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array:23 [ "pii" => "S2253654X15000323" "issn" => "2253654X" "doi" => "10.1016/j.remn.2015.03.005" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "689" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "copyrightAnyo" => "2015" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Esp Med Nucl Imagen Mol. 2015;34:383-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 525 "formatos" => array:3 [ "EPUB" => 14 "HTML" => 394 "PDF" => 117 ] ] "itemSiguiente" => array:18 [ "pii" => "S2253654X1500061X" "issn" => "2253654X" "doi" => "10.1016/j.remn.2015.05.003" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "703" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Esp Med Nucl Imagen Mol. 2015;34:387-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1025 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 881 "PDF" => 132 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>" "titulo" => "Follow-up <span class="elsevierStyleSup">99m</span>Tc EC renal dynamic scintigraphy and DMSA-<span class="elsevierStyleSmallCaps">III</span> SPECT/CT in unmasking a masqueraded case of Horseshoe kidney" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "387" "paginaFinal" => "389" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Seguimiento mediante gammagrafía renal dinámica con <span class="elsevierStyleSup">99m</span>Tc-EC y SPECT/TC con DMSA <span class="elsevierStyleSmallCaps">III</span> para desenmascarar un riñón en herradura" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1212 "Ancho" => 1943 "Tamanyo" => 214467 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">99m</span>Tc-EC: Preop (a) Flow images show normal perfusion in right renal fossa and impaired perfusion in left renal fossa, (b) cortical uptake images revealed normal uptake in right kidney with impaired uptake in grossly enlarged left kidney. Pre-void (c), post-void (d), and delayed 3<span class="elsevierStyleHsp" style=""></span>h (e) static images show the progressive tracer clearance from right kidney while progressive tracer accumulation in left kidney (s/o – normal functioning right kidney while enlarged, hydronephrotic left kidney with impaired function and left PUJO). Postop (f) flow images show normal perfusion in right renal fossa and impaired perfusion in left renal fossa, (g) cortical uptake images revealed normal uptake in right kidney with impaired uptake in mildly enlarged left kidney. Pre-void (h), post-void (i), and delayed 3<span class="elsevierStyleHsp" style=""></span>h (j) static images show tracer clearance from right kidney while moderate tracer clearance in left kidney (s/o suggestive of– normal functioning right kidney while mildly enlarged, hydronephrotic left kidney with mildly impaired function and delayed drainage). In addition to these lower poles of both kidneys appears fused and giving appearance of horseshoe kidney.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "T.K. Jain, R.K. Basher, B.R. Mittal, A. Bhatia, K.L.N. Rao" "autores" => array:5 [ 0 => array:2 [ "nombre" => "T.K." "apellidos" => "Jain" ] 1 => array:2 [ "nombre" => "R.K." "apellidos" => "Basher" ] 2 => array:2 [ "nombre" => "B.R." "apellidos" => "Mittal" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Bhatia" ] 4 => array:2 [ "nombre" => "K.L.N." "apellidos" => "Rao" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X1500061X?idApp=UINPBA00004N" "url" => "/2253654X/0000003400000006/v1_201510300043/S2253654X1500061X/v1_201510300043/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2253654X15000657" "issn" => "2253654X" "doi" => "10.1016/j.remn.2015.05.007" "estado" => "S300" "fechaPublicacion" => "2015-11-01" "aid" => "707" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Esp Med Nucl Imagen Mol. 2015;34:378-82" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 437 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 314 "PDF" => 110 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>" "titulo" => "Mild to moderate increase of serum calcitonin levels only in presence of large medullary thyroid cancer deposits" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "378" "paginaFinal" => "382" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Niveles séricos moderadamente elevados de calcitonina en presencia de grandes lesiones de cáncer medular de tiroides" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1420 "Ancho" => 975 "Tamanyo" => 148603 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">(Patient n. 1). Paraganglioma in the right mesogastrium showed at FDG PET-CT. Anterior abdominal pelvic region.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M.R. Pelizzo, F. Torresan, A. Da Roit, I. Merante Boschin, S. Chondrogiannis, L. Rampin, P.M. Colletti, S. Vinjamury, A.J. Perkins, D. Rubello" "autores" => array:10 [ 0 => array:2 [ "nombre" => "M.R." "apellidos" => "Pelizzo" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Torresan" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Da Roit" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Merante Boschin" ] 4 => array:2 [ "nombre" => "S." "apellidos" => "Chondrogiannis" ] 5 => array:2 [ "nombre" => "L." "apellidos" => "Rampin" ] 6 => array:2 [ "nombre" => "P.M." "apellidos" => "Colletti" ] 7 => array:2 [ "nombre" => "S." "apellidos" => "Vinjamury" ] 8 => array:2 [ "nombre" => "A.J." "apellidos" => "Perkins" ] 9 => array:2 [ "nombre" => "D." "apellidos" => "Rubello" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X15000657?idApp=UINPBA00004N" "url" => "/2253654X/0000003400000006/v1_201510300043/S2253654X15000657/v1_201510300043/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Clinical note</span>" "titulo" => "Incidental pathologic extracardiac uptake of <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin in myocardial perfusion imaging: Importance of patient background evaluation" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "383" "paginaFinal" => "386" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "B. González García, A.M. García Vicente, A. Palomar Muñoz, V.M. Poblete García, G.A. Jiménez Londoño, A.M. Soriano Castrejón" "autores" => array:6 [ 0 => array:4 [ "nombre" => "B." "apellidos" => "González García" "email" => array:1 [ 0 => "bgg-ist@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "A.M." "apellidos" => "García Vicente" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Palomar Muñoz" ] 3 => array:2 [ "nombre" => "V.M." "apellidos" => "Poblete García" ] 4 => array:2 [ "nombre" => "G.A." "apellidos" => "Jiménez Londoño" ] 5 => array:2 [ "nombre" => "A.M." "apellidos" => "Soriano Castrejón" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Medicina Nuclear, Hospital General Universitario de Ciudad Real, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Captación extracardíaca patológica de <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin, detectada incidentalmente en un estudio de perfusión miocárdica: importancia de la evaluación de los antecedentes clínicos del paciente" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1188 "Ancho" => 1950 "Tamanyo" => 205985 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/TC at diagnosis. Maximum-intensity-projection (a), axial (b) and sagital (c) PET/CT images show increased uptake in proximal esophagus due to esophageal carcinoma, without lymphadenopathy or distant metastasis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">99m</span>Tc-tetrofosmin single photon emission computed tomography (<span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT) is a well-established, non-invasive imaging technique in the management of angina and myocardial infarction, and has become widely used for diagnosis and assessment of prognosis in patients with known or suspected coronary artery disease. Furthermore it is important to note that <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin is an agent that has been used as oncotropic radiotracer, and is highly concentrated within neoplastic processes of several varieties because of its uptake in mitochondria, being excreted by hepatobiliary system.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT, although most of the information is obtained from the tomographic slices, the raw projection images should be examined in order to evaluate incidental cardiac or extracardiac findings, and to assess the quality of the study.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a case in which myocardial perfusion imaging (MPI) revealed an unexpected extracardiac activity in posteriomedial region of the right hemithorax. Exhaustive clinical history revision was paramount to a correct evaluation of the finding.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0020" class="elsevierStylePara elsevierViewall">A 71-year-old man, with a history of alcoholism until 5 years ago, without diabetes or hypertension, was referred for a <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT/CT because of chest pain. Patient was diagnosed of one year ago of squamous cell esophageal carcinoma stage pT2N0M0 and underwent esophagectomy. No chemotherapy or radiotherapy was required.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The day of the MPI, the patient underwent adenosine stress, and subsequently 740<span class="elsevierStyleHsp" style=""></span>MBq <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin was injected intravenously. Thirty minutes after radiotracer injection, a SPECT/CT imaging with a dual head gamma-camera (Infinia Hawkeye, GE) was acquired. The cardiac images showed normal myocardial perfusion but, on the raw projection image, an extracardiac uptake, located in right posterior thorax, near the midline, was noted (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Reconstructed SPECT/CT slices confirmed the activity in the right-posterior mediastinum, with a linear morphology, in correspondence with an elongated mass on CT obtained for attenuation correction purpose (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Additionally, this CT showed massive left pleural effusion, without increased activity of the radiotracer.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">This finding led us to consider on a dilemma: Was related to esophageal cancer recurrence or was a complication due to the received treatment? To clarify the finding interpretation, a revision of clinical and surgical patient background was performed. <span class="elsevierStyleSup">18</span>F-FDG PET/CT at diagnosis, revealed the primary tumor in upper thoracic esophagus, without lymphadenopathy or distant metastasis (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Patient underwent surgery (esophagectomy, gastric tube reconstruction and esophagogastric anastomosis), and one month before the MPI request, another <span class="elsevierStyleSup">18</span>F-FDG PET/CT was performed due to suspicion of relapse. The metabolic imaging confirmed locoregional and distant recurrence (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>), showing relapse in proximal esophagus, while no significant increase in glucose metabolism was evident in the lower 2/3 of the gastroplasty (which showed increased activity in <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT).</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">The comparison between SPECT/CT and PET/CT images (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>) showed that gastroplasty was dilated with liquid content, especially in distal region. Careful re-inspection of SPECT/CT determined that the increased activity corresponded to the content of the gastroplasty, so the findings were due to duodeno-gastro-esophageal reflux.