Síntomas de demencia en el síndrome de Down | Revista Médica Internacional sobre el Síndrome de Down

Información del artículo

Resumen

Es un hecho contrastado que las personas con síndrome de Down (SD) desarrollan las características neuropatológicas de la enfermedad de Alzheimer (EA) cuando superan la edad de 40 años. Sorprendentemente, no todos estos pacientes van a manifestar los síntomas clínicos de la demencia. Este artículo es un trabajo de revisión sobre los criterios que se utilizan actualmente para su diagnóstico, e incluye una descripción sobre cómo se manifiestan los síntomas de demencia en las personas con SD.

Palabras clave:

Enfermedad de Alzheimer

Demencia

Síndrome de Down

Envejecimiento

Neuropsicología

Abstract

It has been demonstrated that persons with Down syndrome (DS) develop neuropathological characteristics of Alzheimer's disease (AD) after the age of 40. Surprisingly, not all these patients will show clinical symptoms of dementia. This article is a review of the criteria currently used for diagnosis and includes a description of how dementia symptoms manifest in individuals with DS.

Keywords:

Alzheimer's disease

Dementia

Down syndrome

Aging

Neuropsychology

El Texto completo está disponible en PDF

Bibliografía

[1.]

D.M. Mann.

Alzheimer's disease and Down's syndrome.

Histopathology, 13 (1988), pp. 125-137

Medline

[2.]

S. Deb, P.N. de Silva, H.G. Gemmell, J.A. Besson, F.W. Smith, K.P. Ebmeier.

Alzheimer's disease in adults with Down's syndrome: the relationship between regional cerebral blood flow equivalents and dementia.

Acta Psychiatr Scand, 86 (1992), pp. 340-345

Medline

[3.]

A. Coppus, H. Evenhuis, G.J. Verberne, F. Visser, P. van Gool, P. Eikelenboom, C. van Duijin.

Dementia and mortality in persons with Down's syndrome.

J Intellect Disabil Res, 50 (2006), pp. 768-777

http://dx.doi.org/10.1111/j.1365-2788.2006.00842.x | Medline

[4.]

D.A. Devenny, S.J. Krinsky-McHale, G. Sersen, W.P. Silverman.

Sequence of cognitive decline in dementia in adults with Down's syndrome.

J Intellect Disabil Res, 44 (2000), pp. 654-665

Medline

[5.]

S. Deb, M. Hare, L. Prior.

Symptoms of dementia among adults with Down's syndrome: a qualitative study.

J Intellect Disabil Res, 51 (2007), pp. 726-739

http://dx.doi.org/10.1111/j.1365-2788.2007.00956.x | Medline

[6.]

E.H. Aylward, D.B. Burt, L.U. Thorpe, F. Lai, A. Dalton.

Diagnosis of dementia in individuals with intellectual disability.

J Intellect Disabil Res, 41 (1997), pp. 152-164

Medline

[7.]

G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E.M. Stadlan.

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.

Neurology, 34 (1984), pp. 939-944

Medline

[8.]

R.T. Linn, P.A. Wolf, D.L. Bachman, J.E. Knoefel, J.L. Cobb, A.J. Belanger, E.F. Kaplan, R.B. D’Agostino.

The ‘preclinical phase’ of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort.

Arch Neurol, 52 (1995), pp. 485-490

Medline

[9.]

A.J. Holland, J. Hon, F.A. Huppert, F. Stevens.

Incidence and course of dementia in people with Down's syndrome: findings from a population-based study.

J Intellect Disabil Res, 44 (2000), pp. 138-146

Medline

[10.]

V.P. Prasher, A. Filer.

Behavioural disturbance in people with Down's syndrome and dementia.

J Intellect Disabil Res, 39 (1995), pp. 432-436

Medline

[11.]

H.M. Evenhuis.

The natural history of dementia in Down's syndrome.

Arch Neurol, 47 (1990), pp. 263-267

Medline

[12.]

A.J. Holland, J. Hon, F.A. Huppert, F. Stevens, P. Watson.

Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome.

Br J Psychiatry, 172 (1998), pp. 493-498

Medline

[13.]

S.L. Ball, A.J. Holland, J. Hon, F.A. Huppert, P. Treppner, P.C. Watson.

Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.

Int J Geriatr Psychiatry, 21 (2006), pp. 661-673

http://dx.doi.org/10.1002/gps.1545 | Medline

Indexada en:

Síguenos:

Indexada en:

Síguenos:

Suscríbase a la newsletter