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Tratamiento del ictus de circulación posterior mediante trombectomía mecánica con stent-retriever: un estudio observacional, monocéntrico y retrospectivo
Treatment of posterior circulation strokes by mechanical thrombectomy with a stent-retriever: a retrospective observational study at a single center
P.B. García Juradoa,
Autor para correspondencia
pedroblasgj@gmail.com

Autor para correspondencia.
, I.M. Bravo Reya, E. Jiménez Gómeza, R. Oteros Fernándeza, R. Valverde Moyanob, F.A. Bravo-Rodrígueza, F. Delgado Acostaa
a Sección de Neurorradiología Diagnóstica y Terapéutica, Unidad de Gestión Clínica de Radiodiagnóstico, Hospital Universitario Reina Sofía, Córdoba, España
b Servicio de Neurología, Hospital Universitario Reina Sofía, Córdoba, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Seg&#250;n el Instituto Nacional de Estad&#237;stica&#44; en 2016 fallecieron en Espa&#241;a 27&#46;122 personas &#40;6&#44;6&#37; del total de las defunciones&#41; a causa de enfermedades cerebrovasculares&#44; lo que supone la segunda causa de mortalidad<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">1</span></a>&#46; Dentro de las enfermedades cerebrovasculares&#44; el ictus de circulaci&#243;n posterior presenta un pron&#243;stico infausto y una elevada morbimortalidad<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">2</span></a>&#46; Mientras que para el ictus de circulaci&#243;n anterior con oclusi&#243;n de gran vaso existe evidencia y consenso en cuanto a la seguridad y eficacia del tratamiento con <span class="elsevierStyleItalic">stent-retriever</span><a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">3</span></a>&#44; las estrategias terap&#233;uticas del ictus de circulaci&#243;n posterior no se han estandarizado a&#250;n<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">El objetivo de este trabajo es valorar la tasa de recanalizaci&#243;n&#44; el resultado funcional a 3 meses y los factores pron&#243;sticos independientes de pacientes con ictus de circulaci&#243;n posterior tratados mediante <span class="elsevierStyleItalic">stent-retriever</span>&#44; compar&#225;ndolos con una serie previa tratada con &#8220;m&#233;todos cl&#225;sicos&#8221;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Pacientes</span><p id="par0015" class="elsevierStylePara elsevierViewall">Se ha realizado un muestreo consecutivo entre el 1 de diciembre de 2011 y el 1 de mayo de 2018&#44; reclutando a todos los pacientes con ictus de circulaci&#243;n posterior tratados con <span class="elsevierStyleItalic">stent</span>-<span class="elsevierStyleItalic">retriever</span>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Se han incluido en el estudio aquellos pacientes mayores de 18 a&#241;os con cl&#237;nica de ictus posterior&#44; oclusi&#243;n del sistema vertebrobasilar objetivable angiogr&#225;ficamente y revascularizados con <span class="elsevierStyleItalic">stent-retriever</span> en las primeras 24 horas desde el comienzo de la sintomatolog&#237;a&#46; A todos los pacientes se les realiz&#243; una tomograf&#237;a computarizada &#40;TC&#41; multimodal previa al tratamiento &#40;TC de cr&#225;neo sin contraste intravenoso&#44; TC-perfusi&#243;n y angio-TC de troncos supraa&#243;rticos y arterias intracraneales&#41;&#46; El estudio de TC-perfusi&#243;n no se consider&#243; adecuado en nuestra serie&#44; ya que al poseer solo TC de 4 coronas no nos permit&#237;a realizar estudios homog&#233;neos de la perfusi&#243;n&#44; sobre todo si la sospecha cl&#237;nica no se&#241;alaba a la circulaci&#243;n posterior&#46; Se han excluido los pacientes que mostraron cambios isqu&#233;micos extensos bilaterales en el tronco cerebral y aquellos infartos cerebelosos que produc&#237;an efecto masa o hidrocefalia aguda<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">6</span></a> y establecidos en la TC de cr&#225;neo basal&#44; y aquellos pacientes con una puntuaci&#243;n en la escala NIHSS &#40;National Institutes of Health Stroke Scale&#41; de 3 o menor&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Al tratarse de un estudio retrospectivo no es precisa la autorizaci&#243;n del comit&#233; de &#233;tica en nuestro centro&#46; Todos los pacientes o sus representantes legales firmaron el consentimiento informado&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Registro de datos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se han recogido variables demogr&#225;ficas &#40;edad y sexo&#41; y factores de riesgo cerebrovascular &#91;hipertensi&#243;n arterial &#40;HTA&#41;&#44; diabetes mellitus &#40;DM&#41;&#44; fibrilaci&#243;n auricular &#40;FA&#41;&#44; dislipidemia&#44; h&#225;bito tab&#225;quico&#44; h&#225;bito en&#243;lico&#44; antecedentes de ictus&#44; antecedentes de infartos de miocardio&#44; presencia de foramen oval permeable&#44; consumo de antiagregantes y consumo de estatinas&#93;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Tambi&#233;n se han analizado variables evaluables antes del tratamiento y que podr&#237;an influir en el pron&#243;stico&#44; como la tetraplej&#237;a en el momento del diagn&#243;stico&#44; los ictus en progresi&#243;n&#44; la presencia de arterias comunicantes posteriores&#44; la intubaci&#243;n orotraqueal&#44; la glucemia inicial&#44; el deterioro neurol&#243;gico inicial determinado mediante la escala NIHSS<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">7</span></a> por parte de un facultativo especialista en neurolog&#237;a con 4 a&#241;os de experiencia y el nivel de consciencia inicial determinado mediante la escala de coma de Glasgow &#40;GCS&#44; Glasgow Coma Scale&#41; tambi&#233;n por parte de un neur&#243;logo&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">En cuanto a la etiolog&#237;a del ictus se han valorado cuatro posibles causas &#40;aterotromb&#243;tico&#44; emb&#243;lico&#44; disecci&#243;n o indeterminado&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">La localizaci&#243;n del trombo se determin&#243; con la angio-TC de troncos supraa&#243;rticos y arterias intracraneales y posteriormente se confirm&#243; con la arteriograf&#237;a&#44; estableci&#233;ndose seis segmentos&#58; arteria vertebral extracraneal &#40;V1-V3&#41;&#44; arteria vertebral intracraneal &#40;V4&#41;&#44; arteria basilar proximal &#40;desde la uni&#243;n de las arterias vertebrales hasta el origen de las arterias cerebelosas anteroinferiores&#41;&#44; arteria basilar media &#40;desde las arterias cerebelosas anteroinferiores hasta el origen de las arterias cerebelosas superiores&#41;&#44; arteria basilar distal &#40;desde las arterias cerebelosas superiores hasta la divisi&#243;n en las arterias cerebrales posteriores&#41; y arterias cerebrales posteriores&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">Se han considerado tres intervalos de tiempo&#58; el tiempo transcurrido desde el comienzo de la sintomatolog&#237;a hasta la punci&#243;n arterial &#40;en caso de desconocerse el tiempo de evoluci&#243;n&#44; se tom&#243; como referencia la &#250;ltima vez que el paciente se encontraba asintom&#225;tico<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">8</span></a>&#41;&#44; la duraci&#243;n del procedimiento endovascular y el tiempo transcurrido desde el comienzo de la cl&#237;nica y la revascularizaci&#243;n&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Todos los procedimientos fueron realizados por neurorradi&#243;logos experimentados &#40;entre 28 y 5 a&#241;os de experiencia&#41; en t&#233;cnicas endovasculares&#46; El paciente fue tratado con anestesia general&#46; Los procedimientos se realizaron a trav&#233;s de la v&#237;a arterial femoral&#46; Un introductor de 80&#160;cm 7&#160;F &#40;Super Arrow-Flex Sheath Introducer&#44; Teleflex&#44; Irlanda&#41; se posicion&#243; en la arteria subclavia&#46; Un cat&#233;ter tutor de 5<span class="elsevierStyleHsp" style=""></span>F Navien &#40;Medtronic&#44; EE&#46;&#160;UU&#46;&#41; o Sofia 5<span class="elsevierStyleHsp" style=""></span>F &#40;Microvention Terumo&#44; EE&#46;&#160;UU&#46;&#41; se situ&#243; en la arteria vertebral a la altura del segmento V3&#46; Los microcat&#233;teres seleccionados fueron o bien el Cat&#233;ter Trevo &#40;Stryker&#44; EE&#46;&#160;UU&#46;&#41; o el Rapid Transit &#40;Cordis&#44; Corp&#46; EE&#46;&#160;UU&#46;&#41;&#46; Dichos microcat&#233;teres se colocaron distalmente a la oclusi&#243;n vascular&#46; Una vez confirmada la posici&#243;n con una microangiograf&#237;a se procedi&#243; al despliegue del <span class="elsevierStyleItalic">stent-retriever</span>&#46; Se usaron dos tipos de <span class="elsevierStyleItalic">stent-retrievers</span>&#58; Trevo &#40;Stryker&#44; EE&#46;&#160;UU&#46;&#41; o Preset &#40;Phenox&#44; Alemania&#41;&#46; Una vez colocado el <span class="elsevierStyleItalic">stent-retriever</span> se procedi&#243; a la retirada del <span class="elsevierStyleItalic">stent-retriever</span> abierto mientras se realizaba aspiraci&#243;n manual por el cat&#233;ter tutor&#46; Tras extraer el <span class="elsevierStyleItalic">stent-retriever</span> se realiz&#243; un control angiogr&#225;fico&#44; y en caso necesario se volvi&#243; a realizar un nuevo pase con igual t&#233;cnica&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Los &#8220;m&#233;todos cl&#225;sicos&#8221; empleados fueron tromb&#243;lisis intraarterial con urocinasa &#40;250&#46;000&#160;UI en 10 minutos y a partir de ah&#237; 1&#46;000 UI&#47;minuto&#44; con un m&#225;ximo de 1&#46;000&#46;000 de UI de urocinasa&#41;&#44; angioplastia&#44; sistema Penumbra para la extracci&#243;n de co&#225;gulos &#40;cat&#233;teres de reperfusi&#243;n 032 y 041&#41; &#40;Penumbra&#44; EE&#46;&#160;UU&#46;&#41; y endopr&#243;tesis intracraneales&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Las variables relacionadas con el tratamiento y el procedimiento endovascular analizadas han sido la realizaci&#243;n de tromb&#243;lisis intravenosa previa&#44; el uso de abciximab&#44; de urocinasa&#44; dosis de urocinasa&#44; realizaci&#243;n de angioplastia&#44; colocaci&#243;n de <span class="elsevierStyleItalic">stents</span>&#44; n&#250;mero de pases de trombectom&#237;a y la escala m-TICI &#40;modified Treatment in Cerebral Infarction&#41; &#40;consider&#225;ndose exitosos valores de recanalizaci&#243;n 2<span class="elsevierStyleHsp" style=""></span>b y 3&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">9</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">El resultado funcional ha sido evaluado por un neur&#243;logo mediante la escala mRS &#40;modified Rankin Scale&#41; a los 90 d&#237;as&#44; consider&#225;ndose invalidante si es igual o mayor de 3 puntos<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">10</span></a>&#46; Cuando los pacientes fueron derivados a sus centros de referencia despu&#233;s del tratamiento revascularizador&#44; el resultado funcional se valor&#243; telef&#243;nicamente<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; Tambi&#233;n se han contemplado las embolias distales durante el procedimiento&#44; las transformaciones hemorr&#225;gicas y la necesidad de craniectom&#237;a descompresiva como posibles complicaciones&#46; En cuanto a las transformaciones hemorr&#225;gicas&#44; se han clasificado en infartos hemorr&#225;gicos y en hemorragias parenquimatosas seg&#250;n los criterios de la ECASS &#40;European Cooperative Acute Stroke Study&#41; II<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">11</span></a>&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">An&#225;lisis estad&#237;stico</span><p id="par0075" class="elsevierStylePara elsevierViewall">Las variables cuantitativas se han expresado como media y rango intercuart&#237;lico &#40;RIQ&#41;&#46; Las variables cualitativas se han expresado con el n&#250;mero de pacientes &#40;n&#41; y el porcentaje&#46; En primer lugar se ha realizado un an&#225;lisis univariante determinando la relaci&#243;n entre cada una de las variables recogidas en funci&#243;n de la escala mRS a los 90 d&#237;as &#40;mRS 0-2 vs&#46; mRS 3-6&#41;&#46; Para ello se ha utilizado la prueba de la <span class="elsevierStyleItalic">&#967;</span><span class="elsevierStyleSup">2</span> y la prueba exacta de Fisher para comparar las variables cualitativas&#44; y la prueba de la <span class="elsevierStyleItalic">t</span> de Student para las variables cuantitativas&#46; En segundo lugar&#44; se ha realizado un an&#225;lisis de regresi&#243;n log&#237;stica binaria con el m&#233;todo introductivo para determinar las variables que se asocian de forma independiente con valores de mRS a los 90 d&#237;as no invalidantes&#46; Las variables con <span class="elsevierStyleItalic">p</span>&#160;&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05 en el an&#225;lisis univariante han sido seleccionadas para realizar el modelo multivariante&#46; Finalmente&#44; se han estudiado las diferencias entre la serie de pacientes tratados en nuestro centro con las t&#233;cnicas disponibles antes de los <span class="elsevierStyleItalic">stent-retrievers</span><a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a> y la serie actual&#46; Para ello se han utilizado las mismas pruebas que para el an&#225;lisis univariante&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Para efectuar este an&#225;lisis se ha utilizado el paquete SPSS 23 para Windows&#46;</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Resultados</span><p id="par0085" class="elsevierStylePara elsevierViewall">Un total de 48 pacientes cumplieron los criterios de inclusi&#243;n de este estudio&#44; de los cuales el 60&#44;4&#37; &#40;29&#47;48&#41; presentaba un valor de mRS invalidante a los 90 d&#237;as con una mortalidad del 29&#44;2&#37; &#40;14&#47;48&#41;&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas basales de los pacientes&#44; las variables relacionadas con el tratamiento revascularizador y las complicaciones secundarias al tratamiento y al propio ictus se presentan respectivamente en las <a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1-3</a>&#44; comparando los pacientes en funci&#243;n del grado de dependencia funcional a los 90 d&#237;as seg&#250;n la escala mRS&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">En el modelo de regresi&#243;n log&#237;stica binaria realizado se han incluido las variables que han resultado estad&#237;sticamente significativas en el an&#225;lisis univariante &#40;DM&#44; NIHSS inicial&#44; GCS inicial&#44; glucemia inicial y uso de <span class="elsevierStyleItalic">stents</span>&#41;&#46; En el modelo creado&#44; exclusivamente la GCS se ha relacionado de forma independiente con el resultado funcional a los 90 d&#237;as &#40;<span class="elsevierStyleItalic">odds ratio</span>&#44; 0&#44;67&#59; intervalo de confianza&#44; 0&#44;5-0&#44;91&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">El grupo control tratado con &#8220;m&#233;todos cl&#225;sicos&#8221; estaba compuesto de 27 enfermos<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">5</span></a>&#58; en el 7&#44;4&#37; &#40;2&#47;27&#41; de los casos el procedimiento fue fallido&#44; en el 51&#44;8&#37; &#40;14&#47;27&#41; se realiz&#243; fibrin&#243;lisis local&#44; en el 44&#44;4&#37; &#40;12&#47;27&#41; se implant&#243; una endopr&#243;tesis intracraneal&#44; en el 33&#44;3&#37; &#40;9&#47;27&#41; se realiz&#243; angioplastia&#44; y en el 25&#44;9&#37; &#40;7&#47;27&#41; se realiz&#243; trombectom&#237;a con el sistema Penumbra&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Respecto al estudio comparativo de la serie de pacientes con ictus de circulaci&#243;n posterior tratados con las t&#233;cnicas disponibles antes de los <span class="elsevierStyleItalic">stent-retrievers</span> y la serie actual&#44; no se han encontrado diferencias estad&#237;sticamente significativas en cuanto a la edad media &#91;serie actual&#44; 63&#44;9 a&#241;os &#40;54-73&#44;7&#41;&#59; serie previa&#44; 58&#44;1 a&#241;os &#40;45-70&#41;&#93;&#44; el sexo &#91;serie actual&#44; 79&#44;2&#37; hombres &#40;38&#47;48&#41;&#59; serie previa&#44; 92&#44;6&#37; hombres &#40;25&#47;27&#41;&#93;&#44; la GCS media &#91;serie actual&#44; 9&#44;1 puntos &#40;6-14&#44;5&#41;&#59; serie previa&#44; 7&#44;2 puntos &#40;4-10&#41;&#93;&#44; ni en el resultado funcional a los 90 d&#237;as seg&#250;n la escala mRS &#91;serie actual&#44; 39&#44;6&#37; mRS &#8804; 2 &#40;19&#47;48&#41;&#59; serie previa&#44; 22&#44;2&#37; mRS &#8804; 2 &#40;6&#47;27&#41;&#93;&#46; Se han hallado diferencias estad&#237;sticamente significativas en la media de tiempo transcurrido desde el comienzo de la sintomatolog&#237;a hasta el tratamiento endovascular &#91;serie actual&#44; 406&#44;5 minutos &#40;270-451&#44;5&#41;&#59; serie previa&#44; 1&#46;576&#44;7 minutos &#40;225-1440&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41;&#93;&#44; en el deterioro neurol&#243;gico determinado seg&#250;n la escala NIHSS &#91;serie actual&#44; 15&#44;8 &#40;9-25&#41;&#59; serie previa&#44; 22&#44;5 &#40;18-29&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#93;&#44; el porcentaje de recanalizaciones exitosas seg&#250;n la clasificaci&#243;n mTICI &#91;serie actual&#44; 95&#44;8&#37; casos &#40;46&#47;48&#41;&#59; serie previa&#44; 55&#44;6&#37; casos &#40;15&#47;27&#41;&#59; <span class="elsevierStyleItalic">p</span>&#160;&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#93;&#44; y en la mortalidad &#91;serie actual&#44; 29&#44;2&#37; defunciones &#40;14&#47;48&#41;&#59; serie previa&#44; 55&#44;6&#37; defunciones &#40;15&#47;27&#41;&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;024&#93;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Discusi&#243;n</span><p id="par0115" class="elsevierStylePara elsevierViewall">En este estudio monoc&#233;ntrico se pone de manifiesto que la trombectom&#237;a mec&#225;nica con <span class="elsevierStyleItalic">stent-retriever</span> es una t&#233;cnica que puede lograr elevadas tasas de recanalizaci&#243;n en el ictus de circulaci&#243;n posterior &#40;95&#44;8&#37;&#41; con un resultado de independencia funcional a los 3 meses &#40;39&#44;6&#37;&#41; y una mortalidad &#40;29&#44;2&#37;&#41; similares a otros estudios&#46; En la actualidad no existen ensayos cl&#237;nicos aleatorizados que avalen la trombectom&#237;a mec&#225;nica como tratamiento estandarizado&#44; si bien existen diversas publicaciones que la consideran una estrategia segura y eficaz<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">4&#44;12&#8211;15</span></a>&#46; En estos trabajos se refieren unos resultados similares a los obtenidos en nuestra serie&#44; con una tasa de recanalizaci&#243;n exitosa que oscila entre el 81&#37; y el 95&#44;2&#37;&#44; un resultado de independencia funcional a los 90 d&#237;as que oscila entre el 36&#44;2&#37; y el 46&#44;9&#37;&#44; y una mortalidad que oscila entre el 15&#44;9&#37; y el 30&#37;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">Una de las complicaciones m&#225;s temidas del procedimiento es la transformaci&#243;n hemorr&#225;gica&#46; En el metaan&#225;lisis realizado por Gory et al&#46; se refiere una tasa de hemorragias sintom&#225;ticas del 4&#37; &#40;0-16&#37;&#41;&#44; aunque se ha de tener presente que en este metaan&#225;lisis se incluyen pacientes con trombectom&#237;a mec&#225;nica realizada tanto con <span class="elsevierStyleItalic">stent-retriever</span> como por tromboaspiraci&#243;n<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">15</span></a>&#44; mientras que Kang et al&#46; refieren una tasa de hemorragias sintom&#225;ticas del 1&#44;9&#37;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; La tasa de transformaciones hemorr&#225;gicas en nuestra serie es superior &#40;8&#44;3&#37;&#41; y se asemeja m&#225;s a la referida en el metaan&#225;lisis de Mak et al&#46;&#44; en el que comparan la tromb&#243;lisis intraarterial con la trombectom&#237;a mec&#225;nica con diferentes dispositivos&#44; presentando unas tasas de hemorragia sintom&#225;tica de 9&#44;3&#37; y 9&#44;8&#37;&#44; respectivamente<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">16</span></a>&#46;</p><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Factores predictores pron&#243;sticos tras revascularizaci&#243;n con <span class="elsevierStyleItalic">stent-retriever</span></span><p id="par0125" class="elsevierStylePara elsevierViewall">Aunque se han publicado diferentes estudios para identificar factores predictores pron&#243;sticos en el ictus de circulaci&#243;n posterior tras tratamiento endovascular&#44; existe poca evidencia en el caso del tratamiento con trombectom&#237;a mec&#225;nica mediante <span class="elsevierStyleItalic">stent-retrievers</span> y la metodolog&#237;a empleada para los an&#225;lisis no siempre ha sido la ideal<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">4&#44;12&#44;13&#44;15&#44;17&#8211;19</span></a>&#46; Kang et al&#46; encontraron como factores predictores independientes de buen resultado funcional valores bajos de la escala NIHSS en el diagn&#243;stico&#44; menor longevidad&#44; ausencia de DM y ausencia de hematoma parenquimatoso tras la revascularizaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">4</span></a>&#46; Luo et al&#46; hallaron como factores predictores pron&#243;sticos independientes de buen resultado funcional valores bajos de la escala NIHSS en el diagn&#243;stico&#44; la presencia de ictus de origen ateroescler&#243;tico vs&#46; emb&#243;lico y la escala de pc-ASPECTS &#40;<span class="elsevierStyleItalic">posterior circulation Acute Stroke Prognosis Early CT Score</span>&#41; determinada mediante difusi&#243;n en resonancia magn&#233;tica<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">13</span></a>&#46; Seg&#250;n nuestro trabajo&#44; solamente se puede considerar factor pron&#243;stico independiente de buen resultado funcional un nivel de consciencia elevado al diagn&#243;stico seg&#250;n la GCS&#46; La discrepancia existente al intentar establecer factores pron&#243;sticos independientes probablemente sea debida a que los estudios realizados no sean en la actualidad lo suficientemente robustos&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Tratamiento revascularizador con &#8220;m&#233;todos cl&#225;sicos&#8221; vs&#46; <span class="elsevierStyleItalic">stent-retriever</span></span><p id="par0130" class="elsevierStylePara elsevierViewall">Hasta la irrupci&#243;n de los dispositivos de trombectom&#237;a mec&#225;nica&#44; la revascularizaci&#243;n de las oclusiones en la circulaci&#243;n posterior se llevaba a cabo con los m&#233;todos disponibles hasta entonces &#40;fibrin&#243;lisis intravenosa&#44; fibrin&#243;lisis intraarterial&#44; angioplastia&#44; lazos o endopr&#243;tesis&#41;&#46; Resulta francamente complejo comparar los estudios realizados con los &#8220;m&#233;todos cl&#225;sicos&#8221; y los trabajos que emplean <span class="elsevierStyleItalic">stent-retrievers</span> u otros dispositivos de trombectom&#237;a mec&#225;nica&#44; dado que la metodolog&#237;a de los trabajos es completamente diferente&#46; A pesar de lo expuesto&#44; estimamos necesario analizar los resultados&#44; por lo que hemos pretendido comparar la serie de pacientes que se trataron en nuestro centro con &#8220;m&#233;todos cl&#225;sicos&#8221; y la serie actual&#46; Los resultados son los esperables &#40;mayor tasa de recanalizaci&#243;n y menor mortalidad en los pacientes tratados con <span class="elsevierStyleItalic">stent-retrievers</span>&#41;&#44; aunque se trata de dos cohortes con caracter&#237;sticas basales completamente diferentes&#46; Los pacientes tratados con los &#8220;m&#233;todos cl&#225;sicos&#8221; presentaban mayor deterioro neurol&#243;gico&#44; menor nivel de consciencia y mayores intervalos de tiempo desde el comienzo de la sintomatolog&#237;a hasta el tratamiento&#46; Esto se debe a que en los &#250;ltimos a&#241;os&#44; coincidiendo con el per&#237;odo de la cohorte actual&#44; se han extremado los esfuerzos en mejorar el proceso asistencial de los pacientes con ictus&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Limitaciones</span><p id="par0135" class="elsevierStylePara elsevierViewall">Este trabajo es un estudio retrospectivo monoc&#233;ntrico y presenta limitaciones&#46; En primer lugar&#44; puede existir un sesgo de informaci&#243;n debido a las particularidades que implica el diagn&#243;stico del ictus de circulaci&#243;n posterior y al tipo de dise&#241;o del estudio&#44; ya que en algunos casos no se dispon&#237;a del tiempo de evoluci&#243;n exacto del ictus&#44; de la escala NIHSS o de la ECG iniciales&#46; En segundo lugar&#44; se han incluido a pacientes con oclusiones en la circulaci&#243;n posterior en su conjunto &#40;sistema vertebrobasilar y arterias cerebrales posteriores&#41;&#44; si bien es cierto que gran parte de la evidencia cient&#237;fica se centra exclusivamente en analizar las recanalizaciones basilares&#46; Esto puede dificultar la extrapolaci&#243;n de los resultados&#44; aunque al tratarse del mismo territorio vascular y seguir las mismas estrategias terap&#233;uticas hemos estimado positivo hacerlo de este modo&#46; En tercer lugar&#44; y como ya se ha referido anteriormente&#44; para responder a uno de los objetivos secundarios del trabajo era necesario comparar la serie actual con un trabajo previo realizado con otro m&#233;todo diferente&#44; por lo que la interpretaci&#243;n de los resultados debe tener presente esta peculiaridad&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; la trombectom&#237;a mec&#225;nica con <span class="elsevierStyleItalic">stent-retriever</span> puede lograr elevadas tasas de recanalizaci&#243;n en el ictus de circulaci&#243;n posterior&#46; En nuestra serie hay una tendencia &#40;aunque no llega a ser estad&#237;sticamente significativa&#41; a mejorar los resultados funcionales cuando se compara con los &#8220;m&#233;todos cl&#225;sicos&#8221;&#46; El uso de <span class="elsevierStyleItalic">stent retriever</span> presenta menos complicaciones que los m&#233;todos anteriores&#46; Solo el nivel de consciencia inicial determinado con la GCS es un factor pron&#243;stico independiente del resultado funcional a los 90 d&#237;as&#46;</p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Autor&#237;a</span><p id="par0145" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0150" class="elsevierStylePara elsevierViewall">Responsable de la integridad del estudio&#58; PBGJ&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0155" class="elsevierStylePara elsevierViewall">Concepci&#243;n del estudio&#58; PBGJ&#44; FDA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#46;</span><p id="par0160" class="elsevierStylePara elsevierViewall">Dise&#241;o del estudio&#58; PBGJ&#44; FDA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">4&#46;</span><p id="par0165" class="elsevierStylePara elsevierViewall">Obtenci&#243;n de los datos&#58; PBGJ&#44; IMBR&#44; EJG&#44; ROF&#44; RVM&#44; FABR&#44; FDA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">5&#46;</span><p id="par0170" class="elsevierStylePara elsevierViewall">An&#225;lisis e interpretaci&#243;n de los datos&#58; PBGJ&#44; IMBR&#44; EJG&#44; RVM&#44; ROF&#44; FABR&#44; FDA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">6&#46;</span><p id="par0175" class="elsevierStylePara elsevierViewall">Tratamiento estad&#237;stico&#58; PBGJ&#44; IMBR&#44; EJG&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">7&#46;</span><p id="par0180" class="elsevierStylePara elsevierViewall">B&#250;squeda bibliogr&#225;fica&#58; PBGJ&#44; ROF&#44; RVM&#44; FABR&#44; FDA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">8&#46;</span><p id="par0185" class="elsevierStylePara elsevierViewall">Redacci&#243;n del trabajo&#58; PBGJ&#44; IMBR&#44; EJG&#46;</p></li><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">9&#46;</span><p id="par0190" class="elsevierStylePara elsevierViewall">Revisi&#243;n cr&#237;tica del manuscrito con aportaciones intelectualmente relevantes&#58; RVM&#44; ROF&#44; FABR&#44; FDA&#46;</p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">10&#46;</span><p id="par0195" class="elsevierStylePara elsevierViewall">Aprobaci&#243;n de la versi&#243;n final&#58; PBGJ&#44; IMBR&#44; EJG&#44; ROF&#44; RVM&#44; FABR&#44; FDA&#46;</p></li></ul></p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conflicto de intereses</span><p id="par0200" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflict de intereses&#46;</p></span></span>"
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              "titulo" => "Factores predictores pron&#243;sticos tras revascularizaci&#243;n con stent-retriever"
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              "titulo" => "Tratamiento revascularizador con &#8220;m&#233;todos cl&#225;sicos&#8221; vs&#46; stent-retriever"
