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Vigilancia epidemiológica de la tosferina en Cataluña 2011-2018
Whooping cough surveillance in Catalonia, 2011-2018
Glòria Carmona-Parcerisaa, Laura Ruiz-Mitjavilaa, Carme Fernández-Gutiérreza, Mireia Jané-Checaa,b, Ana Martínez Mateoa,b, Pilar Ciruela Navasa,b,
Autor para correspondencia
pilar.ciruela@gencat.cat

Autor para correspondencia.
a Subdirección General de Vigilancia y Respuesta a Emergencias de Salud, Agència de Salut Pública de Catalunya, Barcelona, España
b Centro Investigación Biológica en Red, Epidemiologia y Salud Pública (CIBERESP), Barcelona, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Introducci&#243;n</span><p id="p0005" class="elsevierStylePara elsevierViewall">Catalu&#241;a&#44; al igual que otros pa&#237;ses del mundo con pol&#237;ticas de vacunaci&#243;n similares a la nuestra &#40;UE&#44; EE&#46; UU&#46;&#44; Canad&#225; o Australia&#41;&#44; ha visto un resurgimiento de la tosferina en los &#250;ltimos a&#241;os&#44; que se ha traducido en un aumento de la incidencia de la enfermedad<a class="elsevierStyleCrossRef" href="#bb0005"><span class="elsevierStyleSup">1</span></a>&#46; En el caso de Catalu&#241;a el incremento se produjo en el a&#241;o 2011 y desde entonces&#44; con algunas oscilaciones seg&#250;n el a&#241;o&#44; se ha mantenido una incidencia elevada&#46;</p><p id="p0010" class="elsevierStylePara elsevierViewall">En este contexto de reemergencia&#44; la tosferina ha aumentado en todos los grupos de edad&#44; pero por su gravedad preocupa especialmente en los lactantes&#46; La estrategia que ha demostrado ser m&#225;s efectiva en la prevenci&#243;n de la enfermedad en los ni&#241;os menores de 3 meses de edad es la vacunaci&#243;n de las madres en el tercer trimestre de la gestaci&#243;n<a class="elsevierStyleCrossRefs" href="#bb0005"><span class="elsevierStyleSup">1&#8211;6</span></a>&#46; Hay diferentes factores que influyen en la reemergencia de la enfermedad&#46; Algunos de ellos son&#58; la evanescencia del efecto protector de la vacuna &#40;efecto <span class="elsevierStyleItalic">waning</span>&#41;&#44; la menor efectividad de la vacuna acelular &#40;DTPa&#41; comparada con la efectividad de la vacuna de c&#233;lulas enteras&#44; la disponibilidad de la reacci&#243;n en cadena por la polimerasa &#40;PCR&#41; en tiempo real&#44; que tiene m&#225;s sensibilidad que el cultivo o la potencial contribuci&#243;n de cambios gen&#233;ticos en las cepas circulantes de <span class="elsevierStyleItalic">Bordetella pertussis</span><a class="elsevierStyleCrossRef" href="#bb0035"><span class="elsevierStyleSup">7</span></a>&#46; El conjunto de todos estos factores ha contribuido a ocasionar el aumento de casos de tosferina en Catalu&#241;a y en otros pa&#237;ses del mundo&#46;</p><p id="p0015" class="elsevierStylePara elsevierViewall">La tosferina es una enfermedad infradiagnosticada y por tanto infranotificada a los sistemas de vigilancia&#44; sobre todo en los adolescentes y los adultos&#46; En estas edades la cl&#237;nica es muy inespec&#237;fica y los profesionales sanitarios piensan en otras enfermedades respiratorias y no sospechan su posible existencia&#46; En este contexto&#44; los adolescentes y los adultos tienen un rol importante como fuente de infecci&#243;n y pueden transmitir la enfermedad sobre todo a los ni&#241;os&#46; Esta circunstancia dificulta su control&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">Catalu&#241;a inici&#243; la vacunaci&#243;n antipert&#250;sica en 1965 y pronto se alcanzaron elevadas coberturas vacunales&#46; A lo largo de los a&#241;os Catalu&#241;a ha realizado cambios en el calendario vacunal de esta enfermedad&#46; En 2004 se cambi&#243; la vacuna de c&#233;lulas enteras &#40;DTPw&#41; por la vacuna acelular &#40;DTPa&#41;&#46; Tambi&#233;n se han producido cambios en la pauta vacunal lo largo de los a&#241;os&#44; as&#237; como la vacunaci&#243;n de las mujeres embarazadas en el tercer trimestre de la gestaci&#243;n a partir de 2014<a class="elsevierStyleCrossRef" href="#bb0066"><span class="elsevierStyleSup">8</span></a>&#46; En este art&#237;culo se describe el comportamiento de la enfermedad en Catalu&#241;a entre los a&#241;os 2011 y 2018&#46;</p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Material y m&#233;todos</span><p id="p0025" class="elsevierStylePara elsevierViewall">La tosferina forma parte del listado de enfermedades sometidas a vigilancia desde el a&#241;o 1982 y es una enfermedad de declaraci&#243;n obligatoria individualizada desde el a&#241;o 1997&#46; Se ha realizado un estudio descriptivo de la incidencia de casos de tosferina declarados al sistema de Enfermedades de Declaraci&#243;n Obligatoria &#40;EDO&#41; en Catalu&#241;a entre los a&#241;os 