COVID-19
Regístrese
metricas
covid
Revista Española de Medicina Nuclear e Imagen Molecular
Suscríbase a esta revista
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular Comparación intraindividual de la PET/TC con 68Ga-DOTATATE vs. PET/TC con 11C-c...
Información de la revista
Volver al artículo

Estadísticas

Siga este enlace para acceder al texto completo del artículo

ORIGINAL
Comparación intraindividual de la PET/TC con 68Ga-DOTATATE vs. PET/TC con 11C-colina en pacientes con cáncer de próstata en recaída bioquímica: evaluación in vivo de la expresión de receptores de la somatostatina
Intraindividual comparison of 68Ga-DOTATATE PET / CT vs 11C-Choline PET / CT in patients with prostate cancer in biochemical relapse: in vivo evaluation of the expression of somatostatin receptors
G. dos Santosa,b,
Autor para correspondencia
gerardo.dossantos@cudim.org
cudim@cudim.org

Autor para correspondencia.
, M. García Fontesa, H. Englera, O. Alonsoa,b
a Centro Uruguayo de Imagenología Molecular (CUDIM)., Montevideo, Uruguay
b Centro de Medicina Nuclear e Imagenología Molecular, Hospital de Clínicas «Dr. Manuel Quintela», Universidad de la República, Montevideo, Uruguay
Leído
95
Veces
se ha leído el artículo
44
Total PDF
51
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S2253654X18300672"
  "issn" => "2253654X"
  "doi" => "10.1016/j.remn.2018.08.005"
  "estado" => "S300"
  "fechaPublicacion" => "2019-01-01"
  "aid" => "1016"
  "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular"
  "copyrightAnyo" => "2018"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:29-37"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 56
    "formatos" => array:2 [
      "HTML" => 34
      "PDF" => 22
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S2253808918301204"
      "issn" => "22538089"
      "doi" => "10.1016/j.remnie.2018.11.008"
      "estado" => "S300"
      "fechaPublicacion" => "2019-01-01"
      "aid" => "1016"
      "copyright" => "Sociedad Española de Medicina Nuclear e Imagen Molecular"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:29-37"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:1 [
        "total" => 0
      ]
      "en" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>"
        "titulo" => "Intraindividual comparison of <span class="elsevierStyleSup">68</span>Ga-DOTATATE PET&#47;CT vs&#46; <span class="elsevierStyleSup">11</span>C-choline PET&#47;CT in patients with prostate cancer in biochemical relapse&#58; In vivo evaluation of the expression of somatostatin receptors"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "tieneResumen" => array:2 [
          0 => "en"
          1 => "es"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "29"
            "paginaFinal" => "37"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Comparaci&#243;n intraindividual de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE vs&#46; PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina en pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica&#58; evaluaci&#243;n in vivo de la expresi&#243;n de receptores de la somatostatina"
          ]
        ]
        "contieneResumen" => array:2 [
          "en" => true
          "es" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0010"
            "etiqueta" => "Fig&#46; 2"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr2.jpeg"
                "Alto" => 2762
                "Ancho" => 2083
                "Tamanyo" => 410739
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Patient number 62&#46; 70-Year-old patient treated with surgery&#44; hormone therapy&#44; radiotherapy and polychemotherapy&#46; Biochemical relapse with a PSA value of 5&#46;26<span class="elsevierStyleHsp" style=""></span>ng&#47;mL&#46; Images of maximum intensity projection &#40;MIP&#41; with <span class="elsevierStyleSup">11</span>C-choline &#40;a&#41; and <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;b&#41;&#46; Both radiotracers showed an internal left iliac metastatic adenopathy&#46; &#40;c&#41; Secondary primitive left iliac adenopathy shown only with <span class="elsevierStyleSup">11</span>C-choline&#46; &#40;d&#41; Bone lesion in the right L2 vertebral hemibody only detected with <span class="elsevierStyleSup">68</span>Ga-DOTATATE e&#41; &#40;yellow arrows&#41;&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "G&#46; dos Santos, M&#46; Garc&#237;a Fontes, H&#46; Engler, O&#46; Alonso"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "dos Santos"
              ]
              1 => array:2 [
                "nombre" => "M&#46;"
                "apellidos" => "Garc&#237;a Fontes"
              ]
              2 => array:2 [
                "nombre" => "H&#46;"
                "apellidos" => "Engler"
              ]
              3 => array:2 [
                "nombre" => "O&#46;"
                "apellidos" => "Alonso"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "es" => array:9 [
          "pii" => "S2253654X18300672"
          "doi" => "10.1016/j.remn.2018.08.005"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "es"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18300672?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918301204?idApp=UINPBA00004N"
      "url" => "/22538089/0000003800000001/v1_201901110618/S2253808918301204/v1_201901110618/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2253654X18301550"
    "issn" => "2253654X"
    "doi" => "10.1016/j.remn.2018.09.007"
    "estado" => "S300"
    "fechaPublicacion" => "2019-01-01"
    "aid" => "1025"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Nuclear e Imagen Molecular"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:38-45"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 146
      "formatos" => array:2 [
        "HTML" => 74
        "PDF" => 72
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">COLABORACI&#211;N ESPECIAL</span>"
      "titulo" => "Desarrollo de un mapa de riesgos para la tomograf&#237;a por emisi&#243;n de positrones"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "38"
          "paginaFinal" => "45"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Development of a positron emission tomography risks map"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2133
              "Ancho" => 2250
              "Tamanyo" => 222989
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Proceso PET&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Rodr&#237;guez Fern&#225;ndez, E&#46;M&#46; Trivi&#241;o Ib&#225;&#241;ez, M&#46; G&#243;mez R&#237;o, J&#46;J&#46; P&#233;rez L&#225;zaro, I&#46; Fern&#225;ndez Ruiz, &#193;&#46; Ram&#237;rez Navarro, Y&#46; Garc&#237;a Rivero, E&#46; C&#243;rdoba Ca&#241;ete, C&#46; Romero Fern&#225;ndez, J&#46;M&#46; Llamas-Elvira"
          "autores" => array:10 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Rodr&#237;guez Fern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "E&#46;M&#46;"
              "apellidos" => "Trivi&#241;o Ib&#225;&#241;ez"
            ]
            2 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "G&#243;mez R&#237;o"
            ]
            3 => array:2 [
              "nombre" => "J&#46;J&#46;"
              "apellidos" => "P&#233;rez L&#225;zaro"
            ]
            4 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Fern&#225;ndez Ruiz"
            ]
            5 => array:2 [
              "nombre" => "&#193;&#46;"
              "apellidos" => "Ram&#237;rez Navarro"
            ]
            6 => array:2 [
              "nombre" => "Y&#46;"
              "apellidos" => "Garc&#237;a Rivero"
            ]
            7 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "C&#243;rdoba Ca&#241;ete"
            ]
            8 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Romero Fern&#225;ndez"
            ]
            9 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Llamas-Elvira"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2253808918301198"
        "doi" => "10.1016/j.remnie.2018.11.007"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918301198?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18301550?idApp=UINPBA00004N"
    "url" => "/2253654X/0000003800000001/v1_201901110626/S2253654X18301550/v1_201901110626/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2253654X18301586"
    "issn" => "2253654X"
    "doi" => "10.1016/j.remn.2018.09.006"
    "estado" => "S300"
    "fechaPublicacion" => "2019-01-01"
    "aid" => "1023"
    "copyright" => "Sociedad Espa&#241;ola de Medicina Nuclear e Imagen Molecular"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Rev Esp Med Nucl Imagen Mol. 2019;38:22-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 106
      "formatos" => array:2 [
        "HTML" => 65
        "PDF" => 41
      ]
    ]
    "es" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original</span>"
      "titulo" => "Valoraci&#243;n de factores predictivos de positividad en PET con <span class="elsevierStyleSup">68</span>Ga-PSMA-11 en el c&#225;ncer de pr&#243;stata"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "22"
          "paginaFinal" => "28"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Assessment of <span class="elsevierStyleSup">68</span>Ga-PSMA-11 PET positivity predictive factors in prostate cancer"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0015"
          "etiqueta" => "Figura 3"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr3.jpeg"
              "Alto" => 864
              "Ancho" => 2167
              "Tamanyo" => 72212
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n de resultados de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-PSMA seg&#250;n los niveles de PSA&#46; Resultados negativos y positivos del estudio PET&#47;TC en distintos tramos de PSA expresados en ng&#47;ml&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46;L&#46; Guti&#233;rrez-Cardo, A&#46; P&#233;rez Duarte, S&#46;F&#46; Garc&#237;a-Arg&#252;ello, B&#46; L&#243;pez Lorenzo, M&#46;E&#46; Lillo Garc&#237;a, P&#46; Valdivielso"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "A&#46;L&#46;"
              "apellidos" => "Guti&#233;rrez-Cardo"
            ]
            1 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "P&#233;rez Duarte"
            ]
            2 => array:2 [
              "nombre" => "S&#46;F&#46;"
              "apellidos" => "Garc&#237;a-Arg&#252;ello"
            ]
            3 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "L&#243;pez Lorenzo"
            ]
            4 => array:2 [
              "nombre" => "M&#46;E&#46;"
              "apellidos" => "Lillo Garc&#237;a"
            ]
            5 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Valdivielso"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S2253808918301101"
        "doi" => "10.1016/j.remnie.2018.09.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808918301101?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18301586?idApp=UINPBA00004N"
    "url" => "/2253654X/0000003800000001/v1_201901110626/S2253654X18301586/v1_201901110626/es/main.assets"
  ]
  "es" => array:19 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">ORIGINAL</span>"
    "titulo" => "Comparaci&#243;n intraindividual de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE vs&#46; PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina en pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica&#58; evaluaci&#243;n in vivo de la expresi&#243;n de receptores de la somatostatina"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "29"
        "paginaFinal" => "37"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "G&#46; dos Santos, M&#46; Garc&#237;a Fontes, H&#46; Engler, O&#46; Alonso"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "G&#46;"
            "apellidos" => "dos Santos"
            "email" => array:2 [
              0 => "gerardo&#46;dossantos&#64;cudim&#46;org"
              1 => "cudim&#64;cudim&#46;org"
            ]
            "referencia" => array:3 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
              2 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "M&#46;"
            "apellidos" => "Garc&#237;a Fontes"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "H&#46;"
            "apellidos" => "Engler"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "O&#46;"
            "apellidos" => "Alonso"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Centro Uruguayo de Imagenolog&#237;a Molecular &#40;CUDIM&#41;&#46;&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Centro de Medicina Nuclear e Imagenolog&#237;a Molecular&#44; Hospital de Cl&#237;nicas &#171;Dr&#46; Manuel Quintela&#187;&#44; Universidad de la Rep&#250;blica&#44; Montevideo&#44; Uruguay"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Autor para correspondencia&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Intraindividual comparison of <span class="elsevierStyleSup">68</span>Ga-DOTATATE PET &#47; CT vs <span class="elsevierStyleSup">11</span>C-Choline PET &#47; CT in patients with prostate cancer in biochemical relapse&#58; in vivo evaluation of the expression of somatostatin receptors"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2762
            "Ancho" => 2083
            "Tamanyo" => 344891
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 62&#46; Paciente de 70 a&#241;os tratado con cirug&#237;a&#44; hormonoterapia&#44; radioterapia y poliquimioterapia&#46; Reca&#237;da bioqu&#237;mica con valor de PSA de 5&#44;26 ng&#47;mL&#46; Im&#225;genes de m&#225;xima ponderaci&#243;n &#40;MIP&#41; con <span class="elsevierStyleSup">11</span>C-colina a&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE b&#41;&#46; Adenopat&#237;a metast&#225;sica il&#237;aca interna izquierda demostrada con ambos radiotrazadores c&#41;&#46; Adenopat&#237;a il&#237;aca primitiva izquierda secundaria demostrada &#250;nicamente con el 11C-colina d&#41; y lesi&#243;n &#243;sea en hemicuerpo vertebral derecho de L2 demostrado &#250;nicamente con el <span class="elsevierStyleSup">68</span>Ga-DOTATATE e&#41; &#40;flechas amarillas&#41;&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El c&#225;ncer de pr&#243;stata es el segundo tumor maligno m&#225;s frecuente en el hombre y una de las enfermedades malignas m&#225;s frecuentes del mundo<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La detecci&#243;n de lesiones vinculadas a una recurrencia de c&#225;ncer de pr&#243;stata en el contexto de una reca&#237;da bioqu&#237;mica &#40;RBQ&#41; constituye un reto importante para todas las modalidades de im&#225;genes<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La PET&#47;TC con radiof&#225;rmacos derivados de la colina ha encontrado un amplio uso para el diagn&#243;stico de recidiva de c&#225;ncer de pr&#243;stata en pacientes con RBQ&#46; Sin embargo&#44; se han publicado numerosos estudios demostrando valores de sensibilidad y especificidad relativamente bajos&#44; especialmente a niveles bajos de PSA<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">En pacientes con c&#225;ncer de pr&#243;stata avanzado&#44; a pesar del &#233;xito terap&#233;utico de las estrategias iniciales&#44; la mayor&#237;a se hacen independientes a los andr&#243;genos y progresan con niveles elevados de ant&#237;geno prost&#225;tico espec&#237;fico &#40;PSA&#41; bajo terap&#233;uticas de supresi&#243;n hormonal&#46; El c&#225;ncer de pr&#243;stata hormonorresistente se define por la progresi&#243;n de la enfermedad a pesar de la terapia de privaci&#243;n de andr&#243;genos&#46; Este evento es un desaf&#237;o cl&#237;nico&#44; ya que el poder del tratamiento para pacientes con c&#225;ncer de pr&#243;stata hormonorresistente con met&#225;stasis a distancia es muy limitado&#46; Son necesarias urgentemente nuevas estrategias terap&#233;uticas capaces de controlar la evoluci&#243;n de la enfermedad en este estadio de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Una serie de investigaciones evaluaron la posible diferenciaci&#243;n neuroendocrina &#40;DNE&#41; de las c&#233;lulas de c&#225;ncer de pr&#243;stata en la fase de resistencia a la castraci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;8</span></a>&#46; La DNE ha recibido especial atenci&#243;n en los &#250;ltimos a&#241;os por las implicaciones pron&#243;sticas y terap&#233;uticas&#44; dada la progresi&#243;n de la enfermedad a pesar de los tratamientos convencionales<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">La DNE se caracteriza por grupos dispersos de c&#233;lulas neuroendocrinas diferenciadas entre una poblaci&#243;n predominante de c&#233;lulas de adenocarcinoma y tiene potencial pron&#243;stico y terap&#233;utico en el c&#225;ncer de pr&#243;stata<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a>&#46; La DNE ha sido asociada con hasta el 85&#37; de pacientes con c&#225;ncer de pr&#243;stata hormonorresistente<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46; La hiperactivaci&#243;n celular neuroendocrina puede jugar un papel clave en la patog&#233;nesis del c&#225;ncer de pr&#243;stata resistente a la castraci&#243;n a trav&#233;s de la producci&#243;n y secreci&#243;n de neurop&#233;ptidos bioactivos<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Existen c&#233;lulas neuroendocrinas en la pr&#243;stata normal que forman una red de comunicaci&#243;n vinculada con la regulaci&#243;n de la proliferaci&#243;n celular<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> y que son independientes de la estimulaci&#243;n androg&#233;nica<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Estas c&#233;lulas expresan receptores de la somatostatina &#40;SSTR&#41; y pueden ser identificadas con an&#225;logos de la somatostatina marcados con <span class="elsevierStyleSup">68</span>Ga &#40;<span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos&#41; que constituyen trazadores PET alternativos y atractivos para la evaluaci&#243;n de pacientes con c&#225;ncer de pr&#243;stata hormonorresistentes<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diversos trabajos han estudiado la sobreexpresi&#243;n de los SSTR en diferentes tumores sobre todo neuroendocrinos<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> y tambi&#233;n en pacientes con c&#225;ncer de pr&#243;stata&#44; mediante <span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A este respecto se ha demostrado que algunas lesiones de c&#225;ncer de pr&#243;stata pueden ser visibles con estos radiotrazadores mediante PET&#47;TC confirmando la expresi&#243;n de estos receptores<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14&#44;15</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Esto motiv&#243; la realizaci&#243;n por parte de nuestro grupo de estudios preliminares usando el <span class="elsevierStyleSup">68</span>Ga-DOTATATE PET&#47;TC en una peque&#241;a serie de pacientes con c&#225;ncer de pr&#243;stata avanzado en RBQ&#46; Se pudo visualizar con esta t&#233;cnica todas las lesiones previamente detectadas por gammagraf&#237;a &#243;sea y&#44; adicionalmente&#44; lesiones prost&#225;ticas y ganglionares p&#233;lvicas<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Recientemente&#44; las terapias de combinaci&#243;n con an&#225;logos de la somatostatina han surgido como posibles opciones terap&#233;uticas para los pacientes con c&#225;ncer de pr&#243;stata avanzado andr&#243;geno independiente&#44; mediante el uso de radiof&#225;rmacos emisores de part&#237;culas &#946;- como <span class="elsevierStyleSup">90</span>Y o <span class="elsevierStyleSup">177</span>Lu para radioterapia<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Es de relevancia cl&#237;nica la cuidadosa determinaci&#243;n de la presencia de c&#233;lulas neuroendocrinas en el c&#225;ncer de pr&#243;stata&#44; con la identificaci&#243;n de subgrupos de potenciales respondedores a estas terapias<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Por lo tanto&#44; el objetivo de este estudio fue comparar prospectivamente la tasa de detecci&#243;n de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE versus la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina en pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica y evaluar in vivo la expresi&#243;n de receptores de la somatostatina con el fin de planificar eventuales terapias dirigidas contra estos blancos moleculares&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Pacientes</span><p id="par0075" class="elsevierStylePara elsevierViewall">Analizamos prospectivamente 64 pacientes con RBQ seg&#250;n los criterios internacionales aceptados&#44; remitidos a nuestro servicio entre marzo de 2012 y enero de 2014&#46; Las caracter&#237;sticas de los pacientes se resumen en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Cuarenta y dos pacientes &#40;65&#37;&#41; hab&#237;an sido sometidos a prostatectom&#237;a radical y 22 pacientes fueron tratados con radioterapia &#40;asociada o no a terapia de deprivaci&#243;n hormonal&#41;&#46; La edad promedio fue de 64&#44;98 &#177; 7&#44;03 a&#241;os&#46; La mediana del nivel de PSA fue de 4&#44;25 ng&#47;mL&#44; oscilando entre 0&#44;22 y 291 ng&#47;mL&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Consideraciones &#233;ticas</span><p id="par0080" class="elsevierStylePara elsevierViewall">El estudio fue aprobado por el Comit&#233; de &#201;tica de nuestro Centro y llevado a cabo de acuerdo con la Declaraci&#243;n de Helsinki&#44; con sus respectivas enmiendas posteriores&#44; y con los requisitos de la ICMJE&#46; Adem&#225;s&#44; se obtuvieron los consentimientos informados de todos los participantes incluidos en el estudio y la autorizaci&#243;n para la publicaci&#243;n de los resultados de forma an&#243;nima&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Radiof&#225;rmacos</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090"><span class="elsevierStyleSup">11</span>C-colina</span><p id="par0085" class="elsevierStylePara elsevierViewall">En un m&#243;dulo autom&#225;tico se desarroll&#243; la s&#237;ntesis de &#91;N-metil-<span class="elsevierStyleSup">11</span>C&#93; colina a partir de <span class="elsevierStyleSup">11</span>CO2 y dimetilaminoetanol&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">La reacci&#243;n y purificaci&#243;n se efectu&#243; en un Sep-PakAccell Plus CM &#40;Millipore&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La pureza radioqu&#237;mica de la <span class="elsevierStyleSup">11</span>C-colina fue mayor al 95&#37;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095"><span class="elsevierStyleSup">68</span>Ga-DOTATATE</span><p id="par0100" class="elsevierStylePara elsevierViewall">Se obtuvo la eluci&#243;n de un generador de <span class="elsevierStyleSup">68</span>Ge&#47;<span class="elsevierStyleSup">68</span>Ga &#40;ITG&#44; Alemania&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Se efectu&#243; un calentamiento durante 10 min a 100<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; pH 3&#46;5-4&#46;2&#44; siendo la cantidad de p&#233;ptido de 20 nmoles o menos&#46; Se purific&#243; el marcado por SPEC &#40;SepPak C 18 light&#41; eluyendo con ETOH 30&#37; y formulando con NACL 0&#44;9&#37;&#44; determinando posteriormente la pureza radionucle&#237;dica y radioqu&#237;mica del <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Adquisici&#243;n de im&#225;genes</span><p id="par0110" class="elsevierStylePara elsevierViewall">No se requiri&#243; de ayuno ni de la suspensi&#243;n de la medicaci&#243;n habitual&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La preparaci&#243;n del paciente incluy&#243; la colocaci&#243;n de un v&#237;a intravenosa y la hidrataci&#243;n con 500<span class="elsevierStyleHsp" style=""></span>ml de soluci&#243;n salina al 0&#44;9&#37;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">En un intervalo no mayor a 2 semanas se realizaron dos estudios PET&#47;TC&#58; uno con <span class="elsevierStyleSup">11</span>C-colina y otro con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; siendo indistinto el orden de ejecuci&#243;n y el posterior an&#225;lisis de los mismos&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Los estudios fueron adquiridos en un equipo PET&#47;TC de 64 cortes &#40;General Electric Discovery 690 VCT&#44; 64 cortes&#44; Waukesha&#44; WI&#44; EE&#46; UU&#46;&#41; inmediatamente despu&#233;s de la inyecci&#243;n de 6&#44;0 MBq&#47;kg de <span class="elsevierStyleSup">11</span>C-colina o 30 min despu&#233;s de la administraci&#243;n intravenosa de 2&#44;0 MBq&#47;kg de <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Se adquirieron im&#225;genes desde cr&#225;neo hasta la mitad de muslo&#46; La adquisici&#243;n y los par&#225;metros de procesamiento de las im&#225;genes de PET fueron los mismos para la <span class="elsevierStyleSup">11</span>C-colina y para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">La tomograf&#237;a computada se realiz&#243; con 80-180<span class="elsevierStyleHsp" style=""></span>mA&#44; 120 Kv &#40;&#171;index noise&#187; 30&#41; y 3&#44;75<span class="elsevierStyleHsp" style=""></span>mm de espesor de corte&#44; pitch de 1&#46;375&#44; tiempo de rotaci&#243;n de 0&#44;8 segundos y movimiento de tabla de 55<span class="elsevierStyleHsp" style=""></span>mm&#47;rotaci&#243;n&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Se adquiri&#243; una PET en modo 3D&#44; tama&#241;o de la matriz de 128 &#215; 128 pixeles&#44; con tiempo de adquisici&#243;n de 3 o 4 min por cada posici&#243;n de cama &#40;<span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE respectivamente&#41;&#44; con superposici&#243;n de corte de 11<span class="elsevierStyleHsp" style=""></span>mm&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Las im&#225;genes fueron reconstruidas mediante un algoritmo de reconstrucci&#243;n iterativa OSEM &#40;Ordered Subset Expectation Maximization&#41; con 28 subconjuntos&#47;2 iteraciones&#44; con correcci&#243;n por &#171;tiempo de vuelo&#187; y reformadas en cortes transversales&#44; coronales y sagitales&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Las im&#225;genes fueron evaluadas en conjunto por dos especialistas en medicina nuclear y por dos m&#233;dicos radi&#243;logos&#46; Ambos juegos de im&#225;genes se evaluaron conjuntamente&#46; Los desacuerdos fueron resueltos por consenso&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Todas las lesiones que se consideraron visualmente como malignas se contaron y se analizaron con respecto a su localizaci&#243;n &#40;recidiva local&#44; met&#225;stasis &#243;seas&#44; ganglionares o de partes blandas&#41; y al valor de captaci&#243;n m&#225;ximo estandarizado &#40;SUVm&#225;x&#41;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Las lesiones sospechosas fueron definidas como cualquier captaci&#243;n focal&#44; en una o m&#225;s localizaciones&#44; de mayor intensidad que la captaci&#243;n de fondo o background circundante o en comparaci&#243;n con el tejido normal&#44; excluyendo zonas articulares y &#225;reas de captaci&#243;n fisiol&#243;gica&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">El patr&#243;n de comparaci&#243;n a considerar fue alguno de los siguientes&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0170" class="elsevierStylePara elsevierViewall">Anatom&#237;a patol&#243;gica de las lesiones mediante estudio histol&#243;gico&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#41;</span><p id="par0175" class="elsevierStylePara elsevierViewall">Comparaci&#243;n de los hallazgos de la PET&#47;TC con otras t&#233;cnicas de imagen&#58; tomograf&#237;a computarizada con contraste intravenoso&#44; resonancia magn&#233;tica&#44; gammagraf&#237;a &#243;sea&#44; ecograf&#237;a transrectal&#44; o nuevos estudios PET&#47;TC&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#41;</span><p id="par0180" class="elsevierStylePara elsevierViewall">Seguimiento bioqu&#237;mico y cl&#237;nico del paciente&#44; por un per&#237;odo superior a 6 meses despu&#233;s de realizados los estudios PET&#47;TC&#46; Para ello&#44; se revisaron historias cl&#237;nicas y entrevistaron telef&#243;nicamente a los pacientes y&#47;o a los m&#233;dicos tratantes&#46;</p></li></ul></p><p id="par0185" class="elsevierStylePara elsevierViewall">Los hallazgos PET&#47;TC se consideraron cl&#237;nicamente verdaderos positivos si se dieron una o m&#225;s de las siguientes circunstancias&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">1&#41;</span><p id="par0190" class="elsevierStylePara elsevierViewall">Confirmaci&#243;n histopatol&#243;gica&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2&#41;</span><p id="par0195" class="elsevierStylePara elsevierViewall">Confirmaci&#243;n de la lesi&#243;n por resultados concordantes con otras t&#233;cnicas de imagen ya sea en la reevaluaci&#243;n de estudios previos o en estudios posteriores&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">3&#41;</span><p id="par0200" class="elsevierStylePara elsevierViewall">Confirmaci&#243;n de la lesi&#243;n en estudios PET&#47;TC posteriores&#44; con aumento de tama&#241;o&#47;captaci&#243;n de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE y&#47;o aparici&#243;n de nuevas lesiones&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">4&#41;</span><p id="par0205" class="elsevierStylePara elsevierViewall">Descenso mayor del 50&#37; de los valores de PSA en pacientes tratados posteriormente a la realizaci&#243;n de los estudios PET&#47;TC&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">5&#41;</span><p id="par0210" class="elsevierStylePara elsevierViewall">Persistencia y empeoramiento de los s&#237;ntomas y&#47;o niveles en ascenso de PSA&#46;</p></li></ul></p><p id="par0215" class="elsevierStylePara elsevierViewall">Se consideraron como cl&#237;nicamente verdaderos negativos&#44; a aquellos pacientes que mostraron una estabilizaci&#243;n duradera en el tiempo &#40;&#62; 6 meses&#41; o normalizaci&#243;n espont&#225;nea de los valores de PSA durante el seguimiento&#44; sin aparici&#243;n de lesiones en otros estudios de imagen o PET&#47;TC de control&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">El an&#225;lisis de las im&#225;genes se realiz&#243; utilizando una plataforma General Electric AW 4&#46;6 &#40;HP Workstation y LINUX OS&#41; y OsiriX v6&#46;5&#46;2 &#40;OS X El Capitan&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">An&#225;lisis estad&#237;stico</span><p id="par0225" class="elsevierStylePara elsevierViewall">Los valores de SUVm&#225;x de las mismas lesiones detectadas con ambos trazadores&#44; <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; se analizaron estad&#237;sticamente utilizando un an&#225;lisis de Wilcoxon para datos apareados &#40;Wilcoxon-Signed test&#41;&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Se evalu&#243; la normalidad de ambos trazadores por separado&#44; gr&#225;ficamente y mediante un test de normalidad &#40;test de Shapiro-Wilk&#41;&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Se realiz&#243; una correlaci&#243;n entre valores de SUVm&#225;x de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE para lesiones concordantes utilizando un coeficiente de correlaci&#243;n no param&#233;trico &#40;rho de Spearman&#41;&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Se determin&#243; la tasa de detecci&#243;n de los trazadores <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE en diversos puntos de corte de PSA&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">Se valor&#243; la relaci&#243;n entre PSA y SUVm&#225;x para ambas investigaciones&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">En todos los an&#225;lisis se consider&#243; un nivel de significaci&#243;n &#945; &#61; 0&#44;05&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Para los an&#225;lisis estad&#237;sticos se utiliz&#243; el GraphPad Prism &#40;versi&#243;n 7&#46;00 para Mac OS X&#44; La Jolla&#44; CA&#44; EE&#46; UU&#41;&#44; el software R versi&#243;n 3&#46;2&#46;2 &#40;-R Core Team &#40;2015&#41;&#46; R&#58; A language and environment for statistical computing&#46; R Foundation for Statistical Computing&#44; Vienna&#44; Austria&#46; URL <a id="intr0005" class="elsevierStyleInterRef" href="https://www.r-project.org/">https&#58;&#47;&#47;www&#46;R-project&#46;org&#47;</a>&#46;&#41; y el RStudioversi&#243;n 0&#46;99&#46;485 &#40;RStudio Team &#40;2015&#41;&#46; RStudio&#58; Integrated Development for R&#46; RStudio&#44; Inc&#46;&#44; Boston&#44; MA URL <a id="intr0010" class="elsevierStyleInterRef" href="http://www.rstudio.com/">http&#58;&#47;&#47;www&#46;rstudio&#46;com&#47;</a>&#41;&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Resultados</span><p id="par0260" class="elsevierStylePara elsevierViewall">La tasa de detecci&#243;n global por paciente fue del 48&#44;43&#37; &#40;31&#47;64&#41; para <span class="elsevierStyleSup">68</span>Ga-DOTATATE y de 46&#44;87&#37; &#40;30&#47;64&#41; para <span class="elsevierStyleSup">11</span>C-colina&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Ambas t&#233;cnicas fueron positivas en 25 pacientes &#40;39&#37;&#41; y negativas en 28 pacientes &#40;43&#44;70&#37;&#41;&#46; Seis pacientes fueron positivos &#250;nicamente con <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;9&#44;4&#37;&#41; y 5 &#250;nicamente con <span class="elsevierStyleSup">11</span>C-colina &#40;7&#44;8&#37;&#41;&#46; Los resultados fueron concordantes en 53 casos &#40;82&#44;81&#37;&#41; &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 y 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0270" class="elsevierStylePara elsevierViewall">Un total de 215 lesiones fueron detectadas con al menos un radiotrazador&#58; 149 para <span class="elsevierStyleSup">68</span>Ga-DOTATATE y 197 para <span class="elsevierStyleSup">11</span>C-colina&#46; La localizaci&#243;n de las lesiones para cada trazador se describe en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">Se evalu&#243; la normalidad de ambos trazadores por separado&#44; gr&#225;ficamente y mediante un test de normalidad&#46; Ninguna de las dos medidas tiene distribuci&#243;n normal &#40;test de Shapiro-Wilk&#44; valor-p &#60; 0&#44;0001&#41;&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Se valor&#243; adem&#225;s la capacidad de detecci&#243;n de enfermedad de la PET&#47;TC &#40;positividad de la prueba&#41; en funci&#243;n de distintos valores del PSA&#58; 1 ng&#47;mL&#44; 4&#44;25 ng&#47;mL y 5 ng&#47;mL &#40;4&#44;25 ng&#47;mL corresponde a la mediana de la distribuci&#243;n de PSA observada en la muestra de pacientes y los otros dos valores corresponden a valores de inter&#233;s cl&#237;nico obtenidos de bibliograf&#237;a&#41;&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall">As&#237;&#44; con un PSA menor a 1 ng&#47;mL se detectan captaciones patol&#243;gicas en un 6&#37; de los pacientes con <span class="elsevierStyleSup">11</span>C-colina y en un 12&#37; de los pacientes con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Con valores entre 1 y 5 ng&#47;mL los porcentajes de detecci&#243;n se elevaban hasta el 54&#37; y 36&#37; respectivamente&#46; Finalmente&#44; se alcanzaron porcentajes del 72&#37; y 80&#37; &#40;<span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE respectivamente&#41; con valores de PSA igual o superiores a 5 ng&#47;mL&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Para la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina&#44; con valores de PSA menores o iguales a 4&#44;25 ng&#47;mL &#40;mediana muestral&#41; se identific&#243; al menos una lesi&#243;n caracter&#237;stica para c&#225;ncer de pr&#243;stata en 25&#37; de los pacientes&#44; mientras que 65&#44;75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Usando el mismo umbral para la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; el 21&#44;8&#37; de los pacientes se present&#243; con al menos una lesi&#243;n con un nivel de PSA de 4&#44;25 ng&#47;mL y menos&#46; Adem&#225;s&#44; el 75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">El SUV m&#225;ximo de la <span class="elsevierStyleSup">11</span>C-colina fue significativamente mayor que el correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE para todas las lesiones concordantes &#40;n &#61; 130&#41;&#58; 6&#44;17 &#40;1&#44;70-15&#44;50&#41; versus 4&#44;38 &#40;1&#44;37-26&#44;70&#41;&#44; mediana &#40;rango&#41;&#44; para cada radiotrazador&#44; respectivamente &#40;p &#60; 0&#44;0001&#41;&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">Se encontr&#243; una correlaci&#243;n significativa entre el SUVm&#225;x de ambos trazadores &#40;r &#61; 0&#44;41&#44; n &#61; 130&#44; p &#60;0&#44;0001&#41;&#46;</p><p id="par0310" class="elsevierStylePara elsevierViewall">Los valores por paciente de sensibilidad y especificidad&#44; con sus intervalos de confianza del 95&#37; fueron los mismos para ambas t&#233;cnicas&#58; 0&#44;82 &#40;0&#44;65 a 0&#44;93&#41; y 0&#44;90 &#40;0&#44;73-0&#44;98&#41;&#44; respectivamente&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">En el grupo de pacientes con PSA &#60; 4&#44;25 la sensibilidad calculada fue de 0&#44;63&#44; mientras que los pacientes con PSA &#62; 4&#44;25 presentaron una sensibilidad de 0&#44;89&#44; mismos valores para ambas t&#233;cnicas&#46;</p><p id="par0320" class="elsevierStylePara elsevierViewall">No se encontr&#243; relaci&#243;n entre el SUVm&#225;x de ambos radiotrazadores&#44; con el tipo de lesi&#243;n detectada ni con el nivel de PSA&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Del total de la poblaci&#243;n&#44; &#250;nicamente cuatro pacientes con resultados positivos fueron operados y la anatom&#237;a patol&#243;gica de los mismos revel&#243; alteraciones inflamatorias&#46;</p><p id="par0330" class="elsevierStylePara elsevierViewall">La comparaci&#243;n de la captaci&#243;n de <span class="elsevierStyleSup">11</span>C-colina con la correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE permitir&#237;a identificar lesiones malignas con expresi&#243;n de receptores de la somatostatina que podr&#237;an constituir un blanco espec&#237;fico prometedor para la terapia mediante <span class="elsevierStyleSup">177</span>Lu-DOTATATE&#46; Si bien existe alta coincidencia entre ambas t&#233;cnicas&#44; parece existir superioridad en el nivel de captaci&#243;n y n&#250;mero de lesiones detectadas con <span class="elsevierStyleSup">11</span>C-colina&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discusi&#243;n</span><p id="par0335" class="elsevierStylePara elsevierViewall">Despu&#233;s de aplicar un tratamiento con intenci&#243;n curativa por c&#225;ncer de pr&#243;stata cl&#237;nicamente localizado con cirug&#237;a o radioterapia&#44; 15-30&#37; de los pacientes evidencia progresi&#243;n bioqu&#237;mica&#44; que precede a una recurrencia cl&#237;nicamente detectable a nivel p&#233;lvico o enfermedad metast&#225;sica en un plazo de meses o a&#241;os<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">La utilidad de la PET&#47;TC con colina radiomarcada en la evaluaci&#243;n de estos pacientes ha sido ampliamente demostrada en varios estudios cl&#237;nicos<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> que han confirmado una captaci&#243;n preferencial por el c&#225;ncer de pr&#243;stata&#44; los ganglios linf&#225;ticos y sus met&#225;stasis<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a>&#46; Sin embargo&#44; la colina no es espec&#237;fica para el c&#225;ncer de pr&#243;stata&#44; tanto en la enfermedad intra- como extraprost&#225;tica&#44; y adem&#225;s una alta afinidad del radiof&#225;rmaco se ha evidenciado por la hiperplasia prost&#225;tica benigna&#46; Como consecuencia&#44; la discriminaci&#243;n entre tejido intraprost&#225;tico benigno y maligno se ve obstaculizada por una baja especificidad<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a>&#46; Adem&#225;s&#44; la sensibilidad de la PET&#47;TC con colina en la detecci&#243;n del c&#225;ncer de pr&#243;stata localmente recurrente es baja&#44; especialmente en el caso de valores bajos de PSA<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;22</span></a>&#46;</p><p id="par0345" class="elsevierStylePara elsevierViewall">Por otro lado&#44; la PET&#47;TC con receptores de la somatostatina emplea trazadores <span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos &#40;DOTA-TOC&#44; DOTA-TATE&#44; DOTA-NOC&#41; que se unen espec&#237;ficamente a estos receptores<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12&#8211;14</span></a>&#46; La diferencia m&#225;s relevante entre los diversos compuestos es la afinidad de uni&#243;n variable para los distintos subtipos de receptores<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a>&#46; Existen 5 subtipos &#40;1-5&#41;&#59; 2A y 2B son los m&#225;s com&#250;nmente expresados en las c&#233;lulas NE &#40;95&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a>&#46; Ha sido reportada la sobreexpresi&#243;n del SSTR2 en pacientes con c&#225;ncer de pr&#243;stata recurrente<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a>&#46;</p><p id="par0350" class="elsevierStylePara elsevierViewall">Por lo tanto&#44; es de valor cl&#237;nico la confirmaci&#243;n de un n&#250;mero suficiente de SSTR con el fin de planificar una terapia dirigida contra estos blancos moleculares mediante el marcaje con is&#243;topos emisores de part&#237;culas &#946;- como <span class="elsevierStyleSup">90</span>Y o <span class="elsevierStyleSup">177</span>Lu&#44; logrando un procedimiento combinado con potencial de permitir un abordaje terap&#233;utico basado en las im&#225;genes moleculares &#40;&#171;theranostics&#187; o &#171;diagnoterapia&#187;&#41;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#44;16&#44;25</span></a>&#46;</p><p id="par0355" class="elsevierStylePara elsevierViewall">Analizamos prospectivamente 64 pacientes en RBQ despu&#233;s de tratamiento convencional de su c&#225;ncer de pr&#243;stata&#46; En un intervalo no mayor a 2 semanas se realizaron dos estudios PET&#47;TC&#58; uno con <span class="elsevierStyleSup">11</span>C-colina y otro con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0360" class="elsevierStylePara elsevierViewall">En un 48&#44;43&#37; de los pacientes se encontraron hallazgos patol&#243;gicos en la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Esto coincide con los datos de la literatura&#44; en donde se demuestra captaci&#243;n de trazadores an&#225;logos de la somatostatina en diversos tipos de tumores que expresan estos receptores<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13&#44;16&#44;26</span></a>&#46;</p><p id="par0365" class="elsevierStylePara elsevierViewall">Por otro lado en un 46&#44;87&#37; de los pacientes se detect&#243; al menos una lesi&#243;n caracter&#237;stica de c&#225;ncer de pr&#243;stata en la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina&#44; similar tambi&#233;n a lo reportado en la literatura<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0370" class="elsevierStylePara elsevierViewall">Ambas t&#233;cnicas fueron positivas en 25 pacientes &#40;39&#37;&#41; y negativas en 28 pacientes &#40;43&#44;70&#37;&#41;&#46; Seis pacientes fueron positivos &#250;nicamente con <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;9&#44;4&#37;&#41; y 5 &#250;nicamente con <span class="elsevierStyleSup">11</span>C-colina &#40;7&#44;8&#37;&#41;&#46; Los resultados fueron concordantes en 53 casos &#40;82&#44;81&#37;&#41;&#46;</p><p id="par0375" class="elsevierStylePara elsevierViewall">En la actualidad persiste controversia sobre la eficiencia de la <span class="elsevierStyleSup">11</span>C-colina en diferentes puntos de corte de PSA y diversos autores establecen valores de entre 1 y 5 ng&#47;mL como discriminador de estudios PET positivos o negativos<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;22&#44;27&#44;28</span></a>&#46;</p><p id="par0380" class="elsevierStylePara elsevierViewall">En nuestro estudio se valor&#243; la capacidad de detecci&#243;n de enfermedad de la PET&#47;TC &#40;positividad de la prueba&#41; en funci&#243;n de los valores del PSA&#44; observando una relaci&#243;n entre ambos par&#225;metros&#46; As&#237;&#44; con un PSA menor a 1 ng&#47;mL se detectan captaciones patol&#243;gicas en un 6&#37; de los pacientes con <span class="elsevierStyleSup">11</span>C-colina y en un 12&#37; de los pacientes con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Con valores entre 1 y 5 ng&#47;mL los porcentajes de detecci&#243;n se elevaban hasta el 54&#37; y 36&#37; respectivamente&#46; Finalmente&#44; se alcanzaron porcentajes del 72&#37; y 80&#37; &#40;<span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE respectivamente&#41; con valores de PSA igual o superiores a 5 ng&#47;mL&#46;</p><p id="par0385" class="elsevierStylePara elsevierViewall">Para la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina&#44; con valores de PSA menores o iguales a 4&#44;25 ng&#47;mL &#40;mediana muestral&#41; se identific&#243; al menos una lesi&#243;n caracter&#237;stica para c&#225;ncer de pr&#243;stata en 25&#37; de los pacientes&#44; mientras que 65&#44;75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46; Nuestros resultados fueron similares a los informados en la literatura<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5&#44;18&#44;21&#44;22&#44;27&#44;28</span></a>&#46;</p><p id="par0390" class="elsevierStylePara elsevierViewall">Usando el mismo umbral para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; el 21&#44;8&#37; de los pacientes present&#243; al menos una lesi&#243;n con un nivel de PSA de 4&#44;25 ng&#47;mL o inferior&#46; Adem&#225;s&#44; el 75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46;</p><p id="par0395" class="elsevierStylePara elsevierViewall">Si bien hay trabajos en la literatura que estudian los valores de SUVm&#225;x de los <span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos en pacientes con tumores neuroendocrinos<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a>&#44; no existen trabajos que lo relacionen con el nivel de PSA en pacientes con c&#225;ncer de pr&#243;stata&#46;</p><p id="par0400" class="elsevierStylePara elsevierViewall">Nuestro estudio demuestra que la tasa de detecci&#243;n del c&#225;ncer de pr&#243;stata recurrente y sus met&#225;stasis mejora conforme la elevaci&#243;n del marcador tumoral&#46; Esto coincide ampliamente con los datos reportados en la literatura<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;27&#44;28</span></a>&#46;</p><p id="par0405" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; se realiz&#243; una correlaci&#243;n entre valores de SUVm&#225;x de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATE utilizando un coeficiente de correlaci&#243;n no param&#233;trico &#40;rho de Spearman&#41; y se demostr&#243; una correlaci&#243;n estad&#237;sticamente significativa&#44; aunque d&#233;bil entre ambas &#40;r &#61; 0&#44;41&#44; n &#61; 130&#44; p &#60; 0&#44;0001&#41;&#46;</p><p id="par0410" class="elsevierStylePara elsevierViewall">Sin embargo&#44; se demostr&#243; que la <span class="elsevierStyleSup">11</span>C-colina detect&#243; mayor cantidad de lesiones con respecto al <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0415" class="elsevierStylePara elsevierViewall">El SUVm&#225;x de la <span class="elsevierStyleSup">11</span>C-colina fue significativamente mayor que el correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE para todas las lesiones concordantes &#40;n &#61; 130&#41;&#58; 6&#44;17 &#40;1&#44;70-15&#44;50&#41; y 4&#44;38 &#40;1&#44;37-26&#44;70&#41;&#44; p &#60; 0&#44;0001&#59; mediana &#40;rango&#41;&#44; respectivamente&#46;</p><p id="par0420" class="elsevierStylePara elsevierViewall">Nuestros resultados fueron similares a los informados en la literatura<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11&#44;13&#8211;15&#44;23&#44;24</span></a>&#46;</p><p id="par0425" class="elsevierStylePara elsevierViewall">Los valores por paciente de sensibilidad y especificidad&#44; con sus intervalos de confianza del 95&#37; fueron los mismos para ambas t&#233;cnicas&#58; 0&#44;82 &#40;0&#44;65 a 0&#44;93&#41; y 0&#44;90 &#40;0&#44;73-0&#44;98&#41;&#44; respectivamente&#46;</p><p id="par0430" class="elsevierStylePara elsevierViewall">Aunque se observ&#243; una tendencia hacia una menor sensibilidad para pacientes con niveles de PSA inferiores&#44; la diferencia no fue estad&#237;sticamente significativa&#58; 0&#44;63 vs&#46; 0&#44;89&#59; p &#61; 0&#44;13&#59; mismos valores para ambos trazadores&#44; para pacientes con PSA &#60; 4&#44;25 y &#8805; 4&#44;25 ng&#47;mL&#44; respectivamente&#46; Esto puede estar influenciado por el tama&#241;o de la muestra y en el hecho de que la mayor&#237;a de los pacientes presentaban valores de PSA elevados&#44; lo que constituy&#243; una limitaci&#243;n en el estudio&#46; Desafortunadamente&#44; nuestro estudio no incluy&#243; suficientes pacientes con valores de PSA m&#225;s bajos&#46;</p><p id="par0435" class="elsevierStylePara elsevierViewall">Se han documentado algunos resultados discordantes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; La diferente captaci&#243;n entre los radiotrazadores puede ser debida a diversidad de factores&#44; como por ejemplo terapias previas&#44; la influencia del tratamiento antiandrog&#233;nico&#44; diferentes variables histol&#243;gicas del c&#225;ncer de pr&#243;stata&#44; caracter&#237;sticas biol&#243;gicas diferentes como la expresi&#243;n de receptores de la somatostatina o los transportadores de colina o tumoral entre otros&#46;</p><p id="par0440" class="elsevierStylePara elsevierViewall">Cuatro pacientes con resultados PET&#47;TC positivos fueron operados &#40;a los pacientes n&#250;mero 7&#44; 32 y 46 se les inform&#243; ganglios positivos&#44; y al paciente n&#250;mero 19 se le inform&#243; de captaci&#243;n en lecho prost&#225;tico&#41; y la anatom&#237;a patol&#243;gica de los mismos revel&#243; alteraciones inflamatorias &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">figs&#46; 3 y 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0445" class="elsevierStylePara elsevierViewall">Se ha visto que los receptores de la somatostatina se expresan tambi&#233;n en los macr&#243;fagos que juegan un rol en los procesos inflamatorios y que adem&#225;s se puede encontrar un aumento en la actividad colinquinasa de estas c&#233;lulas cuando son activadas&#46;</p><p id="par0450" class="elsevierStylePara elsevierViewall">La captaci&#243;n de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE en procesos inflamatorios o infecciosos&#44; puede limitar la especificidad de estas t&#233;cnicas para la detecci&#243;n de enfermedad metast&#225;sica oculta y debe ser tomada en cuenta a la hora de decidir maniobras invasivas<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a>&#46;</p><p id="par0455" class="elsevierStylePara elsevierViewall">Esto motiv&#243; una publicaci&#243;n por parte de nuestro grupo informando de los posibles falsos positivos de estas t&#233;cnicas<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a>&#46;</p><p id="par0460" class="elsevierStylePara elsevierViewall">En esta serie de pacientes se demuestra que tanto la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina como con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; mediante diferentes mecanismos&#44; poseen capacidad de detecci&#243;n de lesiones patol&#243;gicas en el estudio de recidivas bioqu&#237;micas ocultas del carcinoma de pr&#243;stata&#44; y esto parece ser dependiente del nivel del PSA&#46;</p><p id="par0465" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleSup">68</span>Ga-DOTATATE como aplicaci&#243;n diagn&#243;stica busca identificar receptores de la somatostatina en el c&#225;ncer de pr&#243;stata&#46; Como aplicaci&#243;n terap&#233;utica ser&#237;a posible el marcaje de los mismos an&#225;logos de la somatostatina con radiois&#243;topos beta negativos &#40;<span class="elsevierStyleSup">177</span>Lutecio&#41; con la finalidad de irradiar en forma espec&#237;fica estas c&#233;lulas tumorales<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46; La terapia con <span class="elsevierStyleSup">177</span>Lu-DOTATATE puede ser efectiva en aquellos pacientes con c&#225;ncer de pr&#243;stata hormonorresistente que no poseen otras opciones terap&#233;uticas y se demuestra una captaci&#243;n suficiente de <span class="elsevierStyleSup">68</span>Ga-DOTATATE en las lesiones tumorales observadas en la PET&#47;TC&#46;</p><p id="par0470" class="elsevierStylePara elsevierViewall">Dado que existe alta coincidencia entre ambas t&#233;cnicas &#40;aunque con superioridad en el nivel de captaci&#243;n y n&#250;mero de lesiones detectadas con <span class="elsevierStyleSup">11</span>C-colina&#41; creemos que ser&#237;a factible la terapia radioguiada en estos pacientes&#46;</p><p id="par0475" class="elsevierStylePara elsevierViewall">En este trabajo la adquisici&#243;n de las im&#225;genes se realiz&#243; 30 min postinyecci&#243;n del <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Diversos trabajos adquieren las im&#225;genes 45 a 60 min postinyecci&#243;n&#46; Ser&#237;a de inter&#233;s valorar si el tiempo de adquisici&#243;n influye en los resultados&#46;</p><p id="par0480" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene limitaciones&#46; Hubiera sido deseable correlacionar el valor de Gleason con los resultados ya que est&#225; descrito que la diferenciaci&#243;n neuroendocrina parece relacionarse con la agresividad<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a>&#46; Tampoco disponemos de datos de marcadores de tumores espec&#237;ficos de tumores neuroendocrinos como la cromogranina A en nuestros pacientes&#46;</p><p id="par0485" class="elsevierStylePara elsevierViewall">Finalmente&#44; hubi&#233;ramos deseado haber podido realizar estudios dirigidos histol&#243;gicos de las lesiones para conocer el verdadero significado de la captaci&#243;n del <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusiones</span><p id="par0490" class="elsevierStylePara elsevierViewall">La PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE y la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina parecen poseer alta capacidad de detecci&#243;n de lesiones patol&#243;gicas en la evaluaci&#243;n de los pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica&#46;</p><p id="par0495" class="elsevierStylePara elsevierViewall">Se necesitan m&#225;s estudios con el fin de probar el posible valor cl&#237;nico complementario de estas t&#233;cnicas PET&#47;TC&#44; y para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE para la potencial planificaci&#243;n de terapias mediadas por los receptores de somatostatina &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Autor&#237;a&#47;colaboradores</span><p id="par0500" class="elsevierStylePara elsevierViewall">Todos los autores han hecho contribuciones en cada uno de los siguientes aspectos&#58; 1&#41; la concepci&#243;n y el dise&#241;o del estudio&#44; la adquisici&#243;n de datos&#44; el an&#225;lisis y la interpretaci&#243;n de los datos&#44; 2&#41; el borrador del art&#237;culo y la revisi&#243;n cr&#237;tica del contenido intelectual&#44; y 3&#41; la aprobaci&#243;n definitiva de la versi&#243;n que se presenta&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicto de intereses</span><p id="par0505" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:12 [
        0 => array:3 [
          "identificador" => "xres1135774"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Antecedentes y objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Material y m&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1067802"
          "titulo" => "Palabras clave"
        ]
        2 => array:3 [
          "identificador" => "xres1135773"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Background and objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Material and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec1067803"
          "titulo" => "Keywords"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introducci&#243;n"
        ]
        5 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Material y m&#233;todos"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Pacientes"
            ]
            1 => array:2 [
              "identificador" => "sec0020"
              "titulo" => "Consideraciones &#233;ticas"
            ]
            2 => array:3 [
              "identificador" => "sec0025"
              "titulo" => "Radiof&#225;rmacos"
              "secciones" => array:2 [
                0 => array:2 [
                  "identificador" => "sec0030"
                  "titulo" => "C-colina"
                ]
                1 => array:2 [
                  "identificador" => "sec0035"
                  "titulo" => "Ga-DOTATATE"
                ]
              ]
            ]
            3 => array:2 [
              "identificador" => "sec0040"
              "titulo" => "Adquisici&#243;n de im&#225;genes"
            ]
            4 => array:2 [
              "identificador" => "sec0045"
              "titulo" => "An&#225;lisis estad&#237;stico"
            ]
          ]
        ]
        6 => array:2 [
          "identificador" => "sec0050"
          "titulo" => "Resultados"
        ]
        7 => array:2 [
          "identificador" => "sec0055"
          "titulo" => "Discusi&#243;n"
        ]
        8 => array:2 [
          "identificador" => "sec0060"
          "titulo" => "Conclusiones"
        ]
        9 => array:2 [
          "identificador" => "sec0065"
          "titulo" => "Autor&#237;a&#47;colaboradores"
        ]
        10 => array:2 [
          "identificador" => "sec0070"
          "titulo" => "Conflicto de intereses"
        ]
        11 => array:1 [
          "titulo" => "Bibliograf&#237;a"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2018-03-16"
    "fechaAceptado" => "2018-08-30"
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec1067802"
          "palabras" => array:6 [
            0 => "C&#225;ncer de pr&#243;stata"
            1 => "Reca&#237;da bioqu&#237;mica"
            2 => "PET&#47;TC"
            3 => "<span class="elsevierStyleSup">11</span>C-colina"
            4 => "<span class="elsevierStyleSup">68</span>Ga-DOTATATE"
            5 => "Receptores de la somatostatina"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1067803"
          "palabras" => array:6 [
            0 => "Prostate cancer"
            1 => "Biochemical relapse"
            2 => "PET&#47;CT"
            3 => "<span class="elsevierStyleSup">11</span>C-choline"
            4 => "<span class="elsevierStyleSup">68</span>Ga-DOTATATE"
            5 => "Somostatin receptors"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparar prospectivamente la tasa de detecci&#243;n de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE versus <span class="elsevierStyleSup">11</span>C-colina en pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica y evaluar in vivo la expresi&#243;n de receptores de la somatostatina con el fin de planificar terapias dirigidas &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizamos prospectivamente 64 pacientes con reca&#237;da bioqu&#237;mica &#40;mediana PSA&#58; 4&#44;25 ng&#47;mL&#41;&#46; Se realiz&#243; una PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina y otra con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Se midi&#243; el SUVm&#225;x en todas las lesiones&#46; Se consideraron como patr&#243;n de referencia las im&#225;genes correlativas&#44; histopatolog&#237;a y&#47;o seguimiento cl&#237;nico y bioqu&#237;mico&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa de detecci&#243;n global por paciente fue del 48&#44;43&#37; para <span class="elsevierStyleSup">68</span>Ga-DOTATATE y de 46&#44;87&#37; para <span class="elsevierStyleSup">11</span>C-colina&#46; Los resultados fueron concordantes en 53 casos &#40;82&#44;81&#37;&#41;&#46; El SUV m&#225;ximo de la <span class="elsevierStyleSup">11</span>C-colina fue significativamente mayor que el correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE para todas las lesiones concordantes &#40;n &#61; 130&#41;&#58; 6&#44;17 &#40;1&#44;7-15&#44;5&#41; versus 4&#44;38 &#40;1&#44;37-26&#44;7&#41;&#44; mediana &#40;rango&#41;&#44; para cada radiotrazador&#44; respectivamente &#40;P &#60; 0&#44;0001&#41;&#46; Los valores por paciente de sensibilidad y especificidad fueron los mismos para ambas t&#233;cnicas&#58; 0&#44;82 &#40;0&#44;65-0&#44;93&#41; y 0&#44;9 &#40;0&#44;73-0&#44;98&#41;&#44; respectivamente&#46; Aunque la diferencia no fue estad&#237;sticamente significativa&#44; la sensibilidad fue menor para pacientes con niveles de PSA inferiores&#58; 0&#44;63 vs&#46; 0&#44;89&#59; p &#61; 0&#44;13&#46; Se encontr&#243; una correlaci&#243;n significativa entre el SUVm&#225;x de ambos trazadores &#40;r &#61; 0&#44;41&#44; n &#61; 130&#44; p &#60; 0&#44;0001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE y la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina parecen poseer alta capacidad de detecci&#243;n de lesiones patol&#243;gicas en la evaluaci&#243;n de los pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica&#46; Se necesitan m&#225;s estudios con el fin de probar el posible valor cl&#237;nico complementario de estas t&#233;cnicas PET&#47;TC&#44; y para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE para la potencial planificaci&#243;n de terapias mediadas por los receptores de somatostatina &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To prospectively compare the detection rate of <span class="elsevierStyleSup">68</span>Ga-DOTATATE versus <span class="elsevierStyleSup">11</span>C-choline PET&#47;CT in patients with prostate cancer in biochemical relapse&#44; and to evaluate somatostatin receptor expression in vivo to plan targeted therapies &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We prospectively analysed 64 patients with biochemical relapse &#40;median PSA&#58; 4&#46;25 ng&#47;mL&#41;&#46; A PET&#47;CT was performed with <span class="elsevierStyleSup">11</span>C-choline&#44; and another with <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; The SUVmax was measured in all lesions&#46; The correlative images&#44; histopathology and&#47;or clinical and biochemical follow-up were taken as the reference standard&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The overall detection rate per patient was 48&#46;43&#37; for <span class="elsevierStyleSup">68</span>Ga-DOTATATE and 46&#46;87&#37; for <span class="elsevierStyleSup">11</span>C-choline&#46; The results were concordant in 53 cases &#40;82&#46;81&#37;&#41;&#46; The maximum SUV of <span class="elsevierStyleSup">11</span>C-choline was significantly higher than that of <span class="elsevierStyleSup">68</span>Ga-DOTATATE for all the concordant lesions &#40;n&#61;130&#41;&#58; 6&#46;17 &#40;1&#46;7-15&#46;5&#41; versus 4&#46;38 &#40;1&#46;37-26&#46;7&#41;&#44; median &#40;range&#41; for each radiotracer&#44; respectively &#40;<span class="elsevierStyleItalic">p</span> &#60; &#46;0001&#41;&#46; The sensitivity and specificity values per patient were the same for both techniques&#58; 0&#46;82 &#40;0&#46;65-0&#46;93&#41; and 0&#46;9 &#40;0&#46;73-0&#46;98&#41;&#44; respectively&#46; Although the difference was not significant&#44; the sensitivity was lower in patients with lower PSA levels&#58; 0&#46;63 vs&#46; 0&#46;89&#59; <span class="elsevierStyleItalic">p</span>&#61;&#46;13&#46; A significant correlation was found between the SUVmax of both tracers &#40;r &#61; 0&#46;41&#44; n &#61; 130&#44; <span class="elsevierStyleItalic">p</span> &#60;&#46;0001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTATATE PET&#47;CT and <span class="elsevierStyleSup">11</span>C-choline PET&#47;CT seem to have a high capacity to detect pathological lesions in the assessment of patients with prostate cancer with biochemical relapse&#46; Further studies are required to test the potential complementary value of these PET&#47;CT techniques&#44; and to evaluate the potential role of <span class="elsevierStyleSup">8</span>Ga-DOTATATE for planning somostatin receptor-mediated therapies &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 961
            "Ancho" => 1500
            "Tamanyo" => 102355
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 28&#46; Paciente de 57 a&#241;os tratado con prostatectom&#237;a radical&#44; radioterapia y hormonoterapia con elementos de reca&#237;da bioqu&#237;mica &#40;PSA 4&#44;00 ng&#47;mL&#41;&#46; PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina a&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE b&#41; que muestran un resultado concordante positivo en una lesi&#243;n &#243;sea en el il&#237;aco izquierdo &#40;flechas&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2762
            "Ancho" => 2083
            "Tamanyo" => 344891
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 62&#46; Paciente de 70 a&#241;os tratado con cirug&#237;a&#44; hormonoterapia&#44; radioterapia y poliquimioterapia&#46; Reca&#237;da bioqu&#237;mica con valor de PSA de 5&#44;26 ng&#47;mL&#46; Im&#225;genes de m&#225;xima ponderaci&#243;n &#40;MIP&#41; con <span class="elsevierStyleSup">11</span>C-colina a&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE b&#41;&#46; Adenopat&#237;a metast&#225;sica il&#237;aca interna izquierda demostrada con ambos radiotrazadores c&#41;&#46; Adenopat&#237;a il&#237;aca primitiva izquierda secundaria demostrada &#250;nicamente con el 11C-colina d&#41; y lesi&#243;n &#243;sea en hemicuerpo vertebral derecho de L2 demostrado &#250;nicamente con el <span class="elsevierStyleSup">68</span>Ga-DOTATATE e&#41; &#40;flechas amarillas&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figura 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1235
            "Ancho" => 1500
            "Tamanyo" => 134051
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 32&#46; Paciente tratado con prostatectom&#237;a radical sin tratamiento adyuvante y reca&#237;da bioqu&#237;mica con PSA de 4&#44;59 ng&#47;mL&#46; Las im&#225;genes PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina a&#41; no muestran &#225;reas focales de hipercaptaci&#243;n anormal del radiotrazador sugestivas de actividad tumoral&#46; En b&#41; se muestra hipercaptaci&#243;n de <span class="elsevierStyleSup">68</span>Ga-DOTATATE en un ganglio linf&#225;tico perirrectal derecho y en una adenopat&#237;a presacra &#40;flechas rojas&#41; que fueron histol&#243;gicamente confirmados como un resultado falso positivo para met&#225;stasis &#40;inflamaci&#243;n&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figura 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 771
            "Ancho" => 1750
            "Tamanyo" => 108961
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 19&#46; Hombre de 60 a&#241;os con c&#225;ncer de pr&#243;stata irradiado en 2014 y tratado posteriormente con hormonoterapia&#46; Actualmente reca&#237;da bioqu&#237;mica&#46; PSA en ascenso con valores de 1&#44;38 ng&#47;mL&#46; Hipercaptaci&#243;n asim&#233;trica de ambos radiof&#225;rmacos&#44; <span class="elsevierStyleSup">11</span>C-Colina &#40;a-c&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;d-f&#41;&#44; en la gl&#225;ndula prost&#225;tica cuya biopsia posterior revela tejido inflamatorio &#40;falso positivo&#41;&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Cx&#58; cirug&#237;a&#59; HT&#58; hormonoterapia&#59; PQT&#58; poliquimioterapia&#59; PTE&#58; paciente&#59; RT&#58; radioterapia&#59; TTO&#58; tratamiento&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleSup">11</span>C-Colina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleSup">68</span>Ga-DOTATATE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tto&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pr&#243;stata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ganglios linf&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#211;seo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pr&#243;stata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ganglios linf&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#211;seo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">97&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 10&#47;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 14&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 10&#47;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 14&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 17&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 14&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 11&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 13&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">291&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 53&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 11&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 5&#47;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 5&#47;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 17&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 10&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;84&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 7&#47;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 7&#47;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">137&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">HT&#47;RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 7&#47;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 7&#47;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 5&#47;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76&#44;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1937720.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Caracter&#237;sticas de los pacientes y resultado de los estudios PET&#47;TC mostrando localizaci&#243;n de las lesiones de acuerdo a la t&#233;cnica</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:30 [
            0 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Global cancer statistics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46; Jemal"
                            1 => "F&#46; Bray"
                            2 => "M&#46;M&#46; Center"
                            3 => "J&#46; Ferlay"
                            4 => "E&#46; Ward"
                            5 => "D&#46; Forman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3322/caac.20107"
                      "Revista" => array:6 [
                        "tituloSerie" => "CA Cancer J Clin"
                        "fecha" => "2011"
                        "volumen" => "61"
                        "paginaInicial" => "69"
                        "paginaFinal" => "90"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21296855"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Review of salvage therapy for biochemically recurrent prostate cancer&#58; the role of imaging and rationale for systemic salvage targeted anti-prostate-specific membrane antigen radioimmunotherapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46; Kosuri"
                            1 => "N&#46;H&#46; Akhtar"
                            2 => "M&#46; Smith"
                            3 => "J&#46;R&#46; Osborne"
                            4 => "S&#46;T&#46; Tagawa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2012/921674"
                      "Revista" => array:5 [
                        "tituloSerie" => "Adv Urol"
                        "fecha" => "2012"
                        "volumen" => "2012"
                        "paginaInicial" => "921674"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22693495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of &#91;&#40;18&#41;F&#93;-choline PET&#47;CT for staging and restaging of prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;B&#46; Husarik"
                            1 => "R&#46; Miralbell"
                            2 => "DubsM"
                            3 => "H&#46; John"
                            4 => "O&#46;T&#46; Giger"
                            5 => "A&#46; Gelet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "253"
                        "paginaFinal" => "263"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positron emission tomography&#47;computed tomography with F-18- fluorocholine for restaging of prostate cancer patients&#58; meaningful at PSA &#60; 5 ng&#47;mL&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Heinisch"
                            1 => "A&#46; Dirisamer"
                            2 => "W Loidl"
                            3 => "F&#46; Stoiber"
                            4 => "B&#46; Gruy"
                            5 => "S&#46; Haim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11307-005-0023-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "Mol Imaging Biol"
                        "fecha" => "2006"
                        "volumen" => "8"
                        "paginaInicial" => "43"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16315004"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673611600548"
                          "estado" => "S300"
                          "issn" => "01406736"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Kratochwil C&#44; Afshar-Oromieh A&#44; Kopka K&#44; Haberkorn U&#44; Giesel&#44; FL&#46; Current status of prostate-specific membrane antigen targeting in nuclear medicine&#58; clinical translation of chelator containing prostate-specific membrane antigen ligands into diagnostics and therapy for prostate cancer&#46; Semin Nucl Med&#46; 2016&#59;46&#58;405-18&#46;"
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ambrosini V&#44; Campana D&#44; Tomassetti P&#44; Grassetto G&#44; Rubello D&#44; Fanti S&#46; PET&#47;CT with 68Gallium-DOTA-peptides in NET&#58; An overview&#46; Eur J Radiol&#46; 2011&#59;80&#58;e116-9"
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diferenciaci&#243;n neuroendocrina en c&#225;ncer de pr&#243;stata"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46; Arenas Reyes"
                            1 => "L&#46; Manuel Moreno"
                            2 => "A&#46; Carrillo Rodr&#237;guez"
                            3 => "C&#46; Fonseca Buitrago"
                            4 => "F&#46; Daza Almendrales"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Urol Colomb"
                        "fecha" => "2014"
                        "volumen" => "23"
                        "paginaInicial" => "39"
                        "paginaFinal" => "43"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ambrosini V&#44; Campana D&#44; Tomassetti P&#44; Fanti S&#46; 68Ga-labelled peptides for diagnosis of gastroenteropancreatic NET&#46; Eur J Nucl Med Mol Imaging&#46; 2012&#59;39&#58;S52-60o"
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Komiya A&#44; Suzuki H&#44; Imamoto T&#44; Kamiya N&#44; Nihei N&#44; Naya Y&#44; et al&#46; Neuroendocrine differentiation in the progression of prostate cancer&#46; Int J Urol&#46; 2009&#59;16&#58;37-44"
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Matei DV&#44; Renne G&#44; Pimentel M&#44; Sandri MT&#44; Zorzino L&#44; Botteri E&#44; et al&#46; Neuroendocrine differentiation in castration resistant prostate cancer&#58; a systematic diagnostic attempt&#46; Clin Genitourin Cancer&#46; 2012&#59;10&#58;164-73"
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "<span class="elsevierStyleSup">68</span>Ga-DOTATOC-PET&#47;CT detects neuroendocrine differentiation of prostate cancer metastases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Souvatzoglou"
                            1 => "T&#46; Maurer"
                            2 => "U&#46; Treiber"
                            3 => "G&#46; Weirich"
                            4 => "B&#46;J&#46; Krause"
                            5 => "M&#46; Essler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Nuklearmedizin"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "N52"
                        "paginaFinal" => "N54"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PET and PET&#47;CT with 68 gallium-labeled somatostatin analogues in non GEP-NETs tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Sollini"
                            1 => "P&#46;A&#46; Erba"
                            2 => "A&#46; Fraternali"
                            3 => "M&#46; Casali"
                            4 => "M&#46;L&#46; Di Paolo"
                            5 => "A&#46; Froio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Sci World J"
                        "fecha" => "2014"
                        "volumen" => "2014"
                        "paginaInicial" => "194123"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Luboldt W&#44; Z&#246;phel K&#44; Wunderlich G&#44; Abramyuk A&#44; Luboldt HJ&#44; Kotzerke J&#46; Visualization of somatostatin receptors in prostate cancer and its bone metastases with Ga-68-DOTATOC PET&#47;CT&#46; Mol Imaging Biol&#46; 2010&#59;12&#58;78-84"
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Somatostatin receptors over-expression in castration resistant prostate cancer detected by PET&#47;CT&#58; preliminary report of in six patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Savelli"
                            1 => "A&#46; Muni"
                            2 => "R&#46; Falchi"
                            3 => "A&#46; Zaniboni"
                            4 => "R&#46; Barbieri"
                            5 => "G&#46; Valmadre"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3978/j.issn.2305-5839.2015.06.10"
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Transl Med"
