tomás Bosch, A. Gallego Andrés, J. Arastey Gil, Y. Mahmoud, E. Sanz De Galdeano, J.J. Santonja Lucas
Autor para correspondencia
jsantonjal@meditex.es

Correspondencia: Urbanización Soto de Camarena, A–46. 46117 Bétera. Valencia. España
Servei d'Obstetricia i Ginecologia. Hospital General Universitari. Departament de Pediatria, Obstetricia i Ginecologia. Universitat de València. España. Trabajo realizado con una ayuda del FIS 00/1057
Este artículo ha recibido
Información del artículo
Resumen
Objetivo

Presentar las posibilidades diagnósticas de una ecografía practicada a la población general de gestantes alrededor de la semana 12. Presentar la técnica de su realización.

Material y métodos

Estudio de los artículos relevantes aparecidos entre 1985 y 2001, obtenidos del Medline o citados en otros artículos.

Resultados

La aportación más valiosa de esta ecografía es el cribado del síndrome de Down y la definición de la corionicidad en la gestación múltiple, pero también establecer la edad gestacional con precisión e identificar muchas malformaciones.

Conclusiones

La ecografía de la semana 12 debe convertirse en una exploración habitual para todas las gestantes. Sus objetivos y características hacen necesario el consentimiento informado y la evaluación continuada de su eficacia diagnóstica.

Palabras clave:
Translucencia nucal
Cribado ecográfico
Síndrome de Down
Malformacion fetal
Edad gestacional
Corionicidad
Summary
Objective

To show the diagnostic possibilities coming from a sonography performed around 12th week on the general population of pregnancies.

Material and methods

Articles published since 1985 to 2001, retrieved from Medline or cited in other articles.

Results

The most important value is Down's screening and the diagnosis of chorionicity in twin pregnancies, but it is also useful for estimating gestational age and to identify many fetal malformations.

Conclusions

Sonography at 12 weeks (11-13 weeks) is coming to be essential in the conduction of all pregnancies. It is necessary to use informed consent and to keep a continuous audit.

