Uso de rituximab en una paciente con escleritis anterior difusa necrotizante asociada a vasculitis con c-ANCA refractaria a inmunomoduladores convencionales
Rituximab use in a patient with diffuse necrotizing anterior scleritis associated to c-ancas vasculitis refractory to conventional inmunomodulators
Leído
2828
Vecesse ha leído el artículo
1502
Total PDF
1326
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S0121812312700257" "issn" => "01218123" "doi" => "10.1016/S0121-8123(12)70025-7" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "70025" "copyright" => "Asociación Colombiana de Reumatología" "copyrightAnyo" => "2012" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2012;19:183-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1614 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 726 "PDF" => 879 ] ] "itemSiguiente" => array:18 [ "pii" => "S0121812312700269" "issn" => "01218123" "doi" => "10.1016/S0121-8123(12)70026-9" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "70026" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2012;19:190-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3325 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 798 "PDF" => 2518 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Osteomas múltiples faciales asociados a síndrome de Gardner" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "190" "paginaFinal" => "193" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Facial multiple osteomas associated with Gardner syndrome" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Pablo Restrepo, María del Pilar Molina" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Restrepo" ] 1 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Molina" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812312700269?idApp=UINPBA00004N" "url" => "/01218123/0000001900000003/v1_201308290111/S0121812312700269/v1_201308290111/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0121812312700245" "issn" => "01218123" "doi" => "10.1016/S0121-8123(12)70024-5" "estado" => "S300" "fechaPublicacion" => "2012-09-01" "aid" => "70024" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2012;19:172-82" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1773 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 587 "PDF" => 1178 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Abscesos como complicación infrecuente de la granulomatosis de Wegener: descripción de tres casos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "172" "paginaFinal" => "182" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Abscess rare complication of Wegener's granulomatosis: report of three cases" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Álvaro José Pérez, Rosa Elena Salazar, Luis Fernando Giraldo, Víctor Jiménez, María Verónica Pinto, Yenny Paola Varela, Rafael Raúl Valle-Oñate, John Darío Londoño, Walter Villalobos" "autores" => array:9 [ 0 => array:2 [ "nombre" => "Álvaro José" "apellidos" => "Pérez" ] 1 => array:2 [ "nombre" => "Rosa Elena" "apellidos" => "Salazar" ] 2 => array:2 [ "nombre" => "Luis Fernando" "apellidos" => "Giraldo" ] 3 => array:2 [ "nombre" => "Víctor" "apellidos" => "Jiménez" ] 4 => array:2 [ "nombre" => "María Verónica" "apellidos" => "Pinto" ] 5 => array:2 [ "nombre" => "Yenny Paola" "apellidos" => "Varela" ] 6 => array:2 [ "nombre" => "Rafael Raúl" "apellidos" => "Valle-Oñate" ] 7 => array:2 [ "nombre" => "John Darío" "apellidos" => "Londoño" ] 8 => array:2 [ "nombre" => "Walter" "apellidos" => "Villalobos" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812312700245?idApp=UINPBA00004N" "url" => "/01218123/0000001900000003/v1_201308290111/S0121812312700245/v1_201308290111/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Uso de rituximab en una paciente con escleritis anterior difusa necrotizante asociada a vasculitis con c-ANCA refractaria a inmunomoduladores convencionales" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "183" "paginaFinal" => "189" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Liliana María Zuluaga Gómez, Carlos Jaime Velásquez Franco, John Camilo Hernández Foronda, Carlos Felipe Castaño Alzate" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Liliana María" "apellidos" => "Zuluaga Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Carlos