                        "fecha" => "2015"
                        "volumen" => "3"
                        "paginaInicial" => "145"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26207238"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gallium-68 DOTATOC PET&#47;CT In Vivo Characterization of Somatostatin Receptor Expression in the Prostate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;V&#46; Todorovi&#263;-Tirnani&#263;"
                            1 => "M&#46;M&#46; Gaji&#263;"
                            2 => "V&#46;B&#46; Obradovi&#263;"
                            3 => "R&#46;P&#46; Baum"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/cbr.2013.1570"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer Biother Radiopharm"
                        "fecha" => "2014"
                        "volumen" => "29"
                        "paginaInicial" => "108"
                        "paginaFinal" => "115"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24450327"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Advanced prostate cancer evaluation by means of Ga-68-DOTATATE PET-CT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46; Alonso"
                            1 => "J&#46; Gambini"
                            2 => "G&#46; Lago"
                            3 => "J&#46; Gaudiano"
                            4 => "A&#46; Paolino"
                            5 => "M&#46; Gonzalez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Nucl Med"
                        "fecha" => "2011"
                        "volumen" => "52"
                        "paginaInicial" => "39"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PSA doubling time as a predictor of clinical progression after biochemical failure following radical prostatectomy for prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "S&#46;G&#46; Roberts"
                            1 => "M&#46;L&#46; Blute"
                            2 => "E&#46;J&#46; Bergstralh"
                            3 => "J&#46;M&#46; Slezak"
                            4 => "H&#46; Zincke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4065/76.6.576"
                      "Revista" => array:7 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "2001"
                        "volumen" => "76"
                        "paginaInicial" => "576"
                        "paginaFinal" => "581"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11393495"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S1470204512701419"
                          "estado" => "S300"
                          "issn" => "14702045"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of &#91;11C&#93;choline-positron emission tomography for re-staging prostate cancer&#58; a comparison with &#91;18F&#93;fluorodeoxyglucose-positron emission tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Picchio"
                            1 => "C&#46; Messa"
                            2 => "C&#46; Landoni"
                            3 => "L&#46; Gianolli"
                            4 => "S&#46; Sironi"
                            5 => "M&#46; Brioschi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.ju.0000056901.95996.43"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "2003"
                        "volumen" => "169"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12629355"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prostate cancer localization with 18fluorine fluorocholine positron emission tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;A&#46; Kwee"
                            1 => "M&#46;N&#46; Coel"
                            2 => "J&#46; Lim"
                            3 => "J&#46;P&#46; Ko"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.ju.0000142099.80156.85"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "2005"
                        "volumen" => "173"
                        "paginaInicial" => "252"
                        "paginaFinal" => "255"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15592091"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Souvatzoglou M&#44; Weirich G&#44; Schwarzenboeck S&#44; Maurer T&#44; Schuster T&#44; Bundschuh RA&#46; The sensitivity of &#91;11C&#93;choline PET&#47;CT to localize prostate cancer depends on the tumor configuration&#46; Clin Cancer Res Off J Am Assoc Cancer Res&#46; 2011&#59;17&#58;3751-9"
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The detection rate of &#91;11C&#93;choline-PET&#47;CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;J&#46; Krause"
                            1 => "M&#46; Souvatzoglou"
                            2 => "M&#46; Tuncel"
                            3 => "K&#46; Herrmann"
                            4 => "A&#46;K&#46; Buck"
                            5 => "C&#46; Praus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-007-0581-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "18"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17891394"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there a role for &#40;11&#41;C-choline PET&#47;CT in the early detection of metastatic disease in surgically treated prostate cancer patients with a mild PSA increase &#60; 1&#46;5 ng&#47;mL&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Castellucci"
                            1 => "C&#46; Fuccio"
                            2 => "D&#46; Rubello"
                            3 => "R&#46; Schiavina"
                            4 => "I&#46; Santi"
                            5 => "C&#46; Nanni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-010-1604-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "55"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20848281"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Miederer M&#44; Seidl S&#44; Buck A&#44; Scheidhauer K&#44; Wester HJ&#44; Schwaiger M&#44; et al&#46; Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET&#47;CT&#46; Eur J Nucl Med Mol Imaging&#46; 2009&#59;36&#58;48-52"
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Kaemmerer D&#44; Peter L&#44; Lupp A&#44; Schulz S&#44; S&#228;nger J&#44; Prasad V&#44; et al&#46; Molecular imaging with 68Ga-SSTR PET&#47;CT and correlation to immunohistochemistry of somatostatin receptors in neuroendocrine tumors&#46; Eur J Nucl Med Mol Imaging&#46; 2011&#59;38&#58;1659-68"
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "From molecular imaging using Ga-68 labelled tracers and PET&#47;CT to personalized radionuclide therapy&#8211;The Bad Berka Experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46;P&#46; Baum"
                            1 => "H&#46;R&#46; Kulkarni"
                            2 => "Theranostics&#58;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7150/thno.3645"
                      "Revista" => array:6 [
                        "tituloSerie" => "Theranostics"
                        "fecha" => "2012"
                        "volumen" => "2"
                        "paginaInicial" => "437"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22768024"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Nilsson S&#44; Reubi JC&#44; Kalkner KM&#44; Laissue JA&#44; Horisberger U&#44; Olerud C&#44; et al&#46; Metastatic hormone- refractory prostatic adenocarcinoma expresses somatostatin receptors and is visualized in vivo by &#91;111In&#93;-labeled DTPA-D-&#91;Phe1&#93;-octreotide scintigraphy&#46; Cancer Res&#46; 1995&#59;55&#58;5805s-10s"
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "11C-Choline PET&#47;CT in prostate cancer patients with biochemical recurrence after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46; Rinnab"
                            1 => "J&#46; Simon"
                            2 => "R&#46;E&#46; Hautmann"
                            3 => "M&#46;V&#46; Cronauer"
                            4 => "K&#46; Hohl"
                            5 => "A&#46;K&#46; Buck"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "World J Urol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "616"
                        "paginaFinal" => "625"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive factors of &#91;&#40;11&#41;C&#93;choline PET&#47;CT in patients with biochemical failure after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Giovacchini"
                            1 => "M&#46; Picchio"
                            2 => "E&#46; Coradeschi"
                            3 => "V&#46; Bettinardi"
                            4 => "L&#46; Gianolli"
                            5 => "V&#46; Scattoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "301"
                        "paginaFinal" => "309"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rationale for the use of radiolabelled peptides in diagnosis and therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "K&#46;P&#46; Koopmans"
                            1 => "A&#46;W&#46;J&#46;M&#46; Glaudemans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-011-2038-z"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "numero" => "suppl1"
                        "paginaInicial" => "S4"
                        "paginaFinal" => "S10"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22388630"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Alonso O&#44; dos Santos G&#44; Savio E&#44; Engler H&#46; False-Positive results of 68Ga-DOTATATE and 11C-Choline PET&#47;CT in patients with hormoneresistant prostate cancer at biochemical recurrence are related to inflamed lesions&#46; Mol Imaging Radionucl Ther&#46; 2015&#59;24&#58;37-46"
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/2253654X/0000003800000001/v1_201901110626/S2253654X18300672/v1_201901110626/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "7910"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/2253654X/0000003800000001/v1_201901110626/S2253654X18300672/v1_201901110626/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X18300672?idApp=UINPBA00004N"
]
Información del artículo
ISSN: 2253654X
Idioma original: Español
DOI:10.1016/j.remn.2018.08.005
Datos actualizados diariamente
año/Mes Html Pdf Total
2023 Diciembre 1 0 1
2023 Junio 1 2 3
2023 Marzo 0 1 1
2021 Septiembre 4 0 4
2021 Abril 0 4 4
2021 Febrero 4 3 7
2021 Enero 3 2 5
2020 Septiembre 0 1 1
2020 Agosto 0 2 2
2020 Mayo 3 6 9
2020 Marzo 1 1 2
2019 Diciembre 1 2 3
2019 Noviembre 5 2 7
2019 Octubre 3 0 3
2019 Julio 1 0 1
2019 Mayo 1 0 1
2019 Abril 1 2 3
2019 Marzo 1 2 3
2019 Febrero 10 8 18
2019 Enero 11 6 17
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Suscríbase a la newsletter

Publique en
Revista Española de Medicina Nuclear e Imagen Molecular
Revista Española de Medicina Nuclear e Imagen Molecular se adhiere a los principios y procedimientos dictados por el Committee on Publication Ethics (COPE)
www.publicationethics.org.
Artículos de acceso gratuito
Evaluación de la captación cardiaca incidental en...
Rev Esp Med Nucl Imagen Mol. 2024;43:
Possible role of
Rev Esp Med Nucl Imagen Mol. 2022;41:201
Follow-up 18F-FDG...
Rev Esp Med Nucl Imagen Mol. 2021;40:374-5
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos