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Adelaida Álvarez, Simón P. Aristizábal L., Luis Enrique Chaparro, Lizeth J. Ramírez B., Carlos A. Sarassa V." "autores" => array:5 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Adelaida Álvarez" ] 1 => array:2 [ "nombre" => "Simón P." "apellidos" => "Aristizábal L." ] 2 => array:2 [ "nombre" => "Luis Enrique" "apellidos" => "Chaparro" ] 3 => array:2 [ "nombre" => "Lizeth J." "apellidos" => "Ramírez B." ] 4 => array:2 [ "nombre" => "Carlos A." "apellidos" => "Sarassa V." ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0120334710840092?idApp=UINPBA00004N" "url" => "/01203347/0000003800000004/v2_201302061631/S0120334710840092/v2_201302061631/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0120334710840079" "issn" => "01203347" "doi" => "10.1016/S0120-3347(10)84007-9" "estado" => "S300" "fechaPublicacion" => "2010-11-01" "aid" => "7" "copyright" => "Revista Colombiana de Anestesiología" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/3.0/" "subdocumento" => "fla" "cita" => "Rev Colomb Anestesiol. 2010;38:499-507" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2601 "formatos" => array:3 [ "EPUB" => 96 "HTML" => 926 "PDF" => 1579 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ARTÍCULOS DE REFLEXIÓN</span>" "titulo" => "Tromboembolísmo venoso postoperatorio: grave riesgo prevenible" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "499" "paginaFinal" => "507" ] ] "titulosAlternativos" => array:1 [ "en" => array:2 [ "titulo" => "Postoperatory Venous Thromboembolism" "subtitulo" => "A Serious Preventable Risk" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Wilson Valencia, Johnnie Smith Husbands Luque" "autores" => array:2 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Wilson Valencia" ] 1 => array:2 [ "nombre" => "Johnnie Smith" "apellidos" => "Husbands Luque" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0120334710840079?idApp=UINPBA00004N" "url" => "/01203347/0000003800000004/v2_201302061631/S0120334710840079/v2_201302061631/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">ARTÍCULO DE REVISIÓN</span>" "titulo" => "Coagulopatía temprana en trauma: ¿Llegan los pacientes coagulopáticos a la sala de cirugía?" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "510" "paginaFinal" => "525" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Juan Carlos Jiménez B., Jairo de La Peña L., Rubén Teherán M., Andrés Orozco" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Juan Carlos" "apellidos" => "Jiménez B." "email" => array:1 [ 0 => "juanjim170@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "af0005" ] ] ] 1 => array:3 [ "nombre" => "Jairo de La" "apellidos" => "Peña L." "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "af0010" ] ] ] 2 => array:3 [ "nombre" => "Rubén" "apellidos" => "Teherán M." "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "***" "identificador" => "af0015" ] ] ] 3 => array:3 [ "nombre" => "Andrés" "apellidos" => "Orozco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "****" "identificador" => "af0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "MD Especialista en Anestesiología, Universidad de Cartagena. Anestesiólogo Hospital Universitario del Caribe, Cartagena, Colombia" "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "af0005" ] 1 => array:3 [ "entidad" => "Residente de I año Cirugía General, Universidad de Cartagena, Cartagena, Colombia" "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "af0010" ] 2 => array:3 [ "entidad" => "MD. Anestesiólogo director UCI Hospital Universitario del Caribe, Cartagena, Colombia" "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "af0015" ] 3 => array:3 [ "entidad" => "Médico de Planta, UCI Hospital Universitario del Caribe, Cartagena, Colombia" "etiqueta" => "****" "identificador" => "af0020" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:2 [ "titulo" => "Early Coagulopathy in Trauma" "subtitulo" => "Do Coagulopathic patients Reach the operating Room?" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-25" "fechaAceptado" => "2010-07-26" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras claves" "identificador" => "xpalclavsec17608" "palabras" => array:5 [ 0 => "Coagulopatía" 1 => "trauma" 2 => "hemorragia" 3 => "transfusión" 4 => "tromboelastografía (Fuente: DeCS, BIREME)" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec17607" "palabras" => array:5 [ 0 => "Coagulopathy" 1 => "trauma" 2 => "hemorrhage" 3 => "transfusion" 4 => "thromboelastography (Source: MeSH, BIREME)" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "RESUMEN" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0010">Introducción</span><p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">De la coagulopatía aguda en el trauma, resultan múltiples complicaciones como la necesidad de administración de hemoderivados, mayor incidencia de disfunción orgánica, aumento de estancia en unidad de cuidados intensivos y mayor mortalidad. Con el conocimiento actual de la fisiopatología del trauma y la vía celular de la coagulación es ahora posible mejorar el dignóstico y tratamiento de la coagulopatía inicial y conseguir mejores resultados en nuestros centros.</p> <span class="elsevierStyleSectionTitle" id="st0015">Métodos</span><p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Este artículo examina la fisiología básica de la coagulación, la etiología, el diagnóstico y el tratamiento de la coagulopatía temprana en trauma. La búsqueda se realizó con términos Mesh y no Mesh con conectores AND: Anesthesia-coagulophaty, postinjury and trauma thromboelastography, transfusion and trauma, shock- Mechanism and trauma review.</p> <span class="elsevierStyleSectionTitle" id="st0020">Resultados</span><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">La coagulopatía aguda o temprana en trauma está directamente asociada al estado de shock y se caracteriza por anticoagulación e hiperfibrinolisis sistémica; hay evidencia de la implicación de la proteína C en este proceso. Se ha establecido que seis mecanismos fisiopatológicos multifactoriales pueden perpetuar la coagulopatía en los pacientes traumatizados; éstos son: inflamación, acidosis, hipotermia, shock, trauma tisular y hemodilución. El diagnóstico se realiza con las diferentes pruebas (TP, TPT, plaquetas) ya conocidas desde hace mucho tiempo, pero con limitaciones que reducen su utilidad clínica. Ahora la tromboelastografía nos puede ayudar a guiar la transfusión, con el concepto actual de transfusión temprana de glóbulos rojos, plasma y plaquetas, utilizando la mejor proporción según la evidencia disponible.</p> <span class="elsevierStyleSectionTitle" id="st0025">Conclusiones</span><p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Contamos, con algún conocimiento sobre la fisiopatología de la coagulopatía asociada con trauma pero son necesarias más investigaciones, en este campo. El diagnóstico rápido y una intervención directa inmediata son importantes para mejorar el desenlace de nuestros pacientes.</p>" ] "en" => array:2 [ "titulo" => "SUMMARY" "resumen" => "<span class="elsevierStyleSectionTitle" id="st0035">Introduction</span><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Acute coagulopathy in trauma results in multiple complications such as the need for blood products, higher rates of organ dysfunction, longer stay in the ICU and higher mortality. With the current knowledge of the pathophysiology of trauma and of the cellular coagulation pathway it is now possible to improve diagnosis and treatment of the initial coagulopathy and achieve better outcomes in our trauma centers.</p> <span class="elsevierStyleSectionTitle" id="st0040">Methods</span><p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">This paper looks into the basic physiology of coagulation, and the etiology, diagnosis and treatment of early coagulopathy in trauma. The search was done using Mesh and non-Mesh terms with AND connectors: Anesthesia-coagulopathy, postinjury and trauma thromboelastography, transfusion and trauma, shock-Mechanism and trauma review.</p> <span class="elsevierStyleSectionTitle" id="st0045">Results</span><p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Acute or early coagulopathy in trauma is directly associated with a state of shock and is characterized by anticoagulation and systemic hyperfibrinolysis; protein C is known to be implicated in this process. It has also been determined that six multi-factorial pathophysiological mechanisms may perpetuate coagulopathy in trauma patients, namely, inflammation, acidosis, hypothermia, shock, tissue trauma and hemodilution. Diagnosis is made using the different tests (PT, PPT, platelets) that have been in use for a long time; however, these tests have drawbacks that limit their clinical usefulness. Thromboelastography can now help guide early transfusion using the best proportion of red blood cells, plasma and platelets on the basis of the best available evidence.</p> <span class="elsevierStyleSectionTitle" id="st0050">Conclusions</span><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">We have some knowledge about the pathophysiology coagulopathy associated with trauma but more research in this field is needed. Rapid diagnosis and immediate intervention are important to improve the outcomes with our patients.