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Vol. 58. Issue 4.
Pages 156-163 (January 2007)
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Vol. 58. Issue 4.
Pages 156-163 (January 2007)
Tumour Recurrence in Squamous Head and Neck Cancer
Recidivas en el cáncer escamoso de cabeza y cuello
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César Antonio Álvarez Marcosa,
Corresponding author
alvarezmarcos@telefonica.net

Correspondence: Las Alondras, 19. 33013 Oviedo. Asturias. España.
, José Luis Llorente Pendásb, Virginia Franco Gutiérrezb, Humberto Fernández Espinaa, Marta Alonso Guervósc, Carlos Suárez Nietoc, Mario Hermsenc
a Servicio de Otorrinolaringología, Hospital Valle del Nalón, Riaño-Langreo, Asturias, Spain
b Servicio de Otorrinolaringología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain
c Instituto Universitario de Oncología del Principado de Asturias, Oviedo, Asturias, Spain
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Introduction

For most patients with squamous head and neck cancer (HN-SCC), locoregional tumour recurrence (TR) carries an extremely poor prognosis and is therapeutically challenging.

Objective

To define the clinical aspects of TR and their implication on the survival in patients with HN-SCC.

Patients and method

The clinical management and the outcome of 652 patients with HN-SCC were reviewed.

Results

The overall incidence of TR in this series of HN-SCC was 19.9% (n=130). The most frequent locations of the primary cancers were oropharynx (32%), hypopharynx (24%), and oral cavity (21%). The rates of recurrence were locoregional 50%, local 43% and stomal recurrence 7%. The appearance of a TR reduces the overall survival of patients with HN-SCC to 15%. Survival is better in glottic (38%) and supraglottic (27%), carcinomas, and worse in oro-hypopharynx tumours (2-4%).

Conclusions

RT are more frequent in pharyngeal tumours, especially locoregional recurrences. Patients with recurrence in pharynx were definitely associated with poor prognosis and in these cases salvage surgery seems not to improve survival rates.

Key words:
Head and neck cancer
Squamous cell carcinoma
Local recurrence
Locoregional recurrence
Survival
Introducción

Las recidivas tumorales (RT) causan elevada mortalidad en los pacientes con cáncer escamoso de cabeza y cuello (CECC) y complican mucho la actitud terapéutica.

Objetivo

Describir los aspectos clínicos de las RT y su implicación en la supervivencia.

Pacientes y método

Se revisa a 652 pacientes con CECC y se recoge las características clínicas de las RT observadas.

Resultados

Las RT se presentaron en el 19,9% (130 pacientes) de nuestra serie de CECC. Las localizaciones más frecuentes son mesofaringe (32%), hipofaringe (24%) y cavidad oral (21%). El 50% de las RT son de carácter locorregional; el 43%, locales, y el 7%, estomales. La aparición de una RT reduce al 15% la supervivencia general de los pacientes con CECC, es mayor en la laringe glótica (38%) y la supraglótica (27%), y baja al 2-4% en mesofaringe e hipofaringe.

Conclusiones

Las RT son más frecuentes en tumores faríngeos y de tipo locorregional. El pronóstico en esta localización es muy malo y el tratamiento de rescate apenas modifica la supervivencia.

Palabras clave:
Cáncer de cabeza y cuello
Carcinoma escamoso
Recidivas locales
Recidivas locorregionales
Supervivencia

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