Estadísticas

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      "titulo" => "Luxación atloaxoidea en un paciente con enfermedad mixta del tejido conectivo"
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      "titulo" => "Análisis del perfil socioepidemiológico y clínico de los pacientes diagnosticados de artritis reumatoide en la provincia de Valencia"
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    "titulo" => "Tratamiento de la enfermedad ósea de Paget con clodronato en infusión intravenosa"
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        "titulo" => "Treatment of Paget's bone disease with intravenous infusion of clodronate"
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        "resumen" => "<span class="elsevierStyleBold">Objetivo&#58;</span> Evaluar los efectos sobre la actividad bioqu&#237;mica y la seguridad del clodronato en infusi&#243;n i&#46;v&#46; en la enfermedad de Paget&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Pacientes y m&#233;todos&#58;</span> Se incluyeron 17 pacientes con valores de fosfatasa alcalina s&#233;rica superiores a 837 U&#47;l &#40;3 veces el l&#237;mite superior&#41; que recibieron en total 19 ciclos de 300 mg&#47;d&#237;a durante 3 d&#237;as&#44; en infusi&#243;n intravenosa &#40;i&#46;v&#46;&#41; administrada entre 2 y 6h y un ciclo de 600 mg&#47;d&#237;a&#44; 3 d&#237;as&#44; administrado durante 6 h&#46; Se realizaron controles basales&#44; al mes&#44; a los 3&#44; 6 y 12 meses&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Resultados&#58;</span> La reducci&#243;n media de la fosfatasa alcalina era del 44&#37; al mes&#44; el 58&#37; a los 3 meses&#44; el 51&#37; a los 6 meses y el 28&#37; al a&#241;o&#59; estas concentraciones permanec&#237;an por debajo del 50&#37; de los valores basales en el 32&#37; de los pacientes al mes&#44; en el 75&#37; a los 3 meses&#44; en el 56&#37; a los 6meses y en el 28&#37; al a&#241;o de la infusi&#243;n&#46; Las cifras de hidroxiprolina urinaria se redujeron en un 45&#37; al mes&#44; un 43&#37; a los 3 meses&#44; un 39&#37; a los 6meses y un 18&#37; al a&#241;o de la infusi&#243;n&#46; No se registraron efectos secundarios relevantes durante el per&#237;odo del estudio&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Conclusiones&#58;</span> La administraci&#243;n de clodronato i&#46;v&#46; constituye una alternativa eficaz y segura en pacientes con enfermedad de Paget con una perceptible actividad bioqu&#237;mica&#46; La dosis a emplear y la frecuencia de los ciclos depender&#225;n de los valores de los marcadores&#44; ya que las respuestas sufren marcadas variaciones individuales"
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        "resumen" => "<span class="elsevierStyleBold">Objective&#58;</span> To study the effects of intravenous clodronate in biochemical parameters and its safety in Paget&#39;s bone disease&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Patients and methods&#58;</span> 17 patients with alkaline phosphatase values over 837 U&#47;l &#40;3 times the upper limit&#41; were included and treated with clodronate &#40;19 cycles of 300 mg&#47;day intravenously for 3 consecutive days and one cycle of 600 mg&#47;day for 3 consecutive days&#44; administred between 2 and 6 h&#41;&#46; We analysed the results corresponding to the basal situation and after 1&#44; 3&#44;6 and 12 months&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Results&#58;</span> The average reduction of alcaline phosphatase reached 44&#37; after 1 month&#44; 58&#37; after 3&#44; 51&#37; after 6 and 28&#37; after 12 months&#59; these levels remained under 50&#37; of the initial values in 32&#37; of the patients after 1 month&#44; in 75&#37; after 3months&#44; in 56&#37; after 6 months and in 28&#37; 1 year after the infusion&#46; The values of urinary hydroxiproline were reduced by 45&#37; after 1month&#44; 43&#37; after 3 months&#44; 39&#37; after 6 months and 18&#37; 1 year after the infusion&#46; No patient showed relevants side effects&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Conclusions&#58;</span> The administration of intravenous clodronate constitutes a safe and efficient alternative for patients with Paget&#39;s bone disease with severe biochemical activity&#46; The dose and the frecuency of the cycles will depend on the values of the markers&#44; as the responses suffered individual variations&#46;"
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