Keywords:
Nuchal translucency
Sonographic screening
Down's syndrome
Fetal malformation
Gestational age
Chorionicity
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Bibliografía
[1.]
M. Aymerich, C. Almazan, A.J. Jovell.
Evaluation of obstetrical ultrasound examination in the monitoring of normal pregnancy in primary health care, pp. 8
[2.]
L. Bricker, J. García, J. Henderson, M. Mugford, J. Neilson, T. Roberts, et al.
Ultrasound screening in pregnancy: a systematic review of the clinical effectiveness, cost-effectiveness and women's views. Health Technology Assessment.
Finnish Office for Health Care Technology Assessment, 4 (2000), pp. 16
[3.]
C. Baillie, G. Mason, J. Hewison.
Scanning for pleasure.
Br J Obstet Gynaecol, 104 (1997), pp. 1223-1224
[4.]
K.H. Nicolaides, N.J. Sebire, J.M. Snijders.
The 11-14 week scan.
The diagnosis of fetal abnormalities,
[5.]
W. Schmid, G. Saldovelli.
Prävention des Down-Syndroms Med. Genet.
Informationsblatt SGMG, 17 (1986), pp. 13-15
[6.]
G. Sadolvelli, F. Binkert, J. Acherman, W. Schmid.
Ultrasound screening for chromosomal anomalies in the first trimester of pregnancy.
Prenat Diagnosis, 13 (1993), pp. 513-518
[7.]
R.P. Singh, D.H. Carr.
The anatomy and histology of XO embryos and fetuses.
Anat Rec, 155 (1966), pp. 369-384
[8.]
K.H. Nicolaides, G. Azar, D. Byrne, C. Mansur, K. Marks.
Fetal nuchal traslucency: ultrasound screning for chromosomal defects in first trimester of pregnancy.
BMJ, 304 (1992), pp. 867-869
[9.]
J. Szabó, J. Gellén.
Nuchal fluid accumulation in trisomy-21 detected by vaginosonography in first trimester.
Lancet, 2 (1990), pp. 1133
[10.]
J. Szabó, J. Gellén, G. Szemere.
First-trimester ultrasound screening for fetal aneuploidies in women over 35 and under 35 years of age.
Ultrasound Obstet Gynecol, 5 (1995), pp. 161-163
[11.]
K.H. Nicolaides, M.L. Brizot, R.J.M. Snijders.
Fetal nuchal translucency: ultrasound screening for fetal trisomy in the first trimester of pregnancy.
Br J Obstet Gynaecol, 101 (1994), pp. 782-786
[12.]
B. Brambati, C. Cislaghi, L. Tului, E. Alberti, M. Amidani, U. Colombo.
First-trimester Down's syndrome screening using nuchal translucency: a prospective study in patients undergoing chorionic villus sampling.
Ultrasound Obstet Gynecol, 5 (1995), pp. 9-14
[13.]
A. Borrell, D. Costa, J.M. Martínez, R.D. Delgado, T. Farguell, A. Fortuny.
Criteria for fetal nuchal thickness cut-off: a re-evaluation.
Prenat Diagn, 17 (1997), pp. 23-29
[14.]
B.G. Hewitt, L. De Crepigny, A.J. Sampson, A.C.C. Ngh, P. Shekleton, H.P. Robinson.
Correlation between nuchal thickness and abnormal karyotype in first trimester fetuses.
Med J Aust, 165 (1996), pp. 365-368
[15.]
P.P. Pandya, R.J.M. Snijders, S.J. Johnson, M. Brizot, K.H. Nicolaides.
Screening for fetal trisomies by maternal age and fetal nuchal translucency thickness at 10 to 14 weeks of gestation.
Br J Obstet Gynaecol, 102 (1995), pp. 957-962
[16.]
S. Bewley, L.J. Roberts, A.M. Mackinson, C.H. Rodeck.
First trimester fetal nuchal translucency: problems with screening the general population.
Br J Obstet Gynecol, 102 (1995), pp. 386-388
[17.]
R. Zimmermann, A. Hucha, G. Saldovelli, F. Binkert, J. Achermann, J.G. Grudzinskas.
Serum parameters and nuchal translucency in firts trimester screening for fetal chromosomal abnormalities.
Br J Obstet Gynaecol, 103 (1996), pp. 1009-1014
[18.]
P. Taiple, V. Hillesmaa, R. Salonen, P. Ylostalo.
Increased nuchal translucency as a marker for fetal chromosomal defect.
N Engl J Med, 337 (1997), pp. 1654-1657