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:50 [ 0 => array:3 [ "identificador" => "bb0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Davenporta. Acute coagulopathy of trauma: mechanism, identification and effect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Brohi" 1 => "J. Mitchell" 2 => "Cohenb" 3 => "A. Ross" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MCC.0b013e3282f1e78f" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Crit Care" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "680" "paginaFinal" => "685" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17975390" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bb0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bloodtransfusion is an independent predictor of mortality after blunttrauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Charles" 1 => "A.A. Shaikh" 2 => "M. Walters" 3 => "S. Huehl" 4 => "R. Pomerantz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Surg" "fecha" => "2007" "volumen" => "73" "paginaInicial" => "1" "paginaFinal" => "5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17249446" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bb0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivobleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy thanprothrombin time" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.S. Kheirabadi" 1 => "J.M. Crissey" 2 => "R. Deguzman" 3 => "J.B. Holcomb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TA.0b013e318047b805" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2007" "volumen" => "62" "paginaInicial" => "1352" "paginaFinal" => "1359" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17563647" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bb0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of early coagulation abnormalities in trauma patients by rotation thrombelastography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Rugeri" 1 => "A. Levrat" 2 => "J.S. David" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "JThrombHaemost" "fecha" => "2007" "volumen" => "5" "paginaInicial" => "289" "paginaFinal" => "295" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bb0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The ratio of bloodproducts transfused affects mortality in patients receiving massive transfusions at a combat support hospital" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "M.A. Borgman" 1 => "P.C. Spinella" 2 => "J.G. Perkins" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TA.0b013e3181271ba3" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2007" "volumen" => "63" "paginaInicial" => "805" "paginaFinal" => "813" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18090009" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bb0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of trauma deaths: a Reassessment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "A. Sauaia" 1 => "F.A. Moore" 2 => "E.E. Moore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Trauma" "fecha" => "1995" "volumen" => "38" "numero" => "2" "paginaInicial" => "185" "paginaFinal" => "193" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7869433" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bb0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early coagulopathy predicts mortality in trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. MacLeod" 1 => "M. Lynn" 2 => "M. McKenney" 3 => "S. Cohn" 4 => "M. Murtha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.TA.0000075338.21177.EF" "Revista" => array:7 [ "tituloSerie" => "J Trauma" "fecha" => "2003" "volumen" => "55" "numero" => "1" "paginaInicial" => "39" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12855879" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bb0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute traumatic coagulopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K. Brohi" 1 => "J. Singh" 2 => "M. Heron" 3 => "T. Coats" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.TA.0000069184.82147.06" "Revista" => array:7 [ "tituloSerie" => "J. Trauma" "fecha" => "2003" "volumen" => "54" "numero" => "6" "paginaInicial" => "1127" "paginaFinal" => "1130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12813333" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bb0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transfusion Strategies in Posinjury Coagulophaty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.F. Stahel" 1 => "E.E. Moore" 2 => "S.L. Schreier" 3 => "M.A. Flierl" 4 => "J.L. Kashuk" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Anesth" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "289" "paginaFinal" => "298" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bb0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Brohi" 1 => "M.J. Cohen" 2 => "M.T. Ganter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TA.0b013e318169cd3c" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2008" "volumen" => "64" "paginaInicial" => "1211" "paginaFinal" => "1217" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18469643" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bb0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "K. Brohi" 