2011 y 2018&#46; Para la inclusi&#243;n de los casos en el estudio se han utilizado las definiciones de caso sospechoso y de caso confirmado vigentes en Catalu&#241;a<a class="elsevierStyleCrossRef" href="#bb0040"><span class="elsevierStyleSup">9</span></a>&#46; Se defini&#243; como caso sospechoso aquel que ha presentado tos de m&#225;s de 2 semanas de duraci&#243;n y al menos uno de los siguientes s&#237;ntomas&#58; tos parox&#237;stica&#44; estridor inspiratorio&#44; v&#243;mitos postus&#237;genos o apnea&#46; Se defini&#243; como caso confirmado aquel que cumple la descripci&#243;n cl&#237;nica y se ha confirmado en el laboratorio &#40;por cultivo y&#47;o por la detecci&#243;n del genoma por t&#233;cnica de amplificaci&#243;n&#44; PCR&#41; o aquel que cumple la descripci&#243;n cl&#237;nica y est&#225; relacionado epidemiol&#243;gicamente con un caso confirmado&#46; Para el c&#225;lculo de la incidencia de la enfermedad se han incluido los casos sospechosos y los casos confirmados notificados al sistema EDO en el periodo estudiado&#46; Los denominadores utilizados para el c&#225;lculo de las tasas de incidencia han sido los del padr&#243;n continuo de la poblaci&#243;n que publica el IDESCAT&#46;</p><p id="p0030" class="elsevierStylePara elsevierViewall">Se utiliz&#243; la prueba de chi-cuadrado de Pearson para estimar diferencias en la distribuci&#243;n de la tosferina en los hombres y en las mujeres&#46; Asimismo&#44; se formularon <span class="elsevierStyleItalic">test</span> &#40;z&#41; de comparaci&#243;n de proporciones con el fin de establecer si la distribuci&#243;n en los grupos de edad ha sido diferente en 2 periodos de tiempo&#46;</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Resultados</span><p id="p0035" class="elsevierStylePara elsevierViewall">En el a&#241;o 2011 se observ&#243; un aumento importante de la enfermedad y la tasa de incidencia multiplic&#243; por 5 el valor de la tasa de los a&#241;os anteriores<a class="elsevierStyleCrossRef" href="#bb0045"><span class="elsevierStyleSup">10</span></a>&#46; La <a class="elsevierStyleCrossRef" href="#f0005">figura 1</a> muestra la tendencia de la tosferina en el periodo 1993-2018&#46;</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><p id="p0040" class="elsevierStylePara elsevierViewall">Desde el a&#241;o 2011 la incidencia se mantuvo a niveles elevados&#46; El valor m&#225;s alto del periodo 2011-2018 fue el del a&#241;o 2015&#44; a&#241;o epid&#233;mico de tosferina&#44; que se tradujo en un pico de incidencia&#44; alcanzando una tasa de 49&#44;2 por 100&#46;000 habitantes&#46;</p><p id="p0045" class="elsevierStylePara elsevierViewall">Comparadas con las de Espa&#241;a&#44; las tasas de incidencia de tosferina de Catalu&#241;a fueron superiores a las tasas del conjunto de Espa&#241;a &#40;<a class="elsevierStyleCrossRef" href="#f0010">fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0050" class="elsevierStylePara elsevierViewall">En el periodo 2011-2018 las tasas de incidencia en Catalu&#241;a fueron m&#225;s altas en las mujeres que en los hombres&#46; Este comportamiento se mantuvo a lo largo de todos los a&#241;os del periodo&#44; aunque no fue estad&#237;sticamente significativo &#40;p &#61; 0&#44;432&#41; &#40;<a class="elsevierStyleCrossRef" href="#f0015">fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="f0015"></elsevierMultimedia><p id="p0055" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a> muestra la distribuci&#243;n de los casos de tosferina en todos los grupos de edad&#46; Las tasas de incidencia m&#225;s elevadas se concentraron en los ni&#241;os menores de un a&#241;o&#44; grupo de edad donde los casos presentan m&#225;s complicaciones y m&#225;s hospitalizaci&#243;n&#46; La monitorizaci&#243;n de los casos en este grupo de edad ha mostrado una tendencia a la disminuci&#243;n de incidencia&#44; pasando de una tasa de 478&#44;5 por 100&#46;000 habitantes en 2011 a una tasa de 235&#44;7 en 2018 &#40;<a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0060" class="elsevierStylePara elsevierViewall">El porcentaje de casos en los ni&#241;os menores de 2 meses y menores de un a&#241;o disminuy&#243; en el periodo de estudio &#40;a&#241;os 2011 a 2018&#41;&#46; La <a class="elsevierStyleCrossRef" href="#t0010">tabla 2</a> muestra la disminuci&#243;n del porcentaje de casos en estos grupos de edad entre los a&#241;os 2013 &#40;antes de la vacunaci&#243;n de tosferina en las embarazadas&#41; y despu&#233;s de la vacunaci&#243;n &#40;a&#241;os 2014 a 2018&#41; &#40;p &#60; 0&#44;001&#41;&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><p id="p0065" class="elsevierStylePara elsevierViewall">En el grupo de edad de 10-14 a&#241;os la tasa de incidencia aument&#243; a lo largo de 2011 hasta 2018 y