Role of PET-CT with <span class="elsevierStyleSup">18</span>F-fluorocholine in biochemical recurrence after treatment of prostate cancer with curative intent | Actas Urológicas Españolas (English Edition)

 array:24 [
  "pii" => "S2173578617300902"
  "issn" => "21735786"
  "doi" => "10.1016/j.acuroe.2017.06.002"
  "estado" => "S300"
  "fechaPublicacion" => "2017-09-01"
  "aid" => "979"
  "copyright" => "AEU"
  "copyrightAnyo" => "2017"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "fla"
  "cita" => "Actas Urol Esp. 2017;41:437-44"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 1
    "HTML" => 1
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S0210480617300426"
      "issn" => "02104806"
      "doi" => "10.1016/j.acuro.2017.02.002"
      "estado" => "S300"
      "fechaPublicacion" => "2017-09-01"
      "aid" => "979"
      "copyright" => "AEU"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "fla"
      "cita" => "Actas Urol Esp. 2017;41:437-44"
      "abierto" => array:3 [
        "ES" => false
        "ES2" => false
        "LATM" => false
      ]
      "gratuito" => false
      "lecturas" => array:2 [
        "total" => 78
        "formatos" => array:2 [
          "HTML" => 67
          "PDF" => 11
        ]
      ]
      "es" => array:13 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Art&#237;culo original</span>"
        "titulo" => "Papel de la tomograf&#237;a por emisi&#243;n de positrones-tomograf&#237;a computerizada con <span class="elsevierStyleSup">18</span>F-fluorocolina en la recidiva bioqu&#237;mica tras tratamiento con intenci&#243;n curativa del c&#225;ncer de pr&#243;stata"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:2 [
          0 => "es"
          1 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "437"
            "paginaFinal" => "444"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Role of PET-CT with <span class="elsevierStyleSup">18</span>F-fluorocholine in biochemical recurrence after treatment of prostate cancer with curative intent"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1625
                "Ancho" => 3102
                "Tamanyo" => 160544
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A&#46; Curva ROC mostrando capacidad discriminante de la cifra de PSA trigger entre PET-TC <span class="elsevierStyleSup">18</span>F-FCH negativo y positivo&#46; El mejor punto de corte para el PSA trigger fue 3&#44;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; que discrimin&#243; correctamente al 73&#37; de los pacientes con una sensibilidad del 70&#37; y una especificidad del 78&#37;&#46; B&#46; Curva ROC mostrando capacidad discriminante de la cifra de PSAva entre PET-TC <span class="elsevierStyleSup">18</span>F-FCH negativo y positivo&#46; El mejor puno de corte para el PSAva fue de 0&#44;25<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#47;mes&#44; que discrimin&#243; correctamente al 72&#37; de los pacientes con una sensibilidad y una especificidad del 72&#37; y 63&#37;&#44; respectivamente&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "I&#46; Puche-Sanz, E&#46; Trivi&#241;o-Ib&#225;&#241;ez, F&#46; V&#225;zquez-Alonso, J&#46;M&#46; Llamas-Elvira, J&#46;M&#46; C&#243;zar-Olmo, A&#46; Rodr&#237;guez-Fern&#225;ndez"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "I&#46;"
                "apellidos" => "Puche-Sanz"
              ]
              1 => array:2 [
                "nombre" => "E&#46;"
                "apellidos" => "Trivi&#241;o-Ib&#225;&#241;ez"
              ]
              2 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "V&#225;zquez-Alonso"
              ]
              3 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "Llamas-Elvira"
              ]
              4 => array:2 [
                "nombre" => "J&#46;M&#46;"
                "apellidos" => "C&#243;zar-Olmo"
              ]
              5 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Rodr&#237;guez-Fern&#225;ndez"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S2173578617300902"
          "doi" => "10.1016/j.acuroe.2017.06.002"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => false
            "ES2" => false
            "LATM" => false
          ]
          "gratuito" => false
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578617300902?idApp=UINPBA00004N"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480617300426?idApp=UINPBA00004N"
      "url" => "/02104806/0000004100000007/v1_201708260049/S0210480617300426/v1_201708260049/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S2173578617300914"
    "issn" => "21735786"
    "doi" => "10.1016/j.acuroe.2017.06.003"
    "estado" => "S300"
    "fechaPublicacion" => "2017-09-01"
    "aid" => "951"
    "copyright" => "AEU"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "fla"
    "cita" => "Actas Urol Esp. 2017;41:445-50"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1
      "HTML" => 1
    ]
    "en" => array:13 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
      "titulo" => "Experimental murine model of renal cancer"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "445"
          "paginaFinal" => "450"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Modelo murino experimental de c&#225;ncer renal"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0010"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr2.jpeg"
              "Alto" => 1078
              "Ancho" => 1504
              "Tamanyo" => 71938
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Realization of the second implant&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "B&#46; Padilla-Fern&#225;ndez, M&#46;B&#46; Garc&#237;a-Cenador, P&#46; Rodr&#237;guez-Marcos, J&#46;F&#46; L&#243;pez-Marcos, P&#46; Ant&#250;nez-Plaza, J&#46;M&#46; Silva-Abu&#237;n, D&#46; L&#243;pez-Monta&#241;&#233;s, F&#46;J&#46; Garc&#237;a-Criado, M&#46;F&#46; Lorenzo-G&#243;mez"
          "autores" => array:9 [
            0 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Padilla-Fern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "M&#46;B&#46;"
              "apellidos" => "Garc&#237;a-Cenador"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Rodr&#237;guez-Marcos"
            ]
            3 => array:2 [
              "nombre" => "J&#46;F&#46;"
              "apellidos" => "L&#243;pez-Marcos"
            ]
            4 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Ant&#250;nez-Plaza"
            ]
            5 => array:2 [
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Silva-Abu&#237;n"
            ]
            6 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "L&#243;pez-Monta&#241;&#233;s"
            ]
            7 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Garc&#237;a-Criado"
            ]
            8 => array:2 [
              "nombre" => "M&#46;F&#46;"
              "apellidos" => "Lorenzo-G&#243;mez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210480616302030"
        "doi" => "10.1016/j.acuro.2016.11.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480616302030?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578617300914?idApp=UINPBA00004N"
    "url" => "/21735786/0000004100000007/v1_201708260050/S2173578617300914/v1_201708260050/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S2173578617300896"
    "issn" => "21735786"
    "doi" => "10.1016/j.acuroe.2016.08.009"
    "estado" => "S300"
    "fechaPublicacion" => "2017-09-01"
    "aid" => "917"
    "copyright" => "AEU"
    "documento" => "simple-article"
    "crossmark" => 1
    "subdocumento" => "dis"
    "cita" => "Actas Urol Esp. 2017;41:435-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1
      "HTML" => 1
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Commentary</span>"
      "titulo" => "Comment to &#8220;Benign prostatic hyperplasia and lower urinary tract symptoms&#46; A review of current evidence&#8221;"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "435"
          "paginaFinal" => "436"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Comentario editorial a &#171;Hiperplasia prost&#225;tica benigna y s&#237;ntomas del tracto urinario inferior&#46; Revisi&#243;n de las evidencias actuales&#187;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "A&#46; Alc&#225;ntara Montero"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Alc&#225;ntara Montero"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0210480616301243"
        "doi" => "10.1016/j.acuro.2016.08.004"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => false
          "ES2" => false
          "LATM" => false
        ]
        "gratuito" => false
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0210480616301243?idApp=UINPBA00004N"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578617300896?idApp=UINPBA00004N"
    "url" => "/21735786/0000004100000007/v1_201708260050/S2173578617300896/v1_201708260050/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>"
    "titulo" => "Role of PET-CT with <span class="elsevierStyleSup">18</span>F-fluorocholine in biochemical recurrence after treatment of prostate cancer with curative intent"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "437"
        "paginaFinal" => "444"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "I&#46; Puche-Sanz, E&#46; Trivi&#241;o-Ib&#225;&#241;ez, F&#46; V&#225;zquez-Alonso, J&#46;M&#46; Llamas-Elvira, J&#46;M&#46; C&#243;zar-Olmo, A&#46; Rodr&#237;guez-Fern&#225;ndez"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "I&#46;"
            "apellidos" => "Puche-Sanz"
            "email" => array:1 [
              0 => "nacho&#46;puchesanz&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "E&#46;"
            "apellidos" => "Trivi&#241;o-Ib&#225;&#241;ez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "V&#225;zquez-Alonso"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "Llamas-Elvira"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "J&#46;M&#46;"
            "apellidos" => "C&#243;zar-Olmo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Rodr&#237;guez-Fern&#225;ndez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "UGC Urolog&#237;a&#44; Complejo Hospitalario Universitario de Granada&#44; Instituto de Investigaci&#243;n Biosanitaria IBS Granada &#40;IBS Granada Bio-Health Research Institute&#41;&#44; Granada&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "UGC Medicina Nuclear&#44; Complejo Hospitalario Universitario de Granada&#44; Granada&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Papel de la tomograf&#237;a por emisi&#243;n de positrones-tomograf&#237;a computerizada con <span class="elsevierStyleSup">18</span>F-fluorocolina en la recidiva bioqu&#237;mica tras tratamiento con intenci&#243;n curativa del c&#225;ncer de pr&#243;stata"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1641
            "Ancho" => 3102
            "Tamanyo" => 149841
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; ROC curve showing discriminant capacity of the trigger PSA number between negative and positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46; The best cut-off point for the trigger PSA was 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; which correctly discriminated 73&#37; of patients with a sensitivity of 70&#37; and a specificity of 78&#37;&#46; &#40;B&#41; ROC curve showing discriminant capacity of PSArr between negative and positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46; The best cut-off point for PSArr was 0&#46;25<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#47;month&#44; which correctly discriminated 72&#37; of patients with a sensitivity and specificity of 72&#37; and 63&#37;&#44; respectively&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Prostate cancer &#40;PCa&#41; is one of the main health problems in men&#44; and one of the 3 malignancies with the highest incidence and mortality in Spain&#46;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">1</span></a> Despite the high cure rates of radical treatments&#44; radical prostatectomy &#40;RP&#41; or external radiotherapy &#40;ERT&#41;&#44; approximately 1 in 4 patients will experience a relapse or recurrence of the disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">2&#44;3</span></a> Monitoring of prostate specific antigen &#40;PSA&#41; figures is currently the most commonly used tool during follow-up to detect a possible biochemical recurrence &#40;BR&#41;&#46; Once the BR is diagnosed&#44; it is crucial to determine if the PSA elevation is clinically significant and if this potential tumor recurrence is local or systemic&#44; since on this will depend the attitude to be followed&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">At present&#44; neither PSA figures nor conventional imaging techniques &#40;bone scans&#44; computed tomography&#44; magnetic resonance imaging&#41; have proved to be useful for correctly staging the disease in these patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#8211;6</span></a> Therefore&#44; in the last years&#44; several studies have tried to determine the role of functional imaging techniques such as <span class="elsevierStyleSup">18</span>F-fluorocoline &#40;<span class="elsevierStyleSup">18</span>F-FCH&#41; PET-CT in this clinical setting&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">The main objective of our study was to analyze the ability of PET-CT with <span class="elsevierStyleSup">18</span>F-FCH to detect disease at the time of BR of PCa after initial treatment with curative intent&#46; As a secondary objective&#44; we try to determine which clinical variables are capable of optimizing the diagnostic yield of the test&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material and methods</span><p id="par0020" class="elsevierStylePara elsevierViewall">Retrospective study of all <span class="elsevierStyleSup">18</span>F-FCH PET-CTs performed to patients with PCa at our center from January 2010 to October 2012&#46; Only those patients who had received initial treatment with curative intent &#40;RP&#44; ERT&#44; brachytherapy&#41;&#44; fulfilled at the time of PET-CT criteria of BR according to the updated guidelines of the European Association of Urology&#44; and had collected the clinical&#44; pathological&#44; and imaging information necessary for the validation of the results were selected&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The protocol of our center for <span class="elsevierStyleSup">18</span>F-FCH PET-CT scanning was always the same and consisted of&#58; 4&#8211;6<span class="elsevierStyleHsp" style=""></span>h of previous fasting&#44; bladder catheterization immediately before the test if it is estimated to be accurate&#44; and administration of 4<span class="elsevierStyleHsp" style=""></span>Mb&#47;kg of <span class="elsevierStyleSup">18</span>F-fluoromethylcholine&#44; which is supplied by IBA Molecular Spain&#46; PET-CT images were obtained with a Siemens Biograph 16 equipment &#40;Knoxville&#44; Tennessee&#41;&#46; The protocol of their acquisition consisted of&#58; precocious image of the pelvis at 2&#8211;5<span class="elsevierStyleHsp" style=""></span>min postinjection of the radiotracer &#40;2 beds&#44; 3&#8211;4<span class="elsevierStyleHsp" style=""></span>min&#47;bed&#41; and at 15&#8211;30<span class="elsevierStyleHsp" style=""></span>min postinjection an image from the orbitomeatal line to the upper third of the lower limbs &#40;6&#8211;7<span class="elsevierStyleHsp" style=""></span>beds&#44; 3&#8211;4<span class="elsevierStyleHsp" style=""></span>min&#47;bed&#41;&#46; In addition&#44; late pelvic imaging was performed in all patients at 45&#8211;60<span class="elsevierStyleHsp" style=""></span>min postinjection&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">All images were visualized by 2 observers specialists in nuclear medicine&#46; The final results of the <span class="elsevierStyleSup">18</span>F-FCH PET-CT study were categorized as positive or negative&#44; considering as positive those deposits with activity above the background and not explained by physiological phenomena&#46; In the cases of inter-observer discrepancies&#44; the final result of <span class="elsevierStyleSup">18</span>F-FCH PET-CT was reassessed and agreed between both professionals&#46; The positive results were validated according to the results in other imaging techniques and&#47;or clinical follow-up for a minimum of 6 months&#46; All <span class="elsevierStyleSup">18</span>F-FCH PET-CT negative studies were considered as false negatives of the examination&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The relationship between <span class="elsevierStyleSup">18</span>F-FCH PET-CT results and different quantitative and qualitative clinical variables was studied&#44; and an attempt was made to establish a PSA cut-off point as a predictor of the test result&#46; As quantitative clinical variables&#44; we collected&#58; age and PSA figure at the time of initial diagnosis of the disease by biopsy &#40;initial PSA&#41;&#44; lower PSA after radical treatment &#40;PSA nadir&#41;&#44; PSA at the time of PET-CT &#40;PSA trigger&#41;&#44; PSA rise rate &#40;PSArr&#41;&#44; and PSA doubling time &#40;PSAdt&#41;&#44; which was calculated using the computer tool downloadable from the Memorial Sloan-Kettering Cancer Center website &#40;<a href="http://www.mskkc.org/">www&#46;mskkc&#46;org</a>&#41;&#46; As qualitative clinical variables&#44; we collected&#58; T stage&#44; N stage&#44; Gleason score&#44; type of initial radical treatment&#44; whether or not they received second treatment&#44; and whether or not they underwent hormonal treatment at the time of the examination&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In addition&#44; the relationship between metastatic sites in <span class="elsevierStyleSup">18</span>F-FCH PET-CT and the rest of variables was analyzed&#44; and the presence of independent predictive factors associated with the <span class="elsevierStyleSup">18</span>F-FCH PET-CT positive result was studied&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">For the statistical analysis&#44; the SPSS 15&#46;0 software &#40;SPSS Inc&#46;&#44; Chicago&#44; IL&#41; was used&#46; To analyze the association of qualitative data&#44; the Chi-square test or Fisher&#39;s exact test was used&#46; For the comparison of quantitative data between the 2 groups of <span class="elsevierStyleSup">18</span>F-FCH PET-CT results &#40;positive&#47;negative&#41;&#44; Student&#39;s &#8216;<span class="elsevierStyleItalic">t</span>&#8217; was used for parametric independent data and Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> for non-parametric ones&#46; For the comparison of quantitative data according to the final result of <span class="elsevierStyleSup">18</span>F-FCH PET-CT by locations&#44; the analysis of variance &#40;ANOVA&#41; or the Kruskal&#8211;Wallis test was used&#44; depending on the distribution of the data&#44; applying the Bonferroni correction for multiple comparisons&#46; To evaluate the discriminant capacity of the PSA with respect to the <span class="elsevierStyleSup">18</span>F-FCH PET-CT result&#44; the area under the ROC curve was studied&#44; estimating a 95&#37; confidence interval and establishing the best cut-off point&#46; Finally&#44; uni&#47;multivariate binary logistic regression was used to establish independent factors associated with the <span class="elsevierStyleSup">18</span>F-FCH PET-CT result&#46; All statistical tests were considered bilateral and significant with a <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Results</span><p id="par0050" class="elsevierStylePara elsevierViewall">A total of 61 patients who met all the selection criteria were included in the study&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the clinical characteristics of these patients&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleSup">18</span>F-FCH PET-CT identified and located the disease &#40;PET-CT positive&#41; in 21 of the 61 patients&#44; which resulted in a global detection rate of 34&#46;4&#37;&#46; All positive studies were validated as such&#58; in 11 patients &#40;42&#46;4&#37;&#41; according to the PSA evolution in the clinical follow-up for a minimum of 6 months and in 10 patients &#40;47&#46;6&#37;&#41; according to the outcome in other imaging tests &#40;CT&#44; scintigraphy&#44; and&#47;or MRI&#41;&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">When analyzing the associations between the qualitative clinical characteristics of the patients and the positive&#47;negative results of <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#44; we observed that only the type of initial treatment showed significant differences&#44; with a greater probability of positive results in those patients treated with ERT or brachytherapy compared to those who had undergone radical surgery &#40;62&#46;5&#37; vs 3&#46;5&#37;&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Regarding the quantitative variables&#44; we observed that the initial PSA&#44; PSA nadir&#44; trigger PSA&#44; and PSArr presented statistically significant differences according to the result of <span class="elsevierStyleSup">18</span>F-FCH PET-CT &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#41;&#46; The ability of both trigger PSA and PSArr to differentiate between a positive and negative result from <span class="elsevierStyleSup">18</span>F-FCH PET-CT was studied&#44; finding that the best discriminatory cut-off point for the trigger PSA was 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; and for the PSArr 0&#46;25<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#47;month &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">By sites in 9 patients &#40;14&#46;8&#37;&#41;&#44; the disease was limited to the prostate or prostatectomy bed&#59; lymph node disease was detected in 7 patients &#40;11&#46;5&#37;&#41; and in 5 patients &#40;8&#46;2&#37;&#41; there was evidence of metastatic bone or visceral disease&#46; When studying the PSAdt with regard to the location of the disease&#44; we observed that this was significantly lower in patients with distant disease compared to patients with localized disease in the prostate bed &#40;5&#46;1 vs 16&#46;8 months&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; In addition&#44; among patients with a PSAdt<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>6 months&#44; the proportion of patients with distant disease was significantly higher than that of patients with localized disease&#44; thereby estimating that the probability of <span class="elsevierStyleSup">18</span>F-FCH PET-CT detecting distant disease was 3&#46;2 times greater when PSAdt was &#60;6 months &#40;80&#37; vs 20&#37;&#44; OR&#58; 3&#46;2&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#46; The trigger PSA also showed a significant relationship with the disease localization&#44; being significantly higher in patients with distant disease than those with localized disease or without evidence of disease &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0075" class="elsevierStylePara elsevierViewall">In the multivariate analysis by binary logistic regression&#44; only the initial PSA number and the fact of not receiving treatment with radical prostatectomy proved to be independent predictors of positive outcome &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Discussion</span><p id="par0080" class="elsevierStylePara elsevierViewall">Prostate cancer is the second leading cause of cancer death in men older than 50&#44; with a mortality of 30&#46;6 per 100&#44;000 inhabitants and year&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">7</span></a> After initial radical treatment&#44; tumor recurrence is frequent and is assessed by a progressive increase in PSA numbers&#44; which typically precedes detectable clinical recurrence&#46; The management of the patient in this situation depends fundamentally on whether the disease is confined to the prostate bed or if there is distant disease&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">The low sensitivity of conventional imaging techniques in this clinical scenario<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">4&#8211;6</span></a> has led to the development of functional imaging techniques &#40;PET-CT&#41; as powerful tools for the detection of tumor recurrence&#46; In parallel with their development&#44; the appearance of new radiotracers has extended their indications&#46; Of all the new tracers evaluated in PCa&#44; <span class="elsevierStyleSup">11</span>C or <span class="elsevierStyleSup">18</span>F-labeled choline&#44; a substrate for the synthesis of phosphatidylcholine &#40;cell membrane phospholipid&#41;&#44; is the one that has shown the most promising results&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">8</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">In recent years&#44; several studies have shown that PET-CT with choline is particularly useful in the restaging of patients with PCa who are in a situation of biochemical recurrence after radical treatment&#44;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">9&#8211;13</span></a> with a disease detection rate higher than conventional imaging techniques&#46; A recent multicenter study carried out by the PET-Oncology group of the Spanish Society of Nuclear Medicine and Molecular Imaging showed that PET-CT with <span class="elsevierStyleSup">18</span>F-FCH was able to detect disease in 47&#37; of 374 patients in a situation of biochemical relapse after radical treatment with RP or ERT&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">14</span></a> In our series&#44; the disease detection rate was close to 35&#37;&#46; The literature on this subject is heterogeneous&#44; with an overall sensitivity reported between 38 and 98&#37;&#46;<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">15&#8211;20</span></a> This high discrepancy is attributable to the diversity of criterion used for the selection of patients &#40;according to previous treatment&#44; trigger PSA cut-off point&#44; presence or absence of concomitant hormonal treatment&#41; as well as the different validation criteria of PET-CT&#46; Early studies<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">15&#44;16</span></a> reported very high disease detection rates &#40;70&#37;&#41;&#44; as they included patients with advanced metastatic disease and elevated PSA figures&#46; However&#44; the first large prospective study with choline PET-CT to restage PCa patients showed a much lower detection rate&#44; of 47&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">17</span></a> More recently&#44; the group of Giovacchini et al&#46;&#44;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">19&#44;20</span></a> in 2 retrospective studies with 170 and 358 patients&#44; reported a detection rate of 44&#37; and 45&#37; respectively&#44; more in tune with our results&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">It appears that the trigger PSA number is the most powerful predictor of a positive choline PET-CT&#46;<a class="elsevierStyleCrossRefs" href="#bib0240"><span class="elsevierStyleSup">17&#44;19&#44;21&#44;22</span></a> The study by Giovacchini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> describes a detection rate of 80&#37; for PSA between 3 and 5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; reaching a plateau in higher numbers &#40;84&#37; for PSA<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Krause et al&#46;<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">21</span></a> demonstrated a detection rate of 73&#37; in patients with a trigger PSA<span class="elsevierStyleHsp" style=""></span>&#8805;<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46; Likewise&#44; our data showed significant differences between the trigger PSA values of positive PET-CTs and those of negative ones &#40;13&#46;3<span class="elsevierStyleHsp" style=""></span>ng&#47;ml vs 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; Although&#44; in our series&#44; the cut-off point for the trigger PSA that showed a better discrimination between positive and negative PET-CTs was 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; studies similar to ours have proposed lower numbers&#44; of 2&#46;43<span class="elsevierStyleHsp" style=""></span>ng&#47;ml<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">18</span></a> and even up to 1&#46;4<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46;<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">20&#44;23</span></a></p><p id="par0100" class="elsevierStylePara elsevierViewall">However&#44; the absolute number of PSA at the time of the scan is not the only determining factor in the choline PET-CT results&#44; the PSA kinetics being equally important&#46; Different studies have shown that patients with positive choline PET-CT have a PSAdt shorter than patients with a negative scan&#46; Thus&#44; it is accepted that PSAdt along with the absolute number of PSA should be taken into account when requesting examination&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">12&#44;18&#44;19&#44;24</span></a> In our study&#44; the PSAdt did not show significant differences between positive and negative <span class="elsevierStyleSup">18</span>F-FCH PET-CT patients&#44; but we did observe that another kinetic parameter such as PSArr was significantly faster in patients with positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#44; fact demonstrated in similar studies&#46;<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">25</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">The location of the disease at the time of biochemical relapse is a key datum for decision making&#46; The most frequent location was at a distance&#44; the lymph node being more frequent than the bone&#46; These results are similar to those previously published&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> In addition&#44; we observed a relationship between the PSA numbers and the location of the disease&#46; It is known that choline PET-CT is sensitive to tumor growth and that PSAdt is an indirect method of assessing this growth&#46; Consistent with other studies&#44;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">19</span></a> our results show that PSAdt was significantly shorter in patients with disease outside the prostate than in patients with disease in the prostatic bed&#46; It should be noted that there is a radionuclide with greater sensitivity for the detection of bone metastases &#40;<span class="elsevierStyleSup">18</span>F-NaF&#41;&#59; however&#44; it is less specific than <span class="elsevierStyleSup">18</span>F-FCH to differentiate metastases from degenerative-inflammatory bone processes&#46;<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">26</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">In addition to the PSA&#44; we have studied the ability of other parameters to predict the positivity of choline PET-CT&#46; In the case of the Gleason score&#44; the results have been little encouraging&#46;<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">12&#44;19&#44;23</span></a> Although the study by Giovaccini et al&#46;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> found statistical significance in the univariate analysis for a Gleason<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>7&#44; it failed to be demonstrated in the multivariate&#46; Advanced age seems to be related to the early onset of bone metastases after biochemical recurrence&#44;<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">27</span></a> although in our study it did not show a significant relationship with the results of <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46; Giovacchini et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">20</span></a> in their work on 358 patients with BR&#44; did report advanced age as an independent predictor of positive choline PET-CT&#46; Other variables studied as predictors of positive PET-CT have been advanced clinical stage &#40;T&#41;&#44; the existence of lymph node disease at diagnosis &#40;N&#41;&#44; the type of initial radical treatment&#44; or the fact of having received or not hormonal treatment at the time of PET-CT&#46; Although an advanced T stage is intuitively related to a worse prognosis&#44; studies similar to ours did not find a significant relationship with the positive choline PET-CT result either&#46;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a> While in some studies the existence of previous lymph node disease &#40;N&#43;&#41; has proved to predict a positive choline PET-CT&#44;<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">12</span></a> this trend was not observed in our series&#46; However&#44; lymph node assessment with other techniques is also controversial&#44; and the difficulty in obtaining a pathological demonstration of the positivity or negativity of these nodes should be taken into account when assessing these results&#46; Regarding the effect of antiandrogenic therapy on choline uptake&#44; it should be pointed out that it is a point of controversy and recent research&#44; with different studies suggesting a negative influence of hormone therapy on the sensitivity of choline PET-CT&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">19&#8211;21&#44;28&#44;29</span></a> Our work includes patients who were receiving hormonal treatment and others who did not&#44; but the small size of both groups did not allow us to draw conclusions&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">It is important to underline the importance of the type of initial radical treatment received&#46; Most studies include only patients who have received surgical treatment&#46; In our study&#44; the initial treatment modality received was a determining factor&#44; and it was in the group of patients not treated with prostatectomy where the highest number of positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT was found&#44; being this fact an independent risk predictor in the multivariate analysis&#46; Although other publications include patients from different therapeutic categories&#44;<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">13&#44;21&#44;25</span></a> no statistical study had been performed&#46; This data demonstrates the clinical scenario that would most benefit from the <span class="elsevierStyleSup">18</span>F-FCH PET-CT information&#58; patients undergoing treatment other than radical prostatectomy &#40;ERT&#44; brachytherapy&#41; with subsequent biochemical relapse and potential candidates for salvage surgery &#40;both radical prostatectomy and lymphadenectomy&#41;&#46; It is probably in these patients where the detection and&#44; above all&#44; the location of the disease can contribute to a greater clinical profitability&#44;<a class="elsevierStyleCrossRef" href="#bib0305"><span class="elsevierStyleSup">30</span></a> optimizing the planning of such surgery&#46; In the case of patients treated surgically&#44; multiparametric MRI could play a complementary role to PET-CT to detect relapse at the local level&#46;<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">31</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">The main limitation of our study is the lack of a histological gold standard with which to compare the results of the test&#44; as well as the fact of having to resort to different clinical criteria of validation&#44; which may have over or underestimated the true number of positive examinations&#46; However&#44; it should be remembered that this limitation is a fact common to most of the works of this type given the ethical and logistical considerations involved in biopsying the lesions in these patients&#46; In addition to the retrospective nature of the study&#44; the absence of consensus criteria when requesting the choline PET-CT study by the urologist and&#47;or radiotherapist should be taken into account&#44; which may facilitate a selection bias&#46; In addition&#44; some patients were subjected to hormonal treatment at the time of choline PET-CT&#44; which could modify the diagnostic sensitivity of the test&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In conclusion&#44; <span class="elsevierStyleSup">18</span>F-FCH PET-CT proves to be a useful examination in the biochemical recurrence of PCa by detecting disease in a high percentage of patients and providing valuable information on the anatomical location of the same&#46; In our series&#44; a PSA figure of 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml or higher represents the optimum time to request the test&#46; Initial PSA numbers and failure to undergo radical prostatectomy are important variables to consider in order to increase the diagnostic performance of the scan&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflict of interest</span><p id="par0130" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres886500"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Material and methods"
            ]
            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
            ]
            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusions"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec872652"
          "titulo" => "Keywords"
        ]
        2 => array:3 [
          "identificador" => "xres886499"
          "titulo" => "Resumen"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0025"
              "titulo" => "Objetivos"
            ]
            1 => array:2 [
              "identificador" => "abst0030"
              "titulo" => "Material y m&#233;todos"
            ]
            2 => array:2 [
              "identificador" => "abst0035"
              "titulo" => "Resultados"
            ]
            3 => array:2 [
              "identificador" => "abst0040"
              "titulo" => "Conclusiones"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "xpalclavsec872651"
          "titulo" => "Palabras clave"
        ]
        4 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        5 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Material and methods"
        ]
        6 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        7 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        8 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Conflict of interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-12-30"
    "fechaAceptado" => "2017-02-13"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec872652"
          "palabras" => array:4 [
            0 => "Positron emission tomography&#47;computed tomography"
            1 => "<span class="elsevierStyleSup">18</span>F-fluorocholine positron emission tomography&#47;computed tomography"
            2 => "Prostate cancer"
            3 => "Biochemical recurrence"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec872651"
          "palabras" => array:4 [
            0 => "Tomograf&#237;a por emisi&#243;n de positrones&#47;tomograf&#237;a computerizada"
            1 => "Tomograf&#237;a por emisi&#243;n de positrones con <span class="elsevierStyleSup">18</span>F-fluorocolina"
            2 => "C&#225;ncer de pr&#243;stata"
            3 => "Recidiva bioqu&#237;mica"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objectives</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To analyze the ability of the PET-CT with <span class="elsevierStyleSup">18</span>F-fluorocholine &#40;<span class="elsevierStyleSup">18</span>F-FCH&#41; to detect disease on biochemical recurrence after treatment with curative intent&#46; To determine the clinical variables that would be able to optimize the test&#39;s diagnostic yield&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A retrospective study of PET-CTs with <span class="elsevierStyleSup">18</span>F-fluorocholine performed on 61 patients with prostate cancer who had undergone treatment with curative intent and met the criteria for biochemical recurrence&#46; The results of the PET-CT were categorized into positive or negative and were validated using pre-established criteria&#46; The relationship between the result of the PET-CT and the initial PSA nadir&#44; PSA trigger&#44; rising PSA velocity &#40;PSAva&#41; and PSA doubling time &#40;PSAdt&#41;&#46; The relationship between the metastatic sites on the PET-CT and the remaining variables was analyzed&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">There was a 34&#46;4&#37; detection rate of the disease&#46; The initial PSA&#44; PSA nadir&#44; PSA trigger and PSAva showed statistically significant differences according to the result of the PET-CT&#46; The best discriminatory cut-off point between a positive or negative PET-CT for PSA trigger and PSAva was 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml and 0&#46;25<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#47;month respectively&#46; The PSAdt was significantly lower in patients with remote disease compared to patients with localized disease &#40;5&#46;1 vs 16&#46;8 months&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; The probability that the PET-CT would detect remote disease vs localized disease was 3&#46;2 times higher if the PSAdt was under 6 months &#40;80&#37; vs 20&#37;&#44; OR&#58; 3&#46;2&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#46; In the multivariate analysis&#44; only the initial PSA and not having undergone radical prostatectomy were demonstrated as independent predictive factors of a positive PET-CT result&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The PET-CT with <span class="elsevierStyleSup">18</span>F-FCH can detect disease in a high percentage of patients with biochemical recurrence and provides information on its anatomical location&#46; PSA kinetics and the patient&#39;s previous treatment are key variables in increasing the test&#39;s diagnostic&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Material and methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Analizar la capacidad de la PET-TC con <span class="elsevierStyleSup">18</span>F-fluorocolina &#40;<span class="elsevierStyleSup">18</span>F-FCH&#41; para detectar enfermedad en el momento de la recidiva bioqu&#237;mica tras tratamiento con intenci&#243;n curativa&#46; Determinar qu&#233; variables cl&#237;nicas ser&#237;an capaces de optimizar la rentabilidad diagn&#243;stica de la prueba&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material y m&#233;todos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de las PET-TC con <span class="elsevierStyleSup">18</span>F-FCH realizadas a 61 pacientes con c&#225;ncer de pr&#243;stata sometidos a tratamiento con intenci&#243;n curativa y que cumpl&#237;an criterios de recidiva bioqu&#237;mica&#46; Los resultados del estudio PET-TC se categorizaron en positivos o negativos y fueron validados seg&#250;n criterios preestablecidos&#46; Se estudi&#243; la relaci&#243;n entre el resultado de la PET-TC y el PSA inicial&#44; PSA nadir&#44; PSA trigger&#44; velocidad de ascenso del PSA &#40;PSAva&#41; y PSA doubling time &#40;PSAdt&#41;&#46; Se analiz&#243; la relaci&#243;n entre las localizaciones metast&#225;sicas en la PET-TC y el resto de variables&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">La tasa de detecci&#243;n de enfermedad fue del 34&#44;4&#37;&#46; El PSA inicial&#44; el PSA nadir&#44; el PSA trigger y el PSAva demostraron diferencias estad&#237;sticamente significativas seg&#250;n el resultado de la PET-TC&#46; El mejor punto de corte discriminatorio entre una PET-TC positiva o negativa para el PSA trigger y la PSAva fue 3&#44;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml y 0&#44;25<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#47;mes respectivamente&#46; El PSAdt fue significativamente menor en los pacientes con enfermedad a distancia frente a los pacientes con enfermedad localizada &#40;5&#46;1 vs 16&#46;8 meses&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46; La probabilidad de que la PET-TC detectara enfermedad a distancia vs localizada fue 3&#44;2 veces mayor si el PSAdt era menor de 6 meses &#40;80&#37; vs 20&#37;&#44; OR&#58; 3&#44;2&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#41;&#46; En el an&#225;lisis multivariante solo el PSA inicial y el hecho de no haberse sometido a prostatectom&#237;a radical demostraron ser factores predictores independientes del resultado positivo de la PET-TC&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">La PET-TC con <span class="elsevierStyleSup">18</span>F-FCH es capaz de detectar enfermedad en un alto porcentaje de pacientes con recidiva bioqu&#237;mica&#44; y proporciona informaci&#243;n sobre la localizaci&#243;n anat&#243;mica de la misma&#46; La cin&#233;tica del PSA y el tratamiento previo del paciente son variables clave para aumentar el rendimiento diagn&#243;stico de la exploraci&#243;n&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Puche-Sanz I&#44; Trivi&#241;o-Ib&#225;&#241;ez E&#44; V&#225;zquez-Alonso F&#44; Llamas-Elvira JM&#44; C&#243;zar-Olmo JM&#44; Rodr&#237;guez-Fern&#225;ndez A&#46; Papel de la tomograf&#237;a por emisi&#243;n de positrones-tomograf&#237;a computerizada con <span class="elsevierStyleSup">18</span>F-fluorocolina en la recidiva bioqu&#237;mica tras tratamiento con intenci&#243;n curativa del c&#225;ncer de pr&#243;stata&#46; Actas Urol Esp&#46; 2017&#59;41&#58;437&#8211;444&#46;</p>"
      ]
    ]
    "multimedia" => array:6 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1641
            "Ancho" => 3102
            "Tamanyo" => 149841
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; ROC curve showing discriminant capacity of the trigger PSA number between negative and positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46; The best cut-off point for the trigger PSA was 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#44; which correctly discriminated 73&#37; of patients with a sensitivity of 70&#37; and a specificity of 78&#37;&#46; &#40;B&#41; ROC curve showing discriminant capacity of PSArr between negative and positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46; The best cut-off point for PSArr was 0&#46;25<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#47;month&#44; which correctly discriminated 72&#37; of patients with a sensitivity and specificity of 72&#37; and 63&#37;&#44; respectively&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 2010
            "Ancho" => 2446
            "Tamanyo" => 125987
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Relationship between PSA trigger and disease location in <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46; Trigger PSA numbers were significantly higher in patients who demonstrated distant disease than in those who demonstrated localized disease&#44; and in those in whom <span class="elsevierStyleSup">18</span>F-FCH PET-CT was negative &#40;17&#46;9<span class="elsevierStyleHsp" style=""></span>ng&#47;ml vs 6&#46;3<span class="elsevierStyleHsp" style=""></span>ng&#47;ml vs 3&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml respectively&#44; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#46;</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">PSA&#58; prostate specific antigen&#59; PSAdt&#58; PSA figure doubling time&#59; PSA nadir&#58; lower PSA figure after initial treatment&#59; trigger PSA&#58; PSA figure at the time of <span class="elsevierStyleSup">18</span>F-FCH PET-CT scan&#59; PSArr&#58; PSA rise rate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Characteristic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Value &#40;n or mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#37; or range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Age &#40;years&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&#46;44<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&#8211;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Gleason score</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8804;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>6&#8211;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">78&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>&#8805;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">T</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>T3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">N</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Nx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>N1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Radical prostatectomy</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Other treatments</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">52&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Initial PSA &#40;ng&#47;ml&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#46;91<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>24&#46;89&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#46;10&#8211;109&#46;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PSA nadir &#40;ng&#47;ml&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#46;05<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;00&#8211;31&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Trigger PSA &#40;ng&#47;ml&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#46;80<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>11&#46;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;00&#8211;59&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PSAdt &#40;months&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#46;13<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;83&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;58&#8211;51&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">PSArr &#40;ng&#47;ml&#47;month&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;70<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;01&#8211;7&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1497949.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Clinical characteristics of patients&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Positive PET-CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Negative PET-CT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">T1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">2 &#40;33&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;66&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="center" valign="middle">0&#46;850</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">T2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;36&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;63&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">T3</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3 &#40;27&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">8 &#40;72&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Nx</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">15 &#40;39&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;60&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="center" valign="middle">0&#46;286</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">N1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;26&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">17 &#40;74&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Gleason</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">16 &#40;30&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">36 &#40;69&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="center" valign="middle">0&#46;246</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Gleason</span><span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">7</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">4 &#40;50&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Radical prostatectomy</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1 &#40;3&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">28 &#40;96&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="center" valign="middle">&#60;0&#46;001</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">20 &#40;62&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">12 &#40;37&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Second treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10 &#40;34&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">19 &#40;65&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="center" valign="middle">0&#46;993</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">11 &#40;34&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">21 &#40;65&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="4" align="left" valign="top"><span class="elsevierStyleItalic">Hormonal treatment</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">6 &#40;40&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;60&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="center" valign="middle">0&#46;546</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">9 &#40;28&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">23 &#40;71&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1497951.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Comparative analysis of the qualitative variables according to the result of <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46;</p>"
        ]
      ]
      4 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">PSA&#58; prostate specific antigen&#59; PSAdt&#58; PSA figure doubling time&#59; PSA nadir&#58; lowest PSA figure after initial treatment&#59; PSA trigger&#58; PSA figure at the time of <span class="elsevierStyleSup">18</span>F-FCH PET-CT scan&#59; PSArr&#58; PSA rise rate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Positive PET-CT &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Negative PET-CT &#40;mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#46;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">67&#46;45<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;687&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Initial PSA &#40;ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">40&#46;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>33&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;53<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PSA nadir &#40;ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">7&#46;08<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>8&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;15<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trigger PSA &#40;ng&#47;ml&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">13&#46;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>16&#46;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">3&#46;52<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#46;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PSAdt &#40;months&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;36<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#46;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">10&#46;00<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>10&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;863&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PSArr &#40;ng&#47;ml&#47;month&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;39<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;010&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1497952.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Comparative analysis of the quantitative variables according to the result of <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0020"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">PSA&#58; prostate specific antigen&#59; PSA trigger&#58; PSA figure at the time of <span class="elsevierStyleSup">18</span>F-FCH PET-CT scan&#59; PSArr&#58; PSA rise rate&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Radical prostatectomy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;052 &#40;0&#46;005&#8211;0&#46;535&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Initial PSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;078 &#40;0&#46;993&#8211;1&#46;169&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;072&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Trigger PSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;033 &#40;0&#46;790&#8211;1&#46;350&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;814&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">PSArr&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;978 &#40;0&#46;060&#8211;16&#46;002&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#46;988&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1497950.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Results of multivariate binary logistic regression analysis of predictive factors of a positive <span class="elsevierStyleSup">18</span>F-FCH PET-CT&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:31 [
            0 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "National prostate cancer registry 2010 in Spain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; C&#243;zar"
                            1 => "B&#46; Mi&#241;ana"
                            2 => "F&#46; G&#243;mez-Veiga"
                            3 => "A&#46; Rodr&#237;guez-Antol&#237;n"
                            4 => "H&#46; Villavicencio"
                            5 => "A&#46; Cantalapiedra"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.acuro.2012.06.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Urol Esp"
                        "fecha" => "2013"
                        "volumen" => "37"
                        "paginaInicial" => "12"
                        "paginaFinal" => "19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23102541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;J&#46; Stephenson"
                            1 => "P&#46;T&#46; Scardino"
                            2 => "J&#46;A&#46; Eastham"
                            3 => "F&#46;J&#46; Bianco Jr&#46;"
                            4 => "Z&#46;A&#46; Dotan"
                            5 => "P&#46;A&#46; Fearn"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/jnci/djj190"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Natl Cancer Inst"
                        "fecha" => "2006"
                        "volumen" => "98"
                        "paginaInicial" => "715"
                        "paginaFinal" => "717"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16705126"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pretreatment PSA velocity and risk of death from prostate cancer following external beam radiation therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;V&#46; D&#8217;Amico"
                            1 => "A&#46;A&#46; Renshaw"
                            2 => "B&#46; Sussman"
                            3 => "M&#46;H&#46; Chen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1001/jama.294.4.440"
                      "Revista" => array:6 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "2005"
                        "volumen" => "294"
                        "paginaInicial" => "440"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16046650"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Limited role of radionuclide bone scintigraphy in patients with prostate specific antigen elevations after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;L&#46; Cher"
                            1 => "F&#46;J&#46; Bianco Jr&#46;"
                            2 => "J&#46;S&#46; Lam"
                            3 => "L&#46;P&#46; Davis"
                            4 => "D&#46;J&#46; Grignon"
                            5 => "W&#46;A&#46; Sakr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "1998"
                        "volumen" => "160"
                        "paginaInicial" => "1387"
                        "paginaFinal" => "1391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9751361"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radionuclide bone scintigraphy in patients with biochemical recurrence after radical prostatectomy&#58; when is it indicated&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "P&#46; Gomez"
                            1 => "M&#46; Manoharan"
                            2 => "S&#46;S&#46; Kim"
                            3 => "M&#46;S&#46; Soloway"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1464-410X.2004.04927.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "BJU Int"
                        "fecha" => "2004"
                        "volumen" => "94"
                        "paginaInicial" => "299"
                        "paginaFinal" => "302"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15291855"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A model that predicts the probability of positive imaging in prostate cancer cases with biochemical failure after initial de-finitive local therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;K&#46; Choueiri"
                            1 => "R&#46; Dreicer"
                            2 => "A&#46; Paciorek"
                            3 => "P&#46;R&#46; Carroll"
                            4 => "B&#46; Konety"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.juro.2007.10.059"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "2008"
                        "volumen" => "179"
                        "paginaInicial" => "906"
                        "paginaFinal" => "910"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18207194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESMO minimum clinical recommendationsfor diagnosis&#44; treatment and follow-up of prostate cancer"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ESMO Guidelines Task Force"
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;V&#46; Kataja"
                            1 => "J&#46; Bergh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdi826"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2005"
                        "volumen" => "16"
                        "numero" => "Suppl&#46; 1"
                        "paginaInicial" => "i34"
                        "paginaFinal" => "i36"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888746"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of positron emission tomography&#47;computed tomography imaging with radiolabeled choline analogues in prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; Navarro-Pelayo L&#225;inez"
                            1 => "A&#46; Rodr&#237;guez-Fern&#225;ndez"
                            2 => "M&#46; G&#243;mez-R&#237;o"
                            3 => "F&#46; V&#225;zquez-Alonso"
                            4 => "J&#46;M&#46; C&#243;zar-Olmo"
                            5 => "J&#46;M&#46; Llamas-Elvira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.acuro.2013.12.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Urol Esp"
                        "fecha" => "2014"
                        "volumen" => "38"
                        "paginaInicial" => "613"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24548475"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PET-CT for treatment planning inprostatecancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Picchio"
                            1 => "C&#46; Crivellaro"
                            2 => "G&#46; Giovacchini"
                            3 => "L&#46; Gianolli"
                            4 => "C&#46; Messa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Q J Nucl Med Mol Imaging"
                        "fecha" => "2009"
                        "volumen" => "53"
                        "paginaInicial" => "245"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19293771"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0205"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Detection of lymph-node metastaseswith integrated &#91;11C&#93;choline PET&#47;CT in patients with PSA failure after radicalretropubic prostatectomy&#58; results confirmed by open pelvic-retroperitoneal lymphadenectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Scattoni"
                            1 => "M&#46; Picchio"
                            2 => "N&#46; Suardi"
                            3 => "C&#46; Messa"
                            4 => "M&#46; Freschi"
                            5 => "M&#46; Roscigno"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eururo.2007.03.032"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Urol"
                        "fecha" => "2007"
                        "volumen" => "52"
                        "paginaInicial" => "423"
                        "paginaFinal" => "429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17397992"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of choline positron emissiontomography&#47;computed tomography in the management of patients with prostate-specific antigen progression after radical treatment of prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Picchio"
                            1 => "A&#46; Briganti"
                            2 => "S&#46; Fanti"
                            3 => "A&#46; Heidenreich"
                            4 => "B&#46;J&#46; Krause"
                            5 => "C&#46; Messa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.eururo.2010.09.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Urol"
                        "fecha" => "2011"
                        "volumen" => "59"
                        "paginaInicial" => "51"
                        "paginaFinal" => "60"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20869161"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Is there a role for &#40;11&#41;C-choline PET&#47;CT in the early detection of metastatic disease in surgically treated prostate cancer patients with a mild PSA increase &#60;1&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Castellucci"
                            1 => "C&#46; Fuccio"
                            2 => "D&#46; Rubello"
                            3 => "R&#46; Schiavina"
                            4 => "I&#46; Santi"
                            5 => "C&#46; Nanni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-010-1604-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2011"
                        "volumen" => "38"
                        "paginaInicial" => "55"
                        "paginaFinal" => "63"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20848281"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0220"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;18F&#93;fluorocholine PET&#47;CT imagingfor the detection of recurrent prostate cancer at PSA relapse&#58; experience in100 consecutive patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Cimitan"
                            1 => "R&#46; Bortolus"
                            2 => "S&#46; Morassut"
                            3 => "V&#46; Canzonieri"
                            4 => "A&#46; Garbeglio"
                            5 => "T&#46; Baresic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-006-0150-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2006"
                        "volumen" => "33"
                        "paginaInicial" => "1387"
                        "paginaFinal" => "1398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16865395"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0225"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical utility of &#40;18&#41;F-fluorocholine positron-emission tomography&#47;computed tomography &#40;PET&#47;CT&#41; in biochemical relapse of prostate cancer after radical treatment&#58; results of a multicentre study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46; Rodado-Marina"
                            1 => "M&#46; Coronado-Poggio"
                            2 => "A&#46;M&#46; Garc&#237;a-Vicente"
                            3 => "J&#46;R&#46; Garc&#237;a-Garz&#243;n"
                            4 => "J&#46;C&#46; Alonso-Farto"
                            5 => "A&#46;C&#46; de la Jara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bju.12953"
                      "Revista" => array:6 [
                        "tituloSerie" => "BJU Int"
                        "fecha" => "2015"
                        "volumen" => "115"
                        "paginaInicial" => "874"
                        "paginaFinal" => "883"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25307619"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Experience with carbon-11 choline positron emission tomography in prostate carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46; Kotzerke"
                            1 => "J&#46; Prang"
                            2 => "B&#46; Neumaier"
                            3 => "B&#46; Volkmer"
                            4 => "A&#46; Guhlmann"
                            5 => "K&#46; Kleinschmidt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Nucl Med Mol"
                        "fecha" => "2000"
                        "volumen" => "27"
                        "paginaInicial" => "1415"
                        "paginaFinal" => "1419"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "11C-choline positron emission tomography for the evaluation after treatment of localized prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46;J&#46; De Jong"
                            1 => "J&#46; Pruim"
                            2 => "P&#46;H&#46; Elsinga"
                            3 => "W&#46; Vaalburg"
                            4 => "H&#46;J&#46; Mensink"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Urol"
                        "fecha" => "2003"
                        "volumen" => "44"
                        "paginaInicial" => "32"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12814672"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Value of &#91;11C&#93;choline-positron emission tomography for re-staging prostate cancer&#58; a comparison with &#91;18F&#93;fluorodeoxyglucose-positron emission tomography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Picchio"
                            1 => "C&#46; Messa"
                            2 => "C&#46; Landoni"
                            3 => "L&#46; Gianolli"
                            4 => "S&#46; Sironi"
                            5 => "M&#46; Brioschi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.ju.0000056901.95996.43"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "2003"
                        "volumen" => "169"
                        "paginaInicial" => "1337"
                        "paginaFinal" => "1340"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12629355"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0245"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of trigger PSA and PSA kinetics on 11C-Choline PET&#47;CT detection rate in patients with biochemical relapse after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "P&#46; Castellucci"
                            1 => "C&#46; Fuccio"
                            2 => "C&#46; Nanni"
                            3 => "I&#46; Santi"
                            4 => "A&#46; Rizzello"
                            5 => "F&#46; Lodi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2967/jnumed.108.061507"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Nucl Med"
                        "fecha" => "2009"
                        "volumen" => "50"
                        "paginaInicial" => "1394"
                        "paginaFinal" => "1400"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19690023"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0250"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "PSA doubling time for prediction of &#91;&#40;11&#41;C&#93;choline PET&#47;CT findings in prostate cancer patients with biochemical failure after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Giovacchini"
                            1 => "M&#46; Picchio"
                            2 => "V&#46; Scattoni"
                            3 => "R&#46; Garcia Parra"
                            4 => "A&#46; Briganti"
                            5 => "L&#46; Gianolli"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-010-1403-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "1106"
                        "paginaFinal" => "1116"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20306038"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Predictive factors of &#91;&#40;11&#41;C&#93;choline PET&#47;CT in patients with biochemical failure after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Giovacchini"
                            1 => "M&#46; Picchio"
                            2 => "E&#46; Coradeschi"
