was read the article
array:23 [ "pii" => "S0301054616300386" "issn" => "03010546" "doi" => "10.1016/j.aller.2016.02.003" "estado" => "S300" "fechaPublicacion" => "2016-09-01" "aid" => "749" "copyright" => "SEICAP" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2016;44:455-60" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 81 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 61 "PDF" => 14 ] ] "itemSiguiente" => array:18 [ "pii" => "S0301054616300441" "issn" => "03010546" "doi" => "10.1016/j.aller.2016.03.002" "estado" => "S300" "fechaPublicacion" => "2016-09-01" "aid" => "755" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2016;44:461-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 84 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 60 "PDF" => 21 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Awareness of allergic enterocolitis among primary-care paediatricians: A web-based pilot survey" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "461" "paginaFinal" => "466" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 912 "Ancho" => 1576 "Tamanyo" => 68666 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Physicians who made the diagnosis of FPIES in the cohort of children cared by survey respondents.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "P. Comberiati, M. Landi, A. Martelli, G.L. Piacentini, C. Capristo, G. Paiola, D.G. Peroni" "autores" => array:7 [ 0 => array:2 [ "nombre" => "P." "apellidos" => "Comberiati" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Landi" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Martelli" ] 3 => array:2 [ "nombre" => "G.L." "apellidos" => "Piacentini" ] 4 => array:2 [ "nombre" => "C." "apellidos" => "Capristo" ] 5 => array:2 [ "nombre" => "G." "apellidos" => "Paiola" ] 6 => array:2 [ "nombre" => "D.G." "apellidos" => "Peroni" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054616300441?idApp=UINPBA00004N" "url" => "/03010546/0000004400000005/v1_201609110107/S0301054616300441/v1_201609110107/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0301054616000057" "issn" => "03010546" "doi" => "10.1016/j.aller.2015.11.002" "estado" => "S300" "fechaPublicacion" => "2016-09-01" "aid" => "733" "copyright" => "SEICAP" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Allergol Immunopathol (Madr). 2016;44:450-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 121 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 76 "PDF" => 37 ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Novel <span class="elsevierStyleItalic">WASP</span> mutation in a patient with Wiskott–Aldrich syndrome: Case report and review of the literature" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "450" "paginaFinal" => "454" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 350 "Ancho" => 2425 "Tamanyo" => 57577 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Schematic illustration of the WASP gene with 12 exons and five major functional domains. The mutation; insertion of nucleotide (G) in exon 10 in PRR.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. Eghbali, M. Sadeghi-Shabestari, F. Najmi Varzaneh, A. Zare Bidoki, N. Rezaei" "autores" => array:5 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "Eghbali" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Sadeghi-Shabestari" ] 2 => array:2 [ "nombre" => "F." "apellidos" => "Najmi Varzaneh" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Zare Bidoki" ] 4 => array:2 [ "nombre" => "N." "apellidos" => "Rezaei" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054616000057?idApp=UINPBA00004N" "url" => "/03010546/0000004400000005/v1_201609110107/S0301054616000057/v1_201609110107/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Mould and grass pollen allergy as risk factors for childhood asthma in Zaragoza, Spain" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "455" "paginaFinal" => "460" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "N. Segura, J. Fraj, J.L. Cubero, M.T. Sobrevía, A. Lezaun, L. Ferrer, A. Sebastián, C. Colás" "autores" => array:8 [ 0 => array:4 [ "nombre" => "N." "apellidos" => "Segura" "email" => array:1 [ 0 => "nseguraa@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Fraj" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "J.L." "apellidos" => "Cubero" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "M.T." "apellidos" => "Sobrevía" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Lezaun" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "L." "apellidos" => "Ferrer" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "A." "apellidos" => "Sebastián" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 7 => array:3 [ "nombre" => "C." "apellidos" => "Colás" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Allergy Department, University Hospital Lozano Blesa of Zaragoza, Avda. San Juan Bosco, 15, 50009 Zaragoza, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Aragon Health Research Institute (IIS Aragón), Centro de Investigación Biomédica de Aragón (CIBA), Avda. San Juan Bosco, 13, 50009 Zaragoza, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Pneumology Department, University Hospital Lozano Blesa of Zaragoza, Avda. San Juan Bosco, 15, 50009 Zaragoza, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 998 "Ancho" => 1479 "Tamanyo" => 85347 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Relationship between the presence of eczema and rhinitis in asthmatic and non-asthmatic group.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Asthma is a multifactorial disease with a high prevalence in childhood. It involves a significant degree of morbidity, loss of quality of life for the child and parents and great cost, direct and indirect, to the family and Health Administration.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">1,2</span></a> In Spain, following the epidemiological questionnaire of the International Study of Asthma and Allergy in Children (ISAAC),<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">3</span></a> the prevalence of childhood asthma was studied in Huesca,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">4</span></a> Castellón<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a> and all participating areas.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> The later study included 42,417 Spanish children in phase I (1994–1995), and 42,813 in phase III (2002–2003). The prevalence of asthma in children aged 6–7 years, reported by parents, was 7% and 10.7% for boys in phases I and III and 5.3% and 8.2% for girls in phases I and III, respectively. The self-reported prevalence of asthma in adolescents aged 13–14 years was 9% and 9.3% in boys, in phases I and III, and 9.6% and 9.2% in girls in phases I and III, respectively. However, the results on the prevalence of asthma in many Western countries, even within the same country, are not always comparable, given the geographical, cultural and socioeconomic differences that produce wide variations in the frequency of this disease, nationally and internationally. These differences<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a> would probably be due to environmental factors (level of hygiene, allergenic pressure, infections, overuse of antibiotics and other unknown factors).</p><p id="par0010" class="elsevierStylePara elsevierViewall">Following the same ISAAC epidemiological questionnaire, the aim of this study was to estimate the prevalence of asthma and its associated predictors in a school population of the city of Zaragoza, Spain. It is named the LAPIZ study (<span class="elsevierStyleItalic">Estudio epidemi<span class="elsevierStyleBold">L</span>ógico de <span class="elsevierStyleBold">A</span>sma en <span class="elsevierStyleBold">P</span>oblación <span class="elsevierStyleBold">I</span>nfantil de <span class="elsevierStyleBold">Z</span>aragoz</span>a [Epidemiological Study of Asthma in the Juvenile Population of Zaragoza]).</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Patients and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The design was a descriptive, cross-sectional, observational study of a representative population of 468 children aged 10–12 years in the city of Zaragoza. The study was approved by the local health authority (Instituto Aragonés de Ciencias de la Salud – IACS) and its Ethics Committee. Children of this age were chosen for their comprehension and ability to self-complete the questionnaire, which is not possible for younger children, and for being the oldest group that had afternoon classes once our business hours were over. In the random sampling 14 schools were included, public or semi-private, and one private.</p><p id="par0020" class="elsevierStylePara elsevierViewall">The required sample size calculation was 457 children, making a rough estimate of the population group of 10–12 years of 11,219 people (based on official figures from the current census during the design of the study that showed 28,047 children aged 10–14 years), for a confidence level of 95%, accuracy of 2% and prevalence of childhood asthma of 5%. The sample represented different areas of the city and took place during the autumn and winter months of the 2007–2008 school academic year. We excluded spring and summer because hypersensitivity to grass pollen, olive and <span class="elsevierStyleItalic">Chenopodiaceae</span>, which pollinate during those months, is the most relevant in our geographic area. We thus avoided children receiving symptomatic treatment at the time of the study, which could bias the results. The study only included children whose parents had signed the informed consent. Non-participants were sent an anonymous and voluntary survey asking why they had decided not to participate: forgetfulness; being already diagnosed with asthma and/or allergy; the child does not have any health problems; the child did not want to participate; the parents have not received the informed consent to sign; other causes.</p><p id="par0025" class="elsevierStylePara elsevierViewall">At the outset, the children self-completed the validated ISAAC questionnaire<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a> for asthma and allergy under the investigators’ supervision. We chose this questionnaire for validation due to its great relevance worldwide. Self-completion yielded two groups: those who had no symptoms suggestive of asthma and those who, in the last 12 months, had experienced asthmatic symptoms and/or had been diagnosed with asthma. Risk factors for asthma assessed in the questionnaire<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> were genetic risk (family history of asthma) and environmental risk (exposure to tobacco smoke, domestic animals and relevant respiratory illness). The risk for atopy was assessed by testing the presence of immediate hypersensitivity through skin prick test to one of the most significant environmental aeroallergens in our environment (Bial-Arístegui, Bilbao, Spain), including <span class="elsevierStyleItalic">Phleum pratense</span>, <span class="elsevierStyleItalic">Olea europaea</span>, <span class="elsevierStyleItalic">Salsola kali</span>, <span class="elsevierStyleItalic">Parietaria judaica</span>, <span class="elsevierStyleItalic">Platanus acerifolia</span>, <span class="elsevierStyleItalic">Cupressus sempervirens</span>, <span class="elsevierStyleItalic">Dermatophagoides</span> spp., <span class="elsevierStyleItalic">Alternaria alternata</span> and dog and cat dander. Histamine hydrochloride (10<span class="elsevierStyleHsp" style=""></span>mg/mL) and glycerol saline served as positive and negative controls respectively. A skin test was considered positive when its wheal diameter was larger ≥3<span class="elsevierStyleHsp" style=""></span>mm than the negative control.</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Statistical analysis</span><p id="par0030" class="elsevierStylePara elsevierViewall">SPSS (version 15) was used to conduct the statistical analysis. Quantitative variables were expressed by their mean and standard deviation and qualitative variables as proportions. Relationships between paired variables were analysed using contingency tables and Pearson contrasts <span class="elsevierStyleItalic">χ</span><span class="elsevierStyleSup">2</span> for qualitative variables. In the case of a qualitative and quantitative variable, relationships were analysed by Student <span class="elsevierStyleItalic">t</span>-test for comparison of means. Finally, multivariate logistic regression was used to identify factors predicting asthma.</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="par0035" class="elsevierStylePara elsevierViewall">Of an initial sample of 848 children, 468 participated in our study, representing 55%. The demographic characteristics of non-participants did not differ from the sample: the schools and homes of the children were in the same metropolitan area with similar air pollution and they were studying the same academic year. The anonymous and voluntary survey sent to non-participants was returned by 211 parents (55.53%) and the reasons given were: forgetfulness 6.16% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>13); being already diagnosed with asthma and/or allergy 12.79% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>27); the child does not have any health problems 33.17% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>70); the child did not want to participate 18% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>38); the parents have not received the informed consent to sign 2.84% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6), and other causes 27.01% (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>57). <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the general characteristics of the study population. According to the results of the ISAAC questionnaire, 118 of 466 children had symptoms consistent with asthma, those classified as possible asthmatic representing 25.3%. They are children who answered yes to one or both of two questions: “Have you had wheezing or whistling in the chest in the last 12 months?” and, “Have you ever had asthma?” The estimated prevalence of asthma, according to responses to the first question, was 15.8%. An affirmative answer to the second question equates with diagnosed asthma and involves a previous diagnosis by a doctor. In this case the estimated prevalence of asthma was 16.8%. This percentage is similar to that obtained when asked if they had ever presented wheezing or whistling in the chest in the last 12 months. There were no significant differences in gender distribution. Thirty-three point one percent (33.1%) of asthmatic children answered yes to the question, “Is there a history of asthma in the immediate family?”, which is statistically significant (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.78, 95% CI 1.05–3.01, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). A relevant number of asthmatics are assumed to be exposed routinely to tobacco smoke at home, with fathers more likely to be smokers than mothers (39%), but only maternal smoking was slightly associated with the presence of asthma (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.044). The tendency in developed countries to have pets in the homes is confirmed in our series in which we observed that 52% of the total sample of children surveyed had animals at home, the dog being the most common, followed by cat, hamster and parakeet. Within the group of asthmatic children, 52.5% had a pet. However, living with pets showed no statistical significance. Finally, when asked for a prior history of hospitalisations due to lower respiratory illness, 22% of children with asthma responded positively (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6.72, 95% CI 3.08–14.70, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The results of the skin tests in the total sample appear in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>. As expected, hypersensitivity to grass pollen was the most frequent (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>108, 23.2%), followed by hypersensitivity to olive pollen (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>83, 17.8%), aerogenic fungus <span class="elsevierStyleItalic">Alternaria</span> (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>69, 14.8%), <span class="elsevierStyleItalic">Salsola</span> (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>60, 12.9%) and cat dander (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>48, 10.3%). Hypersensitivity to mites, plane tree pollen, <span class="elsevierStyleItalic">Parietaria</span> and dog dander was less relevant. Skin tests that were most frequently positive in asthmatic children were the same as in the total sample. Thirty-four percent (34%) showed hypersensitivity to grass pollen and 26% to olive pollen and <span class="elsevierStyleItalic">Alternaria</span>, equally. Skin tests positive for grass, olive, <span class="elsevierStyleItalic">Alternaria</span>, cypress and mites were present in asthmatic children at a rate higher than that observed in non-asthmatics, resulting in statistically significant data (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>). Positive skin tests to <span class="elsevierStyleItalic">Alternaria</span> (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.00, 95% CI 1.07–3.75, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001) and grass pollen (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.76, 95% CI 1.02–3.01, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001) were predictors of asthma. Overall, children with asthma had more frequent positive skin tests to aeroallergens, both in terms of a single test and two or more positive tests (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.08, 95% CI 1.30–3.40, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.008).</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">More than half of the children (52.4%) answered “yes” to the question whether, at some time, they had suffered symptoms of rhinitis, without it coinciding with a cold. When asked specifically whether they had had symptoms of rhinitis in the past year, the number of children who responded affirmatively dropped to 39.7%. To another question, considered especially relevant (Have you ever had hay fever/rhinitis/allergic conjunctivitis?), 17.8% responded affirmatively. Sixty-three point six percent (63.6%) of asthmatic children presented symptoms of rhinitis in the last 12 months, compared to 31.9% of non-asthmatics, and this difference was statistically significant (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.77, 95% CI 2.30–6.18, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001).</p><p id="par0050" class="elsevierStylePara elsevierViewall">Ninety children (19.2%) of the total sample said they had occasionally suffered an itchy rash compatible with atopic eczema. When asked if it had occurred in the past year, the number decreased to 52 (11.1%). With respect to the relationship between the presence of asthma and eczema, 47% of asthmatics had or had previously presented eczema lesions, whereas only 26.9% of non-asthmatics had or had previously presented these lesions, resulting in a significant difference (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Multivariate logistic regression results are shown in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>.</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="par0060" class="elsevierStylePara elsevierViewall">Fifteen point eight percent (15.8%) of the children reported wheezing in the last 12 months. When we assessed children diagnosed with asthma, meaning diagnosed by a doctor, the percentage was similar: 16.8%. The values are higher than would be expected initially, when compared with those obtained by the ISAAC study in Spain by García-Marcos et al.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a> but lower than Carvajal-Urueña et al.<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a> on Spain's northern Atlantic coast. The high prevalence of children with symptoms compatible with asthma in our study is likely due to our including non-asthmatic children within the group of asthmatics. This is one of the limitations of this type of questionnaire. Like the ISAAC study questionnaire, it allows us to make comparisons between different clinical settings and geographic areas, using the same methodology. We must bear in mind, however, that the purpose of these questionnaires is to conduct an epidemiological study and not to formulate a clinical diagnosis. Other limitations of our study are that the cross-sectional design limits the assessment of risk factors, the low participation, the lack of objective measures of asthma, and the absence of some other risk factors for asthma (social class, truck traffic, maternal age, etc.).</p><p id="par0065" class="elsevierStylePara elsevierViewall">In our study there were no significant differences in gender distribution. Arnedo-Pena et al.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> demonstrate that male gender is a risk factor for asthma.</p><p id="par0070" class="elsevierStylePara elsevierViewall">A family history of asthma is very relevant in asthmatic patients.<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12,13</span></a> This is also reflected in our results, in which we see a significant association between asthma symptoms and a family history of asthma; the presence of close relatives with asthma would be a predictor of the disease. Consequently, early diagnosis is desirable in children with a close family history of symptoms suggestive of asthma.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Smoking is the leading cause of preventable disease in the developed world. We know that inhaling tobacco smoke, both active and passive, can cause asthma exacerbations. Some authors even point to tobacco smoke not only to cause exacerbations but also as a direct inducer.<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14,15</span></a> Arnedo-Pena et al.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> demonstrates that the father smoking at home is a risk factor for asthma. Our epidemiological study found that maternal smoking, but not the father's, was significantly associated with the presence of asthma. This can easily be explained: the mother is with the child far more hours than the child's father. Unfortunately, smoking has increased significantly among women in recent decades, becoming a relevant and completely avoidable risk factor. Hence it is important to continue to promote anti-smoking campaigns.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Many epidemiological studies have attempted to assess the possible correlation between pet exposure and the prevalence of asthma and other allergic diseases.<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">16,17</span></a> In recent years there have been studies that cast doubt on the influence of exposure to these animals as inducing IgE-mediated sensitisation. For Almqvist et al.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> the coexistence of children with certain pets in the early stages of life would not increase the risk of asthma. Arnedo-Pena et al.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> demonstrates that the presence of a dog at home is a risk factor for asthma. In our series, we found no significant relationship between the presence of asthma and exposure to dog, cat or another pet. Much more striking was the correlation between the presence of asthma and a history of hospitalisations for respiratory illness. For years we have known that infant bronchiolitis may act as a factor inducing asthma.<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11,19,20</span></a> Although the questionnaire does not explore the infectious disease that caused the hospitalisation, presumably in many cases it would be bronchiolitis or another severe respiratory infection.</p><p id="par0085" class="elsevierStylePara elsevierViewall">More than half of the children with asthma showed positive allergy skin tests. The positivity to a single allergen, two allergens, or more than two allergens was significantly higher in asthmatic children than in those who were not. The highest percentage of positive skin tests, both in the total study population as well as in asthmatic children, was to grass pollen, followed by olive and <span class="elsevierStyleItalic">Alternaria</span>, consistent with the geographical and climatic characteristics of the middle Ebro valley.<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">21</span></a> Deserving special mention is sensitisation to <span class="elsevierStyleItalic">Alternaria</span>, especially significant in children and adolescents with asthma.<a class="elsevierStyleCrossRefs" href="#bib0260"><span class="elsevierStyleSup">22,23</span></a> In our series it appears as the third most frequent sensitisation, to the point that 26% of asthmatic children showed positive prick test to this fungus. In many cases this sensitisation is associated with more severe forms of asthma and worse outcomes,<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a> so that, for some authors,<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">25</span></a> sensitisation and exposure to <span class="elsevierStyleItalic">Alternaria alternata</span> is a clear predisposing factor for severe exacerbation in children, adolescents and young adults with asthma.</p><p id="par0090" class="elsevierStylePara elsevierViewall">The current scientific community sees rhinitis and asthma as a single disease<a class="elsevierStyleCrossRefs" href="#bib0280"><span class="elsevierStyleSup">26,27</span></a> that affects the different levels of the airway. Hence, from a clinical, pathophysiological and epidemiological standpoint, they are closely interrelated.<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">28</span></a> In our study, 63.6% of asthmatic children had shown symptoms of rhinitis in the last 12 months, compared to 31.9% of non-asthmatics, representing a significant difference. It is well known that the presence of rhinitis is a risk factor associated with the incidence of asthma,<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11,29</span></a> a fact confirmed in our study. In parallel, 47% of asthmatic children presented or had presented eczema occasionally versus 26.9% of non-asthmatics, an equally significant finding. Therefore, in accordance with the general acceptance,<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a> the presence of eczema in our children population was associated with the prevalence of asthma.</p><p id="par0095" class="elsevierStylePara elsevierViewall">In conclusion, we believe that, in relation to the questionnaire responses, between 15.8% and 25.3% of children had symptoms consistent with asthma in the city of Zaragoza. The history of hospital admissions for lower respiratory tract illness, the presence of rhinitis and/or eczema, the prick test positive to certain aeroallergens, especially <span class="elsevierStyleItalic">Alternaria</span>, family history of asthma and maternal smoking are risk factors associated with the development of asthma.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Ethical disclosures</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Confidentiality of data</span><p id="par0100" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Right to privacy and informed consent</span><p id="par0105" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appears in this article.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Protection of human subjects and animals in research</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this investigation.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Funding</span><p id="par0115" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleGrantSponsor" id="gs1">Aragonese Foundation for Research Development in Allergology (FADIA)</span>.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Conflict of interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">None of the authors has a financial relationship with a commercial entity that has an interest in the subject of this manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres729360" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec733413" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "sec0010" "titulo" => "Patients and methods" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Statistical analysis" ] ] ] 4 => array:2 [ "identificador" => "sec0020" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "sec0025" "titulo" => "Discussion" ] 6 => array:3 [ "identificador" => "sec0030" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Confidentiality of data" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Right to privacy and informed consent" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Protection of human subjects and animals in research" ] ] ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Funding" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflict of interest" ] 9 => array:2 [ "identificador" => "xack242410" "titulo" => "Acknowledgments" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-15" "fechaAceptado" => "2016-02-08" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec733413" "palabras" => array:5 [ 0 => "ISAAC questionnaire" 1 => "Asthma predictors" 2 => "Childhood" 3 => "<span class="elsevierStyleItalic">Alternaria</span>" 4 => "Asthma epidemiology" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objective</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Examine the prevalence of asthma and associated predictive factors in a group of 468 students.