pas&#243; de una tasa de 44&#44;4 por 100&#46;000 habitantes en 2011 a una de 88&#44;8 en a&#241;o 2018 &#40;<a class="elsevierStyleCrossRef" href="#t0005">tabla 1</a>&#41;&#46; Concretamente en los ni&#241;os de 7- 9 a&#241;os se registr&#243; un aumento de casos en los a&#241;os 2017 hasta 2018 comparado con los a&#241;os 2014 hasta 2015 &#40;p &#61; 0&#44;006&#41; &#40;<a class="elsevierStyleCrossRef" href="#t0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="t0015"></elsevierMultimedia><p id="p0070" class="elsevierStylePara elsevierViewall">En cuanto a los antecedentes vacunales del conjunto de casos &#40;todas las edades&#41; un 11&#44;5&#37; no estaban vacunados&#44; mientras que un 43&#44;6&#37; estaban vacunados con 4 o 5 dosis &#40;<a class="elsevierStyleCrossRef" href="#f0020">fig&#46; 4</a>&#44; <a class="elsevierStyleCrossRef" href="#t0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="f0020"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0075" class="elsevierStylePara elsevierViewall">En el rango de edad de 5-18 a&#241;os un 3&#44;1&#37; no estaban vacunados&#44; mientras que un 81&#37; hab&#237;an recibido 4 o 5 dosis de vacuna &#40;<a class="elsevierStyleCrossRef" href="#t0025">tabla 5</a>&#41;&#46;</p><elsevierMultimedia ident="t0025"></elsevierMultimedia><p id="p0080" class="elsevierStylePara elsevierViewall">Entre los que ten&#237;an 30 o m&#225;s a&#241;os de edad un 66&#44;4&#37; desconoc&#237;an si estaban o no vacunados &#40;<a class="elsevierStyleCrossRef" href="#t0030">tabla 6</a>&#41;&#46;</p><elsevierMultimedia ident="t0030"></elsevierMultimedia><p id="p0085" class="elsevierStylePara elsevierViewall">En los iguales o menores de un a&#241;o se produjeron 4 defunciones entre 2011-2018&#46; Dos casos ten&#237;an un mes y no estaban vacunados&#44; uno ten&#237;a 2 meses&#58; la madre se vacun&#243; durante el embarazo&#44; pero el ni&#241;o no llevaba ninguna dosis&#44; uno ten&#237;a un a&#241;o y estaba vacunado con 3 dosis&#46; En los menores de un a&#241;o la tasa de letalidad fue de 0&#44;12&#37;&#46;</p><p id="p0090" class="elsevierStylePara elsevierViewall">El comportamiento de la enfermedad mostr&#243; algunas diferencias seg&#250;n el territorio&#46; La provincia de Girona y la regi&#243;n de Vallesos &#40;Barcelona&#41; registraron una mayor incidencia de la enfermedad que el resto de regiones&#46; En la <a class="elsevierStyleCrossRef" href="#t0035">tabla 7</a> se muestran las tasas estandarizadas seg&#250;n territorio correspondiente a cada Unidad de Vigilancia Epidemiol&#243;gica &#40;UVE&#41;&#46;</p><elsevierMultimedia ident="t0035"></elsevierMultimedia><p id="p0095" class="elsevierStylePara elsevierViewall">Caracter&#237;sticamente&#44; la tosferina present&#243; un componente estacional&#44; con un pico de incidencia en los meses de verano &#40;junio a agosto&#41; &#40;<a class="elsevierStyleCrossRef" href="#f0025">fig&#46; 5</a>&#41;&#46;</p><elsevierMultimedia ident="f0025"></elsevierMultimedia><p id="p0100" class="elsevierStylePara elsevierViewall">Globalmente el 65&#37; de los casos de tosferina notificados al sistema EDO que han formado parte del estudio &#40;2011 a 2018&#41; fueron confirmados &#40;por t&#233;cnica de PCR y&#47;o cultivo&#41;&#46; Un 1&#44;7&#37; de los casos se confirmaron por v&#237;nculo epidemiol&#243;gico con un caso confirmado y el 33&#44;3&#37; quedaron clasificados como casos sospechosos &#40;cumpl&#237;an la definici&#243;n cl&#237;nica de tosferina&#44; pero no fueron confirmados por el laboratorio&#41; &#40;<a class="elsevierStyleCrossRef" href="#t0040">tabla 8</a>&#41;&#46;</p><elsevierMultimedia ident="t0040"></elsevierMultimedia></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Discusi&#243;n</span><p id="p0105" class="elsevierStylePara elsevierViewall">En los &#250;ltimos a&#241;os la tosferina ha presentado un comportamiento de enfermedad reemergente en muchos pa&#237;ses&#44; particularmente en aquellos en los que los ni&#241;os han recibido la DTPa ya desde la primera infancia&#44; Este comportamiento se ha observado en Catalu&#241;a y en otros pa&#237;ses que introdujeron la DTPa en sus calendarios&#44; como Francia&#44; Alemania&#44; Holanda&#44; Canad&#225;&#44; EE&#46; UU&#46; y otros&#46;</p><p id="p0110" class="elsevierStylePara elsevierViewall">Hay evidencias de que la DTPa presenta una menor duraci&#243;n de la protecci&#243;n que la vacuna de c&#233;lulas enteras<a class="elsevierStyleCrossRef" href="#bb0055"><span class="elsevierStyleSup">11</span></a>&#46; Algunos estudios con babuinos han detectado que la DTPa protege menos de la colonizaci&#243;n de <span class="elsevierStyleItalic">Bordetella pertussis</span> en la nasofaringe que las personas vacunadas con c&#233;lulas enteras o la infecci&#243;n natural&#44; pero