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    "resumen" => array:2 [
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Valorar la tasa de recanalizaci&#243;n&#44; resultado funcional a 3 meses y factores pron&#243;sticos independientes de pacientes con ictus de circulaci&#243;n posterior &#40;ICP&#41; tratados mediante <span class="elsevierStyleItalic">stent</span>-<span class="elsevierStyleItalic">retriever</span>&#44; compar&#225;ndolos con una serie anterior tratada con &#8220;m&#233;todos cl&#225;sicos&#8221;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">An&#225;lisis retrospectivo monoc&#233;ntrico de pacientes consecutivos con ICP tratados con <span class="elsevierStyleItalic">stent</span>-<span class="elsevierStyleItalic">retriever</span> entre el 1 de diciembre de 2011 y el 1 de mayo de 2018&#46; Las variables principales estudiadas son tasa de recanalizaci&#243;n y escala mRS &#40;Modified Rankin Scale&#41; a 90 d&#237;as&#46; Se valoran datos demogr&#225;ficos&#44; factores de riesgo cerebrovasculares&#44; datos cl&#237;nicos y origen probable&#46; Se ha realizado un an&#225;lisis estad&#237;stico descriptivo y un modelo de regresi&#243;n log&#237;stica binaria&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Grupo <span class="elsevierStyleItalic">stent</span>-<span class="elsevierStyleItalic">retriever</span> &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&#41;&#44; grupo &#8220;m&#233;todos cl&#225;sicos&#8221; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>27&#41;&#46; Edad media de la serie actual 63&#44;9 a&#241;os &#40;20&#44;8&#37; mujeres&#41; con una puntuaci&#243;n media en el NIHSS &#40;National Institute of Health Stroke Score&#41; de 15&#44;8 &#40;rango intercuart&#237;lico &#91;RIQ&#93; 9-25&#41; y una media en la escala de Coma de Glasgow &#40;GCS&#41; de 9&#44;1 &#40;RIQ 6-14&#44;5&#41;&#46; Se consigui&#243; el 95&#44;8&#37; de recanalizaciones TICI 2b-3 &#40;46&#47;48&#41; en el grupo actual frente al 55&#44;6&#37; &#40;15&#47;27&#41; con &#8220;m&#233;todos cl&#225;sicos&#8221; &#40;<span class="elsevierStyleItalic">p</span>&#160;&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;0001&#41;&#46; No existe diferencia significativa en la escala mRS 0-2 a 90 d&#237;as &#91;serie actual&#44; 39&#44;6&#37; &#40;19&#47;48&#41;&#59; serie previa&#44; 22&#44;2&#37; &#40;6&#47;27&#41;&#93;&#46; Hay diferencia significativa &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;024&#41; en la mortalidad&#58; serie actual&#44; 29&#44;2&#37; &#40;14&#47;48&#41;&#59; serie previa&#44; 55&#44;6&#37; &#40;15&#47;27&#41;&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La GCS se relacion&#243; de forma independiente con la mRS a 90 d&#237;as &#40;<span class="elsevierStyleItalic">odds ratio</span>&#44; 0&#44;67&#59; intervalo de confianza&#44; 0&#44;5-0&#44;91&#59; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Los <span class="elsevierStyleItalic">stent</span>-<span class="elsevierStyleItalic">retrievers</span> logran elevadas tasas de recanalizaci&#243;n en el ICP&#44; con independencia funcional a los 3 meses y complicaciones similares a las de otros estudios&#46; La GCS es un factor pron&#243;stico independiente del resultado funcional a 90 d&#237;as&#46;</p></span>"
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        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objectives</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">To determine the rate of recanalization&#44; functional outcome at three months&#44; and independent prognostic factors in patients with posterior circulation strokes treated with stent-retrievers and to compare these results with those of patients in an earlier series treated with &#8220;classical methods&#8221;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">This was a retrospective study of consecutive patients with posterior circulation strokes treated with stent-retrievers at our center between December 1&#44; 2011 and May 1&#44; 2018&#46; The main outcome variables were the rate of recanalization according to the Thrombosis in Cerebral Infarction &#40;TICI&#41; scale and functional independence score 90 days after treatment according to the modified Rankin Scale &#40;mRS&#41;&#46; We analyzed demographics&#44; cerebrovascular risk factors&#44; clinical findings&#44; and probable origin&#46; Descriptive statistics and a binary logistic regression model were used to analyze the data&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">We included 75 patients&#58; 27 treated with &#8220;classical methods&#8221; and 48 treated with stent-retrievers &#40;10 women&#59; mean age&#44; 63&#46;9 years&#59; median National Institute of Health Stroke Score&#44; 15&#46;8 &#40;IQR 9-25&#41;&#59; median Glasgow Coma Scale &#40;GCS&#41;&#44; 9&#46;1 &#40;IQR 6-14&#44;5&#41;&#46; TICI 2b-3 recanalization was achieved in 46 &#40;95&#46;8&#37;&#41; patients treated with stent-retrievers and in 15 &#40;55&#46;6&#37;&#41; patients treated with &#8220;classical methods&#8221; &#40;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46; No significant differences were observed in the rate of patients achieving mRS 0-2 at 90 days &#40;19 &#40;39&#46;6&#37;&#41; of those treated with stent-retrievers vs&#46; 6 &#40;22&#46;2&#37;&#41; of those treated with &#8220;classical methods&#8221;&#41;&#46; Mortality was lower among patients treated with stent-retrievers &#40;14 &#40;29&#46;2&#37; vs&#46; 15 &#40;55&#46;6&#37;&#41; in those treated with &#8220;classical methods&#8221;&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;024&#41;&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">GCS score was independently associated with mRS at 90 days &#40;OR&#58;0&#46;67&#59; 95&#37;<span