[19.]
E. Hafner, K. Schuchter, E. Liebhart, K. Philipp.
Results of routine fetal nuchal translucency measurement at 10-13 weeks in 4233 unselected pregnant women.
Prenat Diag, 18 (1998), pp. 29-34
[20.]
R.J.M. Snijders, P. Nobel, N. Sebire, A. Souka, K.H. Nicolaides.
for the Fetal Medicine Foundation First trimester Screening Group: UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal translucency thickness at 10-14 weeks of gestation.
[21.]
J.M. Braithwaite, M.A. Armstrong, D.L. Economides.
Assessment of fetal anatomy at 12 to 13 weeks of gestation by transabdominal and transvaginal sonography.
Br J Obstet Gynecol, 103 (1996), pp. 82-85
[22.]
A. Souka, S. Bakalis.
Diagnosis of fetal abnormalities at the 11-14 week scan. Abnormal ultrasound findings.
The 11-14 week scan. The Parthenon Publishing Group,, pp. 123-147
[23.]
A.P. Souka, R.J.M. Snidjers, A. Novakov, W. Soares, K.H. Nicolaides.
Defects and syndromes in chromosomally normal fetuses with increased nuchal traslucency thicknes at 10-14 weeks of gestation.
Ultrasound Obstet Gynecol, 11 (1998), pp. 391-400
[24.]
D.L. Economides, J.M. Braithwaite.
First trimester ultrasonographic diagnosis of fetal structural abnormalities in low risk population.
Br J Obstet Gynaecol, 105 (1998), pp. 53-57
[25.]
B.J. Whitlow, D.L. Economides.
The optimal gestational age to examine fetal anatomy and measure nuchal translucency in the firts trimester.
Ultrasound Obstet Gynecol, 11 (1998), pp. 258-261
[26.]
A. Kurjak, S. Kupesic, M. Ivancic-Kosuta.
Three-dimensional transvaginal ultrasound improves measurement of nuchal translucency.
J Perinat Med, 27 (1999), pp. 97-102
[27.]
A. Herman, E. Dreazen, R. Maymon, Y. Tovbin, I. Bukovsky, Z. Weinraub.
Implementation of nuchal translucency imagescoring method during ongoing audit.
Ultrasound Obstet Gynecol, 14 (1999), pp. 388-392
[28.]
E. Pajkrt, B.W. Mol, K. Boer, A.P. Drogtrop, P.M. Bossuyt, C.M. Bilardo.
Intra- and interoperator repeatability of the nuchal translucency measurement.
Ultrasound Obstet Gynecol, 15 (2000), pp. 297-301
[29.]
H.P. Robinson, J.E.E. Fleming.
A critical evaluation of sonar crowrump length measurements.
Br J Obstet Gynaecol, 82 (1975), pp. 702-709
[30.]
J.M. Braithwaite, R.W. Morris, D.L. Economides.
Nuchal translucency measurements: frequency distribution and changes with gestation in a general population.
Br J Obstet Gynaecol, 103 (1996), pp. 1201-1204
[31.]
E. Pajkrt, I.M. De Graaf, B.W.J. Mol, J.M.M. Van Lith, O.P. Bleker, C.M. Bilardo.
Weekly nuchal translucency measurement in normal fetuses.
Obstet Gynecol, 91 (1998), pp. 208-211
[32.]
S. Yagel, E.Y. Anteby, L. Rosen, E. Yaffe, R. Rabinowitz, O. Tadmor.
Assessment of first-trimester nuchal traslucency by daily reference intervals.
Ultrasound Obstet Gynecol, 11 (1998), pp. 262-265
[33.]
A. Herman, R. Maymon, E. Dreazen, E. Caspi, I. Bukovsky, Z. Weinraub.
Image magnification does not contribute to the repeatability of caliper placement in measuring nuchal translucency thickness.
Ultrasound Obstet Gynecol, 11 (1998), pp. 266-270
[34.]
P. Pandya.
Nuchal traslucency thickness.
The 11-14 week scan, pp. 14-29
[35.]
A. Herman, E. Dreazen, A. Samandarov, Y. Bukovsky, Z. Weinraub, R. Maymon.
On to on versus on-to-out nuchal translucency measurements.
Ultrasound Obstet Gynecol, 15 (2000), pp. 126-130
[36.]
B.J. Whitlow, I.K. Chatzipapas, D.L. Economides.
The effect of fetal neck position on nuchal translucency measurement.
Br J Obstet Gynaecol, 105 (1998), pp. 872-876
[37.]
I.M. De Graaf, M.A. Muller, A.A. Van Zuylen-Vie, O.P. Bleker, C.M. Bilardo.
The influence of fetal position on nuchal translucency thickness.
Ultrasound Obstet Gynecol, 15 (2000), pp. 520-522
[38.]
L.J. Roberts, S. Bewley, A.M. Mackinson, C.H. Rodeck.
First trimester fetal nuchal translucency: problems with screening the general population 1.
Br J Obstet Gynaecol, 102 (1995), pp. 381-385
[39.]
M. Schaefer, H. Laurichesse-Delmas, Y. Ville.
The effect of nuchal cord on nuchal translucency measurement at 10-14 weeks.
Ultrasound Obstet Gynecol, 11 (1998), pp. 271-273
[40.]
R. Maymon, A. Herman, E. Dreazen, Y. Tovbin, I. Bukovsky, Z. Weinraub.
Can nuchal cord cause transient increased nuchal translucency thickness?.
Hum Reprod, 14 (1999), pp. 556-559
[41.]
C. Comas, J.M. Martínez, J. Ojuel, E. Casals, B. Puerto, A. Borrell.
First trimester nuchal edema as a marker of aneuploidia.
Ultrasound Obstet Gynecol, 5 (1995), pp. 26-29
[42.]
A. Borrell, D. Costa, J.M. Martínez, M.T. Farré, J. Cararach, A. Fortuny.
Natural evolution of nuchal thickness in trisomy-21 fetuses.
Obstet Gynecol, 91 (1998), pp. 78-81
[43.]
K.H. Nicolaides, R.J.M. Snijders, H.S. Cuckle.
Correct estimation of parameters for ultrasound nuchal screening. Prenat.
Diagn, 14 (1998), pp. 203-208
[44.]
S. Cicero, P. Curcio, A. Papageorghiou, J. Sonek, K. Nicolaides.
Absence of nasal bone in fetuses with trisomy 21 at 11-14 weeks of gestation: an observational study.
Lancet, 358 (2001), pp. 1665-1667
[45.]
L.H. Komman, L.P. Morssink, J.R. Beekhuis, B.T.H.M. De Wolf, M.P. Heringa, A. Mantingh.
Nuchal translucency cannot be used as a screening test for chromosomal abnormalities in the first trimester of pregnancy in a routine ultrasound practice.
Prenat Diagn, 16 (1996), pp. 779-781
[46.]
ACOG.
Committe Opinion n.o 223.
First-trimester screening for fetal anomalies with nuchal translucency, (Octubre, 1999),
[47.]
F.D. Malone, R.L. Berkowitz, J.A. Canick, M.E. D'Alton.
First-trimester screening for aneuploidy: research or standard of care.
Am J Obstet Gynecol, 182 (2000), pp. 490-496
[48.]
B. Thilaganathan, S. Sairam, G. Michailidis, N.C. Wathen.
First trimester nuchal translucency: effective routine screening for Down's syndrome.
Br J Radiol, 72 (1999), pp. 946-948
[49.]
M.A. Zoppi, R.M. Ibba, M. Putzolu, M. Floris, G. Monni.
Assessment of risk for chromosomal abnormalities at 10-14 weeks of gestation by nuchal translucency and maternal age in 5210 fetuses at a single center.
Fetal Diagn Ther, 15 (2000), pp. 170-173
[50.]
M.P. Johnson, A. Johnson, W. Holzgreve, N.B. Isada, R.J. Wapner, M.C. Treadwell, et al.
First trimester simple hygroma: cause and outcome.
Am J Obstet Gynecol, 168 (1993), pp. 156-161
[51.]
M. Jemmali, A.S. Valat, P. Poulain, R. Favre, P. Bourgeot, D. Subtil, et al.
Clarte nucale: despistage des anomalies chromosomiques et des malformations congenitales. Etude multicentrique.
J Gynecol Obstet Biol Reprod (Paris), 28 (1999), pp. 538-543
[52.]
P. Taipale, V. Hilesmaa.
Ultrasonographic screening for fetal chromosomal abnormalities in early pregnancy.
Acta Obstet Gynecol Scand, 78 (1999), pp. 563-572
[53.]
K. Spencer, P. Noble, R.J. Snijders, K.H. Nicolaides.
First-trimester urine free beta hCG, beta core, and total oestriol in pregnancies affected by Down's syndrome: implications for first-trimester screening with nuchal translucency and serum free beta hCG.
Prenat Diagn, 17 (1997), pp. 525-538
[54.]
P. Theodoropoulos, D. Lolis, S. Papageorgiou, S. Papaioannou, N. Plachouras, G. Makrydimas.
