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Vol. 56. Issue 4.
Pages 143-146 (April 2005)
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Vol. 56. Issue 4.
Pages 143-146 (April 2005)
Estudio por inmunohistoquímica de la expresión de EGFR en carcinoma de células escamosas de cabeza y cuello
Immunohistochemistry study of EGFR expression in head and neck squamous cell carcinoma
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X. Altuna Mariezkurrena1,1, J. Algaba Guimerá1, J. Wang Rodríguez2, R. Weisman3, W. Ongkeko3
1 Servicio de Otorrinolaringología, Hospital Donostia, San Sebastián, España
2 Department of Pathology, University of California, San Diego y VA San Diego Healhcare System, San Diego, California, USA
3 Department of Surgery, Head and Neck division, University of California, San Diego, San Diego, California, USA
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Resumen

EGFR es un receptor transmembrana miembro de la familia de tirosín-kinasas que traduce señales tanto del exterior como del interior de la célula y juega un papel importante en numerosos procesos que afectan a la evolución del tumor, crecimiento, progresión, diferenciación, inhibición de apoptosis y al desarrollo de metástasis. Su expresión mediante inmunohistoquímica en carcinoma de células escamosas varía entre el 40-80% y se le ha adjudicado un valor pronóstico independiente en estos carcinomas. El objetivo del presente estudio es el de analizar por inmunohistoquímica la expresión de esta proteína en una serie de carcinomas epidermoides de cabeza y cuello y correlacionarlo con parámetros clínico-patológicos y supervivencia. Se realiza inmunohistoquímica de 44 muestras en las que el 41% es positivo. A pesar de no haber encontrado relación con el pronóstico de estos pacientes, la presencia de EGFR es muy importante por el hecho de que existen fármacos y agentes químicos capaces de inhibir su actividad.

Palabras clave:
Carcinoma de células escamosas de cabeza y cuello
EGFR
Inmunohistoquímica
Abstract

EGFR is an important transmembrane receptor member of the family of tyrosine kinases, that translates signals from both outside and inside the cell and plays a key role in numerous proceses that affect tumour development, growth, progresion, differentiation, inhibition of apoptosis and metastasis. Immunohistochemistry studies have shown that 40-80% of head and neck squamous cell carcinomas express EGFR and it has been suggested as a potential independent prognostic parameter. The objective of this study is to evaluate by immunohistochemistry the expresión of EGFR in a series of Head and Neck Squamous Cell Carcinoma and correlate it to clinico-pathological features and prognostic significance. We investigated expression of EGFR in 44 samples. There was a high expression in 41% of the cases. Even if we have not found that the expression of EGFR correlated with the prognosis of these patients the presence of EGFR is very important because there are chemical agents or drugs that can inhibit its activity.

Keywords:
Head and Neck Squamous Cell Carcinoma
EGFR
Immunohistochemistry

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