metricas
covid
Buscar en
Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Toda la web
Inicio Revista Española de Medicina Nuclear e Imagen Molecular (English Edition) PET/CT FAPI: Procedure and evidence review in oncology
Journal Information
Vol. 43. Issue 2.
Pages 130-140 (March - April 2024)
Share
Share
Download PDF
More article options
Visits
17
Vol. 43. Issue 2.
Pages 130-140 (March - April 2024)
Continuing Education
PET/CT FAPI: Procedure and evidence review in oncology
PET/TC con FAPI: Procedimiento y revisión de la evidencia en oncología
Visits
17
A.P. Caresiaa,
Corresponding author
, J. Jo Rosalesb, M. Rodríguez Fraileb, A. Arçay Öztürkc, C. Artigasc, On behalf of the Oncology Task Force of Spanish Nuclear Medicine and Molecular Imaging Society
a Servei e Medicina Nuclear, Hospital Universitari Germans Trias i Pujol, Badalona, Spain
b Servicio de Medicina Nuclear, Clínica Universidad de Navarra, Pamplona, Spain
c Department of Nuclear Medicine, Institut Jules Bordet, Université Libre de Bruxelles, Brussels, Belgium
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (2)
Tables (1)
Table 1. Articles of theragnosis with radiopharmaceuticals of the FAPI family.
Abstract

Neoplasms are composed of malignant tumor cells, which are surrounded by other non-tumor cellular elements, in what has been defined as the microenvironment or tumor stroma. Evidence on the importance of the tumor microenvironment has not stopped growing in recent years. It plays a central role in cell proliferation, tissue invasion, angiogenesis and cell migration.

The paradigm is the family of new FAPI radiopharmaceuticals that show the density of the fibroblast activation protein (FAP) which is overexpressed in the cell membrane of activated cancer-associated fibroblasts (CAF), and its presence is related to poor prognosis.

This educational document includes the procedure for performing PET/CT FAPI, biodistribution and the main potentially clinical applications in oncology to date.

Keywords:
FAPI
Tumoral microenvironment
PET/CT
Resumen

Las neoplasias se componen de células malignas tumorales, que se encuentran rodeadas de diversos elementos celulares no tumorales, que conforman el microambiente o estroma tumoral. La evidencia sobre la importancia del microambiente tumoral no ha parado de crecer en los últimos años ya que juega un papel necesario para la proliferación celular, invasión tisular, angiogénesis y migración celular.

El paradigma es la familia de los nuevos radiofármacos FAPI que nos muestran la densidad la proteína de activación de fibroblastos (FAP) que se encuentra sobreexpresada en la membrana celular de los fibroblastos activados asociados al cáncer (CAF), y su presencia está relacionada con un mal pronóstico.

En este documento de formación continuada se incluye el procedimiento para la realización de PET/TC con FAPI, la biodistribución y las potenciales aplicaciones clínicas en oncología publicadas hasta el momento.

Palabras clave:
FAPI
Microambiente tumoral
PET/TC

Article

These are the options to access the full texts of the publication Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Revista Española de Medicina Nuclear e Imagen Molecular (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos