Estadísticas

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  "cita" => "Rev Esp Reumatol. 1998;25:4"
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      "titulo" => "Tratamiento de la enfermedad ósea de Paget con clodronato en infusión intravenosa"
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          "titulo" => "Treatment of Paget's bone disease with intravenous infusion of clodronate"
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          "autoresLista" => "L R Arboleya, J Sánchez, G Iglesias, J L Arranz"
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            0 => array:2 [
              "Iniciales" => "L R"
              "apellidos" => "Arboleya"
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              "Iniciales" => "J"
              "apellidos" => "Sánchez"
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            2 => array:2 [
              "Iniciales" => "G"
              "apellidos" => "Iglesias"
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            3 => array:2 [
              "Iniciales" => "J L"
              "apellidos" => "Arranz"
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      "titulo" => "Bisfosfonatos y enfermedad de Paget"
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          "autoresLista" => "JA García Vadillo"
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              "Iniciales" => "JA"
              "apellidos" => "García Vadillo"
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    "titulo" => "Análisis del perfil socioepidemiológico y clínico de los pacientes diagnosticados de artritis reumatoide en la provincia de Valencia"
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        "autoresLista" => "J F Pastor Oliver, M Morales Suárez-Varela, A Llopis González, V Ferriol Casar"
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            "apellidos" => "Pastor Oliver"
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            "apellidos" => "Morales Suárez-Varela"
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            "apellidos" => "Llopis González"
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            "Iniciales" => "V"
            "apellidos" => "Ferriol Casar"
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        "titulo" => "Recurrence of hepatitis c virus in a series of 150 orthotopic liver transplantations"
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        "resumen" => "<span class="elsevierStyleBold">Objective&#46;</span> The objective of this study was to assess the clinical and histological course of liver transplant recipients with hepatitis C virus &#40;HCV&#41; prior to transplantation and of those who acquire HCV after the procedure&#44; correlating the findings with the presence of the infectious HCV genotype&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Patients and method&#46;</span> A group of 26 patients&#44; who underwent 29 orthotopic liver transplant &#40;OLT&#41; procedures&#44; was stu died out of a series of 32 patients who underwent 150 OLT&#46; Twenty-two of the patients presented HCV infection prior to OLT and 4 patients acquired the virus postoperatively&#46; The serological diagnosis was based on the detection of anti-HCV antibodies by ELISA-3 and confirmed by RIBA-III&#46; In addition&#44; viral RNA was examined by polymerase chain reaction and the virus genotype was determined by the InnoLipa probe&#46; The histological study of virus recurrence&#44; based on liver biopsies&#44; identified cases of acute hepatitis&#44; chronic hepatitis &#40;persistent or acute&#41; and liver cirrhosis&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Results&#46;</span> Anti-HCV antibodies remained detectable after OLT in all 26 patients&#46; HCV RNA was analyzed in 16 of the 18 patients studied and was found to be positive in every case&#46; Two patients presented infection with genotype 1a&#44; 6 with 1b&#44; 6 with 3a&#44; 1 with 4a and 1 with 5a&#46; Histological evidence of recurrence in 60&#37; of the patients&#44; 75&#37; of whom presented chronic persistent hepatitis&#44; while chronic active hepatitis was detected in 25&#37;&#46; Four of the 110 patients &#40;3&#46;6&#37;&#41; who had been seronegative prior to OLT acquired de novo HCV post-operatively&#46; The actuarial survival of the patients at one year was 72&#46;5&#37; and 67&#46;6&#37; at 5 years and the actuarial graft survival was 67&#46;3&#37; at one year and 52&#46;3&#37; at 5 years&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Conclusions&#46;</span> We consider OLT to be indicated in patients with end-stage liver disease due to HCV&#44; despite the high rate of recurrence of infection in the liver graft&#44; since the rates of patient and graft survival are similar to the overall survivals recorded for patients undergoing OLT for other reasons&#46;"
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