se requieren m&#225;s estudios para la confirmaci&#243;n de este comportamiento en los humanos<a class="elsevierStyleCrossRef" href="#bb0050"><span class="elsevierStyleSup">12</span></a>&#46;</p><p id="p0115" class="elsevierStylePara elsevierViewall">Comparadas con las de Espa&#241;a&#44; las tasas de incidencia de tosferina de Catalu&#241;a fueron superiores a las tasas del conjunto de Espa&#241;a &#40;<a class="elsevierStyleCrossRef" href="#f0010">fig&#46; 2</a>&#41;&#46; Este hecho podr&#237;a explicarse por una mayor detecci&#243;n y notificaci&#243;n de la enfermedad en Catalu&#241;a&#46; A pesar de este hecho el comportamiento en Espa&#241;a fue el mismo que en Catalu&#241;a&#44; es decir&#44; en 2011 se observ&#243; una reemergencia de la enfermedad y el a&#241;o 2015 fue un a&#241;o epid&#233;mico tambi&#233;n a nivel del territorio de Espa&#241;a&#46;</p><p id="p0120" class="elsevierStylePara elsevierViewall">En el contexto de los pa&#237;ses europeos la incidencia de la tosferina en Catalu&#241;a se encuentra entre la de los pa&#237;ses que presentan una elevada incidencia como Alemania&#44; Holanda&#44; Reino Unido o Polonia &#40;datos correspondientes al a&#241;o 2017&#41;<a class="elsevierStyleCrossRef" href="#bb0055"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="p0125" class="elsevierStylePara elsevierViewall">El alto porcentaje de casos de ni&#241;os en la franja de 5 a 18 a&#241;os con 4-5 dosis de vacuna &#40;81&#37;&#41; puede ser un indicador de la menor efectividad de la DTPa y evidencia la dificultad de controlar la enfermedad&#46;</p><p id="p0130" class="elsevierStylePara elsevierViewall">La implementaci&#243;n en 2014 de la vacunaci&#243;n de la tosferina a las mujeres embarazadas en el tercer trimestre del embarazo &#40;entre las semanas 27 y 36&#41; parece haber impactado en la reducci&#243;n de los casos en los lactantes<a class="elsevierStyleCrossRef" href="#bb0060"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="p0135" class="elsevierStylePara elsevierViewall">Se ha observado una disminuci&#243;n de la incidencia en los menores de un a&#241;o&#44; sobre todo en los menores de 2 meses&#44; que coincide con la recomendaci&#243;n de la vacunaci&#243;n de las mujeres embarazadas en el tercer trimestre del embarazo iniciada en 2014&#46; Este resultado tiene mucha relevancia&#44; pues es en estas edades donde se producen m&#225;s complicaciones y hospitalizaciones&#46; Santos et al&#46; estimaron la incidencia de hospitalizaciones por tosferina en Espa&#241;a en la poblaci&#243;n general en el periodo 1999-2005 y encontraron que el 85&#44;6&#37; de los casos eran ni&#241;os menores de un a&#241;o y el 95&#37; ten&#237;an menos de 5 a&#241;os<a class="elsevierStyleCrossRef" href="#bb0060"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="p0140" class="elsevierStylePara elsevierViewall">En el periodo 2011-2018 se observaron otros cambios en la distribuci&#243;n de los casos&#44; que podr&#237;an estar relacionados con el cambio en la pauta de vacunaci&#243;n introducida durante el a&#241;o 2016&#46; El aumento de casos en los ni&#241;os de 7-9 a&#241;os observado los a&#241;os 2017 y 2018 comparado con los de los a&#241;os 2014 y 2015 &#40;p &#61; 0&#44;006&#41; podr&#237;a estar relacionado en mayor o menor medida con la eliminaci&#243;n de la cuarta dosis de vacuna a los 18 meses de edad que se produjo en el a&#241;o 2016&#46; Sin embargo&#44; a nivel global las tasas de incidencia en los a&#241;os 2017 y 2018 fueron menores a las de 2014 y 2015 &#40;a&#241;o epid&#233;mico&#41;&#44; y por tanto la p&#233;rdida de una dosis de vacuna parece que no habr&#237;a impactado en el comportamiento global de la enfermedad&#46;</p><p id="p0145" class="elsevierStylePara elsevierViewall">Igualmente&#44; en el grupo de edad de 10-14 a&#241;os la tasa de incidencia aument&#243; entre 2011 y 2018&#44; y pas&#243; de una tasa de 44&#44;4 por 100&#46;000 habitantes en 2011 a una de 88&#44;8 del a&#241;o 2018&#46;</p><p id="p0150" class="elsevierStylePara elsevierViewall">La inespecificidad de la cl&#237;nica en los adolescentes y en los adultos hace que muchos casos pasen desapercibidos&#44; y al no detectarse contribuyan a la propagaci&#243;n de la enfermedad&#44; dificultando su control&#46; Un estudio realizado en Catalu&#241;a los a&#241;os 2012 y 2013 para conocer la tasa de transmisi&#243;n de tosferina entre los contactos domiciliarios de casos y los factores asociados a la transmisi&#243;n encontr&#243; una tasa de transmisi&#243;n del 16&#44;1&#37; &#40;IC 95&#37;&#59; 13&#44;4-18&#44;6&#41;<a class="elsevierStyleCrossRef" href="#bb0065"><span class="elsevierStyleSup">14</span></a> en el &#225;mbito domiciliario&#46;</p><p id="p0155" class="elsevierStylePara elsevierViewall">Dentro