Interleukin-23 receptor gene polymorphisms in Iranian patients with juvenile systemic lupus erythematosus

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Comparison of GARP expression between children with and without food-specific IgE in serum (B). 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Rodriguez-Martinez, M.P. Sossa-Briceño, J.A. Castro-Rodriguez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C.E." "apellidos" => "Rodriguez-Martinez" ] 1 => array:2 [ "nombre" => "M.P." "apellidos" => "Sossa-Briceño" ] 2 => array:2 [ "nombre" => "J.A." "apellidos" => "Castro-Rodriguez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054619300540?idApp=UINPBA00004N" "url" => "/03010546/0000004800000001/v2_202012050801/S0301054619300540/v2_202012050801/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Interleukin-23 receptor gene polymorphisms in Iranian patients with juvenile systemic lupus erythematosus" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "62" "paginaFinal" => "66" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Rezaei, S. Harsini, M. Sadr, V. Ziaee, N. Rezaei" "autores" => array:5 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Rezaei" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "S." "apellidos" => "Harsini" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Sadr" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "V." "apellidos" => "Ziaee" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "d" "identificador" => "aff0020" ] ] ] 4 => array:4 [ "nombre" => "N." "apellidos" => "Rezaei" "email" => array:1 [ 0 => "rezaei_nima@tums.ac.ir" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "e" "identificador" => "aff0025" ] 3 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Division of Pediatric Rheumatology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "textoCompleto" => "IntroductionSystemic lupus erythematosus (SLE) is a prototypic autoimmune disorder with diverse clinical manifestations and unclear pathogenesis. The disease is associated with the production of autoantibodies against nuclear and cytoplasmic components, abnormalities of immune-inflammatory system functions and inflammatory manifestations in several organs.<a class="elsevierStyleCrossRef" href="#bib0005">1</a> Juvenile systemic lupus erythematosus (JSLE), constitutes 10–20% of all SLE cases and predominantly appears before the age of 16 years.<a class="elsevierStyleCrossRefs" href="#bib0010">2,3</a> Although JSLE and adult-onset SLE share several features, JSLE is found to be more severe than the adult-onset SLE, leading to higher incidence of organ involvement and more rapid clinical progression.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> A complex interplay between genetic risk factors and environmental events is hypothesized to contribute towards disease initiation and progression.<a class="elsevierStyleCrossRefs" href="#bib0015">3,5</a> Genome-wide association studies have revealed familial tendency for disease expression, such as the evident higher concordance of SLE in monozygotic twins in comparison to healthy subjects.<a class="elsevierStyleCrossRefs" href="#bib0005">1,6</a> The results of such studies together with the data provided by our previous studies have supported the notion that genetic factors such as the genes coding for cytokines and their receptors could play crucial roles in the pathogenesis of inflammatory disorders such as JSLE.<a class="elsevierStyleCrossRefs" href="#bib0035">7–18</a>Interleukin-23 (IL-23) is a heterodimeric cytokine composed of a unique p19 subunit and a common p40 subunit shared with IL-12.<a class="elsevierStyleCrossRef" href="#bib0095">19</a> IL-23 is mainly expressed through activation of phagocytes and dendritic cells<a class="elsevierStyleCrossRefs" href="#bib0100">20,21</a> and has been shown to play an essential role in the activation of a subset of CD4+T cells characterized by the production of the interleukin-17 (IL-17), namely, Th17 cells.<a class="elsevierStyleCrossRefs" href="#bib0110">22,23</a> IL-17 induces the synthesis of proinflammatory cytokines which ultimately leads to chronic inflammation and the destruction of joints.<a class="elsevierStyleCrossRefs" href="#bib0105">21,24</a> All these findings suggest IL-23 pathway as an important actor in the pathogenesis of chronic inflammatory diseases such as SLE.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> IL-23 exerts its effects through binding to the IL-23 receptor (IL-23R) complex with high affinity.<a class="elsevierStyleCrossRef" href="#bib0100">20</a> IL-23R constitutes a common IL-23 receptor and an IL-12 receptor β1 subunit, which are mostly expressed on activated and memory T cells.<a class="elsevierStyleCrossRefs" href="#bib0110">22,25</a> The IL-23R gene is positioned on chromosome 1p31, spanning 2.8kb and comprising 11 exons and 10 introns. The promoter region of the human IL-23R gene is distributed with many single nucleotide polymorphisms.<a class="elsevierStyleCrossRef" href="#bib0130">26</a> A multitude of studies have depicted a strong association between IL-23R polymorphisms and the progression and outcome of several autoimmune disorders, such as ankylosing spondylitis, Crohn’s disease, and rheumatoid arthritis.<a class="elsevierStyleCrossRef" href="#bib0105">21</a> The aim of this study was to investigate the role of IL23R variants in JSLE susceptibility. Herein, we have examined the association between four selected IL-23R polymorphisms and JSLE proneness in Iranian population.Materials and methodsThe study population included 62 consecutive Iranian patients with JSLE (with a mean age of 11 years and range of 4–14 years), who were referred to the Rheumatology Clinic of the Children’s Medical Center Hospital, the pediatrics center of excellence in Iran, between March 2015 and April 2018, and fulfilled the American College of Rheumatology (ACR) classification criteria for SLE.<a class="elsevierStyleCrossRef" href="#bib0020">4</a> Thorough history taking, comprehensive examination and relevant laboratory and radiological studies were carried out for all patients. Patients diagnosed with any other concomitant disorder were excluded from the study. Seventy-eight ethnically, age and sex matched healthy controls with no family history or clinical manifestation of any rheumatologic and autoimmune disorders were also randomly recruited from those who visited for routine check-ups at the same center. All the patients and controls were unrelated individuals. Written informed consent was obtained from all the subjects’ parents or guardians according to the guidelines of the Ethics Committee of Tehran University of Medical Sciences before blood sampling.Genomic DNA samples were obtained from all the participants and were stored at −20°C until administration. DNA samples of patients and healthy controls were extracted from peripheral blood leukocytes using the phenol-chloroform method. Genotyping of the samples was conducted by real-time polymerase chain reaction (RT-PCR), using TaqMan probe (ABI, USA) with an ABI 7300 RT-PCR instrument (Applied Biosystems). Optical 96-well reaction plate 0.2μl (ABI, USA) was administered for the test. The total volume of 20μl in each microwell, consisted of 10μl Master Mix (ABI, USA), 0.5μl Assay Mix (ABI, USA), 4.5μl deionized water, and 5μl DNA samples with a concentration of 20ng/ml. PCR conditions were as follows: 95°C for 10min, followed by 40 cycles of 95°C for 15s and 60°C for 1min. The results were determined using Allelic Discrimination Program (Applied Biosystems).Genotype and allelic frequencies of certain IL-23R SNPs, including rs10489629, rs11209026, rs1343151, and rs7517847 (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>) were compared between JSLE cases and controls using the chi-square test and Fisher’s exact test when appropriate, and odds ratio (OR) and 95% confidence interval (CI) were calculated to assess the relative risk conferred by a particular allele and genotype. Hardy-Weinberg equilibrium evaluation was performed for each polymorphism included in this research. All SNPs were found to be in Hardy–Weinberg equilibrium (HWE) (P>0.05) in the control group. Statistical significance was assumed at the p<0.05 level. The statistical program Epi Info 7 was used for all statistical analyses.<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>ResultsAllelic and genotype frequencies of rs7517847, rs10489629, rs11209026, and rs1343151 polymorphisms in patients with juvenile systemic lupus erythematosus and healthy control subjects are depicted in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>.<elsevierMultimedia ident="tbl0010"></elsevierMultimedia>Analysis of allele and genotype frequency of four selected SNPs revealed a statistically significant positive association between the homozygous variant of rs7517847 (TT) (76.7% vs. 56.4%; P, 0.02; OR, 2.53; 95%CI, 1.20–5.35) and T allele at the same position (88.3% vs. 75.6%; P, 0.01; OR, 2.43; 95%CI, 1.25–4.74) with JSLE vulnerability in our study. There was no significant association between other evaluated SNPs and JSLE susceptibility.DiscussionTo the best of our knowledge, the present investigation is the first to assess the correlation between IL-23R polymorphisms, which have been previously postulated as a possible genetic marker for autoimmunity,<a class="elsevierStyleCrossRef" href="#bib0110">22</a> and JSLE in an Iranian population. Our results showed statistically significant correlation between both the IL-23R rs7517847T allele and TT genotype and individuals’ susceptibility to JSLE. On the other hand, we could not detect any significant difference between the case and control groups in the frequency of IL-23R rs11209026, rs1343151, and rs10489629 variants.The results of the current investigation are not in line with the findings of the study conducted by Yi Li et al. demonstrating no significant differences in the genotype and allele frequencies of rs10889677, rs1884444, and rs7517847 polymorphisms between the patients with SLE and the control group in a Chinese population.<a class="elsevierStyleCrossRef" href="#bib0135">27</a> In another study, Sanchez et al. evaluated eight IL-23R SNPs (rs1004819, rs7517847, rs10489629, rs11209026, rs1343151, rs10889677, rs11209032, and rs1495965) and revealed no statistically significant differences between SLE patients and healthy controls of Spanish origin.<a class="elsevierStyleCrossRef" href="#bib0110">22</a> The results of these above-mentioned investigations are consistent with the findings of a study conducted by Kim et al. showing lack of association between seven IL-23R SNPs (rs1004819, rs7517847, rs10489629, rs2201841, rs1343151, rs11209032, and rs1495965) and SLE susceptibility in a sample of over 600 Korean SLE patients and almost 1000 healthy controls.<a class="elsevierStyleCrossRef" href="#bib0140">28</a> Consistently, Safrany et al. observed no significant difference in the IL-23R rs11805303, rs10889677, rs1004819, rs2201841, rs11209032, 11209026, rs10489629, rs7517847, and rs7530511 variants between the SLE patient and control groups in the Hungarian population.<a class="elsevierStyleCrossRef" href="#bib0145">29</a> In 2018, Imani et al.<a class="elsevierStyleCrossRef" href="#bib0105">21</a> performed a systematic review and meta-analysis, pooling the results of all the four above-said studies, and depicted a significant association between the IL-23R gene rs7517847 T>G SNP and SLE risk, in line with our results. Our literature search also revealed another study,<a class="elsevierStyleCrossRef" href="#bib0150">30</a> assessing IL-23R rs10889677, and rs1884444 SNPs, indicating lack of association of these polymorphisms with SLE susceptibility or severity. Notwithstanding the fact that our investigation implied rs7517847 variant of IL23R as a novel susceptibility gene in JSLE, the lack of association between certain IL-23R gene variants and SLE vulnerability found in a number of previous studies could possibly indicate that IL-23R may play an important role in regulating local inflammation rather than systemic inflammatory processes involved in systemic autoimmune disease such as systemic sclerosis.<a class="elsevierStyleCrossRefs" href="#bib0155">31,32</a> However, IL-23R gene was found to be associated with organ-characteristic autoimmune diseases such as inflammatory bowel disease,<a class="elsevierStyleCrossRef" href="#bib0165">33</a> experimental autoimmune encephalomyelitis,<a class="elsevierStyleCrossRef" href="#bib0170">34</a> rheumatoid arthritis,<a class="elsevierStyleCrossRef" href="#bib0175">35</a> ankylosing spondylitis<a class="elsevierStyleCrossRef" href="#bib0180">36</a> and psoriasis.<a class="elsevierStyleCrossRef" href="#bib0185">37</a> This lack of association could also be partly attributed to the fact that IL-23 preferentially stimulates T cells to produce cytokines, including tumor necrosis factor-a, IL-6, and IL-17, but does not provoke the production of type I interferons, which are assumed to play a relevant role in the development and maintenance of the disease process in SLE.<a class="elsevierStyleCrossRefs" href="#bib0190">38,39</a>It should be noted that the current study has some certain constraints, including the relatively small number of participants in the patients’ category, resulting in diminished statistical power of the analysis; together with our limitation to measure serum levels of IL-23 and IL-17, which altogether limits the ability of our investigation to reach a consolidated answer to the questions considering the precise role of the above-mentioned gene variants in both the cytokines’ production and JSLE pathogenesis.To conclude, the results of the current investigation suggested rs7517847 variant of IL23R as a novel susceptibility gene in JSLE. However, as this gene is not yet widely evaluated in JSLE patients, we are unable to incisively accept or reject the definite role of this gene in the pathogenesis of JSLE. Further multi-center studies enrolling larger sample sizes of different ethnicities are required to confirm this finding.FundingThis study was supported by a grant from Tehran University of Medical Sciences (95-03-154-32285).Conflict of interestIt should be noted that there is no ethical problem (approved by the research ethics committee of Tehran University of Medical Sciences) or conflict of interest in our research. There was no honorarium, grant, or other form of payment to authors to produce the manuscript." "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1427785" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction and objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1304207" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Materials and methods" ] 4 => array:2 [ "identificador" => "sec0015" "titulo" => "Results" ] 5 => array:2 [ "identificador" => "sec0020" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "sec0025" "titulo" => "Funding" ] 7 => array:2 [ "identificador" => "sec0030" "titulo" => "Conflict of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-02-24" "fechaAceptado" => "2019-05-22" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1304207" "palabras" => array:4 [ 0 => "Interleukin-23 receptor" 1 => "Single nucleotide polymorphism" 2 => "Systemic lupus erythematosus" 3 => "Children" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Introduction and objectivesConsidering the possible roles of interleukin-23 receptor (IL-23R) gene in the pathogenesis of juvenile systemic lupus erythematosus (JSLE), the objective of this study was to elucidate whether polymorphisms of the IL23R are associated with susceptibility to JSLE in an Iranian population. Materials and methodsA case-control study on 62 patients with JSLE and 78 healthy controls was performed to investigate the associations of four single nucleotide polymorphisms (SNPs) in IL-23R gene, namely, rs7517847, rs10489629, rs11209026, and rs1343151, with susceptibility to JSLE, using real-time polymerase chain reaction Taqman genotyping technique. ResultsAnalysis of allele and genotype frequency of four selected SNPs revealed statistically significant positive association between homozygous variant of rs7517847 (TT) (P, 0.02) and T allele at the same position (P, 0.01) with JSLE vulnerability. There was no significant association between other evaluated SNPs and JSLE susceptibility. ConclusionThese findings suggest that particular IL-23R gene variants could affect individual susceptibility to JSLE." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction and objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:2 [ 0 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gene location \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Position \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Polymorphism \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SNP \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intron \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67681669 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">G/T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">rs7517847 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intron \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67688349 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C/T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">rs10489629 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Exon \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67705958 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A/G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">rs11209026 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Intron \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67719129 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A/G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">rs1343151 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2449429.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Details of IL-23R gene single nucleotide polymorphisms (SNPs), gene polymorphisms, positions and locations, assessed in the present investigation." ] ] 1 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:3 [ "leyenda" => "JSLE: Juvenile systemic lupus erythematosus; OR: odds ratio; CI: confidence interval." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SNP \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alleles/genotypes \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">JSLE (n=62) N (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control (n=78) N (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">P \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR (95% CI) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle">IL-23R Rs7517847<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a></td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">106 (88.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">118 (75.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.43 (1.25-4.74) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (11.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 (24.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.41 (0.21-0.79) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46 (76.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">44 (56.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.02 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.53 (1.20-5.35) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (23.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 (38.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48 (0.22-1.03) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (5.13) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle">IL-23R Rs10489629</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">T \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">93 (75) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">106 (67.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">024 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.41 (0.83-2.39) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 (25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 (32.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.70 (0.41-1.19) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34 (54.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (47.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.34 (0.68-2.62) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (40.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 (41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.97 (0.49-1.91) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (11.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.38 (0.10-1.05) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle">IL-23R Rs11209026</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">118 (95.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">150 (96.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.78 (0.24-2.50) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (3.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.27 (0.39-4.04) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57 (91.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">72 (92.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 (0.27-3.27) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (6.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (7.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.82 (0.22-3.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (1.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">– \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle">IL-23R Rs1343151</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">G \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">102 (82.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">106 (67.95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.70 (0.95-3.05) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22(17.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 (32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58 (0.32-1.04) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42(67.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41 (52.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.89 (0.94-3.79) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">GA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">18(29) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">32 (41) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.58 (0.28-1.19) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2(3.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (6.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.63 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.48 (0.09-2.59) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2449428.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Number of patients was 60 in this group." ] ] ] "descripcion" => array:1 [ "en" => "Allele and genotype distribution of IL-23R gene in JSLE patients and healthy controls." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:39 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA damage and deficiencies in the mechanisms of its repair: implications in the pathogenesis of systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:4 [ 0 => "M.P. Mireles-Canales" 1 => "S.A. González-Chávez" 2 => "C.M. Quiñonez-Flores" 3 => "E.A. León-López" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2018/9464186" "Revista" => array:5 [ "tituloSerie" => "J Immunol Res" "fecha" => "2018" "volumen" => "2018" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29854852" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109708008735" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Juvenile systemic lupus erythematosus: a diagnostic dilemma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.P. Jaybhaye" 1 => "N.R. Sutay" 2 => "S.V. Chate" 3 => "T.N. Rathod" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0976-9668.92319" "Revista" => array:5 [ "tituloSerie" => "J Nat Sci Biol Med" "fecha" => "2011" "volumen" => "2" "paginaInicial" => "229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22346244" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor necrosis factor-alpha single nucleotide polymorphisms in juvenile systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Tahghighi" 1 => "V. Ziaee" 2 => "M.H. Moradinejad" 3 => "A. Rezaei" 4 => "S. Harsini" 5 => "S. Soltani" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Human Immunol" "fecha" => "2015" "volumen" => "76" "paginaInicial" => "533" "paginaFinal" => "536" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic lupus erythematosus: epidemiology, pathophysiology, manifestations, and management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Fortuna" 1 => "M.T. Brennan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dent Clin" "fecha" => "2013" "volumen" => "57" "paginaInicial" => "631" "paginaFinal" => "655" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Abnormal production of pro-and anti-inflammatory cytokines by lupus monocytes in response to apoptotic cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Sule" 1 => "A. Rosen" 2 => "M. Petri" 3 => "E. Akhter" 4 => "F. Andrade" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0028413" "Revista" => array:4 [ "tituloSerie" => "PLoS One" "fecha" => "2011" "volumen" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22162769" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Gehrke" 1 => "C. Mertens" 2 => "T. Zillinger" 3 => "J. Wenzel" 4 => "T. Bald" 5 => "S. Zahn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.immuni.2013.08.004" "Revista" => array:6 [ "tituloSerie" => "Immunity" "fecha" => "2013" "volumen" => "39" "paginaInicial" => "482" "paginaFinal" => "495" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23993650" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations between interleukin-10 polymorphisms and susceptibility to juvenile idiopathic arthritis: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Harsini" 1 => "A. Saghazadeh" 2 => "S. Nedjat" 3 => "N. Rezaei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ecn.2018.0404" "Revista" => array:5 [ "tituloSerie" => "Eur Cytokine Network" "fecha" => "2018" "volumen" => "29" "paginaInicial" => "16" "paginaFinal" => "26" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of tumour necrosis factor-alpha G/A -238 and G/A -308 single nucleotide polymorphisms with juvenile idiopathic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Maddah" 1 => "S. Harsini" 2 => "V. Ziaee" 3 => "M.H. Moradinejad" 4 => "A. Rezaei" 5 => "S. Zoghi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/iji.12291" "Revista" => array:7 [ "tituloSerie" => "Int J Immunogenet" "fecha" => "2016" "volumen" => "43" "paginaInicial" => "391" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27753221" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0895435616302311" "estado" => "S300" "issn" => "08954356" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of interleukin-1 family gene polymorphisms with juvenile idiopathic arthritis in Iranian population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Ziaee" 1 => "M. Maddah" 2 => "S. Harsini" 3 => "A. Rezaei" 4 => "M. Sadr" 5 => "S. Zoghi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.aller.2016.07.002" "Revista" => array:6 [ "tituloSerie" => "Allergologia et immunopathologia" "fecha" => "2016" "volumen" => "44" "paginaInicial" => "542" "paginaFinal" => "546" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27717726" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of interleukin-6 single nucleotide polymorphisms with juvenile idiopathic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Ziaee" 1 => "M. Maddah" 2 => "M.H. Moradinejad" 3 => "A. Rezaei" 4 => "S. Zoghi" 5 => "M. Sadr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-016-3407-6" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2017" "volumen" => "36" "paginaInicial" => "77" "paginaFinal" => "81" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27646136" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of interleukin-2 and interferon-gamma single nucleotide polymorphisms with Juvenile systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Harsini" 1 => "V. Ziaee" 2 => "F. Tahghighi" 3 => "M. Mahmoudi" 4 => "A. Rezaei" 5 => "S. Soltani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.aller.2015.12.005" "Revista" => array:6 [ "tituloSerie" => "Allergologia et