class="elsevierStyleSmallCaps">C</span>I&#58;0&#46;5-0&#46;91&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">In patients with posterior circulation infarcts&#44; treatment with stent-retrievers achieved high rates of recanalization and functional independence at 90 days&#46; The rate of complications was similar to those reported in other studies&#46; GCS is an independent predictor of functional independence at 90 days&#46;</p></span>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Totaln<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">mRS 90 d&#237;as &#8804; 2n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>19 &#40;39&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">mRS 90 d&#237;as &#62;<span class="elsevierStyleHsp" style=""></span>2n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>29 &#40;60&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Valor de <span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Edad</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Media &#40;RIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63&#44;9 &#40;54-73&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#44;5 &#40;54-63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66&#44;1 &#40;55-77&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;121&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Sexo</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hombres&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;79&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;89&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;72&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;276<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mujeres&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;20&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;27&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Factores de riesgo cardiovascular</span>&#58;</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HTA</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">30 &#40;62&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;52&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;253&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;37&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;47&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">DM</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;27&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;10&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;37&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;037&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;72&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;89&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;62&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FA</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;39&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;47&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;34&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;372&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;60&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;52&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;65&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Dislipidemia</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;37&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;47&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;253&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;62&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">H&#225;bito tab&#225;quico</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">H&#225;bito en&#243;lico</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Ictus previos</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">41 &#40;85&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">IAM previos</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">46 &#40;95&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18 &#40;94&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Antiagregantes</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tetraplej&#237;a</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Ictus en progresi&#243;n</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Comunicante posterior</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Intubaci&#243;n</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t">0&#44;451<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">NIHSS inicial</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Media &#40;RIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;8 &#40;9-25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;9 &#40;6&#44;7-22&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;3 &#40;10-25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;036&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Glasgow</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Media &#40;RIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;1 &#40;6-14&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;9 &#40;9-15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;7 &#40;4-7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Glucemia &#40;mg&#47;dl&#41;&#58;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Media &#40;RIQ&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">157&#44;6 &#40;111&#44;5-189&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;89-143&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185&#44;5 &#40;119&#44;5-224&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Etiolog&#237;a</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aterotromb&#243;tico&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">14 &#40;29&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;36&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;24&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;344&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Emb&#243;lico&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;31&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;47&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;20&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;051&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disecci&#243;n&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Indeterminado&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18 &#40;37&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;51&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;012&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Localizaci&#243;n trombo</span>&#58;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V1-V3&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;3&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>V4&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;6&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Basilar proximal&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;13&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;635<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Basilar media&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;18&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">6 &#40;20&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">mRS 90 d&#237;as<span class="elsevierStyleHsp" style=""></span>&#62; 2n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>29 &#40;60&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Valor de <span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Embolias distales&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;15&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;372<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">43 &#40;89&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;84&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">27 &#40;93&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Transformaci&#243;n hemorr&#225;gica&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;10&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5 &#40;17&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;142<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43 &#40;89&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">19 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">24 &#40;82&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tipo de hemorragia&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43 &#40;89&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">19 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">24 &#40;82&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;142<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infarto hemorr&#225;gico&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;3&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1<a class="elsevierStyleCrossRef" href="#tblfn0015"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hemorragia parenquimatosa&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " colspan="5" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Craniectom&#237;a&#58;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>S&#237;&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Complicaciones secundarias al tratamiento con <span class="elsevierStyleItalic">stent-retrievers</span> y comparaci&#243;n de pacientes con independencia y dependencia funcional a los 90 d&#237;as</p>"
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                0 => array:1 [
                  "referenciaCompleta" => "Defunciones seg&#250;n la Causa de Muerte&#46; A&#241;o 2016&#46; Notas de prensa del Instituto Nacional de Estad&#237;stica&#46; Disponible en&#58; https&#58;&#47;&#47;www&#46;ine&#46;es&#47;prensa&#47;edcm&#95;2016&#46;pdf&#59; 2017 &#91;consultado 11 Nov 2018&#93;&#46;"
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                      "titulo" => "Basilar artery occlusion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;P&#46; Mattle"
                            1 => "M&#46; Arnold"
                            2 => "P&#46;J&#46; Lindsberg"
                            3 => "W&#46;J&#46; Schonewill"
                            4 => "G&#46; Schroth"
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                    0 => array:2 [
                      "doi" => "10.1016/S1474-4422(11)70229-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Neurol&#46;"
                        "fecha" => "2011"
                        "volumen" => "10"
                        "paginaInicial" => "1002"
                        "paginaFinal" => "1014"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22014435"
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                      "titulo" => "Endovascular vs medical management of acute ischemic stroke"
                      "autores" => array:1 [
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                          "autores" => array:6 [
                            0 => "C&#46;J&#46; Chen"
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                            2 => "R&#46;M&#46; Starke"
                            3 => "P&#46; Mehndiratta"
                            4 => "R&#46;W&#46; Crowley"
                            5 => "K&#46;C&#46; Liu"
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                    0 => array:2 [
                      "doi" => "10.1212/WNL.0000000000002176"
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                        "volumen" => "85"
                        "paginaInicial" => "1980"
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