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and methods</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A descriptive, cross-sectional observational study in a randomly selected population of 468 children aged 10–12, in the city of Zaragoza. We used the ISAAC questionnaire on asthma completed by children under supervision of the investigators. We assessed the genetic risk (family history of asthma) and environmental risks. The risk for atopy was assessed by the presence of positive skin prick tests.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">25.3% of the children had symptoms consistent with asthma in the city of Zaragoza. Among them 33.1% reported a history of asthma in close relatives (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.78, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001). The history of hospitalisations for lower respiratory tract illness was strongly associated with the presence of asthma (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6.72, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001). Positive skin tests to <span class="elsevierStyleItalic">Alternaria</span> (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.00, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001) and grass pollen (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.76, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001) were predictors of asthma. 63.6% of asthmatic children had presented clinical rhinitis in the previous 12 months, compared with 32% of non-asthmatics, and this difference was statistically significant (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.89, <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001). 47% of asthmatics presented with or previously had eczema, whereas only 26.9% of non-asthmatics presented with or previously had these types of lesions (<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">The following are predictors of asthma: History of hospital admissions for lower respiratory tract illness, presence of rhinitis and/or eczema, positive prick test for certain aeroallergens, especially <span class="elsevierStyleItalic">Alternaria</span> and grass pollen, and family history of asthma.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objective" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 998 "Ancho" => 1479 "Tamanyo" => 85347 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Relationship between the presence of eczema and rhinitis in asthmatic and non-asthmatic group.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Number \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Percentage (%) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Sex</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">246 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">52.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">222 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">47.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Age (years)</span><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">393 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">84 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1202156.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Characteristics of participating student population.</p>" ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">ns, not significant.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Variable \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">Yes \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">No \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">n</span> (%) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Wheezing at any time (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">100 (21.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">368 (78.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Wheezing in the past 12 months (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">74 (15.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">394 (84.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Asthma at any time (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>465) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">78 (16.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">387 (83.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Wheezing during exercise (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">115 (24.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">353 (75.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dry cough (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">147 (31.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">321 (68.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Family history of asthma (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">101 (21.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">367 (78.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Exposure to maternal tobacco smoke (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>466) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">147 (31.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">319 (68.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.044 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dog at home (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">101 (21.6%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">367 (78.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cat at home (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">51 (10.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">417 (89.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Other animal at home (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">92 (19.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">376 (80.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Visits/hospital admissions for respiratory illness (<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>468) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">39 (8.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">429 (91.7%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1202155.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Prevalence of asthma symptoms and associated risk factors.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">ns, not significant.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td-with-role" title="table-head ; entry_with_role_rowhead " align="left" valign="top" scope="col">Allergen \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">No asthma \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">Asthma \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col">Total sample \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">(<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>350) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">(<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>118) \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Grass \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">19.6% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">33.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">23.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Olive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">15% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">17.