Evaluation of first trimester screening by fetal nuchal translucency and maternal age.
Prenat Diagn, 18 (1998), pp. 133-137
[55.]
J.E. Haddow, G.E. Palomaki.
Down syndrome screening.
Lancet, 347 (1996), pp. 1625
[56.]
R.A. Kadir, D.L. Economides.
The effect of nuchal translucency measurement on second trimester biochemical screening for Down syndrome.
Ultrasound Obstet Gynecol, 9 (1997), pp. 244-247
[57.]
R. Biagiotti, E. Periti, L. Brizzi, E. Vanzi, E. Cariati.
Comparison between two methods of standarization for gestational age differences in fetal nuchal traslucency measurement in first-trimester screening for trisomy 21.
Ultrasound Obstet Gynecol, 9 (1997), pp. 248-252
[58.]
L.S. Penrose.
The relative effects of paternal and maternal age in mongolism.
J Genet, 27 (1933), pp. 219-224
[59.]
H.S. Cuckle, N.J. Wald, S.G. Thompson.
Estimating a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha-fetoprotein level.
Br J Obstet Gynaecol, 94 (1987), pp. 387-402
[60.]
A.D. Carothers, C.A. Hetch, E.B. Hook.
International variation in reported live birth prevalence rates of Down syndrome, adjusted for maternal age.
J Med Genet, 36 (1999), pp. 386-393
[61.]
N.J. Wald, A. Kennard, A. Hackshaw, A. McGuire.
Antenatal screening for Down's syndrome.
Health Technology Assessment, 2 (1998), pp. 1
[62.]
S.P. Pauker, S.G. Pauker.
Prenatal diagnosis- Why is 35 a magic number?.
N Engl J Med, 330 (1994), pp. 1151-1152
[63.]
I. Bernabeu Egea, C. Bovea Beltran, F. Rodríguez Belmonte, P. Matallin Evangelio, G. Fernández Yuste, J.C. Martínez Escoriza.
Estudio de las alteraciones cromosómicas detectadas por amniocentesis genética en nuestro medio.
Cien Ginecol, 2 (2001), pp. 77-81
[64.]
M. Kuppermann, R.F. Nease, L.A. Learman, E. Gates, B. Blumberg, A.E. Washington.
Procedure-related miscarriages and Down syndrome-affected births: implications for prenatal testing based on women's preferences.
Obstet Gynecol, 96 (2000), pp. 511-516
[65.]
J.E. Haddow.
Antenatal screening for Down's syndrome: where are we and where next?.
[66.]
V. Ibáñez, V. Modesto, R. Tosca.
Sobre las likehood ratios.
Med Clin (Barc), 116 (2001), pp. 396
[67.]
S.P. O'Callaghan, W.B. Giles, S.P. Raymond, V. McDougall, K. Morris, J. Boyd.
First trimester ultrasound with nuchal translucency measurement for Down syndrome risk estimation using software developed by Fetal Medicine Foundation, United Kingdom— The first 2000 examinations in Newcastle, New South Wales, Australia.
Aust N Z J Obstet Gynecol, 40 (2000), pp. 292-295
[68.]
P.P. Pandya, M.L. Brizot, P. Kuhn, R.J.M. Snijders, K.H. Nicolaides.
First-trimester fetal nuchal translucency thickness and risk for trisomies.
Obstet Gynecol, 84 (1994), pp. 420-423
[69.]
H. Cuckle, I. Sehmi.
Calculating correct Down's syndrome risks.
Br J Obstet Gynaecol, 106 (1999), pp. 371-372
[70.]
R.J.M. Snijders, K. Sundberg, W. Holzgreve, G. Henry, K.H. Nicolaides.
Maternal age and gestation-specific risk for trisomy 21.
Ultrasound Obstet Gynecol, 13 (1999), pp. 167-170
[71.]
H. Cuckle.
Down syndrome fetal loss rate in early pregnancy.
Prenat Diagn, 19 (1999), pp. 1177-1179
[72.]
P.A. Benn, J.F.X. Egn.
Survival of Down syndrome in utero.
Prenat Diagn, 20 (2000), pp. 432-433
[73.]
A.I. Sokol, R.L. Kramer, Y. Yaron, J.E. O'Brien, F. Muller, M.P. Johnson, et al.
Age-specific variation in aneuploidy incidence among biochemical screening programs.
Am J Obstet Gynecol, 179 (1998), pp. 971-973
[74.]
D.L. Economides, B.J. Whitlow, J.M. Braithwaite.
Ultrasonography in the detection of fetal anomalies in early pregnancy.