                            3 => "V&#46; Bettinardi"
                            4 => "L&#46; Gianolli"
                            5 => "V&#46; Scattoni"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-009-1253-3"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2010"
                        "volumen" => "37"
                        "paginaInicial" => "301"
                        "paginaFinal" => "309"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19756592"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0260"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The detection rate of &#91;11C&#93;choline-PET&#47;CT depends on the serum PSA-value in patients with biochemical recurrence of prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46;J&#46; Krause"
                            1 => "M&#46; Souvatzoglou"
                            2 => "M&#46; Tuncel"
                            3 => "K&#46; Herrmann"
                            4 => "A&#46;K&#46; Buck"
                            5 => "C&#46; Praus"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J N Med Mol"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "18"
                        "paginaFinal" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0265"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Positron emission tomography&#47;computed tomography with F-18-fluorocholine for restaging of prostate cancer patients&#58; meaningful at PSA<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Heinisch"
                            1 => "A&#46; Dirisamer"
                            2 => "W&#46; Loidl"
                            3 => "F&#46; Stoiber"
                            4 => "B&#46; Gruy"
                            5 => "S&#46; Haim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11307-005-0023-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Imaging Biol"
                        "fecha" => "2006"
                        "volumen" => "8"
                        "paginaInicial" => "43"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16315004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0270"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Realationship between PSA kinetics and &#91;18F&#93; fluorocholine PET&#47;CT detection rates of recurrence in patients with prostate cancer after total prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Graute"
                            1 => "N&#46; Jansen"
                            2 => "C&#46; Ubleis"
                            3 => "M&#46; Seitz"
                            4 => "M&#46; Hartenbach"
                            5 => "M&#46;K&#46; Scherr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J N Med Mol Imaging"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "271"
                        "paginaFinal" => "282"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0275"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Influence of PSA&#44; PSA velocity and PSA doubling time on contrast-enhanced 18F-choline PET&#47;CT detection rate in patients with rising PSA after radical prostatectomy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "O&#46; Schillaci"
                            1 => "F&#46; Calabria"
                            2 => "M&#46; Tavolozza"
                            3 => "C&#46;R&#46; Caracciolo"
                            4 => "E&#46; Finazzi Agr&#242;"
                            5 => "R&#46; Miano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-011-2030-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "589"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22231016"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0280"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of total PSA&#44; PSA doubling time and PSA velocity on detection rates of 11C-choline positron emission tomography in recurrent prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Rybalov"
                            1 => "A&#46;J&#46; Breeuwsma"
                            2 => "A&#46;M&#46; Leliveld"
                            3 => "J&#46; Pruim"
                            4 => "R&#46;A&#46; Dierckx"
                            5 => "I&#46;J&#46; de Jong"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00345-012-0908-z"
                      "Revista" => array:6 [
                        "tituloSerie" => "World J Urol"
                        "fecha" => "2013"
                        "volumen" => "31"
                        "paginaInicial" => "319"
                        "paginaFinal" => "323"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22814886"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0285"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of prostate cancer bone metastases with 18F-NaF and 18F-Fluorocholine PET&#47;CT"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Beheshti"
                            1 => "A&#46; Rezaee"
                            2 => "H&#46; Geinitz"
                            3 => "W&#46; Loidi"
                            4 => "C&#46; Piracy"
                            5 => "W&#46; Langsteger"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2967/jnumed.115.169730"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Nucl Med"
                        "fecha" => "2016"
                        "volumen" => "57"
                        "numero" => "Suppl&#46; 3"
                        "paginaInicial" => "55S"
                        "paginaFinal" => "60S"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27694173"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0290"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do younger men have better biochemical outcomes after radical prostatectomy&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;J&#46; Freedland"
                            1 => "J&#46;C&#46; Presti Jr&#46;"
                            2 => "C&#46;J&#46; Kane"
                            3 => "W&#46;J&#46; Atonson"
                            4 => "M&#46;K&#46; Terris"
                            5 => "F&#46; Dorey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.urology.2003.10.045"
                      "Revista" => array:6 [
                        "tituloSerie" => "Urology"
                        "fecha" => "2004"
                        "volumen" => "63"
                        "paginaInicial" => "518"
                        "paginaFinal" => "522"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15028449"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0295"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dual tracer 11C-choline and FDG-PET in the diagnosis of biochemical prostate cancer relapse after radical treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;A&#46; Ritcher"
                            1 => "M&#46; Rodriguez"
                            2 => "J&#46; Rioja"
                            3 => "I&#46; Pe&#241;uelas"
                            4 => "J&#46; Mart&#237;-Climent"
                            5 => "P&#46; Garrastachu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11307-009-0243-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Imaging Biol"
                        "fecha" => "2010"
                        "volumen" => "12"
                        "paginaInicial" => "210"
                        "paginaFinal" => "217"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19543774"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0300"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Evaluation of &#40;18F&#41;-choline PET&#47;CT for staging and restaging of prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;B&#46; Husarik"
                            1 => "R&#46; Mirabell"
                            2 => "M&#46; Dubs"
                            3 => "H&#46; John"
                            4 => "O&#46;T&#46; Giger"
                            5 => "A&#46; Gelet"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00259-007-0552-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Nucl Med Mol Imaging"
                        "fecha" => "2008"
                        "volumen" => "35"
                        "paginaInicial" => "253"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17926036"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0305"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Choline-positron emission tomography&#47;CT in patients with relapsing prostate cancer&#58; to be performed with therapeutic consequences only"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "A&#46; Heidenreich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/bju.12995"
                      "Revista" => array:6 [
                        "tituloSerie" => "BJU Int"
                        "fecha" => "2015"
                        "volumen" => "115"
                        "paginaInicial" => "849"
                        "paginaFinal" => "850"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26018954"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0310"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#40;11&#41;C-choline PET&#47;CT and multiparametric MRI in patients with biochemical relapse of prostate cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;R&#46; Garcia"
                            1 => "N&#46; Romera"
                            2 => "M&#46; Cozar"
                            3 => "M&#46; Solar"
                            4 => "M&#46; Moragas"
                            5 => "M&#46; Escobar"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.acuro.2014.10.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Urol Esp"
                        "fecha" => "2015"
                        "volumen" => "39"
                        "paginaInicial" => "259"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25454265"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/21735786/0000004100000007/v1_201708260050/S2173578617300902/v1_201708260050/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6274"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Original articles"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/21735786/0000004100000007/v1_201708260050/S2173578617300902/v1_201708260050/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578617300902?idApp=UINPBA00004N"
]
Indexed in:

Follow us:

Subscribe:

Purchase article

Indexed in:

Follow us:

Subscribe:

Purchase article

Subscribe to our newsletter
