Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la respuesta al tratamiento en pacientes con trastorno depresivo mayor

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(Cada punto corresponde a un artículo; e.e. de logOR=error estándar de log OR)." ] ] ] "textoCompleto" => "IntroducciónEl trastorno depresivo mayor (TDM) tiene una gran repercusión en la salud social, con unos costes tanto directos como indirectos considerables (<a class="elsevierStyleCrossRefs" href="#bib0115">Greenberg et al., 1993; Sartorius, 2001; Wittchen y Jacobi, 2005</a>). Aunque muchos de estos pacientes responderán al tratamiento, no todos los individuos obtienen un beneficio con él, y el 30-40% de los pacientes no alcanzan una respuesta completa (<a class="elsevierStyleCrossRefs" href="#bib0085">Fava y Davidson, 1996; Fava, 2003</a>). La predicción de la respuesta al tratamiento en pacientes con TDM ha generado un gran interés en el campo de la psicofarmacología.Hay varios factores que pueden contribuir a producir la variación interindividual en la respuesta al tratamiento antidepresivo: sexo, falta de adherencia del paciente, edad de inicio de la enfermedad, diagnóstico erróneo, tratamientos subóptimos, gravedad de la depresión, número de episodios previos, episodios depresivos mayores con manifestaciones psicóticas y presencia de diversas comorbilidades (trastornos de la personalidad, trastornos psiquiátricos, trastornos médicos generales y alteraciones estructurales cerebrales como la enfermedad de la sustancia blanca profunda) (<a class="elsevierStyleCrossRefs" href="#bib0310">Thase y Rush, 1997; Simpson et al., 1998; Souery et al., 1999; Nierenberg, 2003; Iosifescu et al., 2005</a>). Además, los factores genéticos pueden contribuir a producir la variación interindividual en la respuesta al tratamiento antidepresivo, puesto que en los estudios de familias se han descrito patrones de respuesta similares en diversos miembros de la misma familia (<a class="elsevierStyleCrossRefs" href="#bib0220">Pare et al., 1962; Sederer y Thorbeck, 1986; Franchini et al., 1998; Fava, 2000</a>). Así pues, la variación genética en genes que influyen en la atrofia neural y la neurogénesis puede contribuir a producir la variabilidad observada en el tratamiento antidepresivo.El factor neurotrófico de origen cerebral (BDNF), que forma parte de la superfamilia de la neurotropina, interviene de manera crucial en el crecimiento neuronal y en la plasticidad neuronal dependiente de la actividad (<a class="elsevierStyleCrossRef" href="#bib0100">Gartner y Staiger, 2002</a>). Teniendo en cuenta la hipótesis de plasticidad sináptica de los trastornos del estado de ánimo, se ha sugerido que el BDNF desempeña un papel fundamental en la etiología de los trastornos afectivos, así como en el mecanismo de la respuesta al tratamiento antidepresivo (<a class="elsevierStyleCrossRefs" href="#bib0020">Chen et al., 2001; Green y Craddock, 2003</a>). En consecuencia, el gen del BDNF es un candidato importante a tener en cuenta en el tratamiento con la medicación antidepresiva.El gen del BDNF humano se encuentra en el cromosoma 11p13 y está formado por 6 exones 5′ que se cortan y empalman de manera diferente para formar un único exón 3′ terminal (exón 7) que codifica toda la secuencia del BDNF maduro (GenBank acceso AF411339) (<a class="elsevierStyleCrossRef" href="#bib0170">Maisonpierre et al., 1990</a>). Se ha identificado un polimorfismo de nucleótido único (SNP) no sinónimo, funcional, que causa una sustitución aminoácida de valina a metionina en el codón 66 (Val66Met, rs6265) (<a class="elsevierStyleCrossRefs" href="#bib0325">Ventriglia et al., 2002; Egan et al., 2003</a>). La asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM ha sido investigada en múltiples estudios, pero los resultados no son siempre uniformes (<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al., 2003; Choi et al., 2006; Huuhka et al., 2007; Wilkie et al., 2007; Yoshida et al., 2007; Rajewska-Rager et al., 2008; Wu et al., 2008; Domschke et al., 2009; Kang et al., 2009; Licinio et al., 2009</a>). Hay varias explicaciones posibles para esta discordancia, como el pequeño tamaño muestral, los orígenes étnicos, los diferentes métodos de tratamiento antidepresivo, las diferencias en los tipos y dosis de fármacos antidepresivos empleados, los distintos subtipos de TDM, las diferencias en los métodos de evaluación y el sesgo de publicación.Un metaanálisis es un procedimiento estadístico para combinar los resultados de varios estudios con objeto de obtener una única estimación del efecto principal con una mayor precisión. Se considera un instrumento potente para resumir de forma combinada los resultados no uniformes de diferentes estudios (<a class="elsevierStyleCrossRef" href="#bib0195">Munafo y Flint, 2004</a>). Este método resultó útil también para evaluar la posible asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM. Un reciente metaanálisis evaluó la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM en 2008 (<a class="elsevierStyleCrossRef" href="#bib0145">Kato y Serretti, 2008</a>), y puso de manifiesto que se observaba una mejor respuesta en los individuos con la variante Met (4 estudios, 490 participantes, odds ratio (OR)=1,63, p=0,02). Sin embargo, este metaanálisis solamente presentó un fenotipo específico (tasa de respuesta) y el contraste de los genotipos Val/Met+Met/Met frente al Val/Val. Algunos estudios han sugerido que los pacientes heterocigotos y homocigotos presentan respuestas diferentes al tratamiento (<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al., 2003; Yoshida et al., 2007</a>). Así pues, no fue suficiente que el metaanálisis evaluara solamente el contraste de los genotipos Val/Met+Met/Met frente a Val/Val. Además, en el artículo la extracción de los datos del estudio de <a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al. (2007)</a> fue errónea, ya que se extrajeron los datos de la remisión pero no los datos de la respuesta necesarios para el análisis que realizaban. Por otra parte, después de marzo de 2008 se han publicado algunos otros artículos relacionados con la cuestión. Por consiguiente, es necesario llevar a cabo un metaanálisis exhaustivo para volver a evaluar la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM.Procedimientos experimentalesIdentificación de los estudios elegibles para la inclusiónSe seleccionaron cuidadosamente todos los estudios en los que se había examinado la asociación del polimorfismo BDNF Val66Met con la respuesta al tratamiento en pacientes con trastornos del estado de ánimo. Los datos se obtuvieron de las siguientes bases de datos electrónicas: Pubmed, Elsevier Science Direct, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), y Wanfang (chino); la última actualización se realizó hasta agosto de 2009. Se utilizaron para las búsquedas las siguientes palabras clave: («affective» or «depression» or «mood») and «treatment response» and («Brain-derived neurotrophic factor» or «BDNF»).Se incluyeron en el presente metaanálisis los estudios en los que se evaluó la asociación entre la respuesta al tratamiento y el polimorfismo BDNF Val66Met en pacientes con un diagnóstico de TDM según los criterios del Manual Diagnóstico y Estadístico de los Trastornos Mentales (DSM). Se excluyeron del análisis los estudios en los que el resultado no se evaluó mediante la tasa de respuesta o la tasa de remisión (respuesta definida como una disminución de al menos un 50% en la puntuación total de la Hamilton Rating Scale for Depression [HAM-D] o la Montgomery and Asberg Depression Rating Scale [MADRS]; remisión definida como una puntuación total final de la HAM-D de 7 o inferior). Se excluyeron del análisis los estudios cuyas muestras de pacientes estaban solapadas, y se incluyó únicamente el estudio que tenía un mayor número de pacientes. Cuando había datos que no se indicaban en el artículo, se contactó con los autores. Se examinó el equilibrio de Hardy-Weinberg en los estudios en los que se incluían las frecuencias de los genotipos.Además, se llevó a cabo una búsqueda independiente en Pubmed (realizada por Zou YF y Feng XL) con los mismos métodos. Se realizó una búsqueda independiente en Elsevier Science Direct (llevada a cabo por Feng XL y Pan FM) con los mismos métodos. Se efectuaron búsquedas independientes en CBM, CNKI y Wanfang (de las que se encargaron Liao FF y Su H) con los mismos métodos. El contenido de los resúmenes de los artículos fue revisado de manera independiente por 2 de los investigadores (Zou YF y Feng XL) con objeto de determinar si cumplían los criterios de elegibilidad para la inclusión. En caso de discrepancia, un tercer investigador (Ye DQ) realizó una evaluación adicional. Se revisaron las bibliografías de los estudios (de lo cual se encargó Pan FM) para identificar otros estudios adicionales.Extracción de los datosDos investigadores (Zou YF y Feng XL) extrajeron los datos de manera independiente, utilizando el protocolo estándar, y el resultado fue revisado por un tercer investigador (Ye DQ). Las discrepancias se resolvieron mediante un debate con nuestro equipo de investigación. Registramos los siguientes datos: nombre del primer autor, año de publicación, origen de la publicación, tipo de tratamientos, origen racial, tamaño muestral (varones/mujeres), media de edad de los participantes, criterios de inclusión, método de evaluación clínica, número de pacientes respondedores/no respondedores y de pacientes con remisión/sin remisión, e información disponible sobre frecuencia de genotipos y alelos respecto al polimorfismo BDNF Val66Met.Metodología de metaanálisisSe determinaron las frecuencias de alelos en el polimorfismo BDNF Val66Met a partir de los datos de cada estudio, con el método de recuento de alelos. Examinamos el contraste del efecto alélico de Met (alelo menor) frente a Val (alelo común) con modelos de efectos fijos y aleatorios. Al mismo tiempo, examinamos el contraste de los genotipos Val/Met+Met/Met frente a Val/Val, genotipos Met/Met frente a Val/Met+Val/Val, genotipos Met/Met frente a Val/Val, genotipos Val/Met frente a Val/Val, así como genotipos Met/Met frente a Val/Met, con modelos de efectos fijos y aleatorios. El contraste de los genotipos Val/Met+Met/Met frente a Val/Val corresponde a un efecto de genética dominante del alelo Met. El contraste de los genotipos Met/Met frente a Val/Met+Val/Val corresponde a un efecto de genética recesiva del alelo Met. Los otros 3 contrastes de genotipos evalúan la relación dosis-respuesta. Se estimaron, para cada estudio, las estimaciones puntuales del riesgo, la OR y su intervalo de confianza del 95% (IC del 95%). Evaluamos la variación o heterogeneidad intraestudio e interestudios con el estadístico Q de Cochran (<a class="elsevierStyleCrossRef" href="#bib0030">Cochran, 1954</a>). Esta prueba de heterogeneidad evaluaba la hipótesis nula de que todos los estudios estuvieran valorando el mismo efecto. Un valor significativo del estadístico Q (p<0,10) indicaba una heterogeneidad entre los diversos estudios, y por tanto se utilizaba el modelo de efectos aleatorios para el metaanálisis. En caso contrario, se empleaba el modelo de efectos fijos. El modelo de efectos fijos parte del supuesto de que todos los estudios están estimando el mismo efecto subyacente y considera únicamente la variación intraestudio. Cuantificamos también el efecto de la heterogeneidad con el empleo de otro parámetro, el valor de I2=100%×(Q−gl)/Q (<a class="elsevierStyleCrossRef" href="#bib0120">Higgins y Thompson, 2002</a>). El estadístico I2 mide el grado de inconsistencia en los estudios mediante el cálculo del porcentaje de la variación total en los diversos estudios que se debe a la heterogeneidad y no al azar.La estimación global o combinada del riesgo se obtuvo con el método de Mantel-Haenszel en el modelo de efectos fijos y con el método de DerSimonian y Laird en el modelo de efectos aleatorios (<a class="elsevierStyleCrossRefs" href="#bib0175">Mantel y Haenszel, 1959; DerSimonian y Laird, 1986</a>). La OR para los datos combinados en el metaanálisis se determinó ponderando las OR individuales con el inverso de su varianza. La significación de la OR combinada se determinó con la prueba de z.Evaluación del sesgo de publicaciónEl sesgo de publicación se investigó con el gráfico de embudo, en el que se representa el error estándar de log OR de cada estudio frente a su OR. La asimetría del gráfico de embudo se evaluó más detalladamente con el método de la prueba de regresión lineal de Egger (<a class="elsevierStyleCrossRef" href="#bib0070">Egger et al., 1997</a>). Los análisis se llevaron a cabo con el programa informático Review Manager 4.2 (Cochrane Collaboration, <a href="http://www.cc-ims.net/RevMan/relnotes.htm">http://www.cc-ims.net/RevMan/relnotes.htm</a>) y con el programa Stata versión 10 (StataCorp LP, College Station, Texas, EE.UU.). Todos los valores de p fueron bilaterales. Se consideró estadísticamente significativo un valor de p inferior a 0,05.ResultadosCaracterísticas de los estudios elegiblesIncluimos en nuestro metaanálisis 8 estudios (<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>). La búsqueda bibliográfica identificó un total de 577 estudios de posible relevancia (Pubmed: 203; Elsevier Science Direct: 304; CBM: 27; CNKI: 22; Wanfang: 21). Hubo 331 estudios potencialmente relevantes tras la eliminación de las publicaciones duplicadas. Excluimos 311 estudios, por las razones especificadas en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>, tras la revisión del resumen, y 20 estudios (<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al., 2003; Rybakowski et al., 2005; Choi et al., 2006; Lane et al., 2006; Masui et al., 2006; Michelon et al., 2006; Szczepankiewicz et al., 2007; Huuhka et al., 2007; Rybakowski et al., 2007; Wilkie et al., 2007; Yoshida et al., 2007; Bocchio-Chiavetto et al., 2008; Dmitrzak-Weglarz et al., 2008; Gratacòs et al., 2008; Rajewska-Rager et al., 2008; Wu et al., 2008; Domschke et al., 2009; Kang et al., 2009; Licinio et al., 2009; Real et al., 2009</a>) fueron evaluados de manera detallada. Tras esta evaluación excluimos 14 estudios (5 en el trastorno bipolar [<a class="elsevierStyleCrossRefs" href="#bib0255">Rybakowski et al., 2005; Masui et al., 2006; Michelon et al., 2006; Rybakowski et al., 2007; Dmitrzak-Weglarz et al., 2008</a>], uno en la esquizofrenia [<a class="elsevierStyleCrossRef" href="#bib0150">Lane et al., 2006</a>], uno en el trastorno obsesivo-compulsivo [<a class="elsevierStyleCrossRef" href="#bib0230">Real et al., 2009</a>], 2 que incluían casos con trastorno bipolar [<a class="elsevierStyleCrossRefs" href="#bib0015">Bocchio-Chiavetto et al., 2008; Gratacòs et al., 2008</a>], 3 que no utilizaron la respuesta o la remisión (<a class="elsevierStyleCrossRefs" href="#bib0125">Huuhka et al., 2007; Domschke et al., 2009; Licinio et al., 2009</a>], uno correspondiente a una presentación duplicada [<a class="elsevierStyleCrossRef" href="#bib0305">Szczepankiewicz et al., 2007</a>] y uno del que no se dispuso de datos [<a class="elsevierStyleCrossRef" href="#bib0225">Rajewska-Rager et al., 2008</a>]). Finalmente, 6 estudios (<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al., 2003; Choi et al., 2006; Wilkie et al., 2007; Yoshida et al., 2007; Wu et al., 2008; Kang et al., 2009</a>) se incluyeron en el presente metaanálisis.