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.006 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Alternaria</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">26.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">14.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Salsola</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cat \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">12.7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">10.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cypress \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mites \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">16.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Plane tree \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">11% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.5% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dog \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.6% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">7.6% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.9% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Parietaria</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">4.6% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">9.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">5.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">ns \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1202154.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Skin tests in asthmatics. Relationship between the presence of asthma and positive skin tests.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="" valign="top" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">OR (95% CI) \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">History of asthma in close relatives \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.032 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.780 (1.051–3.015) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">History of hospitalisations for lower respiratory tract illness \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.729 (3.081–14.696) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Positive skin tests \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.085 (1.302–3.339) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Symptoms of rhinitis in the last 12 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.771 (2.302–6.176) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Constant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.081 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">History of asthma in close relatives \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.029 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.798 (1.062–3.046) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">History of hospitalisations for lower respiratory tract illness \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">6.381 (2.901–14.036) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Symptoms of rhinitis in the last 12 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">3.891 (2.374–6.378) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Positive skin tests to <span class="elsevierStyleItalic">Alternaria</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.031 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">2.000 (1.067–3.750) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Positive skin tests to grass pollen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.041 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">1.756 (1.024–3.012) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Constant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.000 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="char" valign="top">0.085 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1202153.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Multivariate logistic regression results.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0155" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Out-of-pocket medication costs and use of medications and health care services among children with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Karaca-Mandia" 1 => "A.B. Jena" 2 => "G.F. Joyce" 3 => "D.P. Goldman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.2012.340" "Revista" => array:7 [ "tituloSerie" => "JAMA" "fecha" => "2012" "volumen" => "307" "paginaInicial" => "1284" "paginaFinal" => "1291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22453569" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109712026897" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0160" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma outcomes: health care utilization and costs" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L.J. Akinbami" 1 => "S.D. Sullivan" 2 => "J.D. Campbell" 3 => "R.W. Grundmeier" 4 => "T.V. Hartert" 5 => "T.A. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2011.12.984" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2012" "volumen" => "129" "paginaInicial" => "S49" "paginaFinal" => "S64" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22386509" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0165" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "World-wide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "The International Study of Asthma and Allergies in Childhood (ISAAC) Steering Committee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Lancet" "fecha" => "1998" "volumen" => "351" "paginaInicial" => "1232" "paginaFinal" => "1255" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0170" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factores de riesgo de asma, alergia e hiperreactividad bronquial en niños de 6 a 8 años" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Fuertes Fernández-Espinara" 1 => "J. Meriz Rubioa" 2 => "C. Isanta Pomara" 3 => "C. Pardos Martíneza" 4 => "V. López Cortésa" 5 => "E. González Pérez-Yarza" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "2001" "volumen" => "5" "paginaInicial" => "205" "paginaFinal" => "212" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0175" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asma y síntomas relacionados con el asma en niños escolarizados de 6–7 años y de 13–14 años. Prevalencia y factores de riesgo asociados con sibilancias recientes. Estudio en 7 poblaciones colindantes de la provincia de Castellón" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.J. Bellido" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1997" "editorial" => "Universidad Autónoma" "editorialLocalizacion" => "Barcelona" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0180" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Stabilization of asthma prevalence among adolescents and increase among schoolchildren (ISAAC phases I and III) in Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. García-Marcos" 1 => "A.B. Quirós" 2 => "G.G. Hernández" 3 => "F. Guillén-Grima" 4 => "C.G. Díaz" 5 => "I.C. Ureña" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2004.00562.x" "Revista" => array:7 [ "tituloSerie" => "Allergy" "fecha" => "2004" "volumen" => "59" "paginaInicial" => "1301" "paginaFinal" => "1307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15507099" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673609605523" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0185" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "World-wide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "International Study of Asthma, Allergies in Childhood (ISAAC) Steering Committee" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1998" "volumen" => "12" "paginaInicial" => "315" "paginaFinal" => "335" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9727780" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0190" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International study of asthma and allergies in childhood (ISAAC): rationale and methods" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.I. Asher" 1 => "U. Keil" 2 => "H.R. Anderson" 3 => "R. Beasley" 4 => "J. Crane" 5 => "F. Martinez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "1995" "volumen" => "8" "paginaInicial" => "483" "paginaFinal" => "491" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7789502" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0195" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early childhood predictors of asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.B. Sherman" 1 => "T.D. Tosteson" 2 => "I.B. Tager" 3 => "F.E. Speizer" 4 => "S.T. Weiss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "1990" "volumen" => "132" "paginaInicial" => "83" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2356817" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0200" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographic variation in the prevalence of asthma symptoms in Spanish children and adolescents. International Study of Asthma and Allergies in Childhood (ISAAC) Phase 3, Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Carvajal-Urueña" 1 => "L. García-Marcos" 2 => "R. Busquets-Monge" 3 => "M. Morales Suárez-Varela" 4 => "N. García de Andoin" 5 => "J. Batlles-Garrido" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "659" "paginaFinal" => "666" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16373042" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0205" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors and prevalence of asthma in schoolchildren in Castellon (Spain): a cross-sectional study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Arnedo-Pena" 1 => "J. Puig-Barberà" 2 => "J.B. Bellido-Blasco" 3 => "M.R. Pac-Sa" 4 => "J.B. Campos-Cruañes" 5 => "A. Artero-Sivera" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Allergol Immunopathol (Madr)" "fecha" => "2009" "volumen" => "37" "paginaInicial" => "135" "paginaFinal" => "142" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0210" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Air pollution, genetics, and allergy: an update" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Carlsten" 1 => "E. Melén" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2012" "volumen" => "12" "paginaInicial" => "465" "paginaFinal" => "560" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0215" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic, epigenetic, and environmental factors in asthma and allergy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M.N. Blumenthal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anai.2011.12.003" "Revista" => array:7 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2012" "volumen" => "108" "paginaInicial" => "69" "paginaFinal" => "73" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22289722" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109709034718" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0220" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asthma in the inner city and the indoor environment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E.C. Matsui" 1 => "N.N. Hansel" 2 => "M.C. McCormack" 3 => "R. Rusher" 4 => "P.N. Breysse" 5 => "G.B. Diette" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Immunol Allergy Clin N Am" "fecha" => "2008" "volumen" => "28" "paginaInicial" => "665" "paginaFinal" => "686" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0225" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of environmental tobacco smoke in genetic susceptibility to asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "T. Kurz" 1 => "C. Ober" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2004" "volumen" => "4" "paginaInicial" => "335" "paginaFinal" => "339" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15349030" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0230" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposure to cats: update on risks for sensitization and allergic diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.C. Dharmage" 1 => "C.L. Lodge" 2 => "M.C. Matheson" 3 => "B. Campbell" 4 => "A.J. Lowe" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11882-012-0288-x" "Revista" => array:6 [ "tituloSerie" => "Curr Allergy Asthma Rep" "fecha" => "2012" "volumen" => "12" "paginaInicial" => "413" "paginaFinal" => "423" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22878928" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0235" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pets and birth do not increase allergic disease in at risk children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.J. Lodge" 1 => "A.J. Lowe" 2 => "L.C. Gurrin" 3 => "M.C. Matheson" 4 => "A. Balloch" 5 => "C. Axelrad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2222.2012.04032.x" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2012" "volumen" => "42" "paginaInicial" => "1377" "paginaFinal" => "1385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22925324" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0240" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Direct and indirect exposure to pets-risk of sensitization and asthma at 4 years in a birth cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Almqvist" 1 => "A.C. Egmar" 2 => "G. Hedlin" 3 => "M. Lundqvist" 4 => "S.L. Nordvall" 5 => "G. Pershagen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Allergy" "fecha" => "2003" "volumen" => "33" "paginaInicial" => "1190" "paginaFinal" => "1197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12956738" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0245" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Respiratory repercussions in adults with a history of infantile bronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Gómez" 1 => "C. Colás" 2 => "A. Sebastián" 3 => "J. Arribas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1081-1206(10)61411-1" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2004" "volumen" => "93" "paginaInicial" => "447" "paginaFinal" => "451" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15562883" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0250" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiologic evidence of increased airway reactivity in children with a history of bronchiolitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "M. Kattan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1999" "volumen" => "135" "paginaInicial" => "8" "paginaFinal" => "13" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10431133" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0255" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polinosis en el área de Zaragoza" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Pola" 1 => "C. Zapata" 2 => "E. Sanz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Esp Alergol Inmunol Clin" "fecha" => "1998" "volumen" => "13" "paginaInicial" => "135" "paginaFinal" => "139" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0260" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Correlation between Alt a 1 levels and clinical symptoms in <span class="elsevierStyleItalic">Alternaria alternata</span>-monosensitized patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Feo Brito" 1 => "A.M. Alonso" 2 => "J. Carnés" 3 => "R. Martín-Martín" 4 => "E. Fernández-Caldas" 5 => "P.A. Galindo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2012" "volumen" => "22" "paginaInicial" => "154" "paginaFinal" => "159" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22697004" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109709040741" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0265" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mold and Alternaria skin test reactivity and asthma in children in Connecticut" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.W. Lyons" 1 => "D.B. Wakefield" 2 => "M.M. Cloutier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anai.2010.12.009" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2011" "volumen" => "106" "paginaInicial" => "301" "paginaFinal" => "307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21457878" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0270" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical characteristics of the fatal and near-fatal asthma in <span class="elsevierStyleItalic">Alternaria alternata</span> sensitized patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Plaza" 1 => "J. Serrano" 2 => "C. Picado" 3 => "J. Cosano" 4 => "J. Ancochea" 5 => "A. de Diego" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin" "fecha" => "2003" "volumen" => "121" "paginaInicial" => "721" "paginaFinal" => "724" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0275" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Exposure to and aeroallergen as a possible precipitating factor in respiratory arrest in young patients with asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.T. O’Hollaren" 1 => "J.W. Yunginger" 2 => "K.P. Offord" 3 => "M.J. Somers" 4 => "E.J. O’Connell" 5 => "D.J. Ballard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199102073240602" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1991" "volumen" => "324" "paginaInicial" => "359" "paginaFinal" => "363" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1987459" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0280" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Links between rhinitis and asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Bousquet" 1 => "A.M. Vignola" 2 => "P. Demoly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "691" "paginaFinal" => "706" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12859545" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0285" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The relationships of rhinitis and asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "E.O. Meltzer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy Asthma Proc" "fecha" => "2005" "volumen" => "26" "paginaInicial" => "336" "paginaFinal" => "340" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16450565" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0290" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The connection between allergic rhinitis and bronchial asthma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J. Corren" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MCP.0b013e328010d0db" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Pulm Med" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "13" "paginaFinal" => "18" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17133119" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0295" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic Rhinitis and its impact on Asthma update (ARIA 2008). The perspective from Spain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Mullol" 1 => "A. Valero" 2 => "I. Alobid" 3 => "J. Bartra" 4 => "A.M. Navarro" 5 => "T. Chivato" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2008" "volumen" => "18" "paginaInicial" => "327" "paginaFinal" => "334" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18973095" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0300" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Development of allergies and asthma in infants and young children with atopic dermatitis. A prospective follow-up to 7 years of age" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Gustafsson" 1 => "O. Sjöberg" 2 => "T. Foucard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2000" "volumen" => "55" "paginaInicial" => "240" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10753014" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack242410" "titulo" => "Acknowledgments" "texto" => "<p id="par0125" class="elsevierStylePara elsevierViewall">We thank the nurses of the Allergy Department of the Clinical University Hospital in Zaragoza (Carmen Abadía, Bertha Ariza, Ascensión Bretos, Virginia Roche, Javier Saldaña and Lourdes Sobrino) and the rest of the medical staff (Mar Garcés, María Asunción Domínguez, María Dolores Yécora and Estibalitz Goienetxe).</p> <p id="par0130" class="elsevierStylePara elsevierViewall">The Aragonese Foundation for Research Development in Allergology (FADIA) provided funding for this research.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/03010546/0000004400000005/v1_201609110107/S0301054616300386/v1_201609110107/en/main.assets" "Apartado" => array:4 [ "identificador" => "5554" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03010546/0000004400000005/v1_201609110107/S0301054616300386/v1_201609110107/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054616300386?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 4 | 0 | 4 |
2024 October | 11 | 4 | 15 |
2024 September | 32 | 6 | 38 |
2024 August | 40 | 9 | 49 |
2024 July | 37 | 7 | 44 |
2024 June | 27 | 3 | 30 |
2024 May | 33 | 3 | 36 |
2024 April | 31 | 7 | 38 |
2024 March | 39 | 9 | 48 |
2024 February | 26 | 9 | 35 |
2024 January | 11 | 3 | 14 |
2023 December | 18 | 5 | 23 |
2023 November | 17 | 9 | 26 |
2023 October | 17 | 9 | 26 |
2023 September | 11 | 2 | 13 |
2023 August | 18 | 5 | 23 |
2023 July | 18 | 2 | 20 |
2023 June | 30 | 4 | 34 |
2023 May | 54 | 7 | 61 |
2023 April | 61 | 0 | 61 |
2023 March | 35 | 3 | 38 |
2023 February | 18 | 8 | 26 |
2023 January | 12 | 1 | 13 |
2022 December | 20 | 26 | 46 |
2022 November | 32 | 9 | 41 |
2022 October | 19 | 6 | 25 |
2022 September | 23 | 14 | 37 |
2022 August | 17 | 6 | 23 |
2022 July | 20 | 11 | 31 |
2022 June | 37 | 13 | 50 |
2022 May | 31 | 5 | 36 |
2022 April | 16 | 5 | 21 |
2022 March | 28 | 8 | 36 |
2022 February | 59 | 8 | 67 |
2022 January | 56 | 11 | 67 |
2021 December | 44 | 4 | 48 |
2021 November | 33 | 8 | 41 |
2021 October | 30 | 9 | 39 |
2021 September | 34 | 12 | 46 |
2021 August | 63 | 13 | 76 |
2021 July | 14 | 12 | 26 |
2021 June | 23 | 10 | 33 |
2021 May | 29 | 8 | 37 |
2021 April | 45 | 12 | 57 |
2021 March | 13 | 13 | 26 |
2021 February | 21 | 12 | 33 |
2021 January | 12 | 5 | 17 |
2020 December | 2 | 0 | 2 |
2020 October | 1 | 0 | 1 |
2020 July | 0 | 1 | 1 |
2018 February | 8 | 3 | 11 |
2018 January | 6 | 2 | 8 |
2017 December | 1 | 0 | 1 |
2017 November | 3 | 2 | 5 |
2017 October | 6 | 2 | 8 |
2017 September | 10 | 2 | 12 |
2017 August | 9 | 1 | 10 |
2017 July | 12 | 1 | 13 |
2016 December | 2 | 0 | 2 |
2016 October | 1 | 0 | 1 |
2016 September | 3 | 1 | 4 |