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array:23 [ "pii" => "S2253654X15001262" "issn" => "2253654X" "doi" => "10.1016/j.remn.2015.08.012" "estado" => "S300" "fechaPublicacion" => "2016-03-01" "aid" => "739" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "copyrightAnyo" => "2015" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2016;35:131-2" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 197 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 116 "PDF" => 72 ] ] "itemSiguiente" => array:18 [ "pii" => "S2253654X15001316" "issn" => "2253654X" "doi" => "10.1016/j.remn.2015.09.004" "estado" => "S300" "fechaPublicacion" => "2016-03-01" "aid" => "744" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2016;35:133-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 445 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 317 "PDF" => 118 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting images</span>" "titulo" => "Pulmonary talcosis caused by methadone misuse and mimicking primary lung cancer. FDG-PET/CT findings" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "133" "paginaFinal" => "134" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Talcosis pulmonar por uso inadecuado de metadona que imita cáncer de pulmón. Hallazgos en FDG-PET/TC" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 975 "Ancho" => 1800 "Tamanyo" => 249667 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Sagittal whole-body PET (A), axial CT (B1, C1) and fused FDG-PET/CT images (B2, C2) showing focal areas of increased radiopharmaceutical uptake corresponding to a 3<span class="elsevierStyleHsp" style=""></span>cm pulmonary nodule in the left inferior lobe with a SUVmax of 6.6 (red arrows) and a subcarinal lymph node with a SUVmax of 3.6 (yellow arrows).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Carbonelli, C. Rapicetta, M. Casali, G. Treglia, F. Lococo" "autores" => array:5 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Carbonelli" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Rapicetta" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Casali" ] 3 => array:2 [ "nombre" => "G." "apellidos" => "Treglia" ] 4 => array:2 [ "nombre" => "F." "apellidos" => "Lococo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X15001316?idApp=UINPBA00004N" "url" => "/2253654X/0000003500000002/v1_201602190100/S2253654X15001316/v1_201602190100/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S2253654X15001158" "issn" => "2253654X" "doi" => "10.1016/j.remn.2015.08.003" "estado" => "S300" "fechaPublicacion" => "2016-03-01" "aid" => "728" "copyright" => "Elsevier España, S.L.U. and SEMNIM" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Rev Esp Med Nucl Imagen Mol. 2016;35:129-30" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 240 "formatos" => array:3 [ "EPUB" => 10 "HTML" => 139 "PDF" => 91 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imágenes de interés</span>" "titulo" => "Endocarditis infecciosa detectada mediante PET-TC con <span class="elsevierStyleSup">18</span>F-FDG en un paciente con bacteriemia por gram positivo de origen desconocido" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "130" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Infective endocarditis detected by <span class="elsevierStyleSup">18</span>F-FDG PET-CT in a patient with gram-positive bacteraemia of unknown origin" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 623 "Ancho" => 1500 "Tamanyo" => 168285 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudio PET-TC con <span class="elsevierStyleSup">18</span>F-FDG (Corte axial de TC, fusión PET-TC y PET: A-C) donde se visualiza un depósito patológico focal de radiotrazador (SUV<span class="elsevierStyleInf">máx</span> 4,9) en la porción posterior de la válvula mitral sugestivo de enfermedad inflamatoria-infecciosa activa en relación con endocarditis infecciosa; (Corte coronal: D) sin evidencia de otros hallazgos patológicos. Ecocardiograma transesofágico con un pseudoaneurisma perforado a nivel del velo posterior de la válvula mitral (E, G) e insuficiencia mitral severa con 2 <span class="elsevierStyleItalic">jets</span> de regurgitación, uno central y otro a través de la perforación (F), hallazgos de endocarditis sobre válvula mitral.