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"apellidos" => "Beato Martínez" "email" => array:1 [ 0 => "ainhoilla@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "S." "apellidos" => "Ayala Mejías" ] 2 => array:2 [ "nombre" => "C." "apellidos" => "Molina Quirós" ] 3 => array:2 [ "nombre" => "M." "apellidos" => "Colmenero Ruiz" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Sanz Fernández" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Otorrinolaringología. Hospital Universitario de Getafe. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: C/ Enrique Granados 8 - portal F - 1º B 28224 Pozuelo de Alarcón. Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Sublingual immunotherapy in seasonal allergic rhinitis. Review of 30 cases" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2004-03-30" "fechaAceptado" => "2005-01-24" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec81060" "palabras" => array:4 [ 0 => "Sublingual" 1 => "Inmunoterapia" 2 => "Gramíneas" 3 => "Asma" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec81059" "palabras" => array:4 [ 0 => "Sublingual" 1 => "Immunotherapy" 2 => "Grass pollen" 3 => "Asthma" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La inmunoterapia es la administración de dosis crecientes del antígeno responsable del proceso alérgico para determinar una tolerancia inmunológica adecuada.</p> <span class="elsevierStyleSectionTitle">Pacientes y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se realiza un estudio descriptivo, transversal y retrospectivo en 30 pacientes diagnosticados de rinitis alérgica estacional, tratados con inmunoterapia sublingual. Se analizan una serie de variables (edad, género, síntomas, test cutáneo pre y posvacunación, tratamientos, evolución y efectos secundarios) con el programa estadístico SPS-S.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">El 90% presentaba síntomas moderados y el 10% síntomas severos y asma. Los alergenos más frecuentes fueron las gramíneas (33,3%). El 60% de los pacientes precisaba antihistamínicos y corticoides tópicos prevacunación. En el 80% no hubo efectos secundarios. La desensibilización completa ocurrió en el 53,3% de los pacientes y en el 73% hubo una mejoría clínica. El 54% de los casos no precisaba tratamiento posvacunación.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La inmunoterapia ha demostrado ser el único tratamiento curativo, siendo la vía sublingual una de las más aceptadas, ya que usa mayor dosis de alergeno, es bien tolerada, disminuye la sintomatología y la necesidad de tratamiento y los efectos secundarios son mínimos.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Specific immunotherapy consists in administering increasing doses of antigen, to which the patient is sensitive, to determine a protective immune response.</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A descriptive and retrospective review of 30 patients diagnosed of seasonal allergic rhinitis, all treated with specific immunotherapy. Data on age, gender, symptoms, prick test before and after the immunotherapy administration, drugs, efficacy and side effects, were recorded using the SPS-S statistical program.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">90% had moderated symptoms and 10% had severe symptoms and asthma. 33% were sensitized to grass pollen. 60% needed antihistamines and intranasal corticosteroids before the immunotherapy. In a lot of cases (80%) there were no side effects. The complete desensitization occurred in 53,3% and the reduction of symptoms in 73% of the cases. 54% of the patients didn’t need treatment after specific immunotherapy.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The specific immunotherapy is the only curative therapy. Sublingual therapy is one of the most accepted because is well tolerated, it uses a higher allergen concentration, it reduces the symptoms and the needs of drugs and side effects are uncommon.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:13 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sublingual swallow immunotherapy in the new world" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "T. 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Journal Information
Inmunoterapia sublingual en la rinitis alérgica estacional. Revisión de 30 pacientes
Sublingual immunotherapy in seasonal allergic rhinitis. Review of 30 cases
A. Beato Martínez1
, S. Ayala Mejías, C. Molina Quirós, M. Colmenero Ruiz, R. Sanz Fernández
Corresponding author
ainhoilla@yahoo.es
Correspondencia: C/ Enrique Granados 8 - portal F - 1º B 28224 Pozuelo de Alarcón. Madrid.
Correspondencia: C/ Enrique Granados 8 - portal F - 1º B 28224 Pozuelo de Alarcón. Madrid.
Servicio de Otorrinolaringología. Hospital Universitario de Getafe. Madrid