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Vol. 4. Núm. 2.
Páginas 96-100 (enero 2010)
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Vol. 4. Núm. 2.
Páginas 96-100 (enero 2010)
Acceso a texto completo
Capgras Syndrome associated with the use of psychoactive substances
Síndrome de Capgras asociado al consumo de sustancias psicoactivas
Visitas
1542
Ezequiel N. Mercurio
Hospital Neuropsiquiátrico Braulio A. Moyano, Buenos Aires, Argentina
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Información del artículo
Abstract
Introduction

Capgras syndrome has originally been described as psychiatric syndrome. However, in the last few years reports of patients with this syndrome has significantly increased in patients with neurological, metabolic, and infectious diseases and those who consume alcohol. Different hypotheses have been proposed to explain the neurobiology of this very unusual symptom, such as changes in the dopamine circuit and specific dysfunctions in facial processing.

Case

In this work we present a new case of Capgras syndrome, associated with an acute cocaine overdose, which was transient and reversible.

Discussion

The neurobiological bases of this syndrome are analysed, along with their relationship with the changes induced by cocaine use. Thus, Capgras syndrome could be the expression of functional changes at frontal-temporal level, and the paralimbic region secondary to the consumption of psychoactive substances such as cocaine.

Keywords:
Capgras syndrome
Facial processing
Prosopagnosia
Frontotemporal cortex
Substance abuse
Resumen
Introducción

El síndrome de Capgras ha sido descrito originariamente como un síntoma psiquiátrico, sin embargo en los últimos años se han incrementado notablemente los reportes de pacientes con este síndrome entre pacientes con enfermedades neurológicas, metabólicas, infecciosas y consumo de alcohol. Se han propuesto diferentes hipótesis para explicar la neurobiología de este síntoma tan particular, alteraciones en el circuito de la dopamina y disfunciones específicas en el procesamiento de los rostros.

Caso

En este trabajo se presenta un caso nuevo de síndrome de Capgras asociado a la intoxicación aguda por cocaína, de tipo transitorio y reversible.

Discusión

Se analizan las bases neurobiológicas de dicho síndrome y su correlación con las alteraciones secundarias al consumo de cocaína. Así, el síndrome de Capgras podría ser la expresión de alteraciones funcionales a nivel frontotemporal y la región paralímbica secundarias al consumo de sustancias psicoactivas como la cocaína.

Palabras clave:
Síndrome de Capgras
Procesamiento de rostros
Prosopagnosia
Corteza frontotemporal
Abuso de sustancias
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References
[1.]
J. Capgras, J. Reboul-Lachaux.
L’illusion des sosies dans un dèlire systématisé chronique.
Bull Soc Clin Méd Ment, 2 (1923), pp. 6-16
[2.]
P. Courbon, F. Fail.
Syndrome “d’illusion de Fregoli” et schizofrénie.
Ann Med Psychol, 85 (1927), pp. 289-290
[3.]
M. Courbon, J. Tusques.
L’illusion d’intermetamorphose et de charme.
Ann Med Psychol, 90 (1932), pp. 401-405
[4.]
G.N. Christodoulou.
Syndrome of subjective doubles.
Am J Psychiatry, 135 (1978), pp. 249-251
[5.]
G.N. Christodoulou.
The syndrome of Capgras.
Br J Psychiatry, 130 (1977), pp. 556-564
[6.]
R.J. Berson.
Capgras syndrome.
Am J Psychiatry, 140 (1983), pp. 969-978
[7.]
A. Odom-White, J. de Leon, J. Stanilla, B.S. Cloud, G.M. Simpson.
Misidentification syndromes in schizophrenia: case reviews with implications for classificationand prevalence.
Aust N Z J Psychiatry, 29 (1995), pp. 63-68
[8.]
M.T. Haslam.
A case of Capgras syndrome.
Am J Psychiatry, 130 (1973), pp. 493-494
[9.]
G.N. Christodoulou, M. Margariti, V.P. Kontaxakis, N.G. Christodoulou.
The delusional misidentification syndromes: strange, fascinating, and instructive.
Curr Psychiatry Rep, 11 (2009), pp. 185-189
[10.]
S. Fleminger, A. Burns.
The delusional misidentification syndromes in patients with and without evidence of organic cerebral disorder: a structured review of case reports.
Biol Psychiatry, 33 (1993), pp. 22-32
[11.]
H. Horikawa, A. Monji, M. Sasaki, T. Maekawa, T. Onitsuka, Y. Nitazaka, et al.
Different SPECT findings before and after Capgras’ syndrome in interictal psychosis.
Epilepsy Behav, 9 (2006), pp. 189-192
[12.]
N. Kapur, A. Turner, C. King.
Reduplicative paramnesia: possible anatomical and neuropsychological mechanisms.
J Neurol Neurosurg Psychiatry, 51 (1988), pp. 579-581
[13.]
M.N. Collins, M.E. Hawthorne, N. Gribbin, R. Jacobson.
Capgras’ syndrome with organic disorders.
Postgrad Med J, 66 (1990), pp. 1064-1067
[14.]
F. Assal, M.F. Mendez.
Intermetamorphosis in a patient with Alzheimer's disease.
J Neuropsychiatry Clin Neurosci, 15 (2003), pp. 246-247
[15.]
D.Y. Lee, I.H. Choo, K.W. Kim, J.H. Jhoo, J.C. Youn, U.Y. Lee, et al.
White matter changes associated with psychotic symptoms in Alzheimer's disease patients.
J Neuropsychiatry Clin Neurosci, 18 (2006), pp. 191-198
[16.]
K.A. Josephs.
Capgras syndrome and its relationship to neurodegenerative disease.
Arch Neurol, 64 (2007), pp. 1762-1766
[17.]
A.G. Marantz, J. Verghese.
Capgras’ syndrome in dementia with Lewy bodies.
J Geriatr Psychiatry Neurol, 15 (2002), pp. 239-241
[18.]
A. Sharma, M. Garuba, M. Egbert.
Capgras syndrome in a patient with multiple sclerosis: a case report.
Prim Care Companion J Clin Psychiatry, 11 (2009), pp. 274
[19.]
D.M. Roane, J.D. Rogers, J.H. Robinson, T.E. Feinberg.
Delusional misidentification in association with parkinsonism.
J Neuropsychiatry Clin Neurosci, 10 (1998), pp. 194-198
[20.]
P. Crichton, S. Lewis.
Delusional misidentification, AIDS and the right hemisphere.
Br J Psychiatry, 157 (1990), pp. 608-610
[21.]
W.A.G. MacCallum.
Capgras symptoms with an organic basis.
Br J Psychiatry, 123 (1973), pp. 639-642
[22.]
D. Quinn.
The Capgras syndrome: two case reports and a review.
Can J Psychiatry, 26 (1981), pp. 126-129
[23.]
J. Capgras, P. Carrette.
Illusion de sosies et complexe d’Oedipe.
Ann Méd Psychol, 132 (1924), pp. 48-68
[24.]
H.D. Ellis, A.W. Young.
Accounting for delusional misidentification.
Br J Psychiatry, 157 (1990), pp. 239-248
[25.]
V.S. Ramachandran.
Consciousness and body image: lessons from phantom limbs, Capgras syndrome and pain asymbolia.
PhilTrans R Soc Lond B, 353 (1998), pp. 1851-1859
[26.]
D.G. Daniel, A. Swallows, F. Wolff.
Capgras delusion and seizures in association with therapeutic dosages of disulfiram.
South Med J, 80 (1987), pp. 1577-1579
[27.]
J.A. Silva, G.B. Leong, I.M. Lesser, K.B. Boone.
Bilateral cerebral pathology and the genesis of delusional misidentification.
Can J Psychiatry, 40 (1995), pp. 498-499
[28.]
O. Devinsky.
Delusional misidentifications and duplications Right brain lesions, left brain delusions.
[29.]
A.B. Joseph, D.H. O’Leary, H.G. Wheeler.
Bilateral atrophy of the frontal and temporal lobes in schizophrenic patients with Capgras syndrome: a case-control study using computed tomography.
J Clin Psychiatry, 51 (1990), pp. 322-325
[30.]
M.J. Mentis, E.A. Weinstein, B. Horwitz, A.R. McIntosh, P. Pietrini, G.E. Alexander, et al.
Abnormal brain glucose metabolism in the delusional misidentification syndromes: a positron emission tomography study in Alzheimer disease.
Biol Psychiatry, 38 (1995), pp. 438-449
[31.]
D. Bourget, L. Whitehurst.
Capgras syndrome: a review of the neurophysiological correlates and presenting clinical features in cases involving physical violence.
Can J Psychiatry, 49 (2004), pp. 719-725
[32.]
A.B. Joseph.
Focal nervous system abnormalities in patients with misidentification syndromes.
Biblio Psychiatr, 164 (1986), pp. 68-79
[33.]
H.D. Ellis, K.W. de Pauw, G.N. Christodoulou, L. Papageorgiou, A.B. Milne, A.B. Joseph.
Responses to facial and non-facial stimuli presented tachistoscopically in either or both visual fields by patients with the Capgras delusion and paranoid schizophrenics.
J Neurol Neurosurg Psychiatry, 56 (1993), pp. 215-219
[34.]
A. Vighetto, G. Aimard.
Le délire spatial.
Neuro-Psy, 7 (1992), pp. 351-358
[35.]
V. Bruce, A.W. Young.
Understanding face recognition.
Br J Psychol, 77 (1986), pp. 305-327
[36.]
F. Lopera.
Procesamiento de caras: bases neurológicas, trastornos y evaluación.
Rev Neurol, 30 (2000), pp. 486-490
[37.]
W. Hirstein, V.S. Ramachandran.
Capgras Syndrome: a Novel Probe for Understanding the Neural Representation of the Identity and Familiarity of Persons.
Proc R Soc Lond B Biol Sci, 264 (1997), pp. 437-444
[38.]
G. Lahera Corteza.
Cognición social y delirio.
Rev Asoc Esp Neuropsiq, XXVIII (2008), pp. 197-209
[39.]
H.D. Ellis, et al.
Reduced autonomic responses to faces in Capgras delusión.
Proc R Soc Lond B, 264 (1997), pp. 1085-1092
[40.]
D. Tranel, A.R. Damasio.
Knowledge without awareness: an autonomic index of facial recognition by prosopagnosics.
Science, 228 (1985), pp. 1453-1454
[41.]
R.M. Bauer.
Autonomic recognition of names and faces in prosopagnosia: a neuropsychological application of the guilty knowledge test.
Neuropsychologia, 22 (1984), pp. 457-469
[42.]
E.I. Olivares, J.I. Iglesias.
Bases neurales de la percepción y el reconocimiento de caras.
Rev Neurol, 30 (2000), pp. 946-952
[43.]
N.J. Shah, J.C. Marshall, O. Zafiris, A. Schwab, K. Zilles, H.J. Markowitsch, et al.
The neural correlates of person familiarity. A functional magnetic resonance imaging study with clinical implications.
Brain, 124 (2001), pp. 804-815
[44.]
M.L. Paillère-Martinot, M.H. Dao-Castellana, M.C. Masure, B. Pillon, J.L. Martinot.
Delusional misidentification: a clinical, neuropsychological and brain imaging case study.
Psychopathology, 27 (1994), pp. 200-210
[45.]
Y. Nagahama, T. Okina, N. Suzuki, M. Matsuda, et al.
Neural correlates of psychotic symptoms in dementia with Lewy bodies.
Brain, 133 (2010), pp. 557-567
[46.]
C.J. Mace, M.R. Trimble.
Psychosis following temporal lobe surgery: a report of six cases.
J Neurol Neurosurg Psychiatry, 54 (1991), pp. 639-644
[47.]
A. Verdejo-García, M. Pérez-García, M. Sánchez-Barrera, A. Rodríguez-Fernández, M. Gómez-Río.
Neuroimagen y drogodependencias: correlatos neuroanatómicos del consumo de cocaína, opiáceos, cannabis y éxtasis.
Rev Neurol, 44 (2007), pp. 432-439
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