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Jiménez-Ballvé, M.J. Pérez-Castejón, C. Sánchez-Enrique, I. Vilacosta, L. Lapeña-Gutiérrez, J.L. Carreras-Delgado" "autores" => array:6 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Jiménez-Ballvé" ] 1 => array:2 [ "nombre" => "M.J." "apellidos" => "Pérez-Castejón" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Sánchez-Enrique" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Vilacosta" ] 4 => array:2 [ "nombre" => "L." "apellidos" => "Lapeña-Gutiérrez" ] 5 => array:2 [ "nombre" => "J.L." "apellidos" => "Carreras-Delgado" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S2253808916000069" "doi" => "10.1016/j.remnie.2016.01.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253808916000069?idApp=UINPBA00004N" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X15001158?idApp=UINPBA00004N" "url" => "/2253654X/0000003500000002/v1_201602190100/S2253654X15001158/v1_201602190100/es/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Interesting image</span>" "titulo" => "Paediatric grade-II lymphomatoid granulomatosis: <span class="elsevierStyleSup">18</span>F-FDG PET/CT monitoring of disease activity" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "131" "paginaFinal" => "132" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Martínez-Esteve, R.M. Álvarez-Pérez, F.J. García-Gómez, I. Acevedo-Báñez, J.I. Cuenca-Cuenca, I. Borrego-Dorado" "autores" => array:6 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Martínez-Esteve" "email" => array:1 [ 0 => "andres.martinez.esteve@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "R.M." "apellidos" => "Álvarez-Pérez" ] 2 => array:2 [ "nombre" => "F.J." "apellidos" => "García-Gómez" ] 3 => array:2 [ "nombre" => "I." "apellidos" => "Acevedo-Báñez" ] 4 => array:2 [ "nombre" => "J.I." "apellidos" => "Cuenca-Cuenca" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Borrego-Dorado" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Medicina Nuclear, Hospital Universitario Virgen del Rocío, Sevilla, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Granulomatosis linfomatoide grado-II pediátrica: monitorización de la actividad de la enfermedad mediante <span class="elsevierStyleSup">18</span>F-FDG PET/TC" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1115 "Ancho" => 3250 "Tamanyo" => 128018 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/CT maximum intensity projections (MIP) showing the monitoring of disease activity in both lungs, which allows to modify the treatment in a paediatric patient with grade-II lymphomatoid granulomatosis. A) Staging MIP image shows extense and intense FDG metabolism in both lungs (SUVmax 16.5) corresponding to the known grade-II lymphoid granulomatosis. There is no other anatomo-metabolic evidence. B) Interim MIP image, after the introduction of treatment, domonstrates that lungs involvement has decreased in metabolism (SUVmax 8.8) and size, consistent with partial metabolic response. C) After neurologial decline and subsequent treatment, MIP image shows increased FDG uptake within both lungs, greater than that seen in the previous study, consistent with progression of disease, and allowing to start other chemotherapy regimen. D) and E) Interim and final MIP images show significant volume and metabolic decrease (SUVmax 4.4 and 2.9, respectively).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lymphomatoid granulomatosis (LYG) is a very rare, aggressive extranodal Epstein–Barr virus (EBV)-associated B-cell lymphoproliferative disease.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> It mainly affects the lungs but may have extrapulmonary manifestations, especially in the central nervous system. LYG is most commonly found in older patients, with less than 50 paediatric cases reported in the literature.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a> There are some reports describing <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose positron emission tomography/computed tomography (<span class="elsevierStyleSup">18</span>FDG PET/CT) useful for staging and monitoring treatment responses in patients with LYG. Due to the high mortality associated with LGY, high-dose chemotherapy, corticosteroid therapy, rituximab, immunotherapy and bone marrow or stem cells transplantation, have been tried.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> We report a 6-year-old boy newly diagnosed of grade-II LYG with active EBV infection involving lungs who underwent a staging <span class="elsevierStyleSup">18</span>F-FDG PET/CT that showed extensive bilateral hypermetabolic lung foci (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). A maximum standardized uptake value (SUVmax) of 16.5 was measured. No other abnormalities suggesting malignancy were found. Treatment was initiated with rituximab monotherapy according to some papers that reported encouraging outcomes in these patients. However, due to poor clinical response, the patient started an immunoglobulin plus rituximab–cyclophosphamide–vincristine–prednisone (R-COP) scheme. An interim <span class="elsevierStyleSup">18</span>F-FDG-PET/CT scan was performed 10 days following the second cycle of R-COP, achieving a partial metabolic response (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B, SUVmax: 8.8). However, neurological decline was observed and led to start an etoposide–prednisone–vincristine–cyclophosphamide–hydroxydaunorubicin (EPOCH) based line of treatment with progressive metabolic disease after the forth cycle (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C, SUVmax: 16.8). According to PET findings, a rituximab–fosfamide–carboplatin–etoposide (R-ICE) chemotherapy regimen was started with partial metabolic response and significant decrease in tumour volume in interim and final outcome (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D and E), reaching a SUVmax 4.4 and 2.9, respectively. An autologous hematopoietic stem cells transplantation was performed with no evidence of disease progression. The paediatric LYG is an extremely rare entity that develops during the treatment of leukaemia in half of the cases. We report the PET scans in a case of paediatric LYG in a previously healthy child. The <span class="elsevierStyleSup">18</span>F-FDG PET/CT is an efficient tool for LYG in diagnosis, staging and follow-up treatment monitoring.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0010" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1115 "Ancho" => 3250 "Tamanyo" => 128018 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FDG PET/CT maximum intensity projections (MIP) showing the monitoring of disease activity in both lungs, which allows to modify the treatment in a paediatric patient with grade-II lymphomatoid granulomatosis. A) Staging MIP image shows extense and intense FDG metabolism in both lungs (SUVmax 16.5) corresponding to the known grade-II lymphoid granulomatosis. There is no other anatomo-metabolic evidence. B) Interim MIP image, after the introduction of treatment, domonstrates that lungs involvement has decreased in metabolism (SUVmax 8.8) and size, consistent with partial metabolic response. C) After neurologial decline and subsequent treatment, MIP image shows increased FDG uptake within both lungs, greater than that seen in the previous study, consistent with progression of disease, and allowing to start other chemotherapy regimen. D) and E) Interim and final MIP images show significant volume and metabolic decrease (SUVmax 4.4 and 2.9, respectively).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphomatoid granulomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.A. Liebow" 1 => "C.R. Carrington" 2 => "P.J. Friedman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Pathol" "fecha" => "1972" "volumen" => "3" "paginaInicial" => "457" "paginaFinal" => "558" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4638966" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0025" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Childhood lymphomatoid granulomatosis: a report of 2 cases and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Z.C. Tacke" 1 => "M.J. Eikelenboom" 2 => "R.J. Vermeulen" 3 => "M.S. van der Knaap" 4 => "A.M. Euser" 5 => "P. ven der Valk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MPH.0000000000000090" "Revista" => array:6 [ "tituloSerie" => "J Pediatr Hematol Oncol" "fecha" => "2014" "volumen" => "36" "paginaInicial" => "e416" "paginaFinal" => "e422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24390446" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0030" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PET/CT characterization and monitoring of disease activity in lymphomatoid granulomatosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.C. Roarke" 1 => "B.D. Nguyen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.rlu.0000255247.66398.46" "Revista" => array:6 [ "tituloSerie" => "Clin Nucl Med" "fecha" => "2007" "volumen" => "32" "paginaInicial" => "258" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314617" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/2253654X/0000003500000002/v1_201602190100/S2253654X15001262/v1_201602190100/en/main.assets" "Apartado" => array:4 [ "identificador" => "7907" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Imágenes de interés" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/2253654X/0000003500000002/v1_201602190100/S2253654X15001262/v1_201602190100/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2253654X15001262?idApp=UINPBA00004N" ]