Jaime" "apellidos" => "Velásquez Franco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "John Camilo" "apellidos" => "Hernández Foronda" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] ] 3 => array:4 [ "nombre" => "Carlos Felipe" "apellidos" => "Castaño Alzate" "email" => array:1 [ 0 => "castanomd@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Facultad de Medicina. Escuela de Ciencias de la Salud. Universidad Pontificia Bolivariana. Medellín, Colombia" "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Rituximab use in a patient with diffuse necrotizing anterior scleritis associated to c-ancas vasculitis refractory to conventional inmunomodulators" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-05-13" "fechaAceptado" => "2012-08-29" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec253940" "palabras" => array:4 [ 0 => "Escleritis" 1 => "vasculitis asociada a anticuerpos contra citoplasma del neutrófilo" 2 => "rituximab" 3 => "tratamiento" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec253941" "palabras" => array:4 [ 0 => "Scleritis" 1 => "anti-neutrophil cytoplasmic antibody-associated vasculitis" 2 => "rituximab" 3 => "therapy" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La escleritis es una patología poco frecuente caracterizada por inflamación de la esclera de causa autoinmune o infecciosa. Los casos severos amenazan la visión y presentan riesgo de necrosis y perforación. La vasculitis asociada a c-ANCA es una enfermedad sistémica capaz de causar escleritis. El tratamiento tradicional de ésta se ha enfocado en el uso de antiinflamatorios no esteroideos e inmunomoduladores. En casos refractarios en los que estas opciones no han sido efectivas, se propone el uso de los anticuerpos monoclonales. Se reporta el caso de una paciente con escleritis anterior difusa necrotizante asociada a c-ANCA refractaria al tratamiento con inmunosupresores como ciclofosfamida, en quien solo rituximab indujo remisión.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Scleritis is a rare disease characterized by inflammation of sclera and underlying infectious or systemic disease. Severe cases can compromise vision and cause scleral necrosis and eye perforation. c-ANCA associated vasculitis, a systemic syndrome could cause scleritis. Traditional treatment consists of antinflammatory and immunomodulators administration. Refractory cases could be treated with monoclonal antibodies. We report the case of a woman with diffuse necrotizing anterior scleritis associated to c-ANCA refractory to immunosupressants, such as cyclophosphamide in which only Rituximab could induce remission</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Posterior scleritis: clinical features, systemic associations, and outcome in a large series of patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.J. McCluskey" 1 => "P.G. Watson" 2 => "S. Lightman" 3 => "J. Haybittle" 4 => "M. Restori" 5 => "M. Branley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0161-6420(99)90543-2" "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "1999" "volumen" => "106" "paginaInicial" => "2380" "paginaFinal" => "2386" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10599675" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Episcleritis and scleritis: clinical features and treatment results" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.A. Jabs" 1 => "A. Mudun" 2 => "J.P. Dunn" 3 => "M.J. Marsh" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Ophthalmol" "fecha" => "2000" "volumen" => "130" "paginaInicial" => "469" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11024419" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleritis associated with rheumatoid arthritis and with other systemic immune mediated diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Sainz de la Maza" 1 => "C.S. Foster" 2 => "N.S. Jabbur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "1994" "volumen" => "101" "paginaInicial" => "1281" "paginaFinal" => "1286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8035992" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Okhravi" 1 => "B. Odufuwa" 2 => "P. McCluskey" 3 => "S. Lightman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "SurvOphthalm" "fecha" => "2005" "volumen" => "50" "paginaInicial" => "351" "paginaFinal" => "363" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleritis associated with systemic vasculitic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Sainz de la Maza" 1 => "C.S. Foster" 2 => "N.S. Jabbur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "1995" "volumen" => "102" "paginaInicial" => "687" "paginaFinal" => "692" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7724185" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wegener's Granulomatosis: Clinical Manifestations, differential diagnosis, and management of ocular and systemic disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Tarabishy" 1 => "M. Schulte" 2 => "G. Papalioids" 3 => "G. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Surv Ophthalm" "fecha" => "2010" "volumen" => "55" "paginaInicial" => "429" "paginaFinal" => "444" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunopathology of scleritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L.P. Fong" 1 => "M. Sainz de la Maza" 2 => "B.A. Rice" 3 => "A.E. Kupferman" 4 => "C.S. Foster" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "1991" "volumen" => "98" "paginaInicial" => "472" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1828871" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severity of scleritis and episcleritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Sainz de la Maza" 1 => "N.S. Jabbur" 2 => "C.S. Foster" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "1994" "volumen" => "101" "paginaInicial" => "389" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8115160" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleritis-associated uveitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Sainz de la Maza" 1 => "C.S. Foster" 2 => "N.S. Jabbur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ophthalmology" "fecha" => "1997" "volumen" => "104" "paginaInicial" => "58" "paginaFinal" => "63" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9022105" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EULAR recommendations for the management of primary small and medium vessel vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Mukhtyar" 1 => "L. Guillevin" 2 => "M.C. Cid" 3 => "B. Dasgupta" 4 => "K. de Groot" 5 => "W. Gross" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2008.088096" "Revista" => array:6 [ "tituloSerie" => "Ann Rheum Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "310" "paginaFinal" => "317" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18413444" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab is effective in the treatment of refractory ophthalmic Wegener's granulomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.R. Taylor" 1 => "A.D. Salama" 2 => "L. Joshi" 3 => "C.D. Pusey" 4 => "S.L. Lightman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.24454" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2009" "volumen" => "60" "paginaInicial" => "1540" "paginaFinal" => "1547" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19404964" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab versus Cyclophosphamide for ANCA-Associated Vasculitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Stone" 1 => "P. Merkel" 2 => "R. Spiera" 3 => "P. Seo" 4 => "C. Langford" 5 => "G.S. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0909905" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2010" "volumen" => "363" "paginaInicial" => "221" "paginaFinal" => "232" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20647199" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Biologic therapies for inflammatory eye disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Lim" 1 => "E.B. Suhler" 2 => "J.R. Smith" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1442-9071.2006.01225.x" "Revista" => array:7 [ "tituloSerie" => "Clin Experiment Ophthalmol" "fecha" => "2006 May-Jun" "volumen" => "34" "numero" => "4" "paginaInicial" => "365" "paginaFinal" => "374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16764659" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab treatment for persistent scleritis associated with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "B. Iaccheri" 1 => "S. Androudi" 2 => "E.B. Bocci" 3 => "R. Gerli" 4 => "C. Cagini" 5 => "T. Fiore" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/09273941003739928" "Revista" => array:7 [ "tituloSerie" => "Ocul Immunol Inflamm" "fecha" => "2010 Jun" "volumen" => "18" "numero" => "3" "paginaInicial" => "223" "paginaFinal" => "225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20482403" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab for treatment of scleritis associated with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Chauhan" 1 => "A. Kamal" 2 => "R.N. Thompson" 3 => "C. Estrach" 4 => "R.J. Moots" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bjo.2008.154948" "Revista" => array:7 [ "tituloSerie" => "Br J Ophthalmol" "fecha" => "2009 Jul" "volumen" => "93" "numero" => "7" "paginaInicial" => "984" "paginaFinal" => "985" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19553515" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab versus cyclophosphamide in ANCA-associated renal vasculitis" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "European Vasculitis Study Group" "etal" => false "autores" => array:14 [ 0 => "R.B. Jones" 1 => "J.W. Tervaert" 2 => "T. Hauser" 3 => "R. Luqmani" 4 => "M.D. Morgan" 5 => "C.A. Peh" 6 => "C.O. Savage" 7 => "M. Segelmark" 8 => "V. Tesar" 9 => "P. van Paassen" 10 => "D. Walsh" 11 => "M. Walsh" 12 => "K. Westman" 13 => "D.R. Jayne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0909169" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2010" "volumen" => "363" "paginaInicial" => "211" "paginaFinal" => "220" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20647198" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab for the treatment of ANCA associated vasculitis: the future today?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.A. Alba" 1 => "L.F. Flores-Suárez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Reumatol Clin" "fecha" => "2011" "volumen" => "7Suppl3" "paginaInicial" => "S41" "paginaFinal" => "S46" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab for remission induction in a patient with relapsing necrotizing scleritis associated with limited Wegener's granulomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Onal" 1 => "H. Kazokoglu" 2 => "A. Koc" 3 => "S. Yavuz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "OculImmunol Inflamm" "fecha" => "2008" "volumen" => "16" "paginaInicial" => "230" "paginaFinal" => "232" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of Wegener's granulomatosis associated scleritis with rituximab" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.M. Cheung" 1 => "P.I. Murray" 2 => "C.O. Savage" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bjo.2005.075689" "Revista" => array:5 [ "tituloSerie" => "Br J Ophthalmol" "fecha" => "2005" "volumen" => "89" "paginaInicial" => "1542" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16234479" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rituximab for treatment of ocular inflammatory disease: a series of four cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P.A. Kurz" 1 => "E.B. Suhler" 2 => "D. Choi" 3 => "J.T. Rosenbaum" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bjo.2007.133173" "Revista" => array:6 [ "tituloSerie" => "Br J Ophthalmol" "fecha" => "2009" "volumen" => "93" "paginaInicial" => "546" "paginaFinal" => "548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19321476" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scleritis therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Sainz de la Maza" 1 => "N. Molina" 2 => "L.A. González-González" 3 => "P.P. Doctor" 4 => "J. Tauber" 5 => "C.S. Foster" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ophtha.2011.07.043" "Revista" => array:7 [ "tituloSerie" => "Ophthalmology" "fecha" => "2012 Jan" "volumen" => "119" "numero" => "1" "paginaInicial" => "51" "paginaFinal" => "58" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22015381" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/01218123/0000001900000003/v1_201308290111/S0121812312700257/v1_201308290111/es/main.assets" "Apartado" => array:4 [ "identificador" => "18881" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Reporte de caso" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/01218123/0000001900000003/v1_201308290111/S0121812312700257/v1_201308290111/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0121812312700257?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 5 | 8 | 13 |
| 2024 Septiembre | 6 | 7 | 13 |
| 2024 Agosto | 8 | 7 | 15 |
| 2024 Julio | 15 | 8 | 23 |
| 2024 Junio | 19 | 18 | 37 |
| 2024 Mayo | 12 | 6 | 18 |
| 2024 Abril | 11 | 15 | 26 |
| 2024 Marzo | 18 | 15 | 33 |
| 2024 Febrero | 17 | 10 | 27 |
| 2024 Enero | 10 | 19 | 29 |
| 2023 Diciembre | 18 | 23 | 41 |
| 2023 Noviembre | 19 | 24 | 43 |
| 2023 Octubre | 18 | 31 | 49 |
| 2023 Septiembre | 6 | 16 | 22 |
| 2023 Agosto | 6 | 10 | 16 |
| 2023 Julio | 3 | 13 | 16 |
| 2023 Junio | 11 | 7 | 18 |
| 2023 Mayo | 10 | 8 | 18 |
| 2023 Abril | 9 | 8 | 17 |
| 2023 Marzo | 5 | 5 | 10 |
| 2023 Febrero | 8 | 7 | 15 |
| 2023 Enero | 8 | 6 | 14 |
| 2022 Diciembre | 8 | 9 | 17 |
| 2022 Noviembre | 12 | 18 | 30 |
| 2022 Octubre | 9 | 10 | 19 |
| 2022 Septiembre | 6 | 15 | 21 |
| 2022 Agosto | 12 | 9 | 21 |
| 2022 Julio | 9 | 14 | 23 |
| 2022 Junio | 7 | 7 | 14 |
| 2022 Mayo | 13 | 5 | 18 |
| 2022 Abril | 10 | 18 | 28 |
| 2022 Marzo | 10 | 13 | 23 |
| 2022 Febrero | 27 | 6 | 33 |
| 2022 Enero | 18 | 8 | 26 |
| 2021 Diciembre | 6 | 8 | 14 |
| 2021 Noviembre | 8 | 7 | 15 |
| 2021 Octubre | 12 | 6 | 18 |
| 2021 Septiembre | 7 | 11 | 18 |
| 2021 Agosto | 9 | 7 | 16 |
| 2021 Julio | 8 | 5 | 13 |
| 2021 Junio | 9 | 7 | 16 |
| 2021 Mayo | 8 | 12 | 20 |
| 2021 Abril | 20 | 14 | 34 |
| 2021 Marzo | 11 | 18 | 29 |
| 2021 Febrero | 9 | 13 | 22 |
| 2021 Enero | 7 | 21 | 28 |
| 2020 Diciembre | 5 | 9 | 14 |
| 2020 Noviembre | 14 | 6 | 20 |
| 2020 Octubre | 4 | 3 | 7 |
| 2020 Septiembre | 8 | 14 | 22 |
| 2020 Agosto | 9 | 12 | 21 |
| 2020 Julio | 12 | 10 | 22 |
| 2020 Junio | 6 | 4 | 10 |
| 2020 Mayo | 8 | 5 | 13 |
| 2020 Abril | 7 | 9 | 16 |
| 2020 Marzo | 26 | 17 | 43 |
| 2020 Febrero | 9 | 8 | 17 |
| 2020 Enero | 11 | 8 | 19 |
| 2019 Diciembre | 19 | 13 | 32 |
| 2019 Noviembre | 6 | 11 | 17 |
| 2019 Octubre | 12 | 6 | 18 |
| 2019 Septiembre | 9 | 5 | 14 |
| 2019 Agosto | 6 | 13 | 19 |
| 2019 Julio | 11 | 18 | 29 |
| 2019 Junio | 19 | 33 | 52 |
| 2019 Mayo | 36 | 61 | 97 |
| 2019 Abril | 30 | 49 | 79 |
| 2019 Marzo | 4 | 12 | 16 |
| 2019 Febrero | 5 | 13 | 18 |
| 2019 Enero | 6 | 11 | 17 |
| 2018 Diciembre | 6 | 19 | 25 |
| 2018 Noviembre | 8 | 16 | 24 |
| 2018 Octubre | 16 | 15 | 31 |
| 2018 Septiembre | 2 | 4 | 6 |
| 2018 Agosto | 2 | 11 | 13 |
| 2018 Julio | 3 | 3 | 6 |
| 2018 Junio | 2 | 8 | 10 |
| 2018 Mayo | 3 | 12 | 15 |
| 2018 Abril | 4 | 6 | 10 |
| 2018 Marzo | 4 | 5 | 9 |
| 2018 Febrero | 9 | 4 | 13 |
| 2018 Enero | 10 | 3 | 13 |
| 2017 Diciembre | 11 | 0 | 11 |
| 2017 Noviembre | 3 | 3 | 6 |
| 2017 Octubre | 6 | 9 | 15 |
| 2017 Septiembre | 5 | 10 | 15 |
| 2017 Agosto | 4 | 16 | 20 |
| 2017 Julio | 8 | 3 | 11 |
| 2017 Junio | 8 | 15 | 23 |
| 2017 Mayo | 15 | 5 | 20 |
| 2017 Abril | 6 | 3 | 9 |
| 2017 Marzo | 15 | 19 | 34 |
| 2017 Febrero | 12 | 9 | 21 |
| 2017 Enero | 20 | 4 | 24 |
| 2016 Diciembre | 28 | 14 | 42 |
| 2016 Noviembre | 29 | 17 | 46 |
| 2016 Octubre | 34 | 18 | 52 |
| 2016 Septiembre | 27 | 10 | 37 |
| 2016 Agosto | 25 | 14 | 39 |
| 2016 Julio | 17 | 15 | 32 |
| 2016 Junio | 8 | 35 | 43 |
| 2016 Mayo | 12 | 32 | 44 |
| 2016 Abril | 4 | 18 | 22 |
| 2016 Marzo | 8 | 20 | 28 |
| 2016 Febrero | 2 | 17 | 19 |
| 2016 Enero | 11 | 25 | 36 |
| 2015 Diciembre | 10 | 25 | 35 |
| 2015 Noviembre | 9 | 20 | 29 |
| 2015 Octubre | 14 | 23 | 37 |
| 2015 Septiembre | 6 | 15 | 21 |
| 2015 Agosto | 4 | 8 | 12 |
| 2015 Julio | 5 | 11 | 16 |
| 2015 Junio | 3 | 3 | 6 |
| 2015 Mayo | 3 | 4 | 7 |
| 2015 Abril | 8 | 13 | 21 |
| 2015 Marzo | 7 | 6 | 13 |
| 2015 Febrero | 7 | 8 | 15 |
| 2015 Enero | 5 | 8 | 13 |
| 2014 Diciembre | 9 | 4 | 13 |
| 2014 Noviembre | 4 | 3 | 7 |
| 2014 Octubre | 5 | 1 | 6 |
| 2014 Septiembre | 3 | 4 | 7 |
| 2014 Agosto | 1 | 1 | 2 |
| 2014 Julio | 9 | 5 | 14 |
| 2014 Junio | 3 | 2 | 5 |
| 2014 Mayo | 8 | 0 | 8 |
| 2014 Abril | 4 | 1 | 5 |
| 2014 Marzo | 3 | 2 | 5 |
| 2014 Febrero | 6 | 1 | 7 |
| 2014 Enero | 3 | 1 | 4 |
| 2013 Diciembre | 3 | 5 | 8 |
| 2013 Noviembre | 4 | 5 | 9 |
| 2013 Octubre | 10 | 3 | 13 |
| 2013 Septiembre | 4 | 1 | 5 |
Mostrar todo