</p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">99m</span>Tc-tetrofosmin is cleared from the blood and trapped into mitochondria, reflecting viable myocytes. Furthermore it has shown potential usefulness as tumor-imaging agent. Uptake in tumoral cells depends on the regional blood flow and cell membrane integrity, as well as mitochondrial density, which are increased in these cells. For that reason, many authors have explored the utility of <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin in the diagnosis of various tumors, with a sensitivity and specificity of 82.5% and 100% respectively for esophageal cancer.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In MPI, during SPECT acquisition, the detector of a gammacamera covers most of the thorax and the abdomen. The evaluation of three-dimensional displays on rotating raw data images has the ability to check for possible artifacts during acquisition and discern abnormalities of the organs or tissues above and below the diaphragm (heart, lungs, mediastinum, liver, spleen and kidneys). These abnormalities may occur between 0.69 and 41.3% of cases.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4,5</span></a><a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows a classification of these findings.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">On the other hand, <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin is excreted by the hepatobiliary system, which allows the evaluation of the biliary tract, as well as detection of entero-gastric reflux.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> It has been reported a prevalence of reflux of 8.3% in MPI, being the second most frequent intra-abdominal abnormality.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">To properly interpret the extracardiac uptake in our study, it was necessary to remember the pharmacokinetics of <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin, and to know the patient's clinical background, in which two relevant events were reported: first, he was diagnosed of esophageal cancer, with confirmed relapse one month before the MPI. Second, patient underwent esophagectomy, gastroplasty and esophagogastric anastomosis as treatment of his tumor. This surgical approach carries significant morbidity, including late complications such as stricture (up to 52% of patients), dumping syndrome, delayed gastric emptying, and esophagitis due to acid/bile regurgitation (up to 80% of cases). In order to perform the differential diagnosis of neoplastic recurrence vs bile reflux, it could be reasonable to recommend additional tests, such as a hepatobiliary scintigraphy to confirm reflux, or an endoscopy or any imaging test to confirm recurrence. Our patient underwent <span class="elsevierStyleSup">18</span>F-FDG PET/CT one month before MPI, without evidence of recurrence in the lower 2/3 of the gastroplasty. CT slices showed that gastroplasty was dilated, and had liquid content. A re-inspection of SPECT/CT determined that the increased activity corresponded to the content of the gastroplasty, so we concluded that the findings were due to entero-gastric reflux. Other authors have previously reported bile reflux episodes in <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT studies performed on patients who had undergone gastroesophageal surgery.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">7,8</span></a> In the present case report, we used additional information from <span class="elsevierStyleSup">18</span>F-FDG PET/CT to reach the final diagnosis. This combined assessment has been previously described, but only in the evaluation of tumors.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">9</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Finally, we must remember the reason why the myocardial perfusion imaging was requested: chest pain. The SPECT showed normal myocardial perfusion, so that coronary heart disease was excluded.</p><p id="par0065" class="elsevierStylePara elsevierViewall">As many as 20% of patients with chest pain underwent catheterization have normal coronary arteries. Of them, up to 50% have pain secondary to digestive disorders.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">10</span></a> When bile reflux presents several typical symptoms associated to chest pain, as heartburn, flatulence and/or nausea, is easily identifiable. However, when it only manifests as chest pain is difficult to establish its etiology, being necessary to rule out coronary disease. Our patient had bile reflux evidenced by <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT/CT, which had probably led to an irritation of the plasty wall and esophageal remnant, being a potentially treatable cause of chest pain.</p><p id="par0070" class="elsevierStylePara elsevierViewall">Others might be the causes of the patient's pain: pleuropulmonary disease, with a massive pleural effusion requiring pleurodesis, or psychogenic etiology. The latter was considered the more likely cause by his Oncologist; however, given the MPI findings, it seems obvious that the massive esophagogastric reflux play a role as cause of pain (single or associated with others).</p><p id="par0075" class="elsevierStylePara elsevierViewall">In conclusion, many benign or malignant abnormalities in the thorax and/or abdomen may be evidenced in a <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT/CT. Therefore, it is mandatory to review raw data images, report extracardiac findings and investigate the patient's background, in order to alert clinicians about causes on non-cardiologic chest pain (such bile reflux) or abnormalities that require further investigation.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:3 [ "identificador" => "xres575080" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec591850" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres575081" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec591851" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-02-06" "fechaAceptado" => "2015-03-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec591850" "palabras" => array:4 [ 0 => "Myocardial perfusion SPECT" 1 => "Extracardiac findings" 2 => "Non-cardiac chest pain" 3 => "<span class="elsevierStyleSup">99m</span>Tc-tetrofosmin" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec591851" "palabras" => array:4 [ 0 => "SPECT de perfusión miocárdica" 1 => "Captación extracardíaca" 2 => "Dolor torácico no cardiológico" 3 => "<span class="elsevierStyleSup">99m</span>Tc-tetrofosmin" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">99m</span>Tc-tetrofosmin single photon emission computed tomography (<span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT) has an important role in the assessment of coronary artery disease. Despite being its main indication, this study does not only evaluate myocardial perfusion, but much more. Moreover, during the SPECT acquisition, the field area covered includes many important organs of the thorax and abdomen, so extracardiac abnormalities can be observed. The correct etiologic diagnosis of them is only possible if we understand how <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin works and make a comprehensive investigation of the clinical history of the patient.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La tomografía con <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin (<span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT) desempeña un papel fundamental en la evaluación de la enfermedad coronaria. A pesar de que esta es su principal indicación, debemos recordar que estos estudios no evalúan únicamente la perfusión miocárdica, sino mucho más. Además, durante la adquisición de la SPECT, el campo incluye gran parte del tórax y abdomen, por lo que podemos observar enfermedad extracardíaca en las regiones incluidas. Llegar a un correcto diagnóstico etiológico de esas alteraciones solo es posible si entendemos cómo funciona el <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin y realizamos una exhaustiva investigación de los antecedentes e historia clínica del paciente.</p></span>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 686 "Ancho" => 1300 "Tamanyo" => 59269 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Anterior and lateral raw data of <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT images at stress show vertical extracardiac linear activity, located in right posterior thorax, near the midline.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1046 "Ancho" => 1950 "Tamanyo" => 176623 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">99m</span>Tc-tetrofosmin SPECT (b) and fused SPECT/CT (c) slices reveal an elongated mass with increased activity in right-posterior mediastinum.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1188 "Ancho" => 1950 "Tamanyo" => 205985 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/TC at diagnosis. Maximum-intensity-projection (a), axial (b) and sagital (c) PET/CT images show increased uptake in proximal esophagus due to esophageal carcinoma, without lymphadenopathy or distant metastasis.</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Fig. 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 893 "Ancho" => 1950 "Tamanyo" => 195540 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/CT 1 month before myocardial perfusion study. Maximum-intensity-projection (a) and axial PET/CT images (b,c), show relapse in proximal esophagus while there is no increased activity in gastric tube (arrow).</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Fig. 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 1142 "Ancho" => 800 "Tamanyo" => 108732 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">99m</span>Tc-tetrofosmin coronal SPECT/CT (a) and <span class="elsevierStyleSup">18</span>F-FDG coronal PET/CT (b). The images show increased activity of <span class="elsevierStyleSup">99m</span>Tc-tetrofosmin in SPECT/CT (a) corresponded to the content of the gastroplasty due to reflux. In PET/CT study we can see the dilated gastroplasty, with liquid content, and without hypermetabolism.</p>" ] ] 5 => array:7 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Abnormalities above the diaphragm. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Malignant or benign lesions in thyroid.• Parathyroid lesions (adenoma, hyperplasia, carcinoma).• Malignant (primary/metastatic) or benign lesions in the lungs.• Diffuse and bilateral uptake in the lungs.• Pleural or pericardial effusion.• Mediastinal tumor.• Sarcoidosis.• Duodenogastroesophageal reflux.• Hiatus hernia.• Lyphoma.• Breast cancer.• Sternal uptake in anemia and/or hypoxemia. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Abnormalities of the diaphragm. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Elevation or displacement of the diaphragm. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " align="left" valign="top">Abnormalities below the diaphragm. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">• Hepatomegaly, splenomegaly.• Cirrhosis with ascites.• Gastric empting abnormalities.• Duodenogastric biliary reflux.• Non-visualization of the gallbladder (cholelithiasis, acute cholecystitis, or cholecystectomy).• Focal benign (photopenic) or malignant (primary/metastatic) lesions in abdominal organs.• Vertebral uptake in anemia and/or hypoxemia. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab938504.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Abnormalities in myocardial perfusion SPECT/CT studies.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Technetium-99m-1,2-bis [bis(ethoxyethyl) phosphino] ethane: human biodistribution, dosimetry and safety of a new myocardial perfusion imaging agent" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. 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