1 => "M.J. Cohen" 2 => "M.T. Ganter" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.sla.0000256862.79374.31" "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "2007" "volumen" => "245" "paginaInicial" => "812" "paginaFinal" => "881" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17457176" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bb0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manejo de hemorragia digestiva profusa secundaria a hemangioma intestinal con factorVIIa recombinante [Reporte de caso y revisión de la literatura]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Torres" 1 => "M.U. Torres" 2 => "M.A. Benjumea" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Act Colom de Cuid Inten" "fecha" => "2008" "volumen" => "8" "numero" => "4" "paginaInicial" => "322" "paginaFinal" => "329" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bb0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood Coagulation: Hemostasis and Thrombin Regulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Tanaka" 1 => "A. kenichi" 2 => "N.S. Keil" 3 => "Levy" 4 => "H. Jerrold" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00540-015-1995-y" "Revista" => array:7 [ "tituloSerie" => "Anesth. & Analg" "fecha" => "2009" "volumen" => "108" "numero" => "5" "paginaInicial" => "1433" "paginaFinal" => "1446" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25771761" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bb0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Coagulopathy of Trauma: A Review of Mechanisms" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:12 [ 0 => "R.H. John" 1 => "K. Brohi" 2 => "P.D. Richard" 3 => "J.H. Carl" 4 => "B.H. John" 5 => "Y. Kluger" 6 => "K. Mackway" 7 => "M. Par" 8 => "S.B. Rizoli" 9 => "T. Yukioka" 10 => "D.B. Hoyt" 11 => "B. Bouillon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TA.0b013e3181877a9c" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2008" "volumen" => "65" "paginaInicial" => "748" "paginaFinal" => "754" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18849786" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bb0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The interactions between inflammation and coagulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.T. Esmon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Bj J Haematol" "fecha" => "2005" "volumen" => "131" "paginaInicial" => "417" "paginaFinal" => "430" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bb0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biochemistry and physiology of blood coagulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.G. Mann" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Haemost" "fecha" => "1999" "volumen" => "82" "paginaInicial" => "165" "paginaFinal" => "174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10660426" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bb0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early physiologic predictors of injur Severity and death in blunt multiple trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "J.H. Siegel" 1 => "A.I. Rivkind" 2 => "S. Dalal" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Surg" "fecha" => "1990" "volumen" => "125" "paginaInicial" => "498" "paginaFinal" => "508" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2322117" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bb0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Theresuscitative fluid you choose may potentiate bleeding" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Z.K. Brummel" 1 => "M.F. Whelihan" 2 => "E.G. Ziedins" 3 => "K.G. Mann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ta.0000235525.64176.01" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "1350" "paginaFinal" => "1358" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17159676" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bb0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Are we giving enough coagulation factors during major trauma resuscitation?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Ho" 1 => "M.K. Karmakar" 2 => "P.W. Dion" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.amjsurg.2005.03.034" "Revista" => array:6 [ "tituloSerie" => "Am J Surg" "fecha" => "2005" "volumen" => "190" "paginaInicial" => "479" "paginaFinal" => "484" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16105540" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bb0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Minimizing dilutional coagulopathy in exsanguinating hemorrhage: a computer simulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Hirshberg" 1 => "M. Dugas" 2 => "E.I. Banez" 3 => "B.G. Scott" 4 => "M.J. Wall" 5 => "K.L. Mattox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.TA.0000053245.08642.1F" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2003" "volumen" => "54" "paginaInicial" => "454" "paginaFinal" => "463" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12634523" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bb0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sonoclot coagulation analysis of in-vitro haemodilution with resuscitation solutions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E.V. Brazil" 1 => "T.J. Coats" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J R Soc Med" "fecha" => "2000" "volumen" => "93" "paginaInicial" => "507" "paginaFinal" => "510" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11064686" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bb0110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recommendations on the use of rFVIIa as an adjunctive treatment for massive bleeding -a European perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.L. Vincent" 1 => "R. Rossaint" 2 => "B. Riou" 3 => "Y. Ozier" 4 => "D. Zideman" 5 => "D.R. Spahn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/cc5026" "Revista" => array:5 [ "tituloSerie" => "Critical Care" "fecha" => "2006" "volumen" => "10" "paginaInicial" => "R120" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16919168" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bb0115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hypothermia and blood coagulation: dissociation between enzyme activity and clotting factor levels" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.L. Reed II" 1 => "A.W. Bracey Jr." 2 => "J.D. Hudson" 3 => "T.A. Miller" 4 => "R.P. Fischer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circ Shock" "fecha" => "1990" "volumen" => "32" "paginaInicial" => "141" "paginaFinal" => "152" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2253317" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bb0120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.S. Wolberg" 1 => "Z.H. Meng" 2 => "D.M. Monroe III" 3 => "M. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2004" "volumen" => "56" "paginaInicial" => "1221" "paginaFinal" => "1228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15211129" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bb0125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect oftemperature and pH on the activity of factor VIIa: implications forthe efficacy of high-dose factor VIIa in hypothermic and acidoticpatients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Z.H. Meng" 1 => "A.S. Wolberg" 2 => "D.M. Monroe III" 3 => "M. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.TA.0000066184.20808.A5" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2003" "volumen" => "55" "paginaInicial" => "886" "paginaFinal" => "891" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14608161" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bb0130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "systematic evaluation ofthe effect of temperature on coagulation enzyme activity and platelet function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.S. Wolberg" 1 => "Z.H. Meng" 2 => "D.M. Monroe" 3 => "M.A. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2004" "volumen" => "56" "paginaInicial" => "1221" "paginaFinal" => "1228" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15211129" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bb0135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Independent contributions of hypothermia and acidosis tocoagulopathy in swine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.Z. Martini" 1 => "A.E. Pusateri" 2 => "J.M. Uscilowicz" 3 => "A.V. Delgado" 4 => "J.B. Holcomb" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Trauma [discussion]" "fecha" => "2005" "volumen" => "58" "paginaInicial" => "1009" "paginaFinal" => "1010" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bb0140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predicting life-threatening coagulopathy in the massively transfused trauma patient: hypothermia and acidoses revisited" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Cosgriff" 1 => "E.E. Moore" 2 => "A. Sauaia" 3 => "K. Moynihan" 4 => "J.M. Burch" 5 => "B. Galloway" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Trauma. [discussion]" "fecha" => "1997" "volumen" => "42" "paginaInicial" => "857" "paginaFinal" => "861" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bb0145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of tris-hydroxymethyl aminomethane on reversing coagulation abnormalities caused by acidosis in pigs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "W.Z. Martini" 1 => "M.A. Dubick" 2 => "C.E. Wade" 3 => "J.B. Holcomb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.CCM.0000266682.74602.6A" "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2007" "volumen" => "35" "paginaInicial" => "1568" "paginaFinal" => "1574" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17452929" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bb0150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The cytokine mediated imbalance between coagulant and anticoagulant mechanisms in sepsis and endotoxaemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Levi" 1 => "T. van der Poll" 2 => "H. ten Cate" 3 => "S.J. van Deventer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Invest" "fecha" => "1997" "volumen" => "27" "paginaInicial" => "3" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9041370" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bb0155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of inflammatory mediators in thrombogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.J. Shebuski" 1 => "K.S. Kilgore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pharmacol Exp Ther" "fecha" => "2002" "volumen" => "300" "paginaInicial" => "729" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11861775" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bb0160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase in activated protein c mediates acute traumatic coagulopathy in mice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:9 [ 0 => "B.B. Chesebro" 1 => "P. Rahn" 2 => "M. Carles" 3 => "C. Esmon" 4 => "X. Jun" 5 => "K. Brohi" 6 => "D. Frith" 7 => "J.-P. Pittet" 8 => "M. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Shock" "fecha" => "2009 Dec 32" "volumen" => "6" "paginaInicial" => "659" "paginaFinal" => "665" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bb0165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of early coagulation abnormalitiesin trauma patients by rotation thrombelastography" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "L. Rugeri" 1 => "A. Levrat" 2 => "J.S. David" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1538-7836.2007.02319.x" "Revista" => array:6 [ "tituloSerie" => "J Thromb Haemost" "fecha" => "2007" "volumen" => "5" "paginaInicial" => "289" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17109736" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bb0170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coagulophaty in trauma patients : Importance of thrombocyte function?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Devenport" 1 => "K. Brohi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Anesth" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "261" "paginaFinal" => "266" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bb0175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transfusion in trauma: why and how should we change our current practice?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Oliver" 1 => "D.R Theusinger" 2 => "M. Ganter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Curr Opn Anaesth" "fecha" => "2009" "volumen" => "22" "paginaInicial" => "000" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bb0180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.V. Feliciano" 1 => "K. Mattox" 2 => "E. Moore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "6th Edition" "titulo" => "Trauma" "fecha" => "2008" "editorial" => "McGraw-Hill" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bb0185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current Concepts in Hemorrhagic Shock" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R.P. Dutton" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Anesth Clinics" "fecha" => "2007 March 1" "volumen" => "25" "paginaInicial" => "23" "paginaFinal" => "34" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bb0190" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "American College of Surgeons Committee on Trauma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "Advanced Trauma Life Support(ATLS)Course for Physicians" "edicion" => "edn 7" "serieFecha" => "2008" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bb0195" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tailoring haemostatic treatment to patient requirements - an update on monitoring haemostatic response using thrombelastography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "B. Sorensen" 1 => "J. Ingerslev" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2516.2005.01156.x" "Revista" => array:7 [ "tituloSerie" => "[Suppl] Haemophilia" "fecha" => "2005" "volumen" => "11" "numero" => "1" "paginaInicial" => "1" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16219042" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bb0200" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prospective study of clinical bleeding in intensive care unit patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.B. Brown" 