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia>Además, recientemente nuestro equipo de investigación ha explorado también la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM, y los datos se publicarán pronto en Neuropsychobiology. Estos datos se incluyeron también en el presente metaanálisis. Uno de los estudios elegibles incluía datos por separado de 2 grupos de pacientes diferentes (depresión unipolar y depresión de inicio temprano) y los tratamos de manera independiente (<a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al., 2007</a>). Así pues, consideramos para nuestro metaanálisis 8 estudios diferentes (<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>). Estos 8 estudios correspondían a 6 muestras en población asiática y 2 en población caucásica. Se extrajo de todos ellos la frecuencia de alelos y genotipos del polimorfismo BDNF Val66Met. Las distribuciones del genotipo Val66Met en los 8 estudios estaban en equilibrio de Hardy-Weinberg.Ocho estudios (6 asiáticos y 2 caucásicos) exploraron la asociación del polimorfismo BDNF Val66Met con la tasa de respuesta. Pero solamente 4 estudios (3 asiáticos y uno caucásico) exploraron la asociación del polimorfismo BDNF Val66Met con la tasa de remisión (<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>). Así pues, cuando evaluamos la asociación del polimorfismo BDNF Val66Met con la tasa de respuesta, el metaanálisis se llevó a cabo con el total de 8 estudios, con 6 estudios en pacientes asiáticos y con 2 estudios en pacientes caucásicos. Al evaluar la asociación del polimorfismo BDNF Val66Met con la de remisión, el metaanálisis se realizó con el total de 4 estudios y con 3 estudios en pacientes asiáticos.MetaanálisisAnálisis en la muestra totalMetaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de respuestaSe observó una asociación entre el polimorfismo BDNF Val66Met y la tasa de respuesta para la población global al examinar el contraste de los genotipos Val/Met frente a Val/Val (OR=1,66, IC del 95%=1,07-2,57, p=0,02), y el gráfico de Forest de la distribución de los valores de OR se muestra en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>a (<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 2</a>).<elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia>Sin embargo, no detectamos la asociación entre el polimorfismo BDNF Val66Met y la tasa de respuesta en la población global al examinar el contraste del alelo Met frente al alelo Val (OR=1,11, IC del 95%=0,92-1,34, p=0,30), los genotipos Val/Met+Met/Met frente a Val/Val (OR=1,51, IC del 95%=1,00-2,30, p=0,05), los genotipos Met/Met frente a Val/Met+Val/Val (OR=0,86, IC del 95%=0,62-1,18, p=0,35), los genotipos Met/Met frente a Val/Val (OR=1,09, IC del 95%=0,75-1,58, p=0,66), y los genotipos Met/Met frente a Val/Met (OR=0,71, IC del 95%=0,50-1,01, p=0,06).Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de remisiónNo detectamos la asociación entre el polimorfismo BDNF Val66Met y la tasa de remisión en la población global al examinar el contraste del alelo Met frente al alelo Val (OR=1,04, IC del 95%=0,82-1,31, p=0,75), los genotipos Val/Met+Met/Met frente a Val/Val (OR=1,24; IC del 95%=0,86-1,79, p=0,24), los genotipos Met/Met frente a Val/Met+Val/Val (OR=0,86, IC del 95%=0,56-1,27, p=0,42), los genotipos Met/Met frente a Val/Val (OR=0,99, IC del 95%, 0,60-1,61, p=0,96), los genotipos Val/Met frente a Val/Val (OR=1,36, IC del 95%=0,93-1,99, p=0,12), y los genotipos Met/Met frente a Val/Met (OR=0,76, IC del 95%=0,50-1,17, p=0,22) (<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>).<elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Análisis en pacientes asiáticosMetaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de respuesta (<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 2</a>)Se observó una asociación entre el polimorfismo BDNF Val66Met y la tasa de respuesta para la población asiática al examinar el contraste de los genotipos Val/Met frente a Val/Val (OR=1,83, IC del 95%=1,03-3,26, p=0,04), y el gráfico de Forest de la distribución de los valores de OR se muestra en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>b.Sin embargo, no detectamos la asociación entre el polimorfismo BDNF Val66Met y la tasa de respuesta en la población asiática al examinar el contraste del alelo Met frente al alelo Val (OR=1,18, IC del 95%=0,86-1,62, p=0,32), los genotipos Val/Met+Met/Met frente a Val/Val (OR=1,63, IC del 95%=0,95-2,79, p=0,08), los genotipos Met/Met frente a Val/Met+Val/Val (OR=0,87, IC del 95%=0,63-1,22, p=0,42), los genotipos Met/Met frente a Val/Val (OR=1,13, IC del 95%=0,76-1,66, p=0,55), y los genotipos Met/Met frente a Val/Met (OR=0,73, IC del 95%=0,51-1,04, p=0,08).Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de remisión (<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>)No detectamos la asociación entre el polimorfismo BDNF Val66Met y la tasa de remisión en la población asiática al examinar el contraste del alelo Met frente al alelo Val (OR=1,02, IC del 95%=0,79-1,31, p=0,89), los genotipos Val/Met+Met/Met frente a Val/Val (OR=1,21, IC del 95%=0,86-1,82, p=0,37), los genotipos Met/Met frente a Val/Met+Val/Val (OR=0,86, IC del 95%=0,57-1,30, p=0,46), los genotipos Met/Met frente a Val/Val (OR=1,01, IC del 95%=0,61-1,67, p=0,98), los genotipos Val/Met frente a Val/Val (OR=1,32, IC del 95%=0,86-2,03, p=0,21), y los genotipos Met/Met frente a Val/Met (OR=0,78, IC del 95%=0,51-1,21, p=0,27).Análisis en pacientes caucásicosNo detectamos la asociación entre el polimorfismo BDNF Val66Met y la tasa de respuesta en la población caucásica al examinar el contraste del alelo Met frente al alelo Val (OR=1,11, IC del 95%=0,64-1,91, p=0,72), los genotipos Val/Met+Met/Met frente a Val/Val (OR=1,22, IC del 95%=0,66-2,28, p=0,54), los genotipos Met/Met frente a Val/Met+Val/Val (OR=0,57, IC del 95%=0,12-2,74, p=0,48), los genotipos Met/Met frente a Val/Val (OR=0,63, IC del 95%=0,13-3,01, p=0,56), los genotipos Val/Met frente a Val/Val (OR=1,31, IC del 95%=0,68-2,51, p=0,42), y los genotipos Met/Met frente a Val/Met (OR=0,53, IC del 95%=0,17-1,71, p=0,29).Sin embargo, no evaluamos la asociación entre el polimorfismo BDNF Val66Met y la tasa de remisión en la población caucásica, ya que solamente uno de los estudios presentaba los datos de tasa de remisión.Evaluación del sesgo de publicaciónSe utilizó la prueba de regresión lineal de Egger para medir la asimetría del gráfico de embudo. Si hay una asimetría, de tal manera que los estudios más pequeños muestran unos efectos que difieren de forma sistemática de los de los estudios más grandes, la línea de regresión no pasará por el origen. La intersección a proporciona una medida de la asimetría (cuanto mayor es su desviación respecto al cero, más pronunciada es la asimetría). El resultado de la prueba de regresión lineal de Egger se muestra en la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>, y en la <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> se pone de relieve que no hay un sesgo de publicación para los metaanálisis estadísticamente significativos. Sin embargo, no se aplicó la prueba de Egger en algunas de las comparaciones debido al bajo número de estudios o la poca frecuencia del genotipo Met/Met (polimorfismo BDNF Val66Met y tasa de respuesta en la población caucásica: alelo Met frente a alelo Val, genotipos Val/Met+Met/Met frente a Val/Val, genotipos Met/Met frente a Val/Met+Val/Val, genotipos Met/Met frente a Val/Val, genotipos Val/Met frente a Val/Val, y genotipos Met/Met frente a Val/Met; polimorfismo BDNF Val66Met y tasa de remisión en la población asiática: genotipos Val/Met+Met/Met frente a Val/Val, genotipos Met/Met frente a Val/Val, y genotipos Val/Met frente a Val/Val).<elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia>DiscusiónEl TDM es un trastorno psiquiátrico frecuente, de etiología compleja, en el que intervienen probablemente múltiples genes, además de influencias no genéticas (<a class="elsevierStyleCrossRefs" href="#bib0005">Avissar y Schreiber, 2002; Baron, 2002</a>). El BDNF fomenta la supervivencia, diferenciación y mantenimiento de las neuronas en el desarrollo nervioso periférico y central, influye en el crecimiento axónico y la conectividad, y participa en las respuestas locales a diversos tipos de insultos o tensiones neuronales; y se ha evaluado su empleo como posible candidato en el TDM debido a sus múltiples funciones fisiológicas (<a class="elsevierStyleCrossRefs" href="#bib0135">Jeste et al., 1995; Ventimiglia et al., 1995; Nitta et al., 1999; Schumacher et al., 2005</a>). Los estudios realizados en modelos animales aportan un claro respaldo a la hipótesis de que el BDNF contribuye al tratamiento antidepresivo. La medicación antidepresiva aumenta la expresión y la señalización de BDNF en el hipocampo y la corteza (<a class="elsevierStyleCrossRefs" href="#bib0205">Nibuya et al., 1995; Russo-Neustadt et al., 2000; Saarelainen et al., 2003; Russo-Neustadt et al., 2004; Rogoz y Legutko, 2005</a>). La inyección de BDNF en el cerebro o la sobreexpresión de sus receptores en los ratones transgénicos produce unas respuestas conductuales similares a las que se observan habitualmente después del tratamiento con los fármacos antidepresivos (<a class="elsevierStyleCrossRefs" href="#bib0295">Siuciak et al., 1997; Shirayama et al., 2002</a>). Además, <a class="elsevierStyleCrossRef" href="#bib0190">Monteggia et al. (2007)</a> describieron que la pérdida de BDNF en regiones del prosencéfalo en ratones knockout para BDNF condicional atenúa la eficacia de los antidepresivos. En consecuencia, el gen del BDNF es un candidato importante en relación con el tratamiento antidepresivo.En este trabajo identificamos 8 estudios que incluían datos de 1.115 participantes para evaluar la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM. Nuestro metaanálisis detectó una asociación genética significativa entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM, y que los pacientes heterocigotos Val/Met tienen una tasa de respuesta mejor que la de los pacientes homocigotos Val/Val, sobre todo en la población asiática. En muchos estudios se ha sugerido una asociación entre la baja expresión de BDNF y los trastornos del estado de ánimo (<a class="elsevierStyleCrossRefs" href="#bib0060">Duman et al., 1997; Nestler et al., 2002; Lee et al., 2007</a>). En los animales sometidos al estrés de la natación forzada y la inmovilización crónica, los niveles de expresión de ARNm de BDNF se redujeron de forma significativa (<a class="elsevierStyleCrossRefs" href="#bib0245">Russo-Neustadt et al., 2001; Xu et al., 2002</a>). <a class="elsevierStyleCrossRef" href="#bib0165">Linnarsson et al. (1997)</a> indicaron que la baja expresión de BDNF puede causar un deterioro de la memoria. <a class="elsevierStyleCrossRef" href="#bib0065">Egan et al. (2003)</a> observaron también que el alelo Met se asociaba a una peor memoria episódica y a una disminución de la secreción de BDNF hipocámpica dependiente de la actividad. A la vista de estas observaciones, resulta difícil interpretar el presente resultado. Sin embargo, <a class="elsevierStyleCrossRef" href="#bib0090">Foltynie et al. (2005)</a> observaron que el alelo Met se asociaba a un mejor rendimiento en la tarea de la Torre de Londres (TOL) en la enfermedad de Parkinson. Se observó que la tarea de TOL aumentaba el flujo sanguíneo cerebral regional relativo en la corteza prefrontal dorsolateral, la corteza premotora lateral, la corteza del cíngulo anterior rostral y el núcleo caudado dorsal (<a class="elsevierStyleCrossRef" href="#bib0040">Dagher et al., 1999</a>). En consecuencia, es posible que los efectos funcionales del polimorfismo BDNF Val66Met difieran en las distintas áreas del cerebro y esta diferencia regional puede contribuir a producir el mejor efecto antidepresivo en los pacientes heterocigotos Val/Met. Otra posibilidad es que el polimorfismo pueda estar en desequilibrio de ligamiento con un polimorfismo funcional todavía no identificado, con un efecto heterótico molecular (<a class="elsevierStyleCrossRef" href="#bib0035">Comings y MacMurray, 2000</a>).Nuestro metaanálisis no observó la asociación entre el polimorfismo BDNF Val66Met y la tasa de remisión. La razón puede ser la falta de potencia estadística debido al bajo número de estudios. Además, el resultado del estudio de <a class="elsevierStyleCrossRef" href="#bib0140">Kang et al. (2009)</a> dentro de los estudios elegibles para el análisis es claramente un valor extremo fuera de los límites habituales. Una posible explicación de este valor extremo es que los mecanismos terapéuticos que subyacen en la acción de la mirtazapina sean diferentes de los de los inhibidores selectivos de la recaptación de serotonina (ISRS).Este metaanálisis tiene algunas limitaciones. En primer lugar, se detectó una heterogeneidad significativa entre los estudios en algunas de las comparaciones, y ello puede haber distorsionado el metaanálisis. Hay varias diferencias entre los estudios incluidos en el metaanálisis que es preciso comentar y que podrían explicar la heterogeneidad significativa que observamos en algunas comparaciones: diferentes tipos y dosis de fármacos antidepresivos, origen étnico, diferentes subtipos de TDM, así como diferentes duraciones de la evaluación. En segundo lugar, no pudimos elaborar un gráfico de embudo y realizar una prueba de Egger para cada metaanálisis debido al bajo número de estudios o a la baja frecuencia del genotipo Met/Met, y es posible que haya un sesgo de publicación. En tercer lugar, nuestro metaanálisis se basa en duraciones de la evaluación diferentes y en estimaciones sin ajustar, y podría hacerse un análisis más preciso si se dispusiera de los datos individuales. Por último, el metaanálisis continúa siendo una investigación retrospectiva que está sujeta a diferencias metodológicas entre los diversos estudios incluidos. Redujimos al mínimo