Estadísticas

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      "titulo" => "Requisitos de uniformidad para manuscritos presentados para publicación en revistas biomédicas"
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          "titulo" => "Fibromyalgia, fibromytes and fibronauts"
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          "autoresLista" => "J Mulero Mendoza"
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    "titulo" => "Función pulmonar en la artritis reumatoide"
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        "titulo" => "Pulmonary function in rheumatoid arthritis"
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        "resumen" => "<span class="elsevierStyleBold">Objetivo&#58;</span> Investigar la presencia de anomal&#237;as en la funci&#243;n pulmonar de los pacientes con artritis reumatoide &#40;AR&#41; para poder establecer un diagn&#243;stico temprano&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">M&#233;todo&#58;</span> Se realizaron de forma ambulatoria pruebas funcionales respiratorias con medici&#243;n de los par&#225;metros de flujo-volumen &#40;volumen espiratorio forzado en el primer segundo &#91;VEF1&#93;&#44; capacidad vital espiratoria forzada &#91;FVC&#93;&#44; volumen espirado forzado como porcentaje de la capacidad vital forzada &#91;VEF1&#47;FVC&#93;&#44; flujo espiratorio m&#225;ximo cuando el 50&#37; de la capacidad vital forzada debe ser a&#250;n espirada &#91;FEF50&#37;FVC&#93; y flujo mesospiratorio forzado &#91;FEF25-75&#37;&#93;&#44; la capacidad de difusi&#243;n para el mon&#243;xido de carbono &#91;DLCO&#93; y la fuerza muscular inspiratoria&#41;&#44; en 15 pacientes con AR de forma ambulatoria y en 15 controles sanos de similar edad y sexo&#44; todos no fumadores&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Resultados&#58;</span> Se encontr&#243; diferencia estad&#237;sticamente significativa en &#37;VEF1&#44; &#37;FEF50&#37;FVC y &#37;FEF25-75&#37; entre los enfermos con AR y el grupo control&#46; Los pacientes con AR de larga duraci&#243;n presentaron una reducci&#243;n significativa en &#37;VEF1&#47;FVC &#40;p&#61;0&#44;01&#41;&#44; &#37;FEF50&#37;FVC &#40;p&#61;0&#44;02&#41;&#44; &#37;FEF25-75&#37; &#40;p&#61;0&#44;03&#41; y DLCO &#40;p&#61;0&#44;03&#41;&#46; Los pacientes tratados con metotrexato &#40;MTX&#41; tuvieron una alteraci&#243;n de la &#37;DLCO &#40;p &#61; 0&#44;03&#41; frente a los no tratados&#46; No se observaron diferencias en el grupo tratado con aurotiomalato&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Conclusi&#243;n&#58;</span> Los pacientes con AR de larga duraci&#243;n desarrollaron una obstrucci&#243;n m&#225;s perceptible al flujo a&#233;reo&#44; as&#237; como una limitaci&#243;n en la capacidad de la DLCO&#46; La AR se asocia con un trastorno de la v&#237;a a&#233;rea peque&#241;a&#46;"
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        "resumen" => "<span class="elsevierStyleBold">Objective&#58;</span> The aim of the study was to investigate abnormalities of the lung function in rheumatoid arthritis &#40;RA&#41; patients and to establish an early diagnosis&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Methods&#58;</span> Flow-volume parameters&#58; forced expiratory volume in one second&#44; forced expiratory vital capacity&#44; FEV1 as percentage of capacity forced&#44; maximal expiratory flow when 50&#37; of forced expiratory vital capacity remains to be exhaled&#44; forced mid-expiratory flow &#40;&#37;FEV1&#44; &#37;FVC&#44; &#37;FEV1&#47;FVC&#44; &#37;FEF50&#37;FVC and &#37;FEF25-75&#37;&#41;&#44; diffusing capacity of the lungs for carbon monoxide &#40;&#37;DLCO&#41; and inspiratory muscle strength have been studied in 15 ambulatory RA patients&#46; 15 age-sex matched healthy controls were used as comparative group&#46; Tobacco was an exclusion criteria&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Results&#58;</span> There were significant differences in &#37;FEV1&#44; &#37;FEF50&#37;FVC and &#37;FEF25-75&#37;&#44; between the RA patients and the control group&#46; Patients with RA for a long duration showed a significant reduction in &#37;FEV1&#47;FVC &#40;p&#61;0&#46;01&#41;&#44; &#37;FEF50&#37;FVC &#40;p&#61;0&#46;02&#41;&#44; &#37;FEF25-75&#37; &#40;p&#61;0&#46;03&#41; and &#37;DLCO &#40;p&#61;0&#46;03&#41;&#46; The patients treated with methotrexate had a &#37;DLCO altered compared with RA patients who did not receive this drug&#46; We did not find differences in RA patients treated with gold sodium thiomalate&#46; <br/> <br/> <br/> <br/> <span class="elsevierStyleBold">Conclusion&#58;</span> Patients with RA of long duration developed a more important small airway obstruction and limitation in diffusing capacity of the lung for carbon monoxide&#46; RA seems to be closely related with a small airway disease&#46;"
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