Información del artículo
Resumen
Durante las dos últimas décadas ha habido un cambio en el paradigma de tratamiento de la artritis reumatoide y hay consenso en que la terapia debe iniciarse lo más tempranamente posible con el objeto de controlar la inflamación articular, retrasar el daño estructural y preservar la capacidad funcional y la calidad de vida. El objetivo es lograr la remisión de la enfermedad. Sin embargo, se desconoce cuál es la estrategia terapéutica óptima.
Son indiscutibles las ventajas del tratamiento temprano con fármacos antirreumáticos modificadores de la enfermedad si se compara con el retraso en el inicio del tratamiento. Además, la terapia en combinación con dosis moderadas o altas de esteroides y combinaciones de metotrexato con antagonistas del factor de necrosis tumoral es más eficaz que la monoterapia.
Presentamos una revisión de los distintos tratamientos estudiados en artritis reumatoide precoz.
Palabras clave:
Artritis reumatoide precoz
Artritis de reciente comienzo
Abstract
In the last two decades, there has been a shift in the paradigm of RA treatment and there is consensus for earlier interventions to control inflammation, retard the progression of structural damage and preserve function and quality of life. Thus, the final objective is to obtain the remission of disease. However, the optimal therapeutic strategy remains unknown.
The advantage of treating RA early with DMARD therapy compared to its delayed institution is clear. Moreover, combination therapy including moderate to high doses of glucocorticoids and combinations of methotrexate with tumour necrosis factor blockers are more effective than monotherapies.
We review here the different treatments strategies studied in early RA.
Key words:
Rheumatoid early arthritis
Recent ouset arthritis
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