la probabilidad de sesgo mediante el desarrollo de un protocolo detallado antes de iniciar el estudio, mediante la realización de una búsqueda meticulosa de estudios publicados, y con el empleo de métodos explícitos de selección de los estudios, extracción de los datos y análisis de estos.En conclusión, nuestro metaanálisis pone de manifiesto la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM, y que los pacientes heterocigotos para Val66Met presentan una tasa de respuesta mejor que la de los homocigotos Val/Val, especialmente en la población asiática. Para alcanzar una conclusión definitiva, continúan siendo necesarios nuevos estudios de interacción gen-gen y gen-entorno basados en un tamaño muestral más amplio y estratificadas según la etnicidad.FinanciaciónEste trabajo fue financiado con subvenciones de la National Natural Science Foundation of China (30830089).AutoríaZou YF ha redactado el protocolo del estudio, ha coordinado las actividades de investigación y ha contribuido sustancialmente al análisis y la interpretación de los datos.Ye DQ ha contribuido sustancialmente al diseño del estudio, la obtención de los datos y la coordinación general del estudio.Feng XL ha contribuido a la obtención de los datos, el análisis y las actividades de publicación coordinadas.Su H, Pan FM, Liao FF, han participado en el diseño del estudio y la obtención de los datos.Todos los autores han revisado críticamente el artículo y han aprobado el manuscrito antes de su presentación.Conflicto de interesesLos autores declaran no tener ningún conflicto de intereses.AgradecimientosDamos las gracias a todos aquellos que han colaborado en este estudio. Dispusimos de la amable ayuda del Dr. Min-Soo LEE, Dr. Bernhard T. Baune, Dra. Mònica Gratacòs, Dr. Gillian Smith, y Dra. Aleksandra Szczepankiewicz. En especial el Dr. Min-Soo LEE y la Dra. Mònica Gratacòs nos han proporcionado una explicación detallada de su investigación." "textoCompletoSecciones" => array:1 [ "secciones" => array:13 [ 0 => array:2 [ "identificador" => "xres123611" "titulo" => "Resumen" ] 1 => array:2 [ "identificador" => "xpalclavsec110890" "titulo" => "Palabras clave" ] 2 => array:2 [ "identificador" => "xres123612" "titulo" => "Abstract" ] 3 => array:2 [ "identificador" => "xpalclavsec110891" "titulo" => "Keywords" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introducción" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Procedimientos experimentales" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Identificación de los estudios elegibles para la inclusión" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Extracción de los datos" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Metodología de metaanálisis" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Evaluación del sesgo de publicación" ] ] ] 6 => array:3 [ "identificador" => "sec0035" "titulo" => "Resultados" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Características de los estudios elegibles" ] 1 => array:3 [ "identificador" => "sec0045" "titulo" => "Metaanálisis" "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0050" "titulo" => "Análisis en la muestra total" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de respuesta" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de remisión" ] ] ] 1 => array:3 [ "identificador" => "sec0065" "titulo" => "Análisis en pacientes asiáticos" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0070" "titulo" => "Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de respuesta (tabla 2)" ] 1 => array:2 [ "identificador" => "sec0075" "titulo" => "Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la tasa de remisión (tabla 3)" ] ] ] 2 => array:2 [ "identificador" => "sec0080" "titulo" => "Análisis en pacientes caucásicos" ] ] ] 2 => array:2 [ "identificador" => "sec0085" "titulo" => "Evaluación del sesgo de publicación" ] ] ] 7 => array:2 [ "identificador" => "sec0090" "titulo" => "Discusión" ] 8 => array:2 [ "identificador" => "sec0095" "titulo" => "Financiación" ] 9 => array:2 [ "identificador" => "sec0100" "titulo" => "Autoría" ] 10 => array:2 [ "identificador" => "sec0105" "titulo" => "Conflicto de intereses" ] 11 => array:2 [ "identificador" => "sec0110" "titulo" => "Agradecimientos" ] 12 => array:1 [ "titulo" => "Bibliografía" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec110890" "palabras" => array:5 [ 0 => "Trastorno depresivo mayor" 1 => "Factor neurotrófico de origen cerebral" 2 => "Polimorfismo" 3 => "Respuesta al tratamiento" 4 => "Metaanálisis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec110891" "palabras" => array:5 [ 0 => "Major depressive disorder" 1 => "Brain-derived neurotrophic factor" 2 => "Polymorphism" 3 => "Treatment response" 4 => "Meta-analysis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "El objetivo de nuestro metaanálisis fue evaluar la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con trastorno depresivo mayor (TDM). Se identificaron 8 estudios que incluían datos de 1.115 individuos. Estudiamos 2 fenotipos: tasa de respuesta y tasa de remisión. Se utilizó la OR como medida del efecto de la asociación en un modelo de efectos fijos/aleatorios. Se realizó un metaanálisis para los genotipos Met/Met frente a Val/Val, Val/Met frente a Val/Val, Met/Met frente a Val/Met, Val/Met+Met/Met frente a Val/Val, Met/Met frente a Val/Val+Val/Met, y alelo Met frente a alelo Val. Al combinar todos los grupos, se observó una asociación significativa del genotipo Val/Met con un aumento de la tasa de respuesta en comparación con el Val/Val en la población global (OR=1,66, IC del 95%=1,07-2,57, p=0,02). En el análisis de subgrupos se obtuvieron resultados similares para la población asiática (OR=1,83, IC del 95%, 1,03-3,26, p=0,04), pero no para la población caucásica. No observamos una asociación significativa del polimorfismo BDNF Val66Met con la tasa de remisión. Este metaanálisis pone de manifiesto la asociación entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM, y que los pacientes heterocigotos para Val66Met tienen una tasa de respuesta superior a la de los pacientes homocigotos Val/Val, especialmente en la población asiática." ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "The aim of our meta-analysis was to assess the association between BDNF Val66Met polymorphism and treatment response in patients with MDD. Eight studies that included data from 1115 subjects were identified. We tested two phenotypes: response rate and remission rate. OR was used as a measure of the effect of the association in a fixed/random effect model. Metaanalysis was performed for genotypes Met/Met versus Val/Val, Val/Met versus Val/Val, Met/Met versus Val/Met, Val/Met+Met/Met versus Val/Val, Met/Met versus Val/Val+Val/Met, and Met allele versus Val allele. When all groups were pooled, a significant association of Val/Met genotype and increased response rate was found in comparison to Val/Val in overall population (OR=1.66, 95%CI=1.07-2.57, P=.02). In the subgroup analysis, similar result was shown in Asian population (OR=1.83, 95%CI=1.03-3.26, P=.04), but not in Caucasian population. We didn’t observe a significant association of BDNF Val66Met polymorphism with remission rate. This meta-analysis demonstrates the association between BDNF Val66Met polymorphism and treatment response in patients with MDD, and Val66Met heterozygous patients have a better response rate in comparison to Val/Val homozygote patients, especially in Asian population." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Este artículo ha sido previamente publicado en European Neuropsychopharmacology. 2010;20:535-44." ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2092 "Ancho" => 2474 "Tamanyo" => 331903 ] ] "descripcion" => array:1 [ "es" => "Diagrama de flujo del proceso de selección de los estudios." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 2094 "Ancho" => 3132 "Tamanyo" => 528329 ] ] "descripcion" => array:1 [ "es" => "Gráficos de Forest para los metaanálisis estadísticamente significativos." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figura 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1935 "Ancho" => 2503 "Tamanyo" => 265668 ] ] "descripcion" => array:1 [ "es" => "Gráficos de embudo y gráficos de sesgo de publicación de Egger para los metaanálisis estadísticamente significativos. (Cada punto corresponde a un artículo; e.e. de logOR=error estándar de log OR)." ] ] 3 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Tabla 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "ATC: antidepresivos tricíclicos; IMAO: inhibidor de monoaminooxidasa; ISRN: inhibidor selectivo de recaptación de noradrenalina; ISRS: inhibidor selectivo de la recaptación de serotonina; N: número; ND: no disponible; sem: semana." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Referencia (año) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Tipo de tratamientos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">N (varones/mujeres) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Media de edad (años) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Origen étnico \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Evaluación \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Datos de evaluación seleccionados en el metaanálisis \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0140">Kang et al. (2009)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mirtazapina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">197 (ND) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 1, 2, 4, 8 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 8 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de remisión: 1, 2, 4, 8 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de remisión: 8 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0340">Wu et al. (2008)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Paroxetina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">63 (0/63) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44,6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 4 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 4 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0350">Yoshida et al. (2007)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Milnaciprán \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">134 (50/84) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 1, 2, 4, 6 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 6 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluvoxamina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de remisión: 1, 2, 4, 6 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al. (2007)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ISRS, ATC, IMAO, IRSN, Mirtazapina, Nefazadona, Trazadona \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">163 (ND) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucásicos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tratamiento inicial:Tasa de respuesta: ≥ 6 semTasa de remisión: ≥ 6 semSegundo cambio de tratamiento:Tasa de respuesta: ≥ 6 semTasa de remisión: ≥ 6 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tratamiento inicial:Tasa de respuesta: ≥ 6 semTasa de remisión: ≥ 6 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al. (2007)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ISRS, ATC, IMAO, IRSN, Mirtazapina, Nefazadona, Trazadona \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70 (ND) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ND \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucásicos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 12 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 12 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0025">Choi et al. (2006)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Citalopram \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">83 (24/59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 1, 2, 4, 8 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 8 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0315">Tsai et al. (2003)</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluoxetina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">152 (67/85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45,3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 4 semTasa de remisión: 4 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 4 semTasa de remisión: 4 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Zou et al. (no publicado) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fluoxetina \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">295 (139/156) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34,8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 1, 2, 4, 6 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta: 6 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de remisión: 1, 2, 4, 6 sem \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de remisión: 6 sem \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab210964.png" ] ] ] ] "descripcion" => array:1 [ "es" => "Características de los estudios que investigan la asociación entre respuesta al tratamiento y polimorfismo BDNF Val66Met en pacientes con trastorno depresivo mayor (TDM)" ] ] 4 => array:7 [ "identificador" => "tbl0025" "etiqueta" => "Tabla 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "vs: versus." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comparisons \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Sample size</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No. of studies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Test of association</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Test of heterogeneity</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Responder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-responder \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Fixed model</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Random model</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">χ2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">P-value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I2 (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (95%CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Z \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">P-value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (95%CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Z \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">P-value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met vs Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1350 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">880 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.11 (0.92-1.34) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.30 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.15 (0.99-1.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1118 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">646 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.11 (0.90-1.35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.18 (0.86-1.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">232 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">234 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.11 (0.64-1.91) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.09 (0.62-1.90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Val/Met+Met/Met vs Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">675 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">440 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.39 (1.05-1.84) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.51 (1.00-2.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">559 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">323 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.44 (1.05-1.96) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.63 (0.95-2.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">116 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">117 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.22 (0.66-2.28) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.21 (0.64-2.28) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met/Met vs Val/Val+Val/Met \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">675 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">440 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.86 (0.62-1.18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 (0.61-1.19) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">559 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">323 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.87 (0.63-1.22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.87 (0.60-1.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">116 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">117 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.57 (0.12-2.74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58 (0.10-3.41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met/Met vs Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">351 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">276 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.09 (0.75-1.58) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.11 (0.69-1.80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.66 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">270 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">186 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.13 (0.76-1.66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.18 (0.69-2.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.63 (0.13-3.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.64 (0.11-3.74) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Val/Met vs Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">544 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">352 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.54 (1.14-2.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.66 (1.07-2.57) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">432 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">240 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.61 (1.15-2.24) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.83 (1.03-3.26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12.83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">112 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">112 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.31 (0.68-2.51) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.80 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.30 (0.68-2.51) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met/Met vs Val/Met \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">455 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">252 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.71(0.50-1.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.71 (0.50-1.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.86 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">416 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">220 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.73 (0.51-1.04) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.71 (0.47-1.07) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">77 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.53 (0.17-1.71) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.55 (0.16-1.88) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab210963.png" ] ] ] ] "descripcion" => array:1 [ "es" => "Meta-analysis of BDNF Val66Met polymorphism and response rate association" ] ] 5 => array:7 [ "identificador" => "tbl0015" "etiqueta" => "Tabla 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "vs: versus." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comparisons \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Sample size</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No. of studies \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="6" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Test of association</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Test of heterogeneity</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Remitter \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-remitter \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Fixed model</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Random model</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">χ2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">P-value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I2 (%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (95%CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Z \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">P-value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">OR (95%CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Z \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">P-value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met vs Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">498 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1032 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.04 (0.82-1.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.04 (0.82-1.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">420 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">784 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.02 (0.79-1.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.02 (0.79-1.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.89 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Val/Met+Met/Met vs Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">249 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">516 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.24 (0.86-1.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.23 (0.86-1.77) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.26 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">210 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">392 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.21 (0.80-1.82) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.19 (0.79-1.80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met/Met vs Val/Val+Val/Met \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">249 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">516 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.86 (0.56-1.27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 (0.57-1.27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">210 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">392 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.86 (0.57-1.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.86 (0.57-1.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.69 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met/Met vs Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">124 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">302 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.99 (0.60-1.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.99 (0.60-1.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">206 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.01 (0.61-1.67) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 (0.60-1.67) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.79 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Val/Met vs Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">200 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">408 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.36 (0.93-1.99) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.34 (0.89-2.01) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.41 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.36 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">162 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">289 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.32 (0.86-2.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.27 (0.67-2.40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.73 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Met/Met vs Val/Met \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Overall \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">174 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">322 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.76 (0.50-1.17) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.77 (0.50-1.18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.54 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">161 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">289 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.78 (0.51-1.21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.78 (0.51-1.21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab210962.png" ] ] ] ] "descripcion" => array:1 [ "es" => "Meta-analysis of BDNF Val66Met polymorphism and remission rate association" ] ] 6 => array:7 [ "identificador" => "tbl0020" "etiqueta" => "Tabla 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Todos los valores de p>0,05.NA: no aplicable." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asociación \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="6" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Intersección con eje Y:a (IC del 95%)</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Met frente a Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Val/Met+Met/Met frente a Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Met/Met frente a Val/Val+Val/Met \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Met/Met frente a Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Val/Met frente a Val/Val \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Met/Met frente a Val/Met \t\t\t\t\t\t\n \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de respuesta</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Global \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,39 (−0,43-5,21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,94 (−0,96-6,85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0,03 (−3,06-3,00) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,94 (−2,95-4,84) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,76 (−1,16-6,68) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1,00 (−3,78-1,77) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,68 (−0,92-8,29) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4,10 (−2,06-10,26) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,91 (−3,50-5,33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2,87 (−1,71-7,47) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3,92 (−1,95-9,80) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0,84 (−5,14-3,41) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Caucásicos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="7" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tasa de remisión</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Global \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,85 (−0,62-2,32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−1,88 (−50,88-47,12) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0,05 (−2,77-2,66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0,49 (−3,06-2,06) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−3,03 (−65,31-59,23) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0,32 (−4,68-4,02) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asiáticos \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,75 (−5,70-7,22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0,24 (−14,21-14,71) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−0,04 (−24,39-24,30) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab210961.png" ] ] ] ] "descripcion" => array:1 [ "es" => "Prueba de regresión lineal de Egger para medir la asimetría del gráfico de embudo" ] ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:70 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "Avissar y Schreiber, 2002" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Toward molecular diagnostics of mood disorders in psychiatry" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Avissar" 1 => "G. Schreiber" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Trends. Mol. Med." "fecha" => "2002" "volumen" => "8" "paginaInicial" => "294" "paginaFinal" => "300" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12067616" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "Baron, 2002" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manic-depression genes and the new millennium: poised for discovery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Baron" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.mp.4000998" "Revista" => array:6 [ "tituloSerie" => "Mol. 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Metaanálisis de la asociación del polimorfismo BDNF Val66Met con la respuesta al tratamiento en pacientes con trastorno depresivo mayor

Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder

Yan-Feng Zou, Dong-Qing Ye

Autor para correspondencia

ydq@ahmu.edu.cn

Autor para correspondencia.

, Xiao-Liang Feng, Hong Su, Fa-Ming Pan, Fang-Fang Liao

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

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          "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;ficos de embudo y gr&#225;ficos de sesgo de publicaci&#243;n de Egger para los metaan&#225;lisis estad&#237;sticamente significativos&#46; &#40;Cada punto corresponde a un art&#237;culo&#59; e&#46;e&#46; de logOR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>error est&#225;ndar de log OR&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El trastorno depresivo mayor &#40;TDM&#41; tiene una gran repercusi&#243;n en la salud social&#44; con unos costes tanto directos como indirectos considerables &#40;<a class="elsevierStyleCrossRefs" href="#bib0115">Greenberg et al&#46;&#44; 1993&#59; Sartorius&#44; 2001&#59; Wittchen y Jacobi&#44; 2005</a>&#41;&#46; Aunque muchos de estos pacientes responder&#225;n al tratamiento&#44; no todos los individuos obtienen un beneficio con &#233;l&#44; y el 30-40&#37; de los pacientes no alcanzan una respuesta completa &#40;<a class="elsevierStyleCrossRefs" href="#bib0085">Fava y Davidson&#44; 1996&#59; Fava&#44; 2003</a>&#41;&#46; La predicci&#243;n de la respuesta al tratamiento en pacientes con TDM ha generado un gran inter&#233;s en el campo de la psicofarmacolog&#237;a&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Hay varios factores que pueden contribuir a producir la variaci&#243;n interindividual en la respuesta al tratamiento antidepresivo&#58; sexo&#44; falta de adherencia del paciente&#44; edad de inicio de la enfermedad&#44; diagn&#243;stico err&#243;neo&#44; tratamientos sub&#243;ptimos&#44; gravedad de la depresi&#243;n&#44; n&#250;mero de episodios previos&#44; episodios depresivos mayores con manifestaciones psic&#243;ticas y presencia de diversas comorbilidades &#40;trastornos de la personalidad&#44; trastornos psiqui&#225;tricos&#44; trastornos m&#233;dicos generales y alteraciones estructurales cerebrales como la enfermedad de la sustancia blanca profunda&#41; &#40;<a class="elsevierStyleCrossRefs" href="#bib0310">Thase y Rush&#44; 1997&#59; Simpson et al&#46;&#44; 1998&#59; Souery et al&#46;&#44; 1999&#59; Nierenberg&#44; 2003&#59; Iosifescu et al&#46;&#44; 2005</a>&#41;&#46; Adem&#225;s&#44; los factores gen&#233;ticos pueden contribuir a producir la variaci&#243;n interindividual en la respuesta al tratamiento antidepresivo&#44; puesto que en los estudios de familias se han descrito patrones de respuesta similares en diversos miembros de la misma familia &#40;<a class="elsevierStyleCrossRefs" href="#bib0220">Pare et al&#46;&#44; 1962&#59; Sederer y Thorbeck&#44; 1986&#59; Franchini et al&#46;&#44; 1998&#59; Fava&#44; 2000</a>&#41;&#46; As&#237; pues&#44; la variaci&#243;n gen&#233;tica en genes que influyen en la atrofia neural y la neurog&#233;nesis puede contribuir a producir la variabilidad observada en el tratamiento antidepresivo&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">El factor neurotr&#243;fico de origen cerebral &#40;BDNF&#41;&#44; que forma parte de la superfamilia de la neurotropina&#44; interviene de manera crucial en el crecimiento neuronal y en la plasticidad neuronal dependiente de la actividad &#40;<a class="elsevierStyleCrossRef" href="#bib0100">Gartner y Staiger&#44; 2002</a>&#41;&#46; Teniendo en cuenta la hip&#243;tesis de plasticidad sin&#225;ptica de los trastornos del estado de &#225;nimo&#44; se ha sugerido que el BDNF desempe&#241;a un papel fundamental en la etiolog&#237;a de los trastornos afectivos&#44; as&#237; como en el mecanismo de la respuesta al tratamiento antidepresivo &#40;<a class="elsevierStyleCrossRefs" href="#bib0020">Chen et al&#46;&#44; 2001&#59; Green y Craddock&#44; 2003</a>&#41;&#46; En consecuencia&#44; el gen del BDNF es un candidato importante a tener en cuenta en el tratamiento con la medicaci&#243;n antidepresiva&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El gen del BDNF humano se encuentra en el cromosoma 11p13 y est&#225; formado por 6 exones 5&#8242; que se cortan y empalman de manera diferente para formar un &#250;nico ex&#243;n 3&#8242; terminal &#40;ex&#243;n 7&#41; que codifica toda la secuencia del BDNF maduro &#40;GenBank acceso AF411339&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib0170">Maisonpierre et al&#46;&#44; 1990</a>&#41;&#46; Se ha identificado un polimorfismo de nucle&#243;tido &#250;nico &#40;SNP&#41; no sin&#243;nimo&#44; funcional&#44; que causa una sustituci&#243;n amino&#225;cida de valina a metionina en el cod&#243;n 66 &#40;Val66Met&#44; rs6265&#41; &#40;<a class="elsevierStyleCrossRefs" href="#bib0325">Ventriglia et al&#46;&#44; 2002&#59; Egan et al&#46;&#44; 2003</a>&#41;&#46; La asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM ha sido investigada en m&#250;ltiples estudios&#44; pero los resultados no son siempre uniformes &#40;<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al&#46;&#44; 2003&#59; Choi et al&#46;&#44; 2006&#59; Huuhka et al&#46;&#44; 2007&#59; Wilkie et al&#46;&#44; 2007&#59; Yoshida et al&#46;&#44; 2007&#59; Rajewska-Rager et al&#46;&#44; 2008&#59; Wu et al&#46;&#44; 2008&#59; Domschke et al&#46;&#44; 2009&#59; Kang et al&#46;&#44; 2009&#59; Licinio et al&#46;&#44; 2009</a>&#41;&#46; Hay varias explicaciones posibles para esta discordancia&#44; como el peque&#241;o tama&#241;o muestral&#44; los or&#237;genes &#233;tnicos&#44; los diferentes m&#233;todos de tratamiento antidepresivo&#44; las diferencias en los tipos y dosis de f&#225;rmacos antidepresivos empleados&#44; los distintos subtipos de TDM&#44; las diferencias en los m&#233;todos de evaluaci&#243;n y el sesgo de publicaci&#243;n&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Un metaan&#225;lisis es un procedimiento estad&#237;stico para combinar los resultados de varios estudios con objeto de obtener una &#250;nica estimaci&#243;n del efecto principal con una mayor precisi&#243;n&#46; Se considera un instrumento potente para resumir de forma combinada los resultados no uniformes de diferentes estudios &#40;<a class="elsevierStyleCrossRef" href="#bib0195">Munafo y Flint&#44; 2004</a>&#41;&#46; Este m&#233;todo result&#243; &#250;til tambi&#233;n para evaluar la posible asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#46; Un reciente metaan&#225;lisis evalu&#243; la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM en 2008 &#40;<a class="elsevierStyleCrossRef" href="#bib0145">Kato y Serretti&#44; 2008</a>&#41;&#44; y puso de manifiesto que se observaba una mejor respuesta en los individuos con la variante Met &#40;4 estudios&#44; 490 participantes&#44; <span class="elsevierStyleItalic">odds ratio</span> &#40;OR&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;63&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; Sin embargo&#44; este metaan&#225;lisis solamente present&#243; un fenotipo espec&#237;fico &#40;tasa de respuesta&#41; y el contraste de los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente al Val&#47;Val&#46; Algunos estudios han sugerido que los pacientes heterocigotos y homocigotos presentan respuestas diferentes al tratamiento &#40;<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al&#46;&#44; 2003&#59; Yoshida et al&#46;&#44; 2007</a>&#41;&#46; As&#237; pues&#44; no fue suficiente que el metaan&#225;lisis evaluara solamente el contraste de los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val&#46; Adem&#225;s&#44; en el art&#237;culo la extracci&#243;n de los datos del estudio de <a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al&#46; &#40;2007&#41;</a> fue err&#243;nea&#44; ya que se extrajeron los datos de la remisi&#243;n pero no los datos de la respuesta necesarios para el an&#225;lisis que realizaban&#46; Por otra parte&#44; despu&#233;s de marzo de 2008 se han publicado algunos otros art&#237;culos relacionados con la cuesti&#243;n&#46; Por consiguiente&#44; es necesario llevar a cabo un metaan&#225;lisis exhaustivo para volver a evaluar la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Procedimientos experimentales</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Identificaci&#243;n de los estudios elegibles para la inclusi&#243;n</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se seleccionaron cuidadosamente todos los estudios en los que se hab&#237;a examinado la asociaci&#243;n del polimorfismo BDNF Val66Met con la respuesta al tratamiento en pacientes con trastornos del estado de &#225;nimo&#46; Los datos se obtuvieron de las siguientes bases de datos electr&#243;nicas&#58; Pubmed&#44; Elsevier Science Direct&#44; Chinese Biomedical Literature Database &#40;CBM&#41;&#44; Chinese National Knowledge Infrastructure &#40;CNKI&#41;&#44; y Wanfang &#40;chino&#41;&#59; la &#250;ltima actualizaci&#243;n se realiz&#243; hasta agosto de 2009&#46; Se utilizaron para las b&#250;squedas las siguientes palabras clave&#58; &#40;&#171;affective&#187; or &#171;depression&#187; or &#171;mood&#187;&#41; and &#171;treatment response&#187; and &#40;&#171;Brain-derived neurotrophic factor&#187; or &#171;BDNF&#187;&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Se incluyeron en el presente metaan&#225;lisis los estudios en los que se evalu&#243; la asociaci&#243;n entre la respuesta al tratamiento y el polimorfismo BDNF Val66Met en pacientes con un diagn&#243;stico de TDM seg&#250;n los criterios del Manual Diagn&#243;stico y Estad&#237;stico de los Trastornos Mentales &#40;DSM&#41;&#46; Se excluyeron del an&#225;lisis los estudios en los que el resultado no se evalu&#243; mediante la tasa de respuesta o la tasa de remisi&#243;n &#40;respuesta definida como una disminuci&#243;n de al menos un 50&#37; en la puntuaci&#243;n total de la <span class="elsevierStyleItalic">Hamilton Rating Scale for Depression</span> &#91;HAM-D&#93; o la <span class="elsevierStyleItalic">Montgomery and Asberg Depression Rating Scale</span> &#91;MADRS&#93;&#59; remisi&#243;n definida como una puntuaci&#243;n total final de la HAM-D de 7 o inferior&#41;&#46; Se excluyeron del an&#225;lisis los estudios cuyas muestras de pacientes estaban solapadas&#44; y se incluy&#243; &#250;nicamente el estudio que ten&#237;a un mayor n&#250;mero de pacientes&#46; Cuando hab&#237;a datos que no se indicaban en el art&#237;culo&#44; se contact&#243; con los autores&#46; Se examin&#243; el equilibrio de Hardy-Weinberg en los estudios en los que se inclu&#237;an las frecuencias de los genotipos&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; se llev&#243; a cabo una b&#250;squeda independiente en Pubmed &#40;realizada por Zou YF y Feng XL&#41; con los mismos m&#233;todos&#46; Se realiz&#243; una b&#250;squeda independiente en Elsevier Science Direct &#40;llevada a cabo por Feng XL y Pan FM&#41; con los mismos m&#233;todos&#46; Se efectuaron b&#250;squedas independientes en CBM&#44; CNKI y Wanfang &#40;de las que se encargaron Liao FF y Su H&#41; con los mismos m&#233;todos&#46; El contenido de los res&#250;menes de los art&#237;culos fue revisado de manera independiente por 2 de los investigadores &#40;Zou YF y Feng XL&#41; con objeto de determinar si cumpl&#237;an los criterios de elegibilidad para la inclusi&#243;n&#46; En caso de discrepancia&#44; un tercer investigador &#40;Ye DQ&#41; realiz&#243; una evaluaci&#243;n adicional&#46; Se revisaron las bibliograf&#237;as de los estudios &#40;de lo cual se encarg&#243; Pan FM&#41; para identificar otros estudios adicionales&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Extracci&#243;n de los datos</span><p id="par0045" class="elsevierStylePara elsevierViewall">Dos investigadores &#40;Zou YF y Feng XL&#41; extrajeron los datos de manera independiente&#44; utilizando el protocolo est&#225;ndar&#44; y el resultado fue revisado por un tercer investigador &#40;Ye DQ&#41;&#46; Las discrepancias se resolvieron mediante un debate con nuestro equipo de investigaci&#243;n&#46; Registramos los siguientes datos&#58; nombre del primer autor&#44; a&#241;o de publicaci&#243;n&#44; origen de la publicaci&#243;n&#44; tipo de tratamientos&#44; origen racial&#44; tama&#241;o muestral &#40;varones&#47;mujeres&#41;&#44; media de edad de los participantes&#44; criterios de inclusi&#243;n&#44; m&#233;todo de evaluaci&#243;n cl&#237;nica&#44; n&#250;mero de pacientes respondedores&#47;no respondedores y de pacientes con remisi&#243;n&#47;sin remisi&#243;n&#44; e informaci&#243;n disponible sobre frecuencia de genotipos y alelos respecto al polimorfismo BDNF Val66Met&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metodolog&#237;a de metaan&#225;lisis</span><p id="par0050" class="elsevierStylePara elsevierViewall">Se determinaron las frecuencias de alelos en el polimorfismo BDNF Val66Met a partir de los datos de cada estudio&#44; con el m&#233;todo de recuento de alelos&#46; Examinamos el contraste del efecto al&#233;lico de Met &#40;alelo menor&#41; frente a Val &#40;alelo com&#250;n&#41; con modelos de efectos fijos y aleatorios&#46; Al mismo tiempo&#44; examinamos el contraste de los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val&#44; genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val&#44; genotipos Met&#47;Met frente a Val&#47;Val&#44; genotipos Val&#47;Met frente a Val&#47;Val&#44; as&#237; como genotipos Met&#47;Met frente a Val&#47;Met&#44; con modelos de efectos fijos y aleatorios&#46; El contraste de los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val corresponde a un efecto de gen&#233;tica dominante del alelo Met&#46; El contraste de los genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val corresponde a un efecto de gen&#233;tica recesiva del alelo Met&#46; Los otros 3 contrastes de genotipos eval&#250;an la relaci&#243;n dosis-respuesta&#46; Se estimaron&#44; para cada estudio&#44; las estimaciones puntuales del riesgo&#44; la OR y su intervalo de confianza del 95&#37; &#40;IC del 95&#37;&#41;&#46; Evaluamos la variaci&#243;n o heterogeneidad intraestudio e interestudios con el estad&#237;stico Q de Cochran &#40;<a class="elsevierStyleCrossRef" href="#bib0030">Cochran&#44; 1954</a>&#41;&#46; Esta prueba de heterogeneidad evaluaba la hip&#243;tesis nula de que todos los estudios estuvieran valorando el mismo efecto&#46; Un valor significativo del estad&#237;stico Q &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;10&#41; indicaba una heterogeneidad entre los diversos estudios&#44; y por tanto se utilizaba el modelo de efectos aleatorios para el metaan&#225;lisis&#46; En caso contrario&#44; se empleaba el modelo de efectos fijos&#46; El modelo de efectos fijos parte del supuesto de que todos los estudios est&#225;n estimando el mismo efecto subyacente y considera &#250;nicamente la variaci&#243;n intraestudio&#46; Cuantificamos tambi&#233;n el efecto de la heterogeneidad con el empleo de otro par&#225;metro&#44; el valor de I<span class="elsevierStyleSup">2</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>100&#37;<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>&#40;Q<span class="elsevierStyleHsp" style=""></span>&#8722;<span class="elsevierStyleHsp" style=""></span>gl&#41;&#47;Q &#40;<a class="elsevierStyleCrossRef" href="#bib0120">Higgins y Thompson&#44; 2002</a>&#41;&#46; El estad&#237;stico I<span class="elsevierStyleSup">2</span> mide el grado de inconsistencia en los estudios mediante el c&#225;lculo del porcentaje de la variaci&#243;n total en los diversos estudios que se debe a la heterogeneidad y no al azar&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">La estimaci&#243;n global o combinada del riesgo se obtuvo con el m&#233;todo de Mantel-Haenszel en el modelo de efectos fijos y con el m&#233;todo de DerSimonian y Laird en el modelo de efectos aleatorios &#40;<a class="elsevierStyleCrossRefs" href="#bib0175">Mantel y Haenszel&#44; 1959&#59; DerSimonian y Laird&#44; 1986</a>&#41;&#46; La OR para los datos combinados en el metaan&#225;lisis se determin&#243; ponderando las OR individuales con el inverso de su varianza&#46; La significaci&#243;n de la OR combinada se determin&#243; con la prueba de z&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Evaluaci&#243;n del sesgo de publicaci&#243;n</span><p id="par0060" class="elsevierStylePara elsevierViewall">El sesgo de publicaci&#243;n se investig&#243; con el gr&#225;fico de embudo&#44; en el que se representa el error est&#225;ndar de log OR de cada estudio frente a su OR&#46; La asimetr&#237;a del gr&#225;fico de embudo se evalu&#243; m&#225;s detalladamente con el m&#233;todo de la prueba de regresi&#243;n lineal de Egger &#40;<a class="elsevierStyleCrossRef" href="#bib0070">Egger et al&#46;&#44; 1997</a>&#41;&#46; Los an&#225;lisis se llevaron a cabo con el programa inform&#225;tico Review Manager 4&#46;2 &#40;Cochrane Collaboration&#44; <a href="http://www.cc-ims.net/RevMan/relnotes.htm">http&#58;&#47;&#47;www&#46;cc-ims&#46;net&#47;RevMan&#47;relnotes&#46;htm</a>&#41; y con el programa Stata versi&#243;n 10 &#40;StataCorp LP&#44; College Station&#44; Texas&#44; EE&#46;<span class="elsevierStyleHsp" style=""></span>UU&#46;&#41;&#46; Todos los valores de p fueron bilaterales&#46; Se consider&#243; estad&#237;sticamente significativo un valor de p inferior a 0&#44;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Resultados</span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Caracter&#237;sticas de los estudios elegibles</span><p id="par0065" class="elsevierStylePara elsevierViewall">Incluimos en nuestro metaan&#225;lisis 8 estudios &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; La b&#250;squeda bibliogr&#225;fica identific&#243; un total de 577 estudios de posible relevancia &#40;Pubmed&#58; 203&#59; Elsevier Science Direct&#58; 304&#59; CBM&#58; 27&#59; CNKI&#58; 22&#59; Wanfang&#58; 21&#41;&#46; Hubo 331 estudios potencialmente relevantes tras la eliminaci&#243;n de las publicaciones duplicadas&#46; Excluimos 311 estudios&#44; por las razones especificadas en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#44; tras la revisi&#243;n del resumen&#44; y 20 estudios &#40;<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al&#46;&#44; 2003&#59; Rybakowski et al&#46;&#44; 2005&#59; Choi et al&#46;&#44; 2006&#59; Lane et al&#46;&#44; 2006&#59; Masui et al&#46;&#44; 2006&#59; Michelon et al&#46;&#44; 2006&#59; Szczepankiewicz et al&#46;&#44; 2007&#59; Huuhka et al&#46;&#44; 2007&#59; Rybakowski et al&#46;&#44; 2007&#59; Wilkie et al&#46;&#44; 2007&#59; Yoshida et al&#46;&#44; 2007&#59; Bocchio-Chiavetto et al&#46;&#44; 2008&#59; Dmitrzak-Weglarz et al&#46;&#44; 2008&#59; Gratac&#242;s et al&#46;&#44; 2008&#59; Rajewska-Rager et al&#46;&#44; 2008&#59; Wu et al&#46;&#44; 2008&#59; Domschke et al&#46;&#44; 2009&#59; Kang et al&#46;&#44; 2009&#59; Licinio et al&#46;&#44; 2009&#59; Real et al&#46;&#44; 2009</a>&#41; fueron evaluados de manera detallada&#46; Tras esta evaluaci&#243;n excluimos 14 estudios &#40;5 en el trastorno bipolar &#91;<a class="elsevierStyleCrossRefs" href="#bib0255">Rybakowski et al&#46;&#44; 2005&#59; Masui et al&#46;&#44; 2006&#59; Michelon et al&#46;&#44; 2006&#59; Rybakowski et al&#46;&#44; 2007&#59; Dmitrzak-Weglarz et al&#46;&#44; 2008</a>&#93;&#44; uno en la esquizofrenia &#91;<a class="elsevierStyleCrossRef" href="#bib0150">Lane et al&#46;&#44; 2006</a>&#93;&#44; uno en el trastorno obsesivo-compulsivo &#91;<a class="elsevierStyleCrossRef" href="#bib0230">Real et al&#46;&#44; 2009</a>&#93;&#44; 2 que inclu&#237;an casos con trastorno bipolar &#91;<a class="elsevierStyleCrossRefs" href="#bib0015">Bocchio-Chiavetto et al&#46;&#44; 2008&#59; Gratac&#242;s et al&#46;&#44; 2008</a>&#93;&#44; 3 que no utilizaron la respuesta o la remisi&#243;n &#40;<a class="elsevierStyleCrossRefs" href="#bib0125">Huuhka et al&#46;&#44; 2007&#59; Domschke et al&#46;&#44; 2009&#59; Licinio et al&#46;&#44; 2009</a>&#93;&#44; uno correspondiente a una presentaci&#243;n duplicada &#91;<a class="elsevierStyleCrossRef" href="#bib0305">Szczepankiewicz et al&#46;&#44; 2007</a>&#93; y uno del que no se dispuso de datos &#91;<a class="elsevierStyleCrossRef" href="#bib0225">Rajewska-Rager et al&#46;&#44; 2008</a>&#93;&#41;&#46; Finalmente&#44; 6 estudios &#40;<a class="elsevierStyleCrossRefs" href="#bib0315">Tsai et al&#46;&#44; 2003&#59; Choi et al&#46;&#44; 2006&#59; Wilkie et al&#46;&#44; 2007&#59; Yoshida et al&#46;&#44; 2007&#59; Wu et al&#46;&#44; 2008&#59; Kang et al&#46;&#44; 2009</a>&#41; se incluyeron en el presente metaan&#225;lisis&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; recientemente nuestro equipo de investigaci&#243;n ha explorado tambi&#233;n la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#44; y los datos se publicar&#225;n pronto en <span class="elsevierStyleItalic">Neuropsychobiology</span>&#46; Estos datos se incluyeron tambi&#233;n en el presente metaan&#225;lisis&#46; Uno de los estudios elegibles inclu&#237;a datos por separado de 2 grupos de pacientes diferentes &#40;depresi&#243;n unipolar y depresi&#243;n de inicio temprano&#41; y los tratamos de manera independiente &#40;<a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al&#46;&#44; 2007</a>&#41;&#46; As&#237; pues&#44; consideramos para nuestro metaan&#225;lisis 8 estudios diferentes &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Estos 8 estudios correspond&#237;an a 6 muestras en poblaci&#243;n asi&#225;tica y 2 en poblaci&#243;n cauc&#225;sica&#46; Se extrajo de todos ellos la frecuencia de alelos y genotipos del polimorfismo BDNF Val66Met&#46; Las distribuciones del genotipo Val66Met en los 8 estudios estaban en equilibrio de Hardy-Weinberg&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Ocho estudios &#40;6 asi&#225;ticos y 2 cauc&#225;sicos&#41; exploraron la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de respuesta&#46; Pero solamente 4 estudios &#40;3 asi&#225;ticos y uno cauc&#225;sico&#41; exploraron la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de remisi&#243;n &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; As&#237; pues&#44; cuando evaluamos la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de respuesta&#44; el metaan&#225;lisis se llev&#243; a cabo con el total de 8 estudios&#44; con 6 estudios en pacientes asi&#225;ticos y con 2 estudios en pacientes cauc&#225;sicos&#46; Al evaluar la asociaci&#243;n del polimorfismo BDNF Val66Met con la de remisi&#243;n&#44; el metaan&#225;lisis se realiz&#243; con el total de 4 estudios y con 3 estudios en pacientes asi&#225;ticos&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metaan&#225;lisis</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis en la muestra total</span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metaan&#225;lisis de la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de respuesta</span><p id="par0080" class="elsevierStylePara elsevierViewall">Se observ&#243; una asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de respuesta para la poblaci&#243;n global al examinar el contraste de los genotipos Val&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;66&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;07-2&#44;57&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#44; y el gr&#225;fico de Forest de la distribuci&#243;n de los valores de OR se muestra en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>a &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0085" class="elsevierStylePara elsevierViewall">Sin embargo&#44; no detectamos la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de respuesta en la poblaci&#243;n global al examinar el contraste del alelo Met frente al alelo Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;11&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;92-1&#44;34&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;30&#41;&#44; los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;51&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;00-2&#44;30&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;62-1&#44;18&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;35&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;09&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;75-1&#44;58&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;66&#41;&#44; y los genotipos Met&#47;Met frente a Val&#47;Met &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;71&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;50-1&#44;01&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;06&#41;&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metaan&#225;lisis de la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de remisi&#243;n</span><p id="par0090" class="elsevierStylePara elsevierViewall">No detectamos la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de remisi&#243;n en la poblaci&#243;n global al examinar el contraste del alelo Met frente al alelo Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;04&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;82-1&#44;31&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;75&#41;&#44; los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;24&#59; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86-1&#44;79&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;24&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;56-1&#44;27&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;42&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;99&#44; IC del 95&#37;&#44; 0&#44;60-1&#44;61&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;96&#41;&#44; los genotipos Val&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;36&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;93-1&#44;99&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;12&#41;&#44; y los genotipos Met&#47;Met frente a Val&#47;Met &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;76&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;50-1&#44;17&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;22&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis en pacientes asi&#225;ticos</span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metaan&#225;lisis de la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de respuesta &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 2</a>&#41;</span><p id="par0100" class="elsevierStylePara elsevierViewall">Se observ&#243; una asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de respuesta para la poblaci&#243;n asi&#225;tica al examinar el contraste de los genotipos Val&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;83&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;03-3&#44;26&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#44; y el gr&#225;fico de Forest de la distribuci&#243;n de los valores de OR se muestra en la <a class="elsevierStyleCrossRef" href="#fig0010">figura 2</a>b&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Sin embargo&#44; no detectamos la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de respuesta en la poblaci&#243;n asi&#225;tica al examinar el contraste del alelo Met frente al alelo Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;18&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86-1&#44;62&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;32&#41;&#44; los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;63&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;95-2&#44;79&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;87&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;63-1&#44;22&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;42&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;13&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;76-1&#44;66&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;55&#41;&#44; y los genotipos Met&#47;Met frente a Val&#47;Met &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;73&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;51-1&#44;04&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#41;&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Metaan&#225;lisis de la asociaci&#243;n del polimorfismo BDNF Val66Met con la tasa de remisi&#243;n &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;</span><p id="par0110" class="elsevierStylePara elsevierViewall">No detectamos la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de remisi&#243;n en la poblaci&#243;n asi&#225;tica al examinar el contraste del alelo Met frente al alelo Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;02&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;79-1&#44;31&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;89&#41;&#44; los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;21&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86-1&#44;82&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;37&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;57-1&#44;30&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;46&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;01&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;61-1&#44;67&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;98&#41;&#44; los genotipos Val&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;32&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;86-2&#44;03&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;21&#41;&#44; y los genotipos Met&#47;Met frente a Val&#47;Met &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;78&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;51-1&#44;21&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;27&#41;&#46;</p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">An&#225;lisis en pacientes cauc&#225;sicos</span><p id="par0120" class="elsevierStylePara elsevierViewall">No detectamos la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de respuesta en la poblaci&#243;n cauc&#225;sica al examinar el contraste del alelo Met frente al alelo Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;11&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;64-1&#44;91&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;72&#41;&#44; los genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;22&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;66-2&#44;28&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;54&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;57&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;12-2&#44;74&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;48&#41;&#44; los genotipos Met&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;63&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;13-3&#44;01&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;56&#41;&#44; los genotipos Val&#47;Met frente a Val&#47;Val &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;31&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;68-2&#44;51&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;42&#41;&#44; y los genotipos Met&#47;Met frente a Val&#47;Met &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;53&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;17-1&#44;71&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;29&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Sin embargo&#44; no evaluamos la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de remisi&#243;n en la poblaci&#243;n cauc&#225;sica&#44; ya que solamente uno de los estudios presentaba los datos de tasa de remisi&#243;n&#46;</p></span></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Evaluaci&#243;n del sesgo de publicaci&#243;n</span><p id="par0130" class="elsevierStylePara elsevierViewall">Se utiliz&#243; la prueba de regresi&#243;n lineal de Egger para medir la asimetr&#237;a del gr&#225;fico de embudo&#46; Si hay una asimetr&#237;a&#44; de tal manera que los estudios m&#225;s peque&#241;os muestran unos efectos que difieren de forma sistem&#225;tica de los de los estudios m&#225;s grandes&#44; la l&#237;nea de regresi&#243;n no pasar&#225; por el origen&#46; La intersecci&#243;n <span class="elsevierStyleItalic">a</span> proporciona una medida de la asimetr&#237;a &#40;cuanto mayor es su desviaci&#243;n respecto al cero&#44; m&#225;s pronunciada es la asimetr&#237;a&#41;&#46; El resultado de la prueba de regresi&#243;n lineal de Egger se muestra en la <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#44; y en la <a class="elsevierStyleCrossRef" href="#fig0015">figura 3</a> se pone de relieve que no hay un sesgo de publicaci&#243;n para los metaan&#225;lisis estad&#237;sticamente significativos&#46; Sin embargo&#44; no se aplic&#243; la prueba de Egger en algunas de las comparaciones debido al bajo n&#250;mero de estudios o la poca frecuencia del genotipo Met&#47;Met &#40;polimorfismo BDNF Val66Met y tasa de respuesta en la poblaci&#243;n cauc&#225;sica&#58; alelo Met frente a alelo Val&#44; genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val&#44; genotipos Met&#47;Met frente a Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Val&#44; genotipos Met&#47;Met frente a Val&#47;Val&#44; genotipos Val&#47;Met frente a Val&#47;Val&#44; y genotipos Met&#47;Met frente a Val&#47;Met&#59; polimorfismo BDNF Val66Met y tasa de remisi&#243;n en la poblaci&#243;n asi&#225;tica&#58; genotipos Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val&#44; genotipos Met&#47;Met frente a Val&#47;Val&#44; y genotipos Val&#47;Met frente a Val&#47;Val&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Discusi&#243;n</span><p id="par0135" class="elsevierStylePara elsevierViewall">El TDM es un trastorno psiqui&#225;trico frecuente&#44; de etiolog&#237;a compleja&#44; en el que intervienen probablemente m&#250;ltiples genes&#44; adem&#225;s de influencias no gen&#233;ticas &#40;<a class="elsevierStyleCrossRefs" href="#bib0005">Avissar y Schreiber&#44; 2002&#59; Baron&#44; 2002</a>&#41;&#46; El BDNF fomenta la supervivencia&#44; diferenciaci&#243;n y mantenimiento de las neuronas en el desarrollo nervioso perif&#233;rico y central&#44; influye en el crecimiento ax&#243;nico y la conectividad&#44; y participa en las respuestas locales a diversos tipos de insultos o tensiones neuronales&#59; y se ha evaluado su empleo como posible candidato en el TDM debido a sus m&#250;ltiples funciones fisiol&#243;gicas &#40;<a class="elsevierStyleCrossRefs" href="#bib0135">Jeste et al&#46;&#44; 1995&#59; Ventimiglia et al&#46;&#44; 1995&#59; Nitta et al&#46;&#44; 1999&#59; Schumacher et al&#46;&#44; 2005</a>&#41;&#46; Los estudios realizados en modelos animales aportan un claro respaldo a la hip&#243;tesis de que el BDNF contribuye al tratamiento antidepresivo&#46; La medicaci&#243;n antidepresiva aumenta la expresi&#243;n y la se&#241;alizaci&#243;n de BDNF en el hipocampo y la corteza &#40;<a class="elsevierStyleCrossRefs" href="#bib0205">Nibuya et al&#46;&#44; 1995&#59; Russo-Neustadt et al&#46;&#44; 2000&#59; Saarelainen et al&#46;&#44; 2003&#59; Russo-Neustadt et al&#46;&#44; 2004&#59; Rogoz y Legutko&#44; 2005</a>&#41;&#46; La inyecci&#243;n de BDNF en el cerebro o la sobreexpresi&#243;n de sus receptores en los ratones transg&#233;nicos produce unas respuestas conductuales similares a las que se observan habitualmente despu&#233;s del tratamiento con los f&#225;rmacos antidepresivos &#40;<a class="elsevierStyleCrossRefs" href="#bib0295">Siuciak et al&#46;&#44; 1997&#59; Shirayama et al&#46;&#44; 2002</a>&#41;&#46; Adem&#225;s&#44; <a class="elsevierStyleCrossRef" href="#bib0190">Monteggia et al&#46; &#40;2007&#41;</a> describieron que la p&#233;rdida de BDNF en regiones del prosenc&#233;falo en ratones knockout para BDNF condicional aten&#250;a la eficacia de los antidepresivos&#46; En consecuencia&#44; el gen del BDNF es un candidato importante en relaci&#243;n con el tratamiento antidepresivo&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">En este trabajo identificamos 8 estudios que inclu&#237;an datos de 1&#46;115 participantes para evaluar la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#46; Nuestro metaan&#225;lisis detect&#243; una asociaci&#243;n gen&#233;tica significativa entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#44; y que los pacientes heterocigotos Val&#47;Met tienen una tasa de respuesta mejor que la de los pacientes homocigotos Val&#47;Val&#44; sobre todo en la poblaci&#243;n asi&#225;tica&#46; En muchos estudios se ha sugerido una asociaci&#243;n entre la baja expresi&#243;n de BDNF y los trastornos del estado de &#225;nimo &#40;<a class="elsevierStyleCrossRefs" href="#bib0060">Duman et al&#46;&#44; 1997&#59; Nestler et al&#46;&#44; 2002&#59; Lee et al&#46;&#44; 2007</a>&#41;&#46; En los animales sometidos al estr&#233;s de la nataci&#243;n forzada y la inmovilizaci&#243;n cr&#243;nica&#44; los niveles de expresi&#243;n de ARNm de BDNF se redujeron de forma significativa &#40;<a class="elsevierStyleCrossRefs" href="#bib0245">Russo-Neustadt et al&#46;&#44; 2001&#59; Xu et al&#46;&#44; 2002</a>&#41;&#46; <a class="elsevierStyleCrossRef" href="#bib0165">Linnarsson et al&#46; &#40;1997&#41;</a> indicaron que la baja expresi&#243;n de BDNF puede causar un deterioro de la memoria&#46; <a class="elsevierStyleCrossRef" href="#bib0065">Egan et al&#46; &#40;2003&#41;</a> observaron tambi&#233;n que el alelo Met se asociaba a una peor memoria epis&#243;dica y a una disminuci&#243;n de la secreci&#243;n de BDNF hipoc&#225;mpica dependiente de la actividad&#46; A la vista de estas observaciones&#44; resulta dif&#237;cil interpretar el presente resultado&#46; Sin embargo&#44; <a class="elsevierStyleCrossRef" href="#bib0090">Foltynie et al&#46; &#40;2005&#41;</a> observaron que el alelo Met se asociaba a un mejor rendimiento en la tarea de la Torre de Londres &#40;TOL&#41; en la enfermedad de Parkinson&#46; Se observ&#243; que la tarea de TOL aumentaba el flujo sangu&#237;neo cerebral regional relativo en la corteza prefrontal dorsolateral&#44; la corteza premotora lateral&#44; la corteza del c&#237;ngulo anterior rostral y el n&#250;cleo caudado dorsal &#40;<a class="elsevierStyleCrossRef" href="#bib0040">Dagher et al&#46;&#44; 1999</a>&#41;&#46; En consecuencia&#44; es posible que los efectos funcionales del polimorfismo BDNF Val66Met difieran en las distintas &#225;reas del cerebro y esta diferencia regional puede contribuir a producir el mejor efecto antidepresivo en los pacientes heterocigotos Val&#47;Met&#46; Otra posibilidad es que el polimorfismo pueda estar en desequilibrio de ligamiento con un polimorfismo funcional todav&#237;a no identificado&#44; con un efecto heter&#243;tico molecular &#40;<a class="elsevierStyleCrossRef" href="#bib0035">Comings y MacMurray&#44; 2000</a>&#41;&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Nuestro metaan&#225;lisis no observ&#243; la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la tasa de remisi&#243;n&#46; La raz&#243;n puede ser la falta de potencia estad&#237;stica debido al bajo n&#250;mero de estudios&#46; Adem&#225;s&#44; el resultado del estudio de <a class="elsevierStyleCrossRef" href="#bib0140">Kang et al&#46; &#40;2009&#41;</a> dentro de los estudios elegibles para el an&#225;lisis es claramente un valor extremo fuera de los l&#237;mites habituales&#46; Una posible explicaci&#243;n de este valor extremo es que los mecanismos terap&#233;uticos que subyacen en la acci&#243;n de la mirtazapina sean diferentes de los de los inhibidores selectivos de la recaptaci&#243;n de serotonina &#40;ISRS&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Este metaan&#225;lisis tiene algunas limitaciones&#46; En primer lugar&#44; se detect&#243; una heterogeneidad significativa entre los estudios en algunas de las comparaciones&#44; y ello puede haber distorsionado el metaan&#225;lisis&#46; Hay varias diferencias entre los estudios incluidos en el metaan&#225;lisis que es preciso comentar y que podr&#237;an explicar la heterogeneidad significativa que observamos en algunas comparaciones&#58; diferentes tipos y dosis de f&#225;rmacos antidepresivos&#44; origen &#233;tnico&#44; diferentes subtipos de TDM&#44; as&#237; como diferentes duraciones de la evaluaci&#243;n&#46; En segundo lugar&#44; no pudimos elaborar un gr&#225;fico de embudo y realizar una prueba de Egger para cada metaan&#225;lisis debido al bajo n&#250;mero de estudios o a la baja frecuencia del genotipo Met&#47;Met&#44; y es posible que haya un sesgo de publicaci&#243;n&#46; En tercer lugar&#44; nuestro metaan&#225;lisis se basa en duraciones de la evaluaci&#243;n diferentes y en estimaciones sin ajustar&#44; y podr&#237;a hacerse un an&#225;lisis m&#225;s preciso si se dispusiera de los datos individuales&#46; Por &#250;ltimo&#44; el metaan&#225;lisis contin&#250;a siendo una investigaci&#243;n retrospectiva que est&#225; sujeta a diferencias metodol&#243;gicas entre los diversos estudios incluidos&#46; Redujimos al m&#237;nimo la probabilidad de sesgo mediante el desarrollo de un protocolo detallado antes de iniciar el estudio&#44; mediante la realizaci&#243;n de una b&#250;squeda meticulosa de estudios publicados&#44; y con el empleo de m&#233;todos expl&#237;citos de selecci&#243;n de los estudios&#44; extracci&#243;n de los datos y an&#225;lisis de estos&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; nuestro metaan&#225;lisis pone de manifiesto la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#44; y que los pacientes heterocigotos para Val66Met presentan una tasa de respuesta mejor que la de los homocigotos Val&#47;Val&#44; especialmente en la poblaci&#243;n asi&#225;tica&#46; Para alcanzar una conclusi&#243;n definitiva&#44; contin&#250;an siendo necesarios nuevos estudios de interacci&#243;n gen-gen y gen-entorno basados en un tama&#241;o muestral m&#225;s amplio y estratificadas seg&#250;n la etnicidad&#46;</p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Financiaci&#243;n</span><p id="par0160" class="elsevierStylePara elsevierViewall">Este trabajo fue financiado con subvenciones de la National Natural Science Foundation of China &#40;30830089&#41;&#46;</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Autor&#237;a</span><p id="par0165" class="elsevierStylePara elsevierViewall">Zou YF ha redactado el protocolo del estudio&#44; ha coordinado las actividades de investigaci&#243;n y ha contribuido sustancialmente al an&#225;lisis y la interpretaci&#243;n de los datos&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Ye DQ ha contribuido sustancialmente al dise&#241;o del estudio&#44; la obtenci&#243;n de los datos y la coordinaci&#243;n general del estudio&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Feng XL ha contribuido a la obtenci&#243;n de los datos&#44; el an&#225;lisis y las actividades de publicaci&#243;n coordinadas&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">Su H&#44; Pan FM&#44; Liao FF&#44; han participado en el dise&#241;o del estudio y la obtenci&#243;n de los datos&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Todos los autores han revisado cr&#237;ticamente el art&#237;culo y han aprobado el manuscrito antes de su presentaci&#243;n&#46;</p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Conflicto de intereses</span><p id="par0190" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle">Agradecimientos</span><p id="par0195" class="elsevierStylePara elsevierViewall">Damos las gracias a todos aquellos que han colaborado en este estudio&#46; Dispusimos de la amable ayuda del Dr&#46; Min-Soo LEE&#44; Dr&#46; Bernhard T&#46; Baune&#44; Dra&#46; M&#242;nica Gratac&#242;s&#44; Dr&#46; Gillian Smith&#44; y Dra&#46; Aleksandra Szczepankiewicz&#46; En especial el Dr&#46; Min-Soo LEE y la Dra&#46; M&#242;nica Gratac&#242;s nos han proporcionado una explicaci&#243;n detallada de su investigaci&#243;n&#46;</p></span></span>"
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    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El objetivo de nuestro metaan&#225;lisis fue evaluar la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con trastorno depresivo mayor &#40;TDM&#41;&#46; Se identificaron 8 estudios que inclu&#237;an datos de 1&#46;115 individuos&#46; Estudiamos 2 fenotipos&#58; tasa de respuesta y tasa de remisi&#243;n&#46; Se utiliz&#243; la OR como medida del efecto de la asociaci&#243;n en un modelo de efectos fijos&#47;aleatorios&#46; Se realiz&#243; un metaan&#225;lisis para los genotipos Met&#47;Met frente a Val&#47;Val&#44; Val&#47;Met frente a Val&#47;Val&#44; Met&#47;Met frente a Val&#47;Met&#44; Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met frente a Val&#47;Val&#44; Met&#47;Met frente a Val&#47;Val<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Met&#44; y alelo Met frente a alelo Val&#46; Al combinar todos los grupos&#44; se observ&#243; una asociaci&#243;n significativa del genotipo Val&#47;Met con un aumento de la tasa de respuesta en comparaci&#243;n con el Val&#47;Val en la poblaci&#243;n global &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;66&#44; IC del 95&#37;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;07-2&#44;57&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; En el an&#225;lisis de subgrupos se obtuvieron resultados similares para la poblaci&#243;n asi&#225;tica &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#44;83&#44; IC del 95&#37;&#44; 1&#44;03-3&#44;26&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#41;&#44; pero no para la poblaci&#243;n cauc&#225;sica&#46; No observamos una asociaci&#243;n significativa del polimorfismo BDNF Val66Met con la tasa de remisi&#243;n&#46; Este metaan&#225;lisis pone de manifiesto la asociaci&#243;n entre el polimorfismo BDNF Val66Met y la respuesta al tratamiento en pacientes con TDM&#44; y que los pacientes heterocigotos para Val66Met tienen una tasa de respuesta superior a la de los pacientes homocigotos Val&#47;Val&#44; especialmente en la poblaci&#243;n asi&#225;tica&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The aim of our meta-analysis was to assess the association between BDNF Val66Met polymorphism and treatment response in patients with MDD&#46; Eight studies that included data from 1115 subjects were identified&#46; We tested two phenotypes&#58; response rate and remission rate&#46; OR was used as a measure of the effect of the association in a fixed&#47;random effect model&#46; Metaanalysis was performed for genotypes Met&#47;Met versus Val&#47;Val&#44; Val&#47;Met versus Val&#47;Val&#44; Met&#47;Met versus Val&#47;Met&#44; Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met versus Val&#47;Val&#44; Met&#47;Met versus Val&#47;Val<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Met&#44; and Met allele versus Val allele&#46; When all groups were pooled&#44; a significant association of Val&#47;Met genotype and increased response rate was found in comparison to Val&#47;Val in overall population &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;66&#44; 95&#37;CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;07-2&#46;57&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;02&#41;&#46; In the subgroup analysis&#44; similar result was shown in Asian population &#40;OR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;83&#44; 95&#37;CI<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#46;03-3&#46;26&#44; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>&#46;04&#41;&#44; but not in Caucasian population&#46; We didn&#8217;t observe a significant association of BDNF Val66Met polymorphism with remission rate&#46; This meta-analysis demonstrates the association between BDNF Val66Met polymorphism and treatment response in patients with MDD&#44; and Val66Met heterozygous patients have a better response rate in comparison to Val&#47;Val homozygote patients&#44; especially in Asian population&#46;</p>"
      ]
    ]
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      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara">Este art&#237;culo ha sido previamente publicado en European Neuropsychopharmacology&#46; 2010&#59;20&#58;535-44&#46;</p>"
      ]
    ]
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          "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Diagrama de flujo del proceso de selecci&#243;n de los estudios&#46;</p>"
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          "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;ficos de Forest para los metaan&#225;lisis estad&#237;sticamente significativos&#46;</p>"
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          "es" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Gr&#225;ficos de embudo y gr&#225;ficos de sesgo de publicaci&#243;n de Egger para los metaan&#225;lisis estad&#237;sticamente significativos&#46; &#40;Cada punto corresponde a un art&#237;culo&#59; e&#46;e&#46; de logOR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>error est&#225;ndar de log OR&#41;&#46;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">ATC&#58; antidepresivos tric&#237;clicos&#59; IMAO&#58; inhibidor de monoaminooxidasa&#59; ISRN&#58; inhibidor selectivo de recaptaci&#243;n de noradrenalina&#59; ISRS&#58; inhibidor selectivo de la recaptaci&#243;n de serotonina&#59; N&#58; n&#250;mero&#59; ND&#58; no disponible&#59; sem&#58; semana&#46;</p>"
          "tablatextoimagen" => array:1 [
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              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Referencia &#40;a&#241;o&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Tipo de tratamientos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">N &#40;varones&#47;mujeres&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Media de edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Origen &#233;tnico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Evaluaci&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Datos de evaluaci&#243;n seleccionados en el metaan&#225;lisis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0140">Kang et al&#46; &#40;2009&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mirtazapina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">197 &#40;ND&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 1&#44; 2&#44; 4&#44; 8 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 8 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de remisi&#243;n&#58; 1&#44; 2&#44; 4&#44; 8 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de remisi&#243;n&#58; 8 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0340">Wu et al&#46; &#40;2008&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paroxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;0&#47;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 4 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 4 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0350">Yoshida et al&#46; &#40;2007&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Milnacipr&#225;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">134 &#40;50&#47;84&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 1&#44; 2&#44; 4&#44; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluvoxamina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de remisi&#243;n&#58; 1&#44; 2&#44; 4&#44; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al&#46; &#40;2007&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ISRS&#44; ATC&#44; IMAO&#44; IRSN&#44; Mirtazapina&#44; Nefazadona&#44; Trazadona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">163 &#40;ND&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cauc&#225;sicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamiento inicial&#58;Tasa de respuesta&#58; &#8805; 6 semTasa de remisi&#243;n&#58; &#8805; 6 semSegundo cambio de tratamiento&#58;Tasa de respuesta&#58; &#8805; 6 semTasa de remisi&#243;n&#58; &#8805; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tratamiento inicial&#58;Tasa de respuesta&#58; &#8805; 6 semTasa de remisi&#243;n&#58; &#8805; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0330">Wilkie et al&#46; &#40;2007&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ISRS&#44; ATC&#44; IMAO&#44; IRSN&#44; Mirtazapina&#44; Nefazadona&#44; Trazadona&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70 &#40;ND&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ND&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cauc&#225;sicos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 12 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 12 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0025">Choi et al&#46; &#40;2006&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Citalopram&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;24&#47;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 1&#44; 2&#44; 4&#44; 8 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 8 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><a class="elsevierStyleCrossRef" href="#bib0315">Tsai et al&#46; &#40;2003&#41;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluoxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">152 &#40;67&#47;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 4 semTasa de remisi&#243;n&#58; 4 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 4 semTasa de remisi&#243;n&#58; 4 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Zou et al&#46; &#40;no publicado&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fluoxetina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">295 &#40;139&#47;156&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asi&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 1&#44; 2&#44; 4&#44; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de respuesta&#58; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de remisi&#243;n&#58; 1&#44; 2&#44; 4&#44; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tasa de remisi&#243;n&#58; 6 sem&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "es" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas de los estudios que investigan la asociaci&#243;n entre respuesta al tratamiento y polimorfismo BDNF Val66Met en pacientes con trastorno depresivo mayor &#40;TDM&#41;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">vs&#58; versus&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comparisons&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Sample size</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&#46; of studies&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Test of association</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Test of heterogeneity</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Responder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Non-responder&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Fixed model</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Random model</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#967;<span class="elsevierStyleSup">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">OR &#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Z&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">OR &#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Z&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Met vs Val&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1350&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">880&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;11 &#40;0&#46;92-1&#46;34&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#46;04&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;30&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">41&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1118&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">646&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&#46;11 &#40;0&#46;90-1&#46;35&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">54&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Caucasian&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;11 &#40;0&#46;64-1&#46;91&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;09 &#40;0&#46;62-1&#46;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met vs Val&#47;Val&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">675&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">440&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">49&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Asian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">62&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Caucasian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;22 &#40;0&#46;66-2&#46;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Met&#47;Met vs Val&#47;Val<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Met&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">675&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">440&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;86 &#40;0&#46;62-1&#46;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;94&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Asian&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Caucasian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Met&#47;Met vs Val&#47;Val&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">351&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">276&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;09 &#40;0&#46;75-1&#46;58&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;11 &#40;0&#46;69-1&#46;80&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">270&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">186&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Caucasian&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Met&#47;Met vs Val&#47;Met&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;71&#40;0&#46;50-1&#46;01&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#46;64&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#46;71 &#40;0&#46;47-1&#46;07&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#46;62&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Caucasian&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">77&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">39&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;53 &#40;0&#46;17-1&#46;71&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;56&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;75&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;0&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t">Comparisons&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Study&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Non-remitter&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Fixed model</td><td class="td" title="\n
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                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Random model</td><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">I</span><span class="elsevierStyleSup">2</span> &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">OR &#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black">Z&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">OR &#40;95&#37;CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Z&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Met vs Val&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">498&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1032&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">Val&#47;Met<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Met&#47;Met vs Val&#47;Val&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Met&#47;Met vs Val&#47;Val<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>Val&#47;Met&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">Overall&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Met&#47;Met vs Val&#47;Val&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Val&#47;Met vs Val&#47;Val&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6&#46;2&nbsp;\t\t\t\t\t\t\n
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                  """
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Información del artículo

ISSN: 11345934
Idioma original: Español

DOI:10.1016/j.psiq.2012.07.003

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