Br J Obstet Gynaecol, 106 (1999), pp. 516-523
[75.]
L. Guariglia, P. Rosati.
Transvaginal sonographic detection of embryonic-fetal abnormalities in early pregnancy.
Obstet Gynecol, 96 (2000), pp. 238-242
[76.]
B.J. Whitlow, I.K. Chatzipapa, M.L. Lazanakis, R.A. Kadir, D.L. Economides.
The value of sonography in early pregnancy for the detection of fetal abnormalities in an unselected population.
Br J Obstet Gynaecol, 106 (1999), pp. 929-936
[77.]
K.C. Dundas, J. Walker, I.A. Laing.
Oesophageal and duodenal atresia suspected at the 12 week booking scan.
Br J Obstet Gynaecol, 108 (2001), pp. 225-226
[78.]
S.P. Johnson, N.J. Sebire, R.J.M. Snijders, S. Tunkel, K.H. Nicolaides.
Ultrasound screening for anencephaly at 10-14 weeks of gestation.
Ultrasound Obstet Gynecol, 11 (1997), pp. 14-16
[79.]
A. Souka, V. Heath.
Increased nuchal translucency with normal karyotype.
The 11-14 week scan, pp. 67-93
[80.]
P.P. Pandya, A. Kondylios, L. Hilbert, R.J.M. Snijders, K.H. Nicolaides.
Chromosomal defects and outcome in 1015 fetuses with increased nuchal translucency.
Ultrasound Obstet Gynecol, 5 (1995), pp. 15-19
[81.]
A.P. Souka, R.J.M. Snijdjers, A. Novakov, W. Soares, K.H. Nicolaides.
Defects and syndromes in chromosomally normal fetuses with increased nuchal translucency thickness at 10-14 weeks of gestation.
Ultrasound Obstet Gynecol, 11 (1998), pp. 391-400
[82.]
E. Garne.
and the Eurocat Working Group. Prenatal diagnosis of six major cardiac malformations in Europe — A population based study.
Acta Obstet Gynecol Scand, 80 (2001), pp. 224-228
[83.]
J. Hyett, G. Moscoso, G. Papapanagioutou, M. Perdu, K.H. Nicolaides.
Abnormalities of the heart and great arteries in chromosomally normal fetuses with increased nuchal translucency thickness at 11-13 weeks of gestation.
Ultrasound Obstet Gynecol, 7 (1996), pp. 245-250
[84.]
J.A. Hyett, M. Perdu, G.K. Sharland, R.J.M. Snijders, K.H. Nicolaides.
Using fetal nuchal traslucency to screen for major congenital cardiac deffects at 10-14 weeks of gestation: population based cohort study.
BMJ, 318 (1999), pp. 81-85
[85.]
N. Zosmer, V.L. Souter, C.S.Y. Chan, I.C. Huggon, K.H. Nicolaides.
Early diagnosis of major cardiac defects in chromosomally normal fetuses with increased nuchal translucency.
Br J Obstet Gynecol, 106 (1999), pp. 829-833
[86.]
G.D. Michailidis, D.L. Economides.
Nuchal translucency measurement and pregnancy outcome in karyotypically normal fetuses.
Ultrasound Obstet Gynecol, 17 (2001), pp. 102-105
[87.]
M.A. Rustico, A. Benettoni, G. D'Ottavio, L. Fischer-Tamaro, G.C. Conoscenti, Y. Meir, et al.
Early screening for fetal cardiac anomalies by transvaginal echocardiography in an unselected population: the role of operator experience.
Ultrasound Obstet Gynecol, 16 (2000), pp. 614-619
[88.]
P. Schwarzler, J.S. Carvalho, M.V. Senat, T. Masroor, S. Campbell, Y. Ville.
Screening for fetal aneuploidies and fetal cardiac abnormalities by nuchal translucency thickness measurement at 10-14 weeks of gestation as part of routine antenatal care in an unselected population.
Br J Obstet Gynaecol, 106 (1999), pp. 1029-1034
[89.]
E. Mavrides, F. Cobian-Sánchez, A. Tekay, G. Moscoso, S. Campbell, B. Thilaganathan, J.S. Carvalho.
Limitations of using first-trimester nuchal translucency measurement in routine screening for major congenital heart defects.
Ultrasound Obstet Gynecol, 17 (2001), pp. 106-110
[90.]
O. Adekunle, A. Gopee, M. El-Sayed, B. Thilaganathan.
