Corresponding author. Valdecilla Biomedical Research Institute (IDIVAL), Avda. Cardenal Herrera Oria s/n 39011, Santander, Spain. Tel.: +34 942202520ext73086.
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Tel.: +34 942202520ext73086." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "COVID-19 as a unique opportunity to unravel the link between prenatal maternal infection, brain development and neuropsychiatric disorders in offspring" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Study of the effects of prenatal maternal infection on early offspring brain development has long attracted the interest and endeavors of clinicians and neuroscientists.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Early reports on large-scale ecological data and further birth cohort studies analyzing biomarkers in pregnancy and early life of offspring have yielded evidence that in-utero exposure to infection increases neuropsychiatric disorder risk, particularly schizophrenia and autism spectrum disorders.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2–4</span></a> The main hypothesis derived from these studies is that activation of immune-inflammatory pathways during maternal infection may result in abnormal fetal brain development.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> However, such a hypothesis requires detailed testing to reveal the pathogenic and pathophysiological mechanisms behind these neurodevelopmental alterations.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the current historical milieu, two crucial circumstances converge that could help unravel this link between prenatal maternal infection and the risk of neuropsychiatric disturbances in the offspring. First, coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is by far the largest pandemic of our time.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Second, our capacity for thorough collection of epidemiological and clinical data, combined with accessibility to sophisticated biological research strategies in a scientific context of well-establish collaborative research networks, has enhanced understanding of the biological mechanisms underlying brain development.<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7,8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The uniqueness of the coronavirus pandemic calls for swift action in a moment of great uncertainty and with no time for adaptation.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> The transmission dynamics of COVID-19 and the lack of an effective vaccine until at least the first half of 2021 suggest that the pandemic could affect up to one-third of the world's population.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> The indirect psychosocial consequences of the pandemic may actually be even more harmful than the direct effects of the virus, and we must be able to anticipate the expected high prevalence of mental disorders by setting up preventive plans that identify high-risk subjects in the early stages.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Under this scenario, approximately 100 million pregnant women would be at potential risk of acquiring the SARS-CoV-2 infection, and therefore, there is growing concern about a dramatic increase of neurodevelopmental problems in the offspring of mothers infected during pregnancy in the coming years, similar to that observed after the 1918 influenza pandemic.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,10,11</span></a> From a wider viewpoint, this concurrence could provide a unique opportunity for advancing and refining the hypothesis of how prenatal exposure to infection might jeopardize normal brain development, increasing the likelihood of later neuropsychiatric disorders.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Among the possible etiological and pathophysiological mechanisms by which COVID-19 maternal infection may interfere with fetal brain development, are the direct mechanisms, such as vertical mother-to-child transmission, and indirect, either as a result of uteroplacental insufficiency from thrombosis or gestational hypoxia, or due to the prenatal effects of maternal immune/inflammatory response.<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">10,12</span></a> Alteration of the maternal-fetal immune environment seems to be the key determinant behind breakdown in offspring brain development of women who have been infected during pregnancy.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> Therefore, attention should especially focus on the effects of infection-induced maternal immune activation and the role of cytokines, chemokines, and other inflammatory markers.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In addition, whether infection alters brain development through specific infection-induced mechanisms or a common pathway, how susceptibility of genetic variations and epigenetic mechanisms interact with infection, differentially influence the risk of mental illness, or whether gestational timing is critical to increased vulnerability, are all still unresolved issues.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,13,14</span></a> Finally, other possible factors that might affect brain development, such as high stress hormone levels (maternal cortisol and placental corticotrophin-releasing hormone), bacterial translocation from gut, and the role of maternal psychosocial adversities derived from the coronavirus crisis (lockdowns, general worry about health, work conditions or salary restrictions, infotoxicity, etc.), must be quantified and corroborated.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,13</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">All of the above leads to the conclusion that, as a high priority within the framework of the COVID-19 pandemic, design and implementation of translational research projects, integrating findings from epidemiological and pathophysiological studies, can elucidate the causal mechanisms by which brain development is affected by these prenatal insults. Now is the time to carry out population-based birth cohort studies of COVID-19–infected pregnant women from a diversity of racial, ethnic, and geographic groups which include long-term longitudinal follow-ups of their offspring, as well as comparisons with control populations of non-infected pregnant women.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Along this line, there have been several initiatives around the world, such as the United Kingdom Obstetric Surveillance System (UKOSS) study, which from March 1, 2020 to April 14, 2020, has already collected the perinatal outcomes of 427 pregnant women with confirmed SARS-CoV-2 infection from all 194 hospitals with obstetric units in the United Kingdom.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> These studies provide the possibility to acquire biological (e.g., umbilical cord blood and placenta samples), clinical (e.g., maternal serum samples and neonatal filter paper blood samples) and neurocognitive (e.g., neurodevelopmental and neuropsychological scales) data that would enable the acquisition of invaluable genetic, metabolic, immunological and neurobehavioral information.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Such a large amount of information could overcome the limitations of previous studies and help unravel the complex relationship between maternal infection and later appearance of neurodevelopmental and neurobehavioral disturbances in the offspring. Such a challenging goal will require generous, long-term interdisciplinary collaboration by epidemiologists, geneticists, molecular/cellular neuroscientists, immunologists, microbiologists, gynecologists and obstetricians, neonatologists and pediatricians, child and adolescent mental health professionals, and psychiatrists and psychologists.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> An integrated, collaborative, interdisciplinary team which would have to work hard to overcome the logistical and financial barriers of design and implementation of long-term research projects, a clearly worthwhile effort outweighing the costs. This is why we are calling clinicians, researchers and the competent authorities in research investment and funding to action, so that from the tragedy of the COVID-19 crisis, we can seize the opportunity offered by a pandemic to advance in the knowledge of the etiopathogenesis of neurodevelopmental disorders.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-11-17" "fechaAceptado" => "2020-12-12" "NotaPie" => array:1 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Joint first authors.</p>" "identificador" => "fn0005" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infectious diseases of fetuses and newborn infants" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "J. Remington" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Engl. J. Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "531" "paginaFinal" => "532" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prenatal infection and schizophrenia: a review of epidemiologic and translational studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.S. Brown" 1 => "E.J. Derkits" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/appi.ajp.2009.09030361" "Revista" => array:6 [ "tituloSerie" => "Am J Psychiatry" "fecha" => "2010" "volumen" => "167" "paginaInicial" => "261" "paginaFinal" => "280" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20123911" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Schizophrenia and Influenza at the Centenary of the 1918-1919 Spanish Influenza Pandemic: Mechanisms of Psychosis Risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "A.P. Kepinska" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3389/fpsyt.2020.00072" "Revista" => array:5 [ "tituloSerie" => "Front Psychiatry" "fecha" => "2020" "volumen" => "11" "paginaInicial" => "72" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32174851" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Upper respiratory infection during pregnancy and neurodevelopmental outcomes among offspring" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "S.E. Parker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ntt.2016.06.007" "Revista" => array:6 [ "tituloSerie" => "Neurotoxicol Teratol" "fecha" => "2016" "volumen" => "57" "paginaInicial" => "54" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27343815" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.D. Bauman" 1 => "J. Van de Water" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.nbd.2020.104864" "Revista" => array:5 [ "tituloSerie" => "Neurobiol Dis" "fecha" => "2020" "volumen" => "141" "paginaInicial" => "104864" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32278881" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Are healthcare workers during the COVID-19 pandemic at risk of psychosis? Findings from a scoping review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "I. de Burgos-Berdud" 1 => "M.J. Valdes-Florido" 2 => "A. Lopez-Diaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.genhosppsych.2020.06.015" "Revista" => array:2 [ "tituloSerie" => "Gen Hosp Psychiatry" "fecha" => "2020" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development and evolution of the human neocortex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.H. Lui" 1 => "D.V. Hansen" 2 => "A.R. Kriegstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cell.2011.06.030" "Revista" => array:6 [ "tituloSerie" => "Cell" "fecha" => "2011" "volumen" => "146" "paginaInicial" => "18" "paginaFinal" => "36" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21729779" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CIBERSAM: Ten years of collaborative translational research in mental disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "E. Salagre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rpsm.2018.10.001" "Revista" => array:6 [ "tituloSerie" => "Rev Psiquiatr Salud Ment" "fecha" => "2019" "volumen" => "12" "paginaInicial" => "1" "paginaFinal" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30416047" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mental health and the SARS-CoV-2 pandemic" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "B. Crespo-Facorro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rpsm.2020.04.010" "Revista" => array:6 [ "tituloSerie" => "Rev Psiquiatr Salud Ment" "fecha" => "2020" "volumen" => "13" "paginaInicial" => "55" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32409249" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 Infection During Pregnancy and Risk of Neurodevelopmental Disorders in Offspring: Time for Collaborative Research" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "A. Lopez-Diaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.biopsych.2020.09.011" "Revista" => array:2 [ "tituloSerie" => "Biol Psychiatry" "fecha" => "2020" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 natural herd immunity and risk of neuropsychiatric disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "B. Losilla-Rodriguez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rpsm.2020.07.002" "Revista" => array:2 [ "tituloSerie" => "Rev Psiquiatr Salud Ment" "fecha" => "2020" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "C. Pantelis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0004867420961472" "Revista" => array:2 [ "tituloSerie" => "Aust N Z J Psychiatry" "fecha" => "2020" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal Immune Activation and Neuropsychiatric Illness: A Translational Research Perspective" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.S. Brown" 1 => "U. Meyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1176/appi.ajp.2018.17121311" "Revista" => array:6 [ "tituloSerie" => "Am J Psychiatry" "fecha" => "2018" "volumen" => "175" "paginaInicial" => "1073" "paginaFinal" => "1083" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30220221" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prenatal adverse environment is associated with epigenetic age deceleration at birth and hypomethylation at the hypoxia-responsive EP300 gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "H. Palma-Gudiel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s13148-019-0674-5" "Revista" => array:5 [ "tituloSerie" => "Clin Epigenetics" "fecha" => "2019" "volumen" => "11" "paginaInicial" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31072398" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psychiatry in the aftermath of COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Vieta" 1 => "V. Perez" 2 => "C. Arango" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rpsm.2020.04.004" "Revista" => array:7 [ "tituloSerie" => "Rev Psiquiatr Salud Ment" "fecha" => "2020" "volumen" => "13" "paginaInicial" => "105" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32376131" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1473309917305170" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Characteristics and outcomes of pregnant women admitted to hospital with confirmed SARS-CoV-2 infection in UK: national population based cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "M. Knight" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.m2107" "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "2020" "volumen" => "369" "paginaInicial" => "m2107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32513659" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The placenta as a window to the brain: A review on the role of placental markers in prenatal programming of neurodevelopment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.D. Shallie" 1 => "T. Naicker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijdevneu.2019.01.003" "Revista" => array:6 [ "tituloSerie" => "Int J Dev Neurosci" "fecha" => "2019" "volumen" => "73" "paginaInicial" => "41" "paginaFinal" => "49" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30634053" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/18889891/0000001400000001/v1_202102051057/S1888989120301300/v1_202102051057/es/main.assets" "Apartado" => array:4 [ "identificador" => "7539" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Editorial" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/18889891/0000001400000001/v1_202102051057/S1888989120301300/v1_202102051057/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1888989120301300?idApp=UINPBA00004N" ]
año/Mes | Html | Total | |
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2024 Octubre | 9 | 0 | 9 |
2024 Septiembre | 36 | 12 | 48 |
2024 Agosto | 30 | 8 | 38 |
2024 Julio | 16 | 5 | 21 |
2024 Junio | 21 | 3 | 24 |
2024 Mayo | 28 | 4 | 32 |
2024 Abril | 28 | 31 | 59 |
2024 Marzo | 54 | 8 | 62 |
2024 Febrero | 35 | 5 | 40 |
2024 Enero | 50 | 4 | 54 |
2023 Diciembre | 49 | 5 | 54 |
2023 Noviembre | 44 | 2 | 46 |
2023 Octubre | 67 | 2 | 69 |
2023 Septiembre | 82 | 2 | 84 |
2023 Agosto | 26 | 2 | 28 |
2023 Julio | 11 | 5 | 16 |
2023 Junio | 4 | 0 | 4 |
2023 Mayo | 29 | 3 | 32 |
2023 Abril | 13 | 2 | 15 |
2023 Marzo | 13 | 0 | 13 |
2023 Febrero | 15 | 1 | 16 |
2023 Enero | 11 | 4 | 15 |
2022 Diciembre | 27 | 7 | 34 |
2022 Noviembre | 37 | 6 | 43 |
2022 Octubre | 30 | 3 | 33 |
2022 Septiembre | 18 | 10 | 28 |
2022 Agosto | 38 | 14 | 52 |
2022 Julio | 12 | 15 | 27 |
2022 Junio | 26 | 11 | 37 |
2022 Mayo | 33 | 8 | 41 |
2022 Abril | 33 | 15 | 48 |
2022 Marzo | 28 | 19 | 47 |
2022 Febrero | 74 | 10 | 84 |
2022 Enero | 43 | 3 | 46 |
2021 Diciembre | 20 | 15 | 35 |
2021 Noviembre | 45 | 6 | 51 |
2021 Octubre | 89 | 17 | 106 |
2021 Septiembre | 29 | 19 | 48 |
2021 Agosto | 21 | 7 | 28 |
2021 Julio | 16 | 3 | 19 |
2021 Junio | 1 | 2 | 3 |
2021 Abril | 2 | 0 | 2 |
2021 Marzo | 1 | 0 | 1 |
2021 Febrero | 5 | 6 | 11 |