Article
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
array:24 [ "pii" => "S2253808917301209" "issn" => "22538089" "doi" => "10.1016/j.remnie.2017.10.007" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "909" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2018;37:61-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1 "HTML" => 1 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S2253654X16301421" "issn" => "2253654X" "doi" => "10.1016/j.remn.2017.04.004" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "909" "copyright" => "Elsevier España, S.L.U. y SEMNIM" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2018;37:61-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 71 "formatos" => array:2 [ "HTML" => 36 "PDF" => 35 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imágenes de interés</span>" "titulo" => "Metástasis cerebral única, evidenciada mediante PET/TC con <span class="elsevierStyleSup">68</span>Ga-PSMA en recurrencia de cáncer de mama" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "62" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "A single brain metastasis seen on <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT in recurrent breast cancer" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3004 "Ancho" => 3167 "Tamanyo" => 544812 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se realizaron la RM y la PET/TC con <span class="elsevierStyleSup">68</span>Ga-PSMA 3 meses después de la radioterapia y la quimioterapia. La imagen de proyección de máxima intensidad PET del cuerpo mostraron la distribución normal en las glándulas salivares, mucosa nasal, hígado, bazo, intestino, riñones y vejiga (A). La RM mostró leve realce en las imágenes con contraste potenciadas en T1 en el área témporo-parietal izquierda y edema vasogénico (B); las imágenes de PET/TC (C), PET cerebral (D) y de reconstrucción 3<span class="elsevierStyleHsp" style=""></span>D (E) mostraron una masa pobremente definida ávida de <span class="elsevierStyleSup">68</span>Ga-PSMA en la misma área visualizada con la RM; (F) la muestra de biopsia cerebral mostró un carcinoma ductal de alto grado.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S.S. Medina-Ornelas, F.O. García-Pérez, C. Medel-Gamez, E. Paredes-Amoroto" "autores" => array:4 [ 0 => array:2 [ "nombre" => "S.S." "apellidos" => "Medina-Ornelas" ] 1 => array:2 [ "nombre" => "F.O." "apellidos" => "García-Pérez" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Medel-Gamez" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Paredes-Amoroto" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2253808917301209" "doi" => "10.1016/j.remnie.2017.10.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808917301209?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X16301421?idApp=UINPBA00004N" "url" => "/2253654X/0000003700000001/v1_201801030531/S2253654X16301421/v1_201801030531/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S2253808917301544" "issn" => "22538089" "doi" => "10.1016/j.remnie.2017.06.013" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "934" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Med Nucl Imagen Mol. 2018;37:63-70" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 18 "formatos" => array:2 [ "HTML" => 12 "PDF" => 6 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Continuing Education</span>" "titulo" => "Review of the role of the sentinel node biopsy in neoadjuvant chemotherapy in women with breast cancer and negative or positive axillary node at diagnosis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "63" "paginaFinal" => "70" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Actualización de la biopsia del ganglio centinela tras quimioterapia neoadyuvante en el cáncer de mama sin y con afectación ganglionar al diagnóstico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Ruano Pérez, A.C. Rebollo Aguirre, P. García-Talavera San Miguel, R. Díaz Expósito, S. Vidal-Sicart, J.M. Cordero García, D. Carrera Salazar, M.E. Rioja Martín" "autores" => array:9 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Ruano Pérez" ] 1 => array:2 [ "nombre" => "A.C." "apellidos" => "Rebollo Aguirre" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "García-Talavera San Miguel" ] 3 => array:2 [ "nombre" => "R." "apellidos" => "Díaz Expósito" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Vidal-Sicart" ] 5 => array:2 [ "nombre" => "J.M." "apellidos" => "Cordero García" ] 6 => array:2 [ "nombre" => "D." "apellidos" => "Carrera Salazar" ] 7 => array:2 [ "nombre" => "M.E." "apellidos" => "Rioja Martín" ] 8 => array:1 [ "colaborador" => "Grupo de Trabajo de Cirugía Radioguiada de la SEMNIM" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X17300963" "doi" => "10.1016/j.remn.2017.06.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X17300963?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808917301544?idApp=UINPBA00004N" "url" => "/22538089/0000003700000001/v1_201801100554/S2253808917301544/v1_201801100554/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S225380891730112X" "issn" => "22538089" "doi" => "10.1016/j.remnie.2017.10.002" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "874" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2018;37:59-60" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "HTML" => 2 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "<span class="elsevierStyleSup">18</span>F-florbetapir uptake in a primary intraosseous haemangioma displayed in a cerebral PET/CT" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "59" "paginaFinal" => "60" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Captación de <span class="elsevierStyleSup">18</span>F-florbetapir en un hemangioma intraóseo visualizado en una PET/TC cerebral" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1708 "Ancho" => 3169 "Tamanyo" => 384769 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Axial and sagittal images of <span class="elsevierStyleSup">18</span>F-florbetapir PET. This scan exhibits a florbetapir focus on topography of the right frontal bone. (B) Axial and sagittal images of <span class="elsevierStyleSup">18</span>F-FDG PET that present a similar finding consistent in a hypermetabolic focal uptake in the same location. (C) Axial and sagittal co-registered CT-images showing an intradiploic osteolytic right frontal lesion. (D) Axial and sagittal T1-weighted MRI images exhibit a hyperintense well-defined intradiploic lesion in the right frontal bone with the same estructure as the co-registered CT scans: osteolytic, with an inner trabeculation and honeycomb appearance.