1 => "J. Klar" 2 => "D. Teres" 3 => "S. Lemeshow" 4 => "M. Sands" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Crit Care Med" "fecha" => "1988 Dec" "volumen" => "16" "numero" => "12" "paginaInicial" => "1171" "paginaFinal" => "1176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3191733" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bb0205" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reversal of Coagulopathy in Critically Ill Patients With Traumatic Brain Injury: recombinant Factor VIIa is More Cost-Effective Than Plasma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D. Stein" 1 => "R. Dutton" 2 => "M. Kramer" 3 => "T. Scalea" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/TA.0b013e318191bc8a" "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2009" "volumen" => "66" "paginaInicial" => "63" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19131807" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bb0210" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recombinant factor VIIa in severe trauma: Further study needed" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.A. Galvan" 1 => "M.P. Fink" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Crit care" "fecha" => "2006" "volumen" => "10" "paginaInicial" => "308" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bb0215" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intravenous rFVIIa administered for hemorrhage control in hypothermic coagulopathic swine ith grade V liver injuries" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "U. Martinowitz" 1 => "J.B. Holcomb" 2 => "A.E. Pusateri" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Trauma" "fecha" => "2001" "volumen" => "50" "paginaInicial" => "721" "paginaFinal" => "729" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11303171" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bb0220" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of thromboelastometry and recombinant factor VIIa in trauma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Bartal" 1 => "A. Yitzha" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACO.0b013e328325a6be" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Anaesthesiol" "fecha" => "2009 Apr" "volumen" => "22" "numero" => "2" "paginaInicial" => "281" "paginaFinal" => "288" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19390255" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bb0225" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prothrombin complex concentrates: indications, contraindications, and risks: a task force summary" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:3 [ 0 => "P. Hellstern" 1 => "W.M. Halbmayer" 2 => "M. Kohler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Res" "fecha" => "1999" "volumen" => "95" "paginaInicial" => "S3" "paginaFinal" => "S6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10499902" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bb0230" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indications for prothrombin complex concentrates in massive transfusions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Blauhut" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Res" "fecha" => "1999" "volumen" => "95" "paginaInicial" => "S63" "paginaFinal" => "S69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10499911" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bb0235" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anticoagulants and their reversal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S. Schulman" 1 => "N.R. Bijsterveld" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.tmrv.2006.08.002" "Revista" => array:6 [ "tituloSerie" => "Transfusion Medicine Reviews" "fecha" => "2007" "volumen" => "21" "paginaInicial" => "37" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17174219" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bb0240" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of prothrombin complex concentrates in anticoagulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.Q. Van Veen" 1 => "P.F. Strengers" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajh.21142" "Revista" => array:6 [ "tituloSerie" => "Am J Hematol" "fecha" => "2008" "volumen" => "83" "paginaInicial" => "344" "paginaFinal" => "345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18213649" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bb0245" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Crosstalk between inflammation and thrombosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.T. Esmon" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.maturitas.2003.10.015" "Revista" => array:6 [ "tituloSerie" => "Maturitas" "fecha" => "2004" "volumen" => "47" "paginaInicial" => "305" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15063484" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bb0250" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein S: a conduit between anticoagulation and inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.C. Rigby" 1 => "M.A. Grant" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Crit Care Med" "fecha" => "2004" "volumen" => "32" "paginaInicial" => "S336" "paginaFinal" => "S341" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15118541" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/01203347/0000003800000004/v2_201302061631/S0120334710840080/v2_201302061631/es/main.assets" "Apartado" => array:4 [ "identificador" => "896" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Artículo de revisión" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/01203347/0000003800000004/v2_201302061631/S0120334710840080/v2_201302061631/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0120334710840080?idApp=UINPBA00004N" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Octubre | 11 | 13 | 24 |
2024 Septiembre | 18 | 39 | 57 |
2024 Agosto | 18 | 8 | 26 |
2024 Julio | 7 | 13 | 20 |
2024 Junio | 12 | 13 | 25 |
2024 Mayo | 6 | 6 | 12 |
2024 Abril | 10 | 2 | 12 |
2024 Marzo | 23 | 13 | 36 |
2024 Febrero | 17 | 15 | 32 |
2024 Enero | 15 | 30 | 45 |
2023 Diciembre | 4 | 27 | 31 |
2023 Noviembre | 13 | 19 | 32 |
2023 Octubre | 11 | 16 | 27 |
2023 Septiembre | 3 | 9 | 12 |
2023 Agosto | 15 | 11 | 26 |
2023 Julio | 4 | 12 | 16 |
2023 Junio | 10 | 8 | 18 |
2023 Mayo | 34 | 10 | 44 |
2023 Abril | 35 | 15 | 50 |
2023 Marzo | 23 | 7 | 30 |
2023 Febrero | 10 | 7 | 17 |
2023 Enero | 4 | 4 | 8 |
2022 Diciembre | 5 | 4 | 9 |
2022 Noviembre | 9 | 8 | 17 |
2022 Octubre | 10 | 9 | 19 |
2022 Septiembre | 5 | 11 | 16 |
2022 Agosto | 10 | 7 | 17 |
2022 Julio | 9 | 8 | 17 |
2022 Junio | 5 | 7 | 12 |
2022 Mayo | 12 | 7 | 19 |
2022 Abril | 9 | 17 | 26 |
2022 Marzo | 23 | 9 | 32 |
2022 Febrero | 8 | 6 | 14 |
2022 Enero | 22 | 14 | 36 |
2021 Diciembre | 10 | 6 | 16 |
2021 Noviembre | 2 | 10 | 12 |
2021 Octubre | 12 | 14 | 26 |
2021 Septiembre | 4 | 6 | 10 |
2021 Agosto | 6 | 5 | 11 |
2021 Julio | 5 | 4 | 9 |
2021 Junio | 13 | 7 | 20 |
2021 Mayo | 15 | 4 | 19 |
2021 Abril | 10 | 17 | 27 |
2021 Marzo | 2 | 52 | 54 |
2021 Febrero | 12 | 32 | 44 |
2021 Enero | 6 | 26 | 32 |
2020 Diciembre | 16 | 30 | 46 |
2020 Noviembre | 9 | 23 | 32 |
2020 Octubre | 6 | 27 | 33 |
2020 Septiembre | 7 | 13 | 20 |
2020 Agosto | 6 | 7 | 13 |
2020 Julio | 5 | 4 | 9 |
2020 Junio | 2 | 7 | 9 |
2020 Mayo | 4 | 10 | 14 |
2020 Abril | 3 | 6 | 9 |
2020 Marzo | 3 | 7 | 10 |
2020 Febrero | 2 | 5 | 7 |
2020 Enero | 4 | 4 | 8 |
2019 Diciembre | 4 | 3 | 7 |
2019 Noviembre | 0 | 2 | 2 |
2019 Octubre | 2 | 3 | 5 |
2019 Septiembre | 5 | 1 | 6 |
2019 Agosto | 1 | 0 | 1 |
2019 Julio | 4 | 8 | 12 |
2019 Junio | 0 | 1 | 1 |
2019 Mayo | 1 | 8 | 9 |
2018 Octubre | 1 | 0 | 1 |
2018 Septiembre | 1 | 0 | 1 |
2018 Junio | 9 | 3 | 12 |
2018 Mayo | 42 | 10 | 52 |
2018 Abril | 49 | 19 | 68 |
2018 Marzo | 42 | 13 | 55 |
2018 Febrero | 28 | 10 | 38 |
2018 Enero | 26 | 7 | 33 |
2017 Diciembre | 40 | 28 | 68 |
2017 Noviembre | 43 | 68 | 111 |
2017 Octubre | 36 | 89 | 125 |
2017 Septiembre | 34 | 120 | 154 |
2017 Agosto | 28 | 133 | 161 |
2017 Julio | 26 | 94 | 120 |
2017 Junio | 46 | 148 | 194 |
2017 Mayo | 32 | 136 | 168 |
2017 Abril | 49 | 140 | 189 |
2017 Marzo | 28 | 178 | 206 |
2017 Febrero | 39 | 233 | 272 |
2017 Enero | 26 | 69 | 95 |
2016 Diciembre | 75 | 83 | 158 |
2016 Noviembre | 51 | 110 | 161 |
2016 Octubre | 61 | 127 | 188 |
2016 Septiembre | 136 | 193 | 329 |
2016 Agosto | 176 | 196 | 372 |
2016 Julio | 71 | 105 | 176 |
2016 Febrero | 1 | 0 | 1 |
2015 Diciembre | 5 | 70 | 75 |
2015 Noviembre | 26 | 97 | 123 |
2015 Octubre | 29 | 115 | 144 |
2015 Septiembre | 23 | 107 | 130 |
2015 Agosto | 28 | 76 | 104 |
2015 Julio | 25 | 128 | 153 |
2015 Junio | 19 | 97 | 116 |
2015 Mayo | 27 | 97 | 124 |
2015 Abril | 7 | 63 | 70 |
2015 Marzo | 29 | 63 | 92 |
2015 Febrero | 24 | 62 | 86 |
2015 Enero | 23 | 64 | 87 |
2014 Diciembre | 19 | 40 | 59 |
2014 Noviembre | 19 | 73 | 92 |
2014 Octubre | 18 | 109 | 127 |
2014 Septiembre | 16 | 80 | 96 |
2014 Agosto | 23 | 86 | 109 |
2014 Julio | 22 | 78 | 100 |
2014 Junio | 20 | 89 | 109 |
2014 Mayo | 21 | 74 | 95 |
2014 Abril | 24 | 66 | 90 |
2014 Marzo | 19 | 50 | 69 |
2014 Febrero | 10 | 51 | 61 |
2014 Enero | 22 | 54 | 76 |
2013 Diciembre | 20 | 42 | 62 |
2013 Noviembre | 21 | 65 | 86 |
2013 Octubre | 37 | 81 | 118 |
2013 Septiembre | 18 | 62 | 80 |
2013 Agosto | 28 | 73 | 101 |
2013 Julio | 18 | 47 | 65 |
2013 Junio | 18 | 60 | 78 |
2013 Mayo | 16 | 46 | 62 |
2013 Abril | 20 | 46 | 66 |
2013 Marzo | 16 | 24 | 40 |
2013 Febrero | 9 | 24 | 33 |
2013 Enero | 6 | 31 | 37 |
2012 Diciembre | 3 | 20 | 23 |
2012 Noviembre | 3 | 14 | 17 |
2012 Octubre | 0 | 8 | 8 |
2012 Septiembre | 16 | 0 | 16 |