del contexto de reemergencia de la tosferina&#44; desde 2016 en Catalu&#241;a se ha observado una disminuci&#243;n de la incidencia&#46; La tosferina mantiene un patr&#243;n epid&#233;mico c&#237;clico con olas que se presentan cada 3-5 a&#241;os<a class="elsevierStyleCrossRef" href="#bb0035"><span class="elsevierStyleSup">7</span></a>&#46; Habr&#225; que comprobar si en los pr&#243;ximos a&#241;os la disminuci&#243;n se mantiene o si como es habitual se produce una nueva ola epid&#233;mica&#46;</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Conclusi&#243;n</span><p id="p0160" class="elsevierStylePara elsevierViewall">Las caracter&#237;sticas de las vacunas actualmente disponibles &#40;vacunas acelulares&#41; han contribuido a la reemergencia de la enfermedad en Catalu&#241;a desde el a&#241;o 2011&#46;</p><p id="p0165" class="elsevierStylePara elsevierViewall">Actualmente el control de la tosferina constituye un reto para los servicios de vigilancia de salud p&#250;blica en todos los pa&#237;ses de nuestro entorno &#40;EU&#44; EE&#46; UU&#46;&#41;&#46;</p><p id="p0170" class="elsevierStylePara elsevierViewall">La decisi&#243;n de vacunar a las mujeres embarazadas en el tercer trimestre de gestaci&#243;n en el a&#241;o 2014 ha contribuido a disminuir los casos en los ni&#241;os m&#225;s peque&#241;os &#40;menores de un a&#241;o&#41;&#44; edad en la que se producen m&#225;s complicaciones y hospitalizaciones&#46;</p></span><span id="s2030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st2090">Consideraciones &#233;ticas</span><p id="p2175" class="elsevierStylePara elsevierViewall">Este estudio est&#225; basado en casos sospechosos y casos confirmados declarados al sistema de Enfermedades de Declaraci&#243;n Obligatoria &#40;EDO&#41;&#44; de acuerdo a la definici&#243;n de caso vigente en Catalu&#241;a&#46; Todos los datos incluidos son an&#243;nimos y no requieren consentimiento informado por formar parte de las actividades de vigilancia epidemiol&#243;gica de la Agencia de Salud Publica de Catalu&#241;a&#46;</p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Financiaci&#243;n</span><p id="p0175" class="elsevierStylePara elsevierViewall">Ninguna&#46;</p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Conflicto de intereses</span><p id="p0180" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="as0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0010">Introducci&#243;n</span><p id="sp0070" class="elsevierStyleSimplePara elsevierViewall">el objetivo de este art&#237;culo consiste en describir los principales resultados de la vigilancia de la tosferina en Catalu&#241;a y valorar su evoluci&#243;n en los &#250;ltimos a&#241;os&#46;</p></span> <span id="as0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Material y m&#233;todos</span><p id="sp0075" class="elsevierStyleSimplePara elsevierViewall">en este estudio se han incluido los casos sospechosos y los casos confirmados al sistema de Enfermedades de Declaraci&#243;n Obligatoria &#40;EDO&#41; en el periodo 2011-2018&#44; de acuerdo a la definici&#243;n de caso vigente en Catalu&#241;a&#44; una vez validada la notificaci&#243;n realizada por los profesionales sanitarios a este sistema&#46;</p></span> <span id="as0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Resultados</span><p id="sp0080" class="elsevierStyleSimplePara elsevierViewall">el a&#241;o 2011 en Catalu&#241;a se observ&#243; una reemergencia de la tosferina que se ha mantenido a lo largo del periodo de estudio &#40;2011-2018&#41;&#44; aunque desde 2016 se ha observado una disminuci&#243;n de la incidencia&#46; La tasa m&#225;s alta del periodo fue la del a&#241;o 2015&#44; que registr&#243; una tasa de 49&#44;2 por 100&#46;000 habitantes&#46;</p><p id="sp0085" class="elsevierStyleSimplePara elsevierViewall">Los menores de un a&#241;o presentaron las tasas de incidencia m&#225;s elevadas&#44; pero disminuyeron en los &#250;ltimos a&#241;os del periodo&#46; La recomendaci&#243;n de vacunar contra la tosferina a las mujeres embarazadas en el tercer trimestre de la gestaci&#243;n a partir del a&#241;o 2014 ha impactado en la incidencia en los menores de un a&#241;o y sobre todo en los menores de 2 meses&#44; que ha disminuido de manera significativa&#46; El alto porcentaje de casos en los ni&#241;os entre 5 y 18 a&#241;os con 4-5 dosis de vacuna acelular pone de manifiesto una disminuci&#243;n de la inmunidad vacunal&#46;</p></span> <span id="as0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Conclusiones</span><p id="sp0090" class="elsevierStyleSimplePara elsevierViewall">en la actualidad el control de la tosferina constituye un reto para los servicios de vigilancia de salud p&#250;blica&#46;</p></span>"
        "secciones" => array:4 [
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            "titulo" => "Material y m&#233;todos"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="as0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Introduction</span><p id="sp0095" class="elsevierStyleSimplePara elsevierViewall">The objective of the article is to describe the main results of pertussis surveillance in Catalonia and to evaluate its evolution in recent years&#46;</p></span> <span id="as0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Material and methods</span><p id="sp0100" class="elsevierStyleSimplePara elsevierViewall">According to the case definition in Catalonia&#44; suspicious and confirmed cases notified to the Obligatory Disease Declaration System &#40;MDO&#41; for the period 2011-2018 have been included&#44; after the validation of the notification made by health professionals to this system has been completed&#46;</p></span> <span id="as0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Results</span><p id="sp0105" class="elsevierStyleSimplePara elsevierViewall">In 2011&#44; a reemergence of whooping cough was observed in Catalonia which remained during the study period &#40;2011-2018&#41;&#44; although since 2016 a decrease in incidence has been observed&#46; The highest rate for the period was that of 2015&#44; which reached the value of 49&#46;2 per 100&#44;000 inhabitants&#46; Children under one year showed the highest incidence rates&#44; but decreased over the period&#46;</p><p id="sp0110" class="elsevierStyleSimplePara elsevierViewall">The recommendation to vaccinate against pertussis pregnant women in the third trimester of pregnancy&#44; that started in 2014&#44; has impacted on the incidence in children under the age of 1 and especially in children under 2 months&#44; which has decreased significantly&#46; The high percentage of cases in children between 5-18 years with 4-5 doses of acellular vaccine shows the lower effectiveness of this vaccine induced immunity&#46;</p></span> <span id="as0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Conclusions</span><p id="sp0115" class="elsevierStyleSimplePara elsevierViewall">Control of whooping cough is currently a challenge that public health surveillance services have to face&#46;</p></span>"
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          "es" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Tasas de incidencia de tos ferina en Catalu&#241;a versus tasas de incidencia en Espa&#241;a&#44; 2012-2016&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">A&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#60;<span class="elsevierStyleHsp" style=""></span>1 a&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">1-4 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">5-9 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">10-14 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">15-19 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">20-29 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">30-39 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">40-49 a&#241;os&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">50 a&#241;os o m&#225;s&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">2011</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">478&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">92&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">2012</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">344&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">2013</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">322&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">18&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3458523.png"
              ]
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        "descripcion" => array:1 [
          "es" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Tasa de incidencia de tosferina por grupos de edad&#46; Catalu&#241;a 2011-2018</p>"
        ]
      ]
      6 => array:8 [
        "identificador" => "t0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "al0035"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:2 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">a&#41;&#46; Casos en menores de 2 meses y en menores de 1 a&#241;o y porcentaje&#44; Catalu&#241;a 2013-2018</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Edad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2015&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2017&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2018&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t">&#60; 2 meses n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;7&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">76 &#40;2&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44 &#40;2&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;1&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>1 a&#241;o n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">241 &#40;24&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">218 &#40;19&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">349 &#40;9&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">241 &#40;12&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">171 &#40;9&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">154 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">1&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">1&#46;122&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">3&#46;693&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">1&#46;979&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">1&#46;856&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" style="border-bottom: 2px solid black">1&#46;381&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:1.0px"></span></td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3458520.png"
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            1 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t ; entry_with_role_colgroup " colspan="7" align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">b&#41;&#46; Comparaci&#243;n de proporciones de casos en menores de<span class="elsevierStyleHsp" style=""></span>2 meses y en menores de <span class="elsevierStyleHsp" style=""></span>un a&#241;o entre 2013 y el periodo de 2014 a 2018 &#40;p&#95;valor&#41;</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013 vs&#46; 2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013 vs&#46; 2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013 vs&#46; 2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013 vs&#46; 2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013 vs&#46; 2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">&#60;<span class="elsevierStyleHsp" style=""></span>2 meses</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">&#60;<span class="elsevierStyleHsp" style=""></span>1 a&#241;o</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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        "descripcion" => array:1 [
          "es" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Tosferina y Catalu&#241;a&#58; casos en menores de<span class="elsevierStyleHsp" style=""></span>2 meses y en menores de <span class="elsevierStyleHsp" style=""></span>un a&#241;o antes &#40;2013&#41; y despu&#233;s &#40;2014-2018&#41; de la vacunaci&#243;n frente a la tos ferina de las gestantes en tercer trimestre</p>"
        ]
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      7 => array:8 [
        "identificador" => "t0015"
        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "al0040"
            "detalle" => "Tabla "
            "rol" => "short"
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        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Edad &#40;a&#241;os&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2014-2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2017-2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&#95;valor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">&#60;<span class="elsevierStyleHsp" style=""></span>1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">567&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">325&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">1-2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">385&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">309&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;071&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">3-6</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">881&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">617&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;886&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">7-9</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">588&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">483&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;006&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#46;058&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">728&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;551&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">15-18</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">110&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;387&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Total 0-18</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;589&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">2&#46;530&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "es" => "<p id="sp0040" class="elsevierStyleSimplePara elsevierViewall">Distribuci&#243;n de los casos de tosferina en individuos de menor o igual a 18 a&#241;os&#46; Catalu&#241;a 2014-2015 versus 2017-2018</p>"
        ]
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">43&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Vacunados&#44; n&#250;mero de dosis desconocido</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\tvoid\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">4&#46;534&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
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                  """
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              "imagenFichero" => array:1 [
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        "descripcion" => array:1 [
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                  \t\t\t\t">&#40;1&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;6&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;100&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">1-4</span></td><td class="td" title="\n
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                  \t\t\t\t">175&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">18&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;338&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;7&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;0&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;4&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;8&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;100&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">10-14</span></td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t">&#40;0&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;1&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;6&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#40;66&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&#40;100&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3458516.png"
              ]
            ]
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Antecedentes vacunales de los casos de tosferina por grupos de edad&#46; Catalu&#241;a 2011-2018</p>"
        ]
      ]
      11 => array:8 [
        "identificador" => "t0035"
        "etiqueta" => "Tabla 7"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "al0060"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2012&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2013&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2016&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2017&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">2018&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Barcelona Sud</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">11&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">30&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">20&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">26&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">14&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">10&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">12&#44;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">41&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">21&#44;1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">13&#44;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">17&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Catalunya Central</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">20&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">18&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">24&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Barcelona ciudad</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">14&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">10&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">14&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">43&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">22&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">15&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Girona</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">25&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">68&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">36&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">14&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Lleida</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">7&#44;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">18&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">28&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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Información del artículo
ISSN: 15769887
Idioma original: Español
DOI:10.1016/j.vacun.2023.10.001
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