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Sánchez-Vañó, S. Prado-Wohlwend, P. Sopena-Novales, E. Uruburu-García, M.D. Monedero-Picazo, C. Martínez-Carsí" "autores" => array:6 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Sánchez-Vañó" ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Prado-Wohlwend" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Sopena-Novales" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Uruburu-García" ] 4 => array:2 [ "nombre" => "M.D." "apellidos" => "Monedero-Picazo" ] 5 => array:2 [ "nombre" => "C." "apellidos" => "Martínez-Carsí" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S2253654X16302359" "doi" => "10.1016/j.remn.2017.01.008" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X16302359?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S225380891730112X?idApp=UINPBA00004N" "url" => "/22538089/0000003700000001/v1_201801100554/S225380891730112X/v1_201801100554/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting image</span>" "titulo" => "A single brain metastasis seen on <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT in recurrent of breast cancer" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "62" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S.S. Medina-Ornelas, F.O. García-Pèc)rez, C. Medel-Gamez, E. Paredes-Amoroto" "autores" => array:4 [ 0 => array:4 [ "nombre" => "S.S." "apellidos" => "Medina-Ornelas" "email" => array:1 [ 0 => "dr.sevastian@outlook.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "F.O." "apellidos" => "García-Pèc)rez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Medel-Gamez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Paredes-Amoroto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Departamento de Medicina Nuclear e Imagen Molecular, INCan, Ciudad de Mèc)xico, Mexico" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Nuclear, IMSS, Ciudad de Mèc)xico, Mexico" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Nuclear, HNERM, Lima, Peru" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metastasis cerebral única, evidenciada mediante PET/TC con <span class="elsevierStyleSup">68</span>Ga-PSMA en recurrencia de cáncer de mama" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3004 "Ancho" => 3167 "Tamanyo" => 544812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MRI and <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT were done three months after radiotherapy plus chemotherapy. Maximum intensity projection PET image of the body showed normal biodistribution in salivary glands, nasal mucosa, liver, spleen, bowel, kidneys and bladder (A). MRI showed mild enhancement on the post-contrast T1-weighted images in the left temporo-parietal area and vasogenic edema (B); PET/CT (C), PET of brain (D) and 3D reconstruction (E) images revealed a <span class="elsevierStyleSup">68</span>Ga-PSMA avid mass poorly definedin in the same area seen with MRI (F) brain biopsy specimen showed high grade ductal carcinoma.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 45-year-old woman with a single brain metastases from breast carcinoma HER-2neu positive seen on <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT.</p><p id="par0010" class="elsevierStylePara elsevierViewall">After performing trucut biopsy of the Upper Outer Quadrant (UOQ) right breast, she was categorized (according to AJCC 7<span class="elsevierStyleSup">th</span> ed) as stage IIB (T2, N1, M0). She was undergoing neoadjuvant chemotherapy, receiving 12 cycles of paclitaxel/trastuzumab (with previous ventriculography normal, more than 60%), and then four cycles of colony stimulating factor plus trastuzumab scheme; and continued with trastuzumab three cycles per week. Once she completed chemotherapy she underwent modified radical mastectomy and right pectoralis major impeller. The pathology report was infiltrating ductal carcinoma with 75% of necrosis. The patient fails to attend radiation oncology, and loses track for 6 months for unknown reasons. She returns after 4 months with a history of progressive headache and dizziness. A brain MRI study was performed, showing a supratentorial and intraaxial lesion, with the conclusion of known primary reservoir and central nervous system progression. The patient initiates holocraneal radiotherapy at 30<span class="elsevierStyleHsp" style=""></span>Gy in 10 fractions plus temozolomide, and trastuzumab plus capecitabine. A restaging MRI study and a <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT scan were done three months after radiotherapy plus chemotherapy, showing intense brain uptake in the supratenetorial lesion corresponding to brain metastases (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Biopsy documented disease progression despite treatment.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT is a recent modality of molecular imaging especially used for the diagnosis of recurrence in treated prostate cancer patients, meanwhile the heterogeneity of breast cancer requires a thorough analysis to identify potential patients to receive<span class="elsevierStyleSup">177</span>Lu-PSMA therapy. This case report further highlights the value of PET/CT in this scenario.</p><p id="par0020" class="elsevierStylePara elsevierViewall">15•20% of patients with metastatic breast cancer HER2/neu positive will develop brain metastases. Treatment includes whole brain irradiation, stereotactic radiosurgery or neurosurgery with whole brain radiation, resulting in poor survival. The blood•brain barrier is an obstacle to the delivery of chemotherapeutics to the brain.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">PSMA is heavily expressed by the tumor vascular endothelium in a variety of solid cancers, including prostate cancer, glioblastoma and primary adenocarcinoma of the breast, but is not evident in normal vascular endothelium, and to only very low levels in normal prostate.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Instead, PSMA regulates tumor cell invasion and tumor angiogenesis by modulating integrin signal transduction in endothelial cells. The transcription of PSMA can be selectively activated through a transcriptional enhancer region in endothelial cells of the tumor neovasculature, but this region is absent in normal blood vessels.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2,3</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Molecular imaging with <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT is very useful in the diagnosis of recurrent prostate cancer, mainly retrospective studies describe the value of <span class="elsevierStyleSup">68</span>Ga-PSMA ligand PET/CT in different clinical scenarios in prostate cancer; however, there is insufficient evidence of the usefulness in breast cancer.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">No funding received from any organization for this study.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">None.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflicts of interest" ] 2 => array:2 [ "identificador" => "xack328229" "titulo" => "Acknowledgments" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3004 "Ancho" => 3167 "Tamanyo" => 544812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">MRI and <span class="elsevierStyleSup">68</span>Ga-PSMA PET/CT were done three months after radiotherapy plus chemotherapy. Maximum intensity projection PET image of the body showed normal biodistribution in salivary glands, nasal mucosa, liver, spleen, bowel, kidneys and bladder (A). MRI showed mild enhancement on the post-contrast T1-weighted images in the left temporo-parietal area and vasogenic edema (B); PET/CT (C), PET of brain (D) and 3D reconstruction (E) images revealed a <span class="elsevierStyleSup">68</span>Ga-PSMA avid mass poorly definedin in the same area seen with MRI (F) brain biopsy specimen showed high grade ductal carcinoma.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A systematic review of dual targeting in HER2-positive breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. Kñ/4mler" 1 => "M.K. Tuxen" 2 => "D.L. Nielsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ctrv.2013.09.002" "Revista" => array:6 [ "tituloSerie" => "Cancer Treat Rev" "fecha" => "2014" "volumen" => "40" "paginaInicial" => "259" "paginaFinal" => "270" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24080156" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate specific membrane antigen (PSMA) expression in primary gliomas and breast cancer brain metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Nomura" 1 => "S. Pastorino" 2 => "P. Jiang" 3 => "G. Lambert" 4 => "J.R. Crawford" 5 => "M. Gymnopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1475-2867-14-26" "Revista" => array:5 [ "tituloSerie" => "Cancer Cell Int" "fecha" => "2014" "volumen" => "14" "paginaInicial" => "26" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24645697" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate-specific membrane antigen expression in tumor associated vasculature of breast cancers" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.G. Wernicke" 1 => "S. Varma" 2 => "E.A. Greenwood" 3 => "P.J. Christos" 4 => "K.S. Chao" 5 => "H. 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The Revista Española de Medicina Nuclear e Imagen Molecular (Spanish Journal of Nuclear Medicine and Molecular Imaging), was founded in 1982, and is the official journal of the Spanish Society of Nuclear Medicine and Molecular Imaging, which has more than 700 members. The Journal, which publishes 6 regular issues per year, has the promotion of research and continuing education in all fields of Nuclear Medicine as its main aim. For this, its principal sections are Originals, Clinical Notes, Images of Interest, and Special Collaboration articles. The works may be submitted in Spanish or English and are subjected to a peer review process. In 2009, it became the leading Spanish journal in the field of Medical Imaging on having an Impact Factor , awarded by the Journal Citation Reports.
Science Citation Index Expander, Medline, IME, Bibliomed, EMBASE/Excerpta Medica, Healthstar, Cancerlit, Toxine, Inside Conferences, Scopus
See moreThe Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.
© Clarivate Analytics, Journal Citation Reports 2022
SRJ is a prestige metric based on the idea that not all citations are the same. SJR uses a similar algorithm as the Google page rank; it provides a quantitative and qualitative measure of the journal's impact.
See moreSNIP measures contextual citation impact by wighting citations based on the total number of citations in a subject field.
See moreRevista Española de Medicina Nuclear e Imagen Molecular (English Edition)
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