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"apellidos" => "Cascini" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Neuroimaging PET/MRI Research Unit, Institute of Molecular Bioimaging and Physiology, Italian National Research Council, IBFM-CNR, Catanzaro, Italy" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Diagnostic Imaging, Nuclear Medicine Unit, Magna Graecia University, Catanzaro, Italy" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Department of Biomedicine and Prevention, University “Tor Vergata”, Rome, Italy" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Department of Nuclear Medicine and Molecular Imaging, IRCCS Neuromed, Pozzilli (IS), Italy" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Captación de <span class="elsevierStyleSup">64</span>Cu-PSMA en un meningioma: falso positivo de un radiofármaco prometedor" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1248 "Ancho" => 2067 "Tamanyo" => 280803 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Early PET/CT scan at 1 h: PET images (a, a’), CT (b) and PET/CT (b’). Late PET/CT scan at 4h: CT (c) and PET/CT (c’). MRI: T2-weighted (d) and T1-weighted (e) images. <span class="elsevierStyleSup">64</span>Cu-PSMA uptake in the neck corresponding to a hyperdense area in the foramen magnum on CT and a high signal intensity lesion with mild contrast enhancement on MRI. The final diagnosis was meningioma.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 64-year-old patient undergone <span class="elsevierStyleSup">64</span>Cu-Prostate-Specific-Membrane-Antigen (<span class="elsevierStyleSup">64</span>Cu-PSMA) Positron Emission Tomography/Computed Tomography (PET/CT) for rising PSA (0.46<span class="elsevierStyleHsp" style=""></span>ng/ml), 2 years after radical prostatectomy for prostate cancer (PC). Intense <span class="elsevierStyleSup">64</span>Cu-PSMA uptake (SUV<span class="elsevierStyleInf">max</span> 3.8) was detected in the early PET/CT scan (1<span class="elsevierStyleHsp" style=""></span>h after the tracer administration) in the neck (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> a, a′), corresponding to a slightly hyperdense area in the foramen magnum in co-registered CT and PET/CT views (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> b, b′). A late PET/CT, 4<span class="elsevierStyleHsp" style=""></span>h after the injection, confirmed unchanged uptake (SUV<span class="elsevierStyleInf">max</span> 3.9) in the lesion (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> c, c′). Considering this finding equivocal, a following Magnetic Resonance Imaging (MRI) diagnosed a high signal intensity lesion on T2-weighted view (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> d) with mild contrast enhancement on T1-weighted (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a> e) view. The diagnosis was meningioma.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The radiolabeled compounds of PSMA have been widely investigated in the management of PC patients, due to the specific link with PC: in fact, several studies emphasize the usefulness of radiolabeled PSMA PET/CT and PET/MRI in PC imaging.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Conversely, recent reports suggest the possibility of tracer uptake in some malignant conditions other than PC.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">2</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Therefore, similarly to other radiopharmaceuticals,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> caution is needed when observing abnormal sites of radiolabeled PSMA uptake, not related to PC. The molecular pathway on the basis of PSMA uptake in meningiomas could be due to angiogenesis, increased vascular permeability or faster cellular metabolism. Anyway, this feature still needs to be addressed.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Disclosure of funding</span><p id="par0025" class="elsevierStylePara elsevierViewall">The Authors declare that they did not received funding for this work by any of the following organizations: National Institutes of Health (NIH), Wellcome Trust, Howard Hughes Medical Institute (HHMI), or others.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest to declare.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Disclosure of funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1248 "Ancho" => 2067 "Tamanyo" => 280803 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Early PET/CT scan at 1 h: PET images (a, a’), CT (b) and PET/CT (b’). Late PET/CT scan at 4h: CT (c) and PET/CT (c’). MRI: T2-weighted (d) and T1-weighted (e) images. <span class="elsevierStyleSup">64</span>Cu-PSMA uptake in the neck corresponding to a hyperdense area in the foramen magnum on CT and a high signal intensity lesion with mild contrast enhancement on MRI. The final diagnosis was meningioma.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0020" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "PSMA ligands for radionuclide imaging and therapy of prostate cancer: clinical status" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Lütje" 1 => "S. Heskamp" 2 => "A.S. Cornelissen" 3 => "T.D. Poeppel" 4 => "S.A. van den Broek" 5 => "S. 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