covid
Buscar en
Revista Médica Internacional sobre el Síndrome de Down (English Edition)
Toda la web
Inicio Revista Médica Internacional sobre el Síndrome de Down (English Edition) Dementia Symptoms in Down Syndrome
Información de la revista
Vol. 13. Núm. 2.
Páginas 18-21 (julio 2009)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 13. Núm. 2.
Páginas 18-21 (julio 2009)
Acceso a texto completo
Dementia Symptoms in Down Syndrome
Visitas
565
Bessy Benejam1,
Autor para correspondencia
1 Down Medical Centre, Fundació Catalana Síndrome de Down, C/Comte Borrell 201-203, entresuelo, 08029 Barcelona. Spain
Este artículo ha recibido
Información del artículo
Abstract

It has been demonstrated that persons with Down syndrome (DS) develop neuropathological characteristics of Alzheimer's disease (AD) after the age of 40. Surprisingly, not all these patients will show clinical symptoms of dementia. This article is a review of the criteria currently used for diagnosis and includes a description of how dementia symptoms manifest in individuals with DS.

Keywords:
Alzheimer's disease
Dementia
Down syndrome
Aging
Neuropsychology
El Texto completo está disponible en PDF
Bibliography
[1.]
D.D.M. Mann.
Alzheimer's disease and Down's syndrome.
Histopathology, 13 (1988), pp. 125-137
[2.]
S. Deb, P.N. de Silva, H.G. Gemmell, J.A. Besson, F.W. Smith, K.P. Ebmeier.
Alzheimer's disease in adults with Down's syndrome: the relationship between regional cerebral blood flow equivalents and dementia.
Acta Psychiatr Scand, 86 (1992), pp. 340-345
[3.]
A. Coppus, H. Evenhuis, G.J. Verberne, F. Visser, P. van Gool, P. Eikelenboom, C. van Duijin.
Dementia and mortality in persons with Down's syndrome.
J Intellect Disabil Res, 50 (2006), pp. 768-777
[4.]
D.A. Devenny, S.J. Krinsky-McHale, G. Sersen, W.P. Silverman.
Sequence of cognitive decline in dementia in adults with Down's syndrome.
J Intellect Disabil Res, 44 (2000), pp. 654-665
[5.]
S. Deb, M. Hare, L. Prior.
Symptoms of dementia among adults with Down's syndrome: a qualitative study.
J Intellect Disabil Res, 51 (2007), pp. 726-739
[6.]
E.H. Aylward, D.B. Burt, L.U. Thorpe, F. Lai, A. Dalton.
Diagnosis of dementia in individuals with intellectual disability.
J Intellect Disabil Res, 41 (1997), pp. 152-164
[7.]
G. McKhann, D. Drachman, M. Folstein, R. Katzman, D. Price, E.M. Stadlan.
Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under auspices of Department of Health and Human Services Task Force on Alzheimer's Disease.
Neurology, 34 (1984), pp. 939-944
[8.]
R.T. Linn, P.A. Wolf, D.L. Bachman, J.E. Knoefel, J.L. Cobb, A.J. Belanger, E.F. Kaplan, R.B. D’Agostino.
The ‘preclinical phase’ of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort.
Arch Neurol, 52 (1995), pp. 485-490
[9.]
A.J. Holland, J. Hon, F.A. Huppert, F. Stevens.
Incidence and course of dementia in people with Down's syndrome: findings from a populationbased study.
J Intellect Disabil Res, 44 (2000), pp. 138-146
[10.]
V.P. Prasher, A. Filer.
Behavioural disturbance in people with Down's syndrome and dementia.
J Intellect Disabil Res, 39 (1995), pp. 432-436
[11.]
H.M. Evenhuis.
The natural history of dementia in Down's syndrome.
Arch Neurol, 47 (1990), pp. 263-267
[12.]
A.J. Holland, J. Hon, F.A. Huppert, F. Stevens, P. Watson.
Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome.
Br J Psychiatry, 172 (1998), pp. 493-498
[13.]
S.L. Ball, A.J. Holland, J. Hon, F.A. Huppert, P. Treppner, P.C. Watson.
Personality and behaviour changes mark the early stages of Alzheimer's disease in adults with Down's syndrome: findings from a prospective population-based study.
Int J Geriatr Psychiatry, 21 (2006), pp. 661-673
Copyright © 2009. Fundació Catalana Síndrome Down
Opciones de artículo