immunopathologia" "fecha" => "2016" "volumen" => "44" "paginaInicial" => "422" "paginaFinal" => "426" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27255473" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin 10 and transforming growth factor beta 1 gene polymorphisms in juvenile idiopathic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Harsini" 1 => "V. Ziaee" 2 => "M. Maddah" 3 => "A. Rezaei" 4 => "M. Sadr" 5 => "S. Zoghi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4149/bll_2016_050" "Revista" => array:6 [ "tituloSerie" => "Bratislavske lekarske listy" "fecha" => "2016" "volumen" => "117" "paginaInicial" => "258" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27215961" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of Interleukin-2, but not Interferon-Gamma, single nucleotide polymorphisms with juvenile idiopathic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Maddah" 1 => "S. Harsini" 2 => "A. Rezaei" 3 => "M. Sadr" 4 => "S. Zoghi" 5 => "M.H. Moradinejad" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.aller.2015.10.005" "Revista" => array:6 [ "tituloSerie" => "Allergologia et immunopathologia" "fecha" => "2016" "volumen" => "44" "paginaInicial" => "303" "paginaFinal" => "306" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27040810" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Ziaee" 1 => "A. Rezaei" 2 => "S. Harsini" 3 => "M. Maddah" 4 => "S. Zoghi" 5 => "M. Sadr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-016-3224-y" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2016" "volumen" => "35" "paginaInicial" => "1943" "paginaFinal" => "1948" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26951255" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumor necrosis factor-alpha single nucleotide polymorphisms in juvenile systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "F. Tahghighi" 1 => "V. Ziaee" 2 => "M.H. Moradinejad" 3 => "A. Rezaei" 4 => "S. Harsini" 5 => "S. Soltani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.humimm.2015.06.011" "Revista" => array:5 [ "tituloSerie" => "Human Immunol" "fecha" => "2015" "volumen" => "76" "paginaInicial" => "533" "paginaFinal" => "536" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of association between interleukin-10, transforming growth factor-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Rezaei" 1 => "V. Ziaee" 2 => "F.T. Sharabian" 3 => "S. Harsini" 4 => "M. Mahmoudi" 5 => "S. Soltani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-015-2877-2" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2015" "volumen" => "34" "paginaInicial" => "1059" "paginaFinal" => "1064" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25633651" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-4 single nucleotide polymorphisms in juvenile systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Mahmoudi" 1 => "F. Tahghighi" 2 => "V. Ziaee" 3 => "S. Harsini" 4 => "A. Rezaei" 5 => "S. Soltani" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/iji.12152" "Revista" => array:6 [ "tituloSerie" => "Int J Immunogenet" "fecha" => "2014" "volumen" => "41" "paginaInicial" => "512" "paginaFinal" => "517" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25320043" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-6, interleukin-1 gene cluster and interleukin-1 receptor polymorphisms in Iranian patients with juvenile systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Ziaee" 1 => "F. Tahghighi" 2 => "M.H. Moradinejad" 3 => "S. Harsini" 4 => "M. Mahmoudi" 5 => "A. Rezaei" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1684/ecn.2014.0352" "Revista" => array:5 [ "tituloSerie" => "Eur Cytokine Network" "fecha" => "2014" "volumen" => "25" "paginaInicial" => "35" "paginaFinal" => "40" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-23 drives a pathogenic T cell population that induces autoimmune inflammation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.L. Langrish" 1 => "Y. Chen" 2 => "W.M. Blumenschein" 3 => "J. Mattson" 4 => "B. Basham" 5 => "J.D. Sedgwick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1084/jem.20041257" "Revista" => array:6 [ "tituloSerie" => "J Exp Med" "fecha" => "2005" "volumen" => "201" "paginaInicial" => "233" "paginaFinal" => "240" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15657292" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Oppmann" 1 => "R. Lesley" 2 => "B. Blom" 3 => "J.C. Timans" 4 => "Y. Xu" 5 => "B. Hunte" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s1074-7613(00)00070-4" "Revista" => array:6 [ "tituloSerie" => "Immunity" "fecha" => "2000" "volumen" => "13" "paginaInicial" => "715" "paginaFinal" => "725" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11114383" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of IL-23R gene rs7517847 T> G SNP and susceptibility to systemic lupus erythematosus: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Imani" 1 => "R. Rezaei" 2 => "A. Poorsheikhani" 3 => "S. Alizadeh" 4 => "M. Mahmoudi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rheumatol Res" "fecha" => "2018" "volumen" => "3" "paginaInicial" => "13" "paginaFinal" => "20" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0110" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of interleukin‐23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Sanchez" 1 => "B. Rueda" 2 => "J. Callejas" 3 => "J. Sabio" 4 => "N. Ortego‐Centeno" 5 => "J. Jimenez‐Alonso" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1399-0039.2007.00881.x" "Revista" => array:6 [ "tituloSerie" => "Tissue Antigens" "fecha" => "2007" "volumen" => "70" "paginaInicial" => "233" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17661912" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0115" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Understanding the IL-23–IL-17 immune pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.S. McKenzie" 1 => "R.A. Kastelein" 2 => "D.J. Cua" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Trend Immunol" "fecha" => "2006" "volumen" => "27" "paginaInicial" => "17" "paginaFinal" => "23" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0120" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "IL-17 and Th17 Cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T. Korn" 1 => "E. Bettelli" 2 => "M. Oukka" 3 => "V.K. Kuchroo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Rev Immunol" "fecha" => "2009" "volumen" => "27" "paginaInicial" => "485" "paginaFinal" => "517" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0125" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Trinchieri" 1 => "S. Pflanz" 2 => "R.A. Kastelein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s1074-7613(03)00296-6" "Revista" => array:6 [ "tituloSerie" => "Immunity" "fecha" => "2003" "volumen" => "19" "paginaInicial" => "641" "paginaFinal" => "644" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14614851" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0130" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis: genetic associations and immune system changes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y. Liu" 1 => "J. Krueger" 2 => "A. Bowcock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.gene.6364351" "Revista" => array:5 [ "tituloSerie" => "Genes Immunity" "fecha" => "2007" "volumen" => "8" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17093502" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0135" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association between interleukin-23 receptor gene polymorphisms and systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Li" 1 => "W.-B. Liang" 2 => "C. Li" 3 => "L.-B. Gao" 4 => "B. Zhou" 5 => "Y.-Y. Wang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/dna.2009.0913" "Revista" => array:6 [ "tituloSerie" => "DNA Cell Biol" "fecha" => "2010" "volumen" => "29" "paginaInicial" => "79" "paginaFinal" => "82" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19895338" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0140" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.-S. Kim" 1 => "I. Kim" 2 => "J.O. Kim" 3 => "J.S. Bae" 4 => "H.D. Shin" 5 => "S.-C. Bae" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00296-009-0893-8" "Revista" => array:6 [ "tituloSerie" => "Rheumatol Int" "fecha" => "2009" "volumen" => "30" "paginaInicial" => "33" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19306001" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0145" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Safrany" 1 => "R. Hobor" 2 => "L. Jakab" 3 => "T. Tarr" 4 => "V. Csongei" 5 => "L. Jaromi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00011-009-0089-4" "Revista" => array:6 [ "tituloSerie" => "Inflamm Res" "fecha" => "2010" "volumen" => "59" "paginaInicial" => "159" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19757086" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0150" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.M. Chen" 1 => "C.C. Feng" 2 => "Q.L. Ye" 3 => "J. Wang" 4 => "H. Cen" 5 => "R. Li" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00011-013-0636-x" "Revista" => array:7 [ "tituloSerie" => "Inflamm Res" "fecha" => "2013" "volumen" => "62" "paginaInicial" => "791" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23754344" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0735109716324032" "estado" => "S300" "issn" => "07351097" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0155" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Rueda" 1 => "J. Broen" 2 => "O. Torres" 3 => "C. Simeon" 4 => "N. Ortego-Centeno" 5 => "M.M. Schrijvenaars" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2008.096719" "Revista" => array:6 [ "tituloSerie" => "Ann Rheumat Dis" "fecha" => "2009" "volumen" => "68" "paginaInicial" => "253" "paginaFinal" => "256" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18713787" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0160" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Farago" 1 => "L. Magyari" 2 => "E. Safrany" 3 => "V. Csongei" 4 => "L. Jaromi" 5 => "K. Horvatovich" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/ard.2007.072819" "Revista" => array:6 [ "tituloSerie" => "Ann Rheumat Dis" "fecha" => "2008" "volumen" => "67" "paginaInicial" => "248" "paginaFinal" => "250" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17606463" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0165" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.H. Duerr" 1 => "K.D. Taylor" 2 => "S.R. Brant" 3 => "J.D. Rioux" 4 => "M.S. Silverberg" 5 => "M.J. Daly" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1126/science.1135245" "Revista" => array:5 [ "tituloSerie" => "Science (NY)" "fecha" => "2006" "volumen" => "314" "paginaInicial" => "1461" "paginaFinal" => "1463" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0170" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.J. Cua" 1 => "J. Sherlock" 2 => "Y. Chen" 3 => "C.A. Murphy" 4 => "B. Joyce" 5 => "B. Seymour" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nature01355" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "2003" "volumen" => "421" "paginaInicial" => "744" "paginaFinal" => "748" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12610626" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0175" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of interleukin 23 receptor gene polymorphisms (rs10489629, rs7517847) with rheumatoid arthritis in European population: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Zhai" 1 => "K. Xu" 2 => "F. Huang" 3 => "H. Peng" 4 => "C.C. Feng" 5 => "K.K. Zhu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11033-012-1768-8" "Revista" => array:6 [ "tituloSerie" => "Mol Biol Rep" "fecha" => "2012" "volumen" => "39" "paginaInicial" => "8987" "paginaFinal" => "8994" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22718508" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0180" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T. Karaderi" 1 => "D. Harvey" 2 => "C. Farrar" 3 => "L.H. Appleton" 4 => "M.A. Stone" 5 => "R.D. Sturrock" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/ken501" "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford, England)" "fecha" => "2009" "volumen" => "48" "paginaInicial" => "386" "paginaFinal" => "389" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0185" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Cargill" 1 => "S.J. Schrodi" 2 => "M. Chang" 3 => "V.E. Garcia" 4 => "R. Brandon" 5 => "K.P. Callis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/511051" "Revista" => array:5 [ "tituloSerie" => "Am J Human Genet" "fecha" => "2007" "volumen" => "80" "paginaInicial" => "273" "paginaFinal" => "290" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0190" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Sanchez" 1 => "S. Morales" 2 => "L. Paco" 3 => "M.A. Lopez-Nevot" 4 => "C. Hidalgo" 5 => "J. Jimenez-Alonso" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/rheumatology/keh697" "Revista" => array:5 [ "tituloSerie" => "Rheumatology (Oxford, England)" "fecha" => "2005" "volumen" => "44" "paginaInicial" => "1136" "paginaFinal" => "1139" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0195" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The type I interferon system in systemic lupus erythematosus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L. Ronnblom" 1 => "M.L. Eloranta" 2 => "G.V. Alm" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.21571" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheumatism" "fecha" => "2006" "volumen" => "54" "paginaInicial" => "408" "paginaFinal" => "420" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16447217" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/03010546/0000004800000001/v2_202012050801/S0301054619300990/v2_202012050801/en/main.assets" "Apartado" => array:4 [ "identificador" => "5554" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/03010546/0000004800000001/v2_202012050801/S0301054619300990/v2_202012050801/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054619300990?idApp=UINPBA00004N"]

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A. Rezaeia, S. Harsinia,b, M. Sadrc, V. Ziaeed, N. Rezaeia,b,e,

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rezaei_nima@tums.ac.ir

Corresponding author.

a Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

b Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

c Molecular Immunology Research Center, Tehran University of Medical Sciences, Tehran, Iran

d Division of Pediatric Rheumatology, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

e Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Systemic lupus erythematosus &#40;SLE&#41; is a prototypic autoimmune disorder with diverse clinical manifestations and unclear pathogenesis&#46; The disease is associated with the production of autoantibodies against nuclear and cytoplasmic components&#44; abnormalities of immune-inflammatory system functions and inflammatory manifestations in several organs&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Juvenile systemic lupus erythematosus &#40;JSLE&#41;&#44; constitutes 10&#8211;20&#37; of all SLE cases and predominantly appears before the age of 16 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;3</span></a> Although JSLE and adult-onset SLE share several features&#44; JSLE is found to be more severe than the adult-onset SLE&#44; leading to higher incidence of organ involvement and more rapid clinical progression&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> A complex interplay between genetic risk factors and environmental events is hypothesized to contribute towards disease initiation and progression&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;5</span></a> Genome-wide association studies have revealed familial tendency for disease expression&#44; such as the evident higher concordance of SLE in monozygotic twins in comparison to healthy subjects&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;6</span></a> The results of such studies together with the data provided by our previous studies have supported the notion that genetic factors such as the genes coding for cytokines and their receptors could play crucial roles in the pathogenesis of inflammatory disorders such as JSLE&#46;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7&#8211;18</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Interleukin-23 &#40;IL-23&#41; is a heterodimeric cytokine composed of a unique p19 subunit and a common p40 subunit shared with IL-12&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> IL-23 is mainly expressed through activation of phagocytes and dendritic cells<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">20&#44;21</span></a> and has been shown to play an essential role in the activation of a subset of CD4<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>T cells characterized by the production of the interleukin-17 &#40;IL-17&#41;&#44; namely&#44; Th17 cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;23</span></a> IL-17 induces the synthesis of proinflammatory cytokines which ultimately leads to chronic inflammation and the destruction of joints&#46;<a class="elsevierStyleCrossRefs" href="#bib0105"><span class="elsevierStyleSup">21&#44;24</span></a> All these findings suggest IL-23 pathway as an important actor in the pathogenesis of chronic inflammatory diseases such as SLE&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> IL-23 exerts its effects through binding to the IL-23 receptor &#40;IL-23R&#41; complex with high affinity&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> IL-23R constitutes a common IL-23 receptor and an IL-12 receptor &#946;1 subunit&#44; which are mostly expressed on activated and memory T cells&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22&#44;25</span></a> The <span class="elsevierStyleItalic">IL-23R</span> gene is positioned on chromosome 1p31&#44; spanning 2&#46;8<span class="elsevierStyleHsp" style=""></span>kb and comprising 11 exons and 10 introns&#46; The promoter region of the human <span class="elsevierStyleItalic">IL-23R</span> gene is distributed with many single nucleotide polymorphisms&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a> A multitude of studies have depicted a strong association between <span class="elsevierStyleItalic">IL-23R</span> polymorphisms and the progression and outcome of several autoimmune disorders&#44; such as ankylosing spondylitis&#44; Crohn&#8217;s disease&#44; and rheumatoid arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> The aim of this study was to investigate the role of <span class="elsevierStyleItalic">IL23R</span> variants in JSLE susceptibility&#46; Herein&#44; we have examined the association between four selected <span class="elsevierStyleItalic">IL-23R</span> polymorphisms and JSLE proneness in Iranian population&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Materials and methods</span><p id="par0015" class="elsevierStylePara elsevierViewall">The study population included 62 consecutive Iranian patients with JSLE &#40;with a mean age of 11 years and range of 4&#8211;14 years&#41;&#44; who were referred to the Rheumatology Clinic of the Children&#8217;s Medical Center Hospital&#44; the pediatrics center of excellence in Iran&#44; between March 2015 and April 2018&#44; and fulfilled the American College of Rheumatology &#40;ACR&#41; classification criteria for SLE&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Thorough history taking&#44; comprehensive examination and relevant laboratory and radiological studies were carried out for all patients&#46; Patients diagnosed with any other concomitant disorder were excluded from the study&#46; Seventy-eight ethnically&#44; age and sex matched healthy controls with no family history or clinical manifestation of any rheumatologic and autoimmune disorders were also randomly recruited from those who visited for routine check-ups at the same center&#46; All the patients and controls were unrelated individuals&#46; Written informed consent was obtained from all the subjects&#8217; parents or guardians according to the guidelines of the Ethics Committee of Tehran University of Medical Sciences before blood sampling&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Genomic DNA samples were obtained from all the participants and were stored at &#8722;20<span class="elsevierStyleHsp" style=""></span>&#176;C until administration&#46; DNA samples of patients and healthy controls were extracted from peripheral blood leukocytes using the phenol-chloroform method&#46; Genotyping of the samples was conducted by real-time polymerase chain reaction &#40;RT-PCR&#41;&#44; using TaqMan probe &#40;ABI&#44; USA&#41; with an ABI 7300 RT-PCR instrument &#40;Applied Biosystems&#41;&#46; Optical 96-well reaction plate 0&#46;2<span class="elsevierStyleHsp" style=""></span>&#956;l &#40;ABI&#44; USA&#41; was administered for the test&#46; The total volume of 20<span class="elsevierStyleHsp" style=""></span>&#956;l in each microwell&#44; consisted of 10<span class="elsevierStyleHsp" style=""></span>&#956;l Master Mix &#40;ABI&#44; USA&#41;&#44; 0&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;l Assay Mix &#40;ABI&#44; USA&#41;&#44; 4&#46;5<span class="elsevierStyleHsp" style=""></span>&#956;l deionized water&#44; and 5<span class="elsevierStyleHsp" style=""></span>&#956;l DNA samples with a concentration of 20<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#46; PCR conditions were as follows&#58; 95<span class="elsevierStyleHsp" style=""></span>&#176;C for 10<span class="elsevierStyleHsp" style=""></span>min&#44; followed by 40 cycles of 95<span class="elsevierStyleHsp" style=""></span>&#176;C for 15<span class="elsevierStyleHsp" style=""></span>s and 60<span