array:23 [ "pii" => "S1699885523000685" "issn" => "16998855" "doi" => "10.1016/j.patol.2023.09.003" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "747" "copyright" => "Sociedad Española de Anatomía Patológica" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Esp Patol. 2024;57:120-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S1699885523000697" "issn" => "16998855" "doi" => "10.1016/j.patol.2023.10.002" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "748" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Esp Patol. 2024;57:123-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Metastasizing pleomorphic adenoma of the parotid gland: A common tumour with a very unusual presentation" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "123" "paginaFinal" => "127" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Metástasis de adenoma pleomorfo de la glándula parótida: un tumor frecuente con una presentación muy poco habitual" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2433 "Ancho" => 2917 "Tamanyo" => 1114450 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(a, b) Coronal and transverse section of magnetic resonance imaging exhibiting heterogeneously enhancing mass of left parotid region. (c) Gross examination revealed an encapsulated solid, grey-white homogeneous tumour. (d, e) Haematoxylin and eosin stained sections from primary tumour depicting cords and nests of epithelial and myoepithelial cells in a characteristic chondromyxoid matrix [×10, ×40]. (f) Haematoxylin and eosin stained sections from level II cervical dissection showed multiple encapsulated deposits of tumour of varying sizes recapitulating the benign nature of the metastasis [×10]. (g) Haematoxylin and eosin stained sections from the metastatic deposit show benign epithelial and myoepithelial cells with no mitosis or necrosis [×40]. (h, i) The epithelial and myoepithelial cells highlighted by EMA and S-100 immunohistochemistry [×40].</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Sherrin Jacob, Sana Ahuja, Sufian Zaheer, Mukul Singh" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Sherrin" "apellidos" => "Jacob" ] 1 => array:2 [ "nombre" => "Sana" "apellidos" => "Ahuja" ] 2 => array:2 [ "nombre" => "Sufian" "apellidos" => "Zaheer" ] 3 => array:2 [ "nombre" => "Mukul" "apellidos" => "Singh" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885523000697?idApp=UINPBA00004N" "url" => "/16998855/0000005700000002/v1_202404090738/S1699885523000697/v1_202404090738/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699885523000661" "issn" => "16998855" "doi" => "10.1016/j.patol.2023.09.002" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "745" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Rev Esp Patol. 2024;57:116-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Stromal osseous metaplasia in urothelial carcinoma of the bladder: An unusual and challenging feature. A case report" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "116" "paginaFinal" => "119" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma urotelial de vejiga con metaplasia ósea estromal: una característica inusual y desafiante. Presentación de un caso" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 484 "Ancho" => 1300 "Tamanyo" => 281796 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">(A) GATA 3. ×100 magnification. Strong nuclear staining in the urothelial carcinoma cells and negative expression in the osseus metaplasia component. (B) SATB2. ×100 magnification. Strong nuclear staining in the osteoblasts and negative expression in urothelial carcinoma cells.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Irene Iglesias de Ussel Galarreta, Francisco Javier Queipo Gutiérrez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Irene" "apellidos" => "Iglesias de Ussel Galarreta" ] 1 => array:2 [ "nombre" => "Francisco Javier" "apellidos" => "Queipo Gutiérrez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885523000661?idApp=UINPBA00004N" "url" => "/16998855/0000005700000002/v1_202404090738/S1699885523000661/v1_202404090738/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Diffuse coexpression of thyroid transcription factor-1 and p40 in a non-small cell carcinoma of the lung: Second case in the female population" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "120" "paginaFinal" => "122" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marta Segado Martínez, Gema Ruiz García" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Marta" "apellidos" => "Segado Martínez" "email" => array:1 [ 0 => "martasegadomrtnz@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Gema" "apellidos" => "Ruiz García" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Coexpresión difusa del factor de transcripción tiroidea 1 y p40 en un carcinoma de célula no pequeña del pulmón: segundo caso en la población de sexo femenino" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 482 "Ancho" => 1667 "Tamanyo" => 213134 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A) Positive p53 and (B) maintenance of PTEN.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Coexpression of TTF1 and p40 in the same tumor cells is an extremely rare event. So far, only six cases have been reported.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> TTF1 is considered the most sensitive and specific marker for lung adenocarcinoma; approximately 75–80% of adenocarcinomas are positive for TTF1 and with a cutoff value of more than 5% weak or strong positivity, the sensitivity reaches 0.8 and the specificity 0.9. Unlike TTF1, despite p40 being the most specific marker for non-small cell squamous cell carcinoma, focal and weak positivity is not diagnostic and the cutoff value should be positivity in more than 50% of tumor nuclei.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> In those cases in which the tumor does not show glandular, squamous or neuroendocrine differentiation in its morphology, positivity for mucin staining or a determinant immunohistochemical study, it is classified, according to the WHO classification of 2021, as non-special type non-small cell carcinoma (NOS).<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> The case presented is about a lung carcinoma with coexpression of TTF1 and p40.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 70-year-old woman, smoker of six cigarettes a day and with a history of primary biliary cirrhosis. A thoracoabdominal CT scan is performed and showed a solitary pulmonary nodule in the right lower lobe. A PET-CT scan showed a slight metabolic increase, so it was decided to perform surgery.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Anatomic pathology received a lung segment presenting a nodular, solid, grayish-brown tumor with slightly irregular borders measuring 1<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1.1<span class="elsevierStyleHsp" style=""></span>cm. Microscopic study reveals an infiltrating epithelial neoplasm, arranged in plaques, without glandular lumina, with large cells of moderate cytoplasm and a high nucleus/cytoplasm ratio. The nuclei show occasional nucleoli and a rate of 2 mitoses/2<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Some of the cells of the plaques at the central level show focal keratinization, as well as many associated with a significant acute inflammatory infiltrate with necrosis. The immunohistochemical study reveals an intense positivity for p40, as well as a diffusely staining TTF1 with moderate intensity in the same neoplastic cells, without identifying mucus secretion with Pas-Diastase (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Besides, the Idylla™ EGFR mutation test was performed with negative results and immunohistochemical studies of ALK (clone D5F3), ROS1 (clone D4D6) and PDL1C (clone 22C3) were also negative.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">The differential diagnosis of non-small cell lung carcinoma with a poorly differentiated morphology and positivity for TTF1 and p40 should be made with adenocarcinoma (especially solid pattern), squamous carcinoma and adenosquamous carcinoma. In the case of adenocarcinoma, the presence of mucin should be revealed, and in our case, there is negativity with Pas-Diastase. Squamous carcinoma should not be positive for TTF1, and for the diagnosis of adenosquamous carcinoma, we must have foci of glandular and squamous differentiation, and each of them must represent at least 10% of the tumor.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> When neither morphologically nor immunohistochemically it fits into an adenocarcinoma, a squamous carcinoma or an adenosquamous carcinoma, a definitive diagnosis of non-small cell carcinoma with adenosquamous immunophenotype is made.</p><p id="par0030" class="elsevierStylePara elsevierViewall">A possible proposed origin for this type of tumors expressing TTF1 and p40 in the same tumor cells is the bronchial basal cells, since some of these basal progenitor cells can be double positive and can differentiate to this phenotype. In addition, a molecular alteration of FGFR1 has been observed in these tumors, which could explain this phenomenon.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3,4</span></a> Therefore, some authors consider the term basal cell carcinoma for these tumors, as well as Savari et al. propose the classification of these tumors in a separate category: “non-small cell lung carcinoma with biphenotypic differentiation”.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> These are some of the proposals when it comes to designating this type of tumors, since the WHO of 2021 still does not provide a clear way to classify them.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Five of the six reported cases present a common mutation in TP53, and this appears mutated in our case as well. However, it maintains PTEN expression in contrast to the case published by Hayashi et al. (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Of the published cases, we found five males and one female, all of them smokers.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> It is of vital importance to add this case as the seventh in the literature and the second in the female population, in order to obtain a better understanding of the entity and for future classifications.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical approval</span><p id="par0045" class="elsevierStylePara elsevierViewall">The author has ensured that the article was conducted in accordance with the WHO code of ethics (Declaration of Helsinki) on human experimentation.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres2124572" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1806568" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2124571" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1806569" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0020" "titulo" => "Ethical approval" ] 8 => array:2 [ "identificador" => "sec0025" "titulo" => "Conflict of interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-03-06" "fechaAceptado" => "2023-09-21" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1806568" "palabras" => array:4 [ 0 => "TTF1" 1 => "p40" 2 => "Lung adenocarcinoma" 3 => "Lung squamous cell carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1806569" "palabras" => array:4 [ 0 => "TTF1" 1 => "p40" 2 => "Adenocarcinoma de pulmón" 3 => "Carcinoma de célula no pequeña del pulmón" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Some non-small cell carcinomas of the lung can express TTF1 and p40 in the same tumor cells. This event has been described in only six cases prior to this one, and only in one other female. It is an extraordinary event that appears as a new entity yet to be defined. The case presented is a woman with a non-small cell lung carcinoma with diffuse coexpression of TTF1 and p40 in the same cells.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Algunos carcinomas de célula no pequeña del pulmón pueden expresar TTF1 y p40 en las mismas células tumorales. Este evento se ha descrito únicamente en 6 casos anteriores a este, y solo en otra persona del sexo femenino. Se trata de un evento extraordinario que se muestra como una nueva entidad todavía por definir. El caso que se presenta versa sobre una mujer con un carcinoma de pulmón de célula no pequeña con coexpresión difusa en las mismas células de TTF1 y p40.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 317 "Ancho" => 1667 "Tamanyo" => 177015 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">(A) H&E, 5×: infiltrating epithelial neoplasm, arranged in plaques, without glandular lumina. Some of the cells of the plaques at the central level show a significant acute inflammatory infiltrate with necrosis. (B) H&E, 20×: focal squamous metaplasia. (C) H&E, 25×: large cells of moderate cytoplasm and a high nucleus/cytoplasm ratio. The nuclei show occasional nucleoli.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 714 "Ancho" => 1667 "Tamanyo" => 401869 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">(A) H&E, 10×. (B) TTF1, 10×. Diffuse positivity in most cells. (C) p40, 10×. Intense positivity in all cells. (A)–(C) are images of the same section of the tumor, and, therefore, the same neoplastic cells.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 482 "Ancho" => 1667 "Tamanyo" => 213134 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A) Positive p53 and (B) maintenance of PTEN.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TP53, NOTCH2, and STK11 mutations in a rare tumor of non-small cell lung carcinoma with diffuse coexpression of TTF1 and p40 in the same tumor cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "X. 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Brief report
Diffuse coexpression of thyroid transcription factor-1 and p40 in a non-small cell carcinoma of the lung: Second case in the female population
Coexpresión difusa del factor de transcripción tiroidea 1 y p40 en un carcinoma de célula no pequeña del pulmón: segundo caso en la población de sexo femenino
Marta Segado Martínez
, Gema Ruiz García
Autor para correspondencia
Servicio de Anatomía Patológica, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain