Metastatic progression, cancer-specific mortality and need for secondary treatments in patients with clinically high-risk prostate cancer treated initially with radical prostatectomy
Progresión metastática, mortalidad cáncer específica y necesidad de tratamientos de segunda línea en pacientes con cáncer de próstata de alto riesgo tratados inicialmente mediante prostatectomía radical
J. Rubio-Briones
, I. Iborra, M. Trassierra, A. Collado, J. Casanova, A. Gómez-Ferrer, J.V. Ricós, J.L. Monrós, R. Dumont, E. Solsona
Corresponding author
Department of Urology, Instituto Valenciano de Oncología, Valencia, Spain
Read
909
Timeswas read the article
789
Total PDF
120
Total HTML
Share statistics
array:23 [ "pii" => "S2173578610701499" "issn" => "21735786" "doi" => "10.1016/S2173-5786(10)70149-9" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70149" "copyright" => "AEU" "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2010;34:610-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 416 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 117 "PDF" => 296 ] ] "itemSiguiente" => array:18 [ "pii" => "S2173578610701505" "issn" => "21735786" "doi" => "10.1016/S2173-5786(10)70150-5" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70150" "copyright" => "AEU" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2010;34:618-24" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 399 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 87 "PDF" => 305 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Analysis of overactive bladder and urinary incontinence in working women aged between 25 and 64 years. EPICC study" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "618" "paginaFinal" => "624" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Análisis del síndrome de vejiga hiperactiva y de la incontinencia urinaria en mujeres laboralmente activas entre 25–64 años. Estudio EPICC" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Martínez-Agulló, J.L. Ruiz-Cerdá, S. Arlandis, P. Rebollo, M. Pérez, J. Chaves" "autores" => array:7 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Martínez-Agulló" ] 1 => array:2 [ "nombre" => "J.L." "apellidos" => "Ruiz-Cerdá" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Arlandis" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Rebollo" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Pérez" ] 5 => array:2 [ "nombre" => "J." "apellidos" => "Chaves" ] 6 => array:1 [ "colaborador" => "the Cooperative Study Group EPICC" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578610701505?idApp=UINPBA00004N" "url" => "/21735786/0000003400000007/v1_201304251610/S2173578610701505/v1_201304251610/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2173578610701487" "issn" => "21735786" "doi" => "10.1016/S2173-5786(10)70148-7" "estado" => "S300" "fechaPublicacion" => "2010-01-01" "aid" => "70148" "copyright" => "AEU" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Urol Esp. 2010;34:603-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 668 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 139 "PDF" => 517 ] ] "en" => array:10 [ "idiomaDefecto" => true "titulo" => "Practical treatment approach of radiation induced cystitis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "603" "paginaFinal" => "609" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Guía práctica para el manejo y tratamiento ante la cistitis radical" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Martínez-Rodríguez, J. Areal Calama, O. Buisan Rueda, C. González Satue, J. Sanchez Macias, M. Arzoz Fabregas, J. Gago Ramos, S. Bayona Arenas, L. Ibarz Servio, J.M. Saladié Roig" "autores" => array:10 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Martínez-Rodríguez" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Areal Calama" ] 2 => array:2 [ "nombre" => "O." "apellidos" => "Buisan Rueda" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "González Satue" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Sanchez Macias" ] 5 => array:2 [ "nombre" => "M." "apellidos" => "Arzoz Fabregas" ] 6 => array:2 [ "nombre" => "J." "apellidos" => "Gago Ramos" ] 7 => array:2 [ "nombre" => "S." "apellidos" => "Bayona Arenas" ] 8 => array:2 [ "nombre" => "L." "apellidos" => "Ibarz Servio" ] 9 => array:2 [ "nombre" => "J.M." "apellidos" => "Saladié Roig" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578610701487?idApp=UINPBA00004N" "url" => "/21735786/0000003400000007/v1_201304251610/S2173578610701487/v1_201304251610/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "titulo" => "Metastatic progression, cancer-specific mortality and need for secondary treatments in patients with clinically high-risk prostate cancer treated initially with radical prostatectomy" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "610" "paginaFinal" => "617" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J. Rubio-Briones, I. Iborra, M. Trassierra, A. Collado, J. Casanova, A. Gómez-Ferrer, J.V. Ricós, J.L. Monrós, R. Dumont, E. Solsona" "autores" => array:10 [ 0 => array:4 [ "nombre" => "J." "apellidos" => "Rubio-Briones" "email" => array:1 [ 0 => "jrubio@fivo.org" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "I." "apellidos" => "Iborra" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Trassierra" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Collado" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Casanova" ] 5 => array:2 [ "nombre" => "A." "apellidos" => "Gómez-Ferrer" ] 6 => array:2 [ "nombre" => "J.V." "apellidos" => "Ricós" ] 7 => array:2 [ "nombre" => "J.L." "apellidos" => "Monrós" ] 8 => array:2 [ "nombre" => "R." "apellidos" => "Dumont" ] 9 => array:2 [ "nombre" => "E." "apellidos" => "Solsona" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Department of Urology, Instituto Valenciano de Oncología, Valencia, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Progresión metastática, mortalidad cáncer específica y necesidad de tratamientos de segunda línea en pacientes con cáncer de próstata de alto riesgo tratados inicialmente mediante prostatectomía radical" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2010-01-14" "fechaAceptado" => "2010-03-31" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85960" "palabras" => array:9 [ 0 => "Death" 1 => "Gleason score" 2 => "Metastases" 3 => "Prediction" 4 => "Prostate cancer" 5 => "PSA" 6 => "Radical prostatectomy" 7 => "Risk groups" 8 => "Treatment failure" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85959" "palabras" => array:9 [ 0 => "Muerte" 1 => "Gleason score" 2 => "Metástasis" 3 => "Predicción" 4 => "Cáncer de próstata" 5 => "PSA" 6 => "Prostatectomía radical" 7 => "Grupos de riesgo" 8 => "Fallo de tratamiento" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Purpose</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">To determine our results in high risk (HR) prostate cancer (PCa) patients treated with radical prostatectomy (RP) and to establish preoperative prognosis factors.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Retrospective study of 925 RP. Mean follow-up for the HR group was 89.8+/−53.6 months. Following NCCN criteria, we operated 210 (22.7%) HR and 715 (77.3%) low/intermediate risk patients. The endpoint was metastatic progression. Kaplan-Meier method for survival comparison among groups and Cox regression model for multivariate analysis of preoperative prognostic factors were used.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Revised period; 1986–2007. Fifty-four patients (25.7%) were free of disease and 8 patients (3.8%) died for other causes free of disease. Disease progressed in 148 patients (70.5%); death due to tumour progression occurred in 42 cases (20%) and due to other causes in 25 patients (11.9%). Seventy-nine patients in HR group (38%) vs 549 low/intermediate risk group (78.5%) did not deserve further treatments (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). The uni and multivariate analysis for metastatic progression showed both Gleason score at biopsy (RR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.922; 95% CI 1.106–3.341, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.020) and clinical stage (RR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.290; 95% CI 1.269–4.133, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.006) showed independent prognostic value for metastatic progression, but not PSA.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">An HR patient can be cured in a third of the cases and will need multimodal treatments in more than half of the times. We prompt surgery in a young healthy patient with a resectable tumour, mainly if just one bad prognostic factor is present and defiantly if this is just PSA elevation.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Determinar nuestros resultados en pacientes con cáncer de próstata (CaP) de alto riesgo (AR) tratados mediante prostatectomía radical (PR) y establecer criterios pronósticos preoperatorios.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo de 925 PR. El seguimiento medio fue 89,8+/−53,6 meses para el grupo de CaP de AR. Siguiendo los criterios NCCN, operamos 210 (22,7%) PR de AR y 715 (77,3%) de riesgo bajo/intermedio. Se utilizó el método Kaplan-Meier para análisis de supervivencia y el modelo de Cox para el análisis multivariado de factores pronósticos para progresión metastática.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Periodo revisado; 1986–2007. Cincuenta y cuatro pacientes de AR (25,7%) estaban libres de progresión y 8 pacientes (3,8%) murieron por otras causas libres de enfermedad. El CaP progresó en 148 pacientes (70,5%). Murieron por progresión tumoral 42 pacientes (20%) y por otras causas 25 pacientes (11,9%). Setenta y nueve pacientes de AR (38%) frente a 549 de riesgo bajo/intermedio (78,5%) no necesitaron más líneas de tratamiento (p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0,001). Los análisis uni y multivariados demostraron que tanto el score Gleason en biopsia (RR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1,922; IC 95% 1,106–3,341, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,020) como el estadio clínico (RR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2,290; IC 95% 1,269–4,133, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,006) mostraron valor pronóstico independiente para progresión metastásica, pero no el PSA.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Un paciente con CaP de AR que se opere tiene un 25% de posibilidades de curarse y podrá necesitar un tratamiento multimodal en más de la mitad de los casos. Recomendamos PR en un paciente joven si el tumor se considera resecable, sobre todo si el único factor pronóstico que lo encasilla como AR es la elevación del PSA.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EAU guidelines on prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Heidenreich" 1 => "G. Aus" 2 => "M. Bolla" 3 => "S. Joniau" 4 => "V.B. Matveev" 5 => "H.P. Schmid" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2007.09.002" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2008" "volumen" => "53" "paginaInicial" => "68" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17920184" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Secondary therapy, metastatic progression, and cancer-specific mortality in men with clinically high-risk prostate cancer treated with radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O. Yossepowitch" 1 => "S.E. Eggener" 2 => "A.M. Serio" 3 => "B.S. Carver" 4 => "F.J. Bianco" 5 => "P.T. Scardino" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2007.10.008" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2008" "volumen" => "53" "paginaInicial" => "950" "paginaFinal" => "959" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17950521" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Surgical management of high risk prostate cancer: the Mayo Clinic experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.A. Boorjian" 1 => "M.L. Blute" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urolonc.2008.03.009" "Revista" => array:6 [ "tituloSerie" => "Urol Oncol" "fecha" => "2008" "volumen" => "26" "paginaInicial" => "530" "paginaFinal" => "532" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18774468" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Timing of biochemical failure and distant metastatic disease for low-, intermediate-, and high-risk prostate cancer after radiotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.B. Morgan" 1 => "A.L. Hanlon" 2 => "E.M. Horwitz" 3 => "M.K. Buyyounouski" 4 => "R.G. Uzzo" 5 => "A. Pollack" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.22755" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2007" "volumen" => "110" "paginaInicial" => "68" "paginaFinal" => "80" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17520705" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term outcome of high dose intensity modulated radiation therapy for patients with clinically localized prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M.J. Zelefsky" 1 => "H. Chan" 2 => "M. Hunt" 3 => "Y. Yamada" 4 => "A.M. Shippy" 5 => "H. Amols" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.06.002" "Revista" => array:7 [ "tituloSerie" => "J Urol" "fecha" => "2006" "volumen" => "176" "numero" => "4 Pt 1" "paginaInicial" => "1415" "paginaFinal" => "1419" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16952647" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term outcome following radical prostatectomy in men with clinical stage T3 prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.S. Carver" 1 => "F.J. Bianco" 2 => "P.T. Scardino" 3 => "J.A. Eastham" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.03.093" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2006" "volumen" => "176" "paginaInicial" => "564" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16813890" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current treatment in high risk and locally advanced prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Esquena Fernandez" 1 => "P. Maroto Rey" 2 => "G. Sancho Pardo" 3 => "J. Palou Redorta" 4 => "H. Villavicencio Mavrich" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Actas Urol Esp" "fecha" => "2007" "volumen" => "31" "paginaInicial" => "445" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17711162" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673604172723" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "NCCN prostate cancer Clinical Practice Guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P. Scardino" 1 => "Update:" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:8 [ "tituloSerie" => "J Natl Compr Canc Netw" "fecha" => "2005" "volumen" => "3" "numero" => "Suppl 1" "paginaInicial" => "S29" "paginaFinal" => "S33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16280109" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S147020450970004X" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neoadjuvant androgen ablation before radical prostatectomy in cT2bNxMo prostate cancer: 5-year results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.S. Soloway" 1 => "K. Pareek" 2 => "R. Sharifi" 3 => "Z. Wajsman" 4 => "D. McLeod" 5 => "D.P. Wood" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2002" "volumen" => "167" "paginaInicial" => "112" "paginaFinal" => "116" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11743286" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changing nature of high risk patients undergoing radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.J. Kane" 1 => "J.C. Presti" 2 => "C.L. Amling" 3 => "W.J. Aronson" 4 => "M.K. Terris" 5 => "S.J. Freedland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.08.057" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2007" "volumen" => "177" "paginaInicial" => "113" "paginaFinal" => "117" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17162017" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of patients with high risk localized prostate cancer: results from cancer of the prostate strategic urological research endeavor (CaPSURE)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.V. Meng" 1 => "E.P. Elkin" 2 => "D.M. Latini" 3 => "J. Duchane" 4 => "P.R. Carroll" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.ju.0000154610.81916.81" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2005" "volumen" => "173" "paginaInicial" => "1557" "paginaFinal" => "1561" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15821485" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An analysis of radical prostatectomy in advanced stage and high-grade prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H. Van Poppel" 1 => "S. Joniau" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2007.10.009" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2008" "volumen" => "53" "paginaInicial" => "253" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17949893" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of surgery for clinical unilateral T3a prostate cancer: a single-institution experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.Y. Hsu" 1 => "S. Joniau" 2 => "R. Oyen" 3 => "T. Roskams" 4 => "H. Van Poppel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.eururo.2006.05.024" "Revista" => array:6 [ "tituloSerie" => "Eur Urol" "fecha" => "2007" "volumen" => "51" "paginaInicial" => "121" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16797831" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical prostatectomy versus watchful waiting in early prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Bill-Axelson" 1 => "L. Holmberg" 2 => "M. Ruutu" 3 => "M. Haggman" 4 => "S.O. Andersson" 5 => "S. Bratell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa043739" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2005" "volumen" => "352" "paginaInicial" => "1977" "paginaFinal" => "1984" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15888698" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oncologic outcome after radical prostatectomy in men with PSA values above 20<span class="elsevierStyleHsp" style=""></span>ng/ml: a monocentric experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Nguyen" 1 => "S. Eltz" 2 => "S.J. Drouin" 3 => "E. Comperat" 4 => "F. Audenet" 5 => "R. Renard-Penna" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00345-009-0419-8" "Revista" => array:7 [ "tituloSerie" => "World J Urol" "fecha" => "2009" "volumen" => "27" "paginaInicial" => "653" "paginaFinal" => "658" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19466429" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510709026133" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.A. Inman" 1 => "J.D. Davies" 2 => "L.J. Rangel" 3 => "E.J. Bergstralh" 4 => "E.D. Kwon" 5 => "M.L. Blute" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.23767" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2008" "volumen" => "113" "paginaInicial" => "1544" "paginaFinal" => "1551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18680171" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trends and predictors of aggressive therapy for clinical locally advanced prostate carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.D. Denberg" 1 => "L.M. Glode" 2 => "J.F. Steiner" 3 => "E.D. Crawford" 4 => "R.M. Hoffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2006.06260.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2006" "volumen" => "98" "paginaInicial" => "335" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16879674" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The changing face of prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.R. Cooperberg" 1 => "J.W. Moul" 2 => "P.R. Carroll" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2005.02.9751" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2005" "volumen" => "23" "paginaInicial" => "8146" "paginaFinal" => "8151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16278465" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Four prognostic groups predict long-term survival from prostate cancer following radiotherapy alone on Radiation Therapy Oncology Group clinical trials" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Roach" 1 => "J. Lu" 2 => "M.V. Pilepich" 3 => "S.O. Asbell" 4 => "M. Mohiuddin" 5 => "R. Terry" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Radiat Oncol Biol Phys" "fecha" => "2000" "volumen" => "47" "paginaInicial" => "609" "paginaFinal" => "615" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10837943" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term survival in men with high grade prostate cancer: a comparison between conservative treatment, radiation therapy and radical prostatectomy–a propensity scoring approach" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Tewari" 1 => "G. Divine" 2 => "P. Chang" 3 => "M.M. Shemtov" 4 => "M. Milowsky" 5 => "D. Nanus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2006.10.040" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2007" "volumen" => "177" "paginaInicial" => "911" "paginaFinal" => "915" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17296374" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical prostatectomy as primary treatment modality for locally advanced prostate cancer: a prospective analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.K. Berglund" 1 => "J.S. Jones" 2 => "J.C. Ulchaker" 3 => "A. Fergany" 4 => "I. Gill" 5 => "J. Kaouk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2005.12.003" "Revista" => array:6 [ "tituloSerie" => "Urology" "fecha" => "2006" "volumen" => "67" "paginaInicial" => "1253" "paginaFinal" => "1256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16678888" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical prostatectomy for clinically advanced (cT3) prostate cancer since the advent of prostate-specific antigen testing: 15-year outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.F. Ward" 1 => "J.M. Slezak" 2 => "M.L. Blute" 3 => "E.J. Bergstralh" 4 => "H. Zincke" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1464-410X.2005.05394.x" "Revista" => array:6 [ "tituloSerie" => "BJU Int" "fecha" => "2005" "volumen" => "95" "paginaInicial" => "751" "paginaFinal" => "756" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15794776" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intermediateterm potency, continence, and survival outcomes of radical prostatectomy for clinically high-risk or locally advanced prostate cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Loeb" 1 => "N.D. Smith" 2 => "K.A. Roehl" 3 => "W.J. Catalona" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.urology.2007.02.054" "Revista" => array:7 [ "tituloSerie" => "Urology" "fecha" => "2007" "volumen" => "69" "paginaInicial" => "1170" "paginaFinal" => "1175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17572209" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S147020451070125X" "estado" => "S300" "issn" => "14702045" ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Postoperative radiotherapy after radical prostatectomy: a randomised controlled trial (EORTC trial 22911)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Bolla" 1 => "H. van Poppel" 2 => "L. Collette" 3 => "P. van Cangh" 4 => "K. Vekemans" 5 => "L. Da Pozzo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(05)67101-2" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2005" "volumen" => "366" "paginaInicial" => "572" "paginaFinal" => "578" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16099293" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adjuvant radiotherapy for pathological T3N0M0 prostate cancer significantly reduces risk of metastases and improves survival: long-term followup of a randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I.M. Thompson" 1 => "C.M. Tangen" 2 => "J. Paradelo" 3 => "M.S. Lucia" 4 => "G. Miller" 5 => "D. Troyer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.juro.2008.11.032" "Revista" => array:6 [ "tituloSerie" => "J Urol" "fecha" => "2009" "volumen" => "181" "paginaInicial" => "956" "paginaFinal" => "962" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19167731" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predicting the outcome of salvage radiation therapy for recurrent prostate cancer after radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Stephenson" 1 => "P.T. Scardino" 2 => "M.W. Kattan" 3 => "T.M. Pisansky" 4 => "K.M. Slawin" 5 => "E.A. Klein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2006.08.9607" "Revista" => array:6 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2007" "volumen" => "25" "paginaInicial" => "2035" "paginaFinal" => "2041" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17513807" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prostate cancer-specific survival following salvage radiotherapy vs observation in men with biochemical recurrence after radical prostatectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.J. Trock" 1 => "M. Han" 2 => "S.J. Freedland" 3 => "E.B. Humphreys" 4 => "T.L. DeWeese" 5 => "A.W. Partin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.299.23.2760" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2008" "volumen" => "299" "paginaInicial" => "2760" "paginaFinal" => "2769" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18560003" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immediate versus deferred androgen deprivation treatment in patients with node-positive prostate cancer after radical prostatectomy and pelvic lymphadenectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Messing" 1 => "J. Manola" 2 => "J. Yao" 3 => "M. Kiernan" 4 => "D. Crawford" 5 => "G. Wilding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(06)70700-8" "Revista" => array:7 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "472" "paginaFinal" => "479" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16750497" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510709025322" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Radical radiation for localized prostate cancer: local persistence of disease results in a late wave of metastases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.J. Coen" 1 => "A.L. Zietman" 2 => "H. Thakral" 3 => "W.U. Shipley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1200/JCO.2002.01.086" "Revista" => array:7 [ "tituloSerie" => "J Clin Oncol" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "3199" "paginaFinal" => "3205" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12149291" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016510710001434" "estado" => "S300" "issn" => "00165107" ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tratamiento adyuvante y de rescate tras prostatectomía radical" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.L. Mengual Cloquell" 1 => "M. PPEP" 2 => "M.L. Casaña Giner" 3 => "J.L. Chust Vicente" 4 => "L.A.A. Guinot Rodríguez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Urologicas Españolas" "fecha" => "2005" "volumen" => "29" "paginaInicial" => "8" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15786760" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/21735786/0000003400000007/v1_201304251610/S2173578610701499/v1_201304251610/en/main.assets" "Apartado" => array:4 [ "identificador" => "6464" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original – Prostate cancer" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/21735786/0000003400000007/v1_201304251610/S2173578610701499/v1_201304251610/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2173578610701499?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 0 | 6 | 6 |
| 2024 September | 0 | 14 | 14 |
| 2024 August | 0 | 13 | 13 |
| 2024 July | 0 | 9 | 9 |
| 2024 June | 0 | 10 | 10 |
| 2024 May | 0 | 12 | 12 |
| 2024 April | 0 | 15 | 15 |
| 2024 March | 0 | 9 | 9 |
| 2024 February | 0 | 7 | 7 |
| 2024 January | 0 | 11 | 11 |
| 2023 December | 0 | 6 | 6 |
| 2023 November | 0 | 8 | 8 |
| 2023 October | 0 | 19 | 19 |
| 2023 September | 0 | 8 | 8 |
| 2023 August | 0 | 12 | 12 |
| 2023 July | 0 | 52 | 52 |
| 2023 May | 0 | 3 | 3 |
| 2023 April | 0 | 32 | 32 |
| 2023 March | 3 | 8 | 11 |
| 2023 February | 0 | 12 | 12 |
| 2023 January | 0 | 11 | 11 |
| 2022 December | 0 | 5 | 5 |
| 2022 November | 0 | 17 | 17 |
| 2022 October | 0 | 13 | 13 |
| 2022 September | 0 | 8 | 8 |
| 2022 August | 0 | 13 | 13 |
| 2022 June | 0 | 2 | 2 |
| 2022 May | 0 | 4 | 4 |
| 2022 April | 0 | 6 | 6 |
| 2022 March | 0 | 3 | 3 |
| 2021 December | 0 | 3 | 3 |
| 2021 November | 0 | 3 | 3 |
| 2021 October | 0 | 3 | 3 |
| 2021 September | 0 | 2 | 2 |
| 2021 August | 0 | 4 | 4 |
| 2021 July | 0 | 2 | 2 |
| 2021 May | 0 | 5 | 5 |
| 2021 April | 0 | 2 | 2 |
| 2021 March | 0 | 2 | 2 |
| 2021 February | 0 | 1 | 1 |
| 2021 January | 0 | 4 | 4 |
| 2020 October | 0 | 4 | 4 |
| 2020 September | 0 | 2 | 2 |
| 2020 August | 0 | 2 | 2 |
| 2020 July | 0 | 4 | 4 |
| 2020 June | 0 | 36 | 36 |
| 2020 May | 0 | 2 | 2 |
| 2020 April | 0 | 3 | 3 |
| 2020 March | 0 | 61 | 61 |
| 2020 February | 0 | 2 | 2 |
| 2020 January | 0 | 8 | 8 |
| 2019 December | 0 | 8 | 8 |
| 2019 November | 0 | 3 | 3 |
| 2019 October | 0 | 6 | 6 |
| 2019 September | 0 | 5 | 5 |
| 2019 August | 0 | 3 | 3 |
| 2019 July | 0 | 30 | 30 |
| 2019 June | 0 | 17 | 17 |
| 2019 May | 0 | 74 | 74 |
| 2019 April | 0 | 40 | 40 |
| 2019 March | 0 | 1 | 1 |
| 2019 February | 0 | 6 | 6 |
| 2019 January | 0 | 3 | 3 |
| 2018 December | 0 | 11 | 11 |
| 2018 November | 0 | 5 | 5 |
| 2018 October | 0 | 3 | 3 |
| 2018 September | 0 | 2 | 2 |
| 2018 August | 0 | 1 | 1 |
| 2018 July | 0 | 3 | 3 |
| 2018 June | 0 | 2 | 2 |
| 2018 May | 0 | 5 | 5 |
| 2018 March | 1 | 0 | 1 |
| 2018 February | 2 | 2 | 4 |
| 2018 January | 5 | 2 | 7 |
| 2017 December | 6 | 5 | 11 |
| 2017 November | 3 | 2 | 5 |
| 2017 October | 9 | 2 | 11 |
| 2017 September | 6 | 6 | 12 |
| 2017 August | 7 | 4 | 11 |
| 2017 July | 11 | 3 | 14 |
| 2017 June | 6 | 2 | 8 |
| 2017 May | 7 | 1 | 8 |
| 2017 April | 3 | 2 | 5 |
| 2017 March | 6 | 13 | 19 |
| 2017 February | 12 | 0 | 12 |
| 2016 December | 3 | 3 | 6 |
| 2016 November | 9 | 3 | 12 |
| 2016 October | 11 | 5 | 16 |
| 2016 September | 2 | 1 | 3 |
| 2016 August | 7 | 2 | 9 |
| 2016 July | 1 | 0 | 1 |
Show all
