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=> "Gutiérrez-Rojas" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1134593413000262?idApp=UINPBA00004N" "url" => "/11345934/0000002000000012/v1_201307310837/S1134593413000262/v1_201307310837/es/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1134593413000183" "issn" => "11345934" "doi" => "10.1016/j.psiq.2013.06.001" "estado" => "S300" "fechaPublicacion" => "2013-01-01" "aid" => "103" "documento" => "article" "crossmark" => 0 "subdocumento" => "ssu" "cita" => "Psiquiatr Biol . 2013;20:2-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 36048 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 34294 "PDF" => 1748 ] ] "es" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisión</span>" "titulo" => "Desvenlafaxina, un nuevo IRSN para el tratamiento de la depresión mayor: Revisión de la literatura" 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class="elsevierStyleTextfn">Revisión</span>" "titulo" => "Eficacia de los ácidos grasos omega-3 como tratamiento suplementario en la esquizofrenia" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "8" "paginaFinal" => "13" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Miquel Bioque, Javier Goti, Jorge Capapey, Miguel Bernardo" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Miquel" "apellidos" => "Bioque" "email" => array:1 [ 0 => "mbioque@yahoo.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Javier" "apellidos" => "Goti" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 2 => array:3 [ "nombre" => "Jorge" "apellidos" => "Capapey" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Miguel" "apellidos" => "Bernardo" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Unidad de Esquizofrenia Clínic, Instituto Clínic de Neurociencias, Hospital Clínic de Barcelona, Barcelona, España" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), G04, España" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Psiquiatría Infanto-Juvenil, Instituto Clínic de Neurociencias, Hospital Clínic de Barcelona, Barcelona, España" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), Barcelona, España" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Universidad de Barcelona, Barcelona, España" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Efficacy of Omega-3 Fatty Acids as a Supplementary Treatment in Schizophrenia" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Referencias no citadas</span><p id="par0005" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRefs" href="#bib0005">[1–54]</a>.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:6 [ 0 => array:2 [ "identificador" => "xres238726" "titulo" => "Resumen" ] 1 => array:2 [ "identificador" => "xpalclavsec224587" "titulo" => "Palabras clave" ] 2 => array:2 [ "identificador" => "xres238725" "titulo" => "Abstract" ] 3 => array:2 [ "identificador" => "xpalclavsec224586" "titulo" => "Keywords" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Referencias no citadas" ] 5 => array:1 [ "titulo" => "Bibliografía" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec224587" "palabras" => array:4 [ 0 => "Esquizofrenia" 1 => "Ácidos grasos poliinsaturados Omega-3" 2 => "Tratamiento suplementario" 3 => "Suplementación" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec224586" "palabras" => array:2 [ 0 => "Schizophrenia Polyunsaturated fatty acids Omega-3" 1 => "Treatment Supplementation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La teoría de la membrana fosfolípidica en torno a la etiopatogenia de la esquizofrenia sostiene que una deficiencia en la composición de ácidos grasos poliinsaturados (PUFA) de los lípidos en la membrana neuronal es un factor relevante en la fisiopatología de este trastorno. Diversos ensayos clínicos evalúan el papel terapéutico de la suplementación con PUFA omega-3 en la esquizofrenia. Una revisión sistemática de la literatura publicada identificó siete ensayos clínicos realizados en condiciones de doble ciego y control con placebo que evaluaron la eficacia de dicha suplementación. Los resultados de estos estudios son heterogéneos. Parte de los datos indica una eficacia moderada de la suplementación con ácido eicosapentaenoico en dosis de 2<span class="elsevierStyleHsp" style=""></span>g/día en pacientes con esquizofrenia establecida. Dos estudios se centraron en psicosis incipiente, con resultados alentadores a corto plazo. Sin embargo, los estudios que reclutaron mayor número de pacientes no advirtieron diferencias respecto a placebo.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The phospholipid membrane theory about the aetiopathogenesis of schizophrenia supports the idea that a deficiency in the polyunsaturated fatty acids (PUFA) of the lipids in the neuronal membrane is a significant factor in the pathophysiology of this disorder. Various clinical trials have evaluated the therapeutic role of omega-3 PUFA supplements in schizophrenia. A systematic review of the published literature was performed, identifying 7 double-blind, placebo controlled clinical trials that evaluated the efficacy of these supplements. The study results are heterogeneous. The data suggest that there is a moderate effect with supplements containing eicosapentaenoic acid in a dose of 2<span class="elsevierStyleHsp" style=""></span>g/day in patients with established schizophrenia. Two studies focused on incipient psychosis, with encouraging results in the short term. However, the studies that recruited a larger number of patients did not observe any differences compared to the placebo.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:54 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Leucht" 1 => "M. Tardy" 2 => "K. Komossa" 3 => "S. Heres" 4 => "W. Kissling" 5 => "G. Salanti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(12)60239-6" "Revista" => array:7 [ "tituloSerie" => "Lancet." "fecha" => "2012" "volumen" => "379" "paginaInicial" => "2063" "paginaFinal" => "2071" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22560607" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508508004551" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "[2]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pharmacological treatment of schizophrenia: a critical review of the pharmacology and clinical effects of current and future therapeutic agents" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Miyamoto" 1 => "N. Miyake" 2 => "L.F. Jarskog" 3 => "W.W. Fleischhacker" 4 => "J.A. 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Eficacia de los ácidos grasos omega-3 como tratamiento suplementario en la esquizofrenia
Efficacy of Omega-3 Fatty Acids as a Supplementary Treatment in Schizophrenia
Miquel Bioquea,b,
, Javier Gotib,c, Jorge Capapeya, Miguel Bernardoa,b,d,e
Autor para correspondencia
a Unidad de Esquizofrenia Clínic, Instituto Clínic de Neurociencias, Hospital Clínic de Barcelona, Barcelona, España
b Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), G04, España
c Servicio de Psiquiatría Infanto-Juvenil, Instituto Clínic de Neurociencias, Hospital Clínic de Barcelona, Barcelona, España
d Institut d’Investigació Biomèdica Agustí Pi Sunyer (IDIBAPS), Barcelona, España
e Universidad de Barcelona, Barcelona, España