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Inicio Actas Urológicas Españolas (English Edition) New perspectives of treatment with fesoterodine fumarate in patients with overac...
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Vol. 37. Issue 2.
Pages 83-91 (February 2013)
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Vol. 37. Issue 2.
Pages 83-91 (February 2013)
Original article
New perspectives of treatment with fesoterodine fumarate in patients with overactive bladder
Nuevas perspectivas de tratamiento con el fumarato de fesoterodina en pacientes con vejiga hiperactiva
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R. García-Baqueroa,
Corresponding author
rgbaquero@hotmail.com

Corresponding author.
, B. Madurgaa, M.V. Garcíab, M.A. Fernándezb, J.M. Rosetya, J.L. Álvarez-Ossorioa
a Unidad de Urología Funcional, Unidad de Gestión Clínica de Urología, Hospital Universitario Puerta del Mar, Cádiz, Spain
b Servicio de Medicina Preventiva, Hospital Universitario Puerta del Mar, Cádiz, Spain
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Table 1. Characteristics of the study population.
Abstract
Objective

To evaluate the effect of the treatment with fesoterodine fumarate in patients with overactive bladder, as an alternative in case of failure of the usual anticholinergic treatment, due to either lack of therapeutic efficacy or intolerance to side effects.

Material and method

A retrospective review of 158 patients with overactive bladder was carried out. The patients were divided into two groups: the first group consisting of 56 patients where the anticholinergic treatment was shown to be ineffective, and the second group; 102 patients who presented intolerance to anticholinergic side effects.

Results

For the first group where fesoterodine fumarate was used to improve effectiveness of the anticholinergics, improvement in the components of urinary urgency (p=0.001), insufficient emptying (p=0.001), incontinence (p=0.009), and in the number of pads/day (p<0.001) was detected. As to the second group where fesoterodine fumarate was used as an alternative to anticholinergics to avoid side effects, a high reduction in the incidence of dry mouth (p<0.001) and constipation (p=0.015) was seen, as well as a significant clinical improvement.

Conclusion

Fesoterodine fumarate is an optimal treatment option when the clinical response to anticholinergics has not been satisfactory, either by the lack of therapeutic action or by intolerance to side effects, and especially when the treatment is expected to be long.

Keywords:
Fesoterodine
Intolerance
Overactive bladder
Resumen
Objetivos

Valorar el efecto del empleo del fumarato de fesoterodina como rescate ante un tratamiento previo fallido con anticolinérgicos en pacientes con vejiga hiperactiva, por falta de efectividad terapéutica o por intolerancia a los efectos secundarios.

Material y métodos

Revisión retrospectiva de 158 pacientes afectos de vejiga hiperactiva que se distribuyeron en 2 grupos, uno donde el fumarato de fesoterodina se empleó como rescate ante una inefectividad del anticolinérgico previo (n=56) y otro donde se empleó ante una intolerancia manifiesta al mismo (n=102).

Resultados

En el grupo en el que se empleó como rescate a una inefectividad, se apreció una mejoría en los componentes de urgencia miccional (p=0,001), vaciado insuficiente (p=0,001) eincontinencia de esfuerzo (p=0,009), y en el número de compresas/día (p<0,001). En el grupo en el que se empleó como fármaco de segunda línea ante efectos secundarios a otros anticolinérgicos se apreció una reducción en la incidencia de sequedad de boca (p<0,001) y de estreñimiento (p=0,015), además de una mejora clínica significativa.

Conclusiones

El fumarato de fesoterodina es una alternativa de tratamiento válida si los resultados con otros anticolinérgicos previamente no han sido satisfactorios, bien sea por falta de efecto terapéutico esperado, bien por intolerancia a los efectos secundarios, sobre todo cuando el tratamiento se plantea prolongado.

Palabras clave:
Fesoterodina
Intolerancia
Vejiga hiperactiva

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