Hemorragia alveolar difusa y nefropatía en dos pacientes con síndrome antifosfolipídico primario

Información del artículo

Resumen

Informamos dos pacientes clasificadas como síndrome antifosfolipídico primario que presentaron hemorragia alveolar y nefropatía durante su evolución. La primera paciente presentó una glomerulonefritis membranoproliferativa con patrón “full house” en la inmunofluorescencia; los autoanticuerpos específicos de LES fueron persistentemente negativos y los niveles de complemento sérico permanecieron normales; la segunda paciente presentó una proteinuria en rango no nefrótico y síndrome HELLP y, posteriormente, una hemorragia pulmonar. Ninguna de las pacientes ha desarrollado un cuadro definitivo de LES luego de varios años de seguimiento.

Palabras clave:

hemorragia alveolar

síndrome antifosfolipídico

nefropatía

Summary

We report two patient with primary antiphospholipid syndrome with pulmonary haemorraghe and nefropathy. First patient had a membranoprolipherative glomerulonephritis and shown “full house pattern” in her renal biopsy; specific SLE autoantibodies were negative and complement levels was normal. The second patient presents with no nephrotic proteinuria, HELLP syndrome followed by pulmonary hemorrhage. They don't developed full blown SLE during several years of follow up.

Key words:

alveolar hemorrhage

antiphospholipid syndrome

nephropathy

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Los autores declaran no presentar ningún conflicto de interés al momento de la redacción del manuscrito.

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