metricas
covid
Buscar en
Actas Urológicas Españolas (English Edition)
Toda la web
Inicio Actas Urológicas Españolas (English Edition) Impact of adipose tissue distribution on prostate cancer recurrence after radica...
Journal Information
Vol. 47. Issue 2.
Pages 104-110 (March 2023)
Share
Share
Download PDF
More article options
Visits
5
Vol. 47. Issue 2.
Pages 104-110 (March 2023)
Original article
Impact of adipose tissue distribution on prostate cancer recurrence after radical prostatectomy
Impacto de la distribución del tejido adiposo en la recidiva del cáncer de próstata tras la prostatectomía radical
Visits
5
D. Vertullia, D. Santuccia, F. Espertob, B. Beomonte Zobela, R.F. Grassoa, E. Faiellaa,
Corresponding author
e.faiella@unicampus.it

Corresponding author.
a Department of Radiology, University of Rome, Campus Bio-medico, Rome, Italy
b Department of Urology, University of Rome, Campus Bio-medico, Rome, Italy
This item has received
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (5)
Show moreShow less
Tables (2)
Table 1. Distribution of GS, pT and Histology in the recurrence group (A) and in control group (B).
Table 2. Mean, median value and range of VAT, SCAT, TAT, PPAT and time passed between RP and BCR in the group with recurrence and in the control group.
Show moreShow less
Abstract
Objective

The aim of our study is to correlate the CT adipose tissue distribution and recurrence risk of Prostatic Cancer (PCa) after Radical Prostatectomy (RP). Furthermore, we evaluated the association of adipose tissue and PCa aggressiveness.

Materials and methods

We identified two groups of patients based on presence (group A) and absence (group B or control group) of Bio-chemical Recurrence (BCR) after RP. A semi-automatic function able to recognize the typical attenuation values of adipose tissue was used for sub-cutaneous (SCAT), visceral (VAT), total (TAT) and periprostatic (PPAT) adipose tissues. For both groups of patients, a descriptive analysis of continuous variables and categorical variables was performed.

Results

After comparing between groups, a statistically significant difference was found for VAT (p<0.001) and for VAT/TAT ratio (p=0.013). No statistically significant correlation was found for PPAT and SCAT, even if higher values were found in patients with high grade tumors.

Conclusion

This study confirms visceral adipose tissue as a quantitative imaging parameter related to oncological risk of PCa recurrence development, and the role of abdominal fat distribution measured with CT before RP as an important tool to predict the PCa recurrence risk, particularly in patients with high grade tumors.

Keywords:
mp-MRI
Prostate cancer
PCa recurrence
Resumen
Objetivo

El objetivo de nuestro estudio es correlacionar la distribución del tejido adiposo en la TC y el riesgo de recurrencia del cáncer de próstata (CaP) después de la prostatectomía radical (PR). Además, evaluamos la asociación del tejido adiposo y la agresividad del CaP.

Materiales y métodos

Identificamos dos grupos de pacientes en función de la presencia (grupo A) y la ausencia (grupo B o grupo de control) de recidiva bioquímica (RBQ) tras la PR. Se utilizó una función semiautomática capaz de reconocer los valores de atenuación típicos del tejido adiposo para el tejido adiposo subcutáneo (TAS), visceral (TAV), total (TAT) y periprostático (TAP). Para ambos grupos de pacientes se realizó un análisis descriptivo de las variables continuas y categóricas.

Resultados

Al comparar los dos grupos, hubo una diferencia estadísticamente significativa para el TAV (p<0,001) y para la proporción TAV/TAT (p=0,013). No se encontró una correlación estadísticamente significativa para el TAP y el TAS, aunque se encontraron valores más altos en los pacientes con tumores de grado alto.

Conclusión

Este estudio confirma que el tejido adiposo visceral es un parámetro de imagen cuantitativo relacionado con el riesgo oncológico de desarrollo de recidiva del CaP, y el papel de la distribución de la grasa abdominal en la TC antes de la PR como una herramienta importante en la predicción del riesgo de recidiva del CaP, particularmente en pacientes con tumores de alto grado.

Palabras clave:
RMmp
Cáncer de próstata
Recidiva del CaP

Article

These are the options to access the full texts of the publication Actas Urológicas Españolas (English Edition)
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Actas Urológicas Españolas (English Edition)

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
E-mail
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos