Información del artículo
Abstract
Thyroid conditions, particularly hypothyroidism, are common in people with Down syndrome (DS). Hyperthyroidism is also found at a higher-than-average rate in patients with DS, although only isolated case reports and short series had been published up until now. We recently published the longest series so far examining the relationship between hyperthyroidism and DS. A systematic review of the 1,856 patients seen at Fundació Catalana Síndrome de Down (FCSD) from 1991 to 2006 was undertaken, and 12 cases of hyperthyroidism were diagnosed. The etiological cause was found to be Graves disease in all cases. After initial treatment with antithyroid drugs, all patients required permanent treatment with radioactive iodine I-131. Annual biochemical screening for early diagnosis is less effective than it is for hypothyroidism. Hyperthyroidism may influence growth and development in children with DS; treatment can reverse its impact.
Keywords:
Hyperthyroidism
Down syndrome
Graves disease
Thyroid gland
Growth
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Bibliography
[1.]
K.N. Carroll, P.G. Arbogast, J.A. Dudley, W.O. Cooper.
Increase in Incidence of Medically Treated Thyroid Disease in Children With Down Syndrome After Rerelease of American Academy of Pediatrics Health Supervision Guidelines.
Pediatrics, 122 (2008), pp. e493-e498
[2.]
J. Murphy, H.M. Hoey, M. Philip, E.F. Roche, S. Macken, et al.
Guidelines for the medical management of Irish children and adolescents with Down syndrome.
Ir Med J, 98 (2005), pp. 48-52
[3.]
American Academy of Pediatrics.
Committee on Genetics. Health supervision for children with Down syndrome.
Pediatrics, 107 (2001), pp. 442-449
[4.]
P.A. Gibson, R.W. Newton, K. Selby, D.A. Price, K. Leyland, G.M. Addison.
Longitudinal study of thyroid function in Down's syndrome in the first two decades.
Arch Dis Child, 90 (2005), pp. 574-578
[5.]
S.M. Pueschel, I.M. Jackson, P. Giesswein, M.K. Dean, J.C. Pezzullo.
Thyroid function in Down syndrome.
Res Dev Disabil, 12 (1991), pp. 287-296
[6.]
P. Fort, F. Lifshitz, R. Beellisario, J. Davis, R. Lanes, et al.
Abnormalities of thyroid function in infants with Down Syndrome.
J Pediatr, 104 (1984), pp. 545-549
[7.]
M.L. Colombo, G. Bona, P. Quaglia, M. Zaffaroni, D. Mania, D. Luotti.
La funzionalità tiroidea in bambini affetti da sindrome di Down.
Minerva Pediatr, 44 (1992), pp. 11-16
[8.]
S. Rooney, E. Walsh.
Prevalence of abnormal thyroid function in a Down's syndrome population.
Ir J Med Sci, 166 (1997), pp. 80-82
[9.]
C. Toledo, Y. Alembik, B. Dott, S. Kink, C. Stoll.
Anomalies of thyroid function in children with Down's syndrome.
Arch Pediatr, 4 (1997), pp. 116-120
[10.]
J.C. Murdoch, W.A. Ratcliffe, D.G. McLarty, J.C. Rodger, J.G. Ratcliffe.
Thyroid function in adults with Down's syndrome.
J Clin Endocrinol Metab, 44 (1977), pp. 453-458
[11.]
M.M. Loudon, R.A. Day, M.C. Duke.
Thyroid dysfunction in Down's syndrome.
Arch Dis Child, 60 (1985), pp. 1149-1151
[12.]
A. Goday-Arno, M. Cerdà-Esteva, J.A. Flores-Le-Roux, J.J. Chillarón-Jordan, J.M. Corretger, J.F. Cano-Pérez.
Hyperthyroidism in a population with Down syndrome.
Clin Endocrinol (Oxf), (2008),
[13.]
K. Unachak, P. Tanpaiboon, Y. Pongprot, R. Sittivangkul, S. Silvilairat, P. Dejkhamron, J. Sudasna.
Thyroid functions in children with Down's syndrome.
J Med Assoc Thai, 91 (2008 Jan), pp. 56-66
[14.]
L. Gruneiro de Pappendieck, A. Chiesa, M.G. Bastida, G. Alonso, G. Finkielstain, J.J. Heinrich.
Thyroid dysfunction and high thyroid stimulating hormone levels in children with Down's syndrome.
J. Pediatr Endocrinol Metab, 15 (2002), pp. 1543-1548
[15.]
V.M. Dias, J.C. Nunes, S.S. Araujo, E.M. Goulart.
Etiological assessment of hyperthyrotropinemia in children with Down's syndrome.
J Pediatr (Rio J), 81 (2005), pp. 79-84
[16.]
A. Castro Lobera, R. Linares Garcia-Valdecasas.
Estudio de la función tiroidea en personas con síndrome de Down.
Aten Primaria, 23 (1999), pp. 87-90
[17.]
L. Lavard, I. Ranlov, H. Perrild, O. Andersen, B.B. Jacobsen.
Incidence of juvenile thyrotoxicosis in Denmark, 1982–1988. A nationwide study.
Eur J Endocrinol, 130 (1994), pp. 565-568
[18.]
K. Ashizawa.
Epidemiology of Basedow disease and other thyroid diseases.
Nippon Rinsho, 64 (2006 Dec), pp. 2194-2200
[19.]
J.C. Galofré, R.V. Garcia-Mayor, E. Fluiters, L. Fernández-Calvet, A. Rego, C. Paramo, et al.
Incidence of different forms of thyroid dysfunction and its degrees in an iodine sufficent area.
Thyroidology, 6 (1994), pp. 49-54
[20.]
S.M. Pueschel, I. Jackson, P. Giesswein, M.K. Dean, J.C. Pezzullo.
Thyroid function in Down syndrome.
Res Dev Disabil, 12 (1991), pp. 287-296
[21.]
A.T. Cutler, Benezra-Obeiter, S.J. Brink.
Thyroid function in young children with Down syndrome.
AJDC, 140 (1986), pp. 479-483
[22.]
M. Selikowitz.
A five-year longitudinal study of thyroid function in children with Down syndrome.
Dev Med Child Neurol, 35 (1993), pp. 396-401
[23.]
R.T. Zori, D.A. Schatz, H. Ostrer, C.A. Williams, R. Spillar, W.J. Rilell.
Relationship of autoimmunity to thyroid dysfunction in children and adults with Down syndrome.
Am J Med Genet, 7 (1990), pp. 238-241
[24.]
L. Soriano Guillen, M.T. Munoz Calvo, J. Pozo Roman, J. Martinez Pérez, A. Bano Rodrigo, J. Argente Oliver.
Graves’ disease in patients with Down syndrome.
An Pediatr (Barc), 58 (2003), pp. 63-66
[25.]
J. Chemli, N. Braham, S. Boughattas, A. Harbi.
Basedow's disease and celiac disease in an adolescent with Down syndrome.
Rev Med Interne, 27 (2006), pp. 791-793
[26.]
J. Sanz.
Down syndrome and hyperthyroidism. Report of three cases.
Rev Med Chil, 127 (1999), pp. 967-969
[27.]
H.B. Burch, L. Wartofsky.
Graves. Ophthalmopathy: current concepts regarding pathogenesis and management.
Endocr Rev, 14 (1993), pp. 747
[28.]
A. Cassio, A. Corrias, S. Gualandi, et al.
Influence of gender and pubertal stage at diagnosis on growth outcome in childhood thyrotoxicosis: results of a collaborative study.
Clin Endocrinol (Oxf), 64 (2006), pp. 53
[29.]
G. Weber, M.C. Vigone, L. Stroppa, G. Chiumello.
Thyroid function and puberty.
J Pediatr Endocrinol Metab, 16 (2003), pp. 253-257
[30.]
S.M. Pueschel, J.C. Pezzullo.
Thyroid disfunction in Down syndrome.
Am J Dis Child, 139 (1985), pp. 636-639
[31.]
G.B. Pozzan, F. Rigon, M.E. Girelli, D. Rubello, B. Busnardo, C. Baccichetti.
Thyroid function in patients with Down syndrome: Preliminary results from non-institutionalized patients in veneto region.
Am J Med Genet, 7 (1990), pp. 57-58
[32.]
D.R. Hollingsworth, H.E. McKean, I. Roeckel.
Goiter, immunological observations, and thyroid function tests in Down Syndrome.
Am J Dis Child, 127 (1974), pp. 524-527
[33.]
F. Kaguelidou, C. Alberti, M. Castanet, M.A. Guitteny, P. Czernichow, Leger J, For the French Childhood Graves’ Disease Study Group.
Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment.
J Clin Endocrinol Metab, 93 (2008), pp. 3817-3826
[34.]
M. Sahin, N.B. Tutuncu, M. Kanbay, N.D. Guvener.
Surgery for hyperthyroidism in Down syndrome: Case report.
Mt Sinai J Med, 73 (2006), pp. 784-786
[35.]
J. Sherman, G.B. Thompson, A. Lteif, W.F. Schwenk 2nd., J. Van Heerden, D.R. Farley, et al.
Surgical management of Graves’ disease in childhood and adolescence: an institutional experience.
Surgery, 140 (2006), pp. 1056-1061
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