Increased first trimester nuchal translucency: pregnancy and infant outcomes after routine screening for Down's syndrome in an unselected antenatal population.
Br J Radiol, 72 (1999), pp. 457-460
[91.]
E. Pajkrt, B.W. Mol, O.P. Blecker, C.M. Bilardo.
Pregnancy outcome and nuchal translucency measurements in fetuses with normal karyotype.
Prenat Diagn, 12 (1999), pp. 1104-1108
[92.]
R. Maymon, E. Jauniaux, O. Cohen, E. Dreazen, Z. Weinraub, A. Herman.
Pregnancy outcome and infant follow-up of fetuses with abnormally increased first trimester nuchal translucency Human Reprod, 15 (2000), pp. 2023-2027
[93.]
Y. Fukada, T. Yasumizu, K. Hoshi.
Nuchal translucency: association of size and persistence with fetal abnormalities.
Int J Gynaecol Obstet, 71 (2000), pp. 281-282
[94.]
N.J. Sebire, K.H. Nicolaides.
Screening for fetal abnormalities in multiple pregnancies.
Ballière's Clinical Obstet Gynecol, 12 (1998), pp. 19-36
[95.]
M. Ezcurdia, M.J. Cerqueira, P. De la Fuente, N. González, L. Peñalosa, J. Quero.
Embarazo múltiple.
Documento de Consenso,
[96.]
S.L. Wood, R. St Onge, G. Connors, P.D. Elliot.
Evaluation of the twin peak lambda or twin-chorionic peak sign in dichorionic twin pregnancies.
Obstet Gynecol, 88 (1996), pp. 6-9
[97.]
W. Sepulveda, N.J. Sebire, K. Hughhes, A. Kalogeropoulos, K.H. Nicolaides.
Evolution of the lambda or twin-chorionic peak sign in dichorionic twuin pregnancies.
Obstet Gynecol, 89 (1997), pp. 439-441
[98.]
J. Sánchez Ramos, C. Bedoya, M. Martínez Benavides.
Embarazo gemelar: una relación peligrosa.
Acta Obstet Gynecol, 13 (2000), pp. 261-275
[99.]
H. Cuckle.
Down syndrome screening in twins.
J Med Screen, 5 (1998), pp. 3-4
[100.]
L.M. Neveux, G.E. Palomaki, G.J. Knight, J.E. Haddow.
Multiple marker screening for Down syndrome in twin pregnancies.
[101.]
R. Maymon, E. Dreazen, S. Rozinsky, I. Bukovsky, Z. Weinraub, A. Herman.
Comparison of nuchal translucency measurement and second-trimester triple serum screening in twin versus singleton pregnancies.
Prenat Diagn, 19 (1999), pp. 727-731
[102.]
P.L. Nobel, R.J.M. Snijders, K. Hughes, W. Sepulveda, K.H. Nicolaides.
Maternal serum free beta-hCG at 10 to 14 weeks in trisomic twin pregnancies.
Br J Obstet Gynecol, 104 (1997), pp. 741-743
[103.]
N.J. Sebire, R.J.M. Snijders, K. Hughes, W. Sepulveda, K.H. Nicolaides.
Screening for trisomy 21 in twin pregnancies by maternal age and fetal nuchal translucency thickness at 10-14 weeks of gestation.
Br J Obstet Gynecol, 103 (1996), pp. 999-1003
[104.]
R. Maymon, E. Dreazen, S. Rozinsky, I. Bukovsky, Z. Weinraub, A. Herman.
Comparison of nuchal translucency measurement and mid-gestation serum screening in assisted reproduction versus naturally conceived singleton pregnancies.
Prenat Diagn, 19 (1999), pp. 1007-1011
[105.]
R.E. Gilbert, C. Augood, R. Gupta, A.E. Ades, S. Logan, M. Sculpher, et al.
Screening for Down's syndrome: effects, safety, and cost effectiveness of first and second trimester strategies.
BMJ, 323 (2001), pp. 1-6
[106.]
A.M. Vintzileos, C.V. Ananth, A.J. Fisher, J.C. Smulian, D. Day-Salvatore, T. Beazoglou.
An economic evaluation of first-trimester genetic sonography for prenatal detection of Down Syndrome.
Obstet Gynecol, 91 (1998), pp. 535-539
[107.]
A. Fortuny Estivill, A. Borrell Vilaseca, M. Cortés León, M. Gallo Vallejo, R. González de Agüero Laborda, A. González González, et al.
Screening de cromosomopatías fetales.
Documentos de Consenso sego, (2000),
Copyright © 2003. Sociedad Española de Ginecología y Obstetricia
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