class="elsevierStyleHsp" style=""></span>&#176;C for 1<span class="elsevierStyleHsp" style=""></span>min&#46; The results were determined using Allelic Discrimination Program &#40;Applied Biosystems&#41;&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Genotype and allelic frequencies of certain <span class="elsevierStyleItalic">IL-23R</span> SNPs&#44; including rs10489629&#44; rs11209026&#44; rs1343151&#44; and rs7517847 &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41; were compared between JSLE cases and controls using the chi-square test and Fisher&#8217;s exact test when appropriate&#44; and odds ratio &#40;OR&#41; and 95&#37; confidence interval &#40;CI&#41; were calculated to assess the relative risk conferred by a particular allele and genotype&#46; Hardy-Weinberg equilibrium evaluation was performed for each polymorphism included in this research&#46; All SNPs were found to be in Hardy&#8211;Weinberg equilibrium &#40;HWE&#41; &#40;P<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41; in the control group&#46; Statistical significance was assumed at the p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05 level&#46; The statistical program Epi Info 7 was used for all statistical analyses&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="par0030" class="elsevierStylePara elsevierViewall">Allelic and genotype frequencies of rs7517847&#44; rs10489629&#44; rs11209026&#44; and rs1343151 polymorphisms in patients with juvenile systemic lupus erythematosus and healthy control subjects are depicted in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Analysis of allele and genotype frequency of four selected SNPs revealed a statistically significant positive association between the homozygous variant of rs7517847 &#40;TT&#41; &#40;76&#46;7&#37; vs&#46; 56&#46;4&#37;&#59; P&#44; 0&#46;02&#59; OR&#44; 2&#46;53&#59; 95&#37;CI&#44; 1&#46;20&#8211;5&#46;35&#41; and T allele at the same position &#40;88&#46;3&#37; vs&#46; 75&#46;6&#37;&#59; P&#44; 0&#46;01&#59; OR&#44; 2&#46;43&#59; 95&#37;CI&#44; 1&#46;25&#8211;4&#46;74&#41; with JSLE vulnerability in our study&#46; There was no significant association between other evaluated SNPs and JSLE susceptibility&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Discussion</span><p id="par0040" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; the present investigation is the first to assess the correlation between <span class="elsevierStyleItalic">IL-23R</span> polymorphisms&#44; which have been previously postulated as a possible genetic marker for autoimmunity&#44;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> and JSLE in an Iranian population&#46; Our results showed statistically significant correlation between both the <span class="elsevierStyleItalic">IL-23R</span> rs7517847<span class="elsevierStyleHsp" style=""></span>T allele and TT genotype and individuals&#8217; susceptibility to JSLE&#46; On the other hand&#44; we could not detect any significant difference between the case and control groups in the frequency of <span class="elsevierStyleItalic">IL-23R</span> rs11209026&#44; rs1343151&#44; and rs10489629 variants&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The results of the current investigation are not in line with the findings of the study conducted by Yi Li et al&#46; demonstrating no significant differences in the genotype and allele frequencies of rs10889677&#44; rs1884444&#44; and rs7517847 polymorphisms between the patients with SLE and the control group in a Chinese population&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> In another study&#44; Sanchez et al&#46; evaluated eight <span class="elsevierStyleItalic">IL-23R</span> SNPs &#40;rs1004819&#44; rs7517847&#44; rs10489629&#44; rs11209026&#44; rs1343151&#44; rs10889677&#44; rs11209032&#44; and rs1495965&#41; and revealed no statistically significant differences between SLE patients and healthy controls of Spanish origin&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> The results of these above-mentioned investigations are consistent with the findings of a study conducted by Kim et al&#46; showing lack of association between seven <span class="elsevierStyleItalic">IL-23R</span> SNPs &#40;rs1004819&#44; rs7517847&#44; rs10489629&#44; rs2201841&#44; rs1343151&#44; rs11209032&#44; and rs1495965&#41; and SLE susceptibility in a sample of over 600 Korean SLE patients and almost 1000 healthy controls&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> Consistently&#44; Safrany et al&#46; observed no significant difference in the <span class="elsevierStyleItalic">IL-23R</span> rs11805303&#44; rs10889677&#44; rs1004819&#44; rs2201841&#44; rs11209032&#44; 11209026&#44; rs10489629&#44; rs7517847&#44; and rs7530511 variants between the SLE patient and control groups in the Hungarian population&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">29</span></a> In 2018&#44; Imani et al&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> performed a systematic review and meta-analysis&#44; pooling the results of all the four above-said studies&#44; and depicted a significant association between the <span class="elsevierStyleItalic">IL-23R</span> gene rs7517847 T<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>G SNP and SLE risk&#44; in line with our results&#46; Our literature search also revealed another study&#44;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">30</span></a> assessing <span class="elsevierStyleItalic">IL-23R</span> rs10889677&#44; and rs1884444 SNPs&#44; indicating lack of association of these polymorphisms with SLE susceptibility or severity&#46; Notwithstanding the fact that our investigation implied rs7517847 variant of <span class="elsevierStyleItalic">IL23R</span> as a novel susceptibility gene in JSLE&#44; the lack of association between certain <span class="elsevierStyleItalic">IL-23R</span> gene variants and SLE vulnerability found in a number of previous studies could possibly indicate that IL-23R may play an important role in regulating local inflammation rather than systemic inflammatory processes involved in systemic autoimmune disease such as systemic sclerosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31&#44;32</span></a> However&#44; <span class="elsevierStyleItalic">IL-23R</span> gene was found to be associated with organ-characteristic autoimmune diseases such as inflammatory bowel disease&#44;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> experimental autoimmune encephalomyelitis&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a> rheumatoid arthritis&#44;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a> ankylosing spondylitis<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> and psoriasis&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> This lack of association could also be partly attributed to the fact that IL-23 preferentially stimulates T cells to produce cytokines&#44; including tumor necrosis factor-a&#44; IL-6&#44; and IL-17&#44; but does not provoke the production of type I interferons&#44; which are assumed to play a relevant role in the development and maintenance of the disease process in SLE&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">38&#44;39</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">It should be noted that the current study has some certain constraints&#44; including the relatively small number of participants in the patients&#8217; category&#44; resulting in diminished statistical power of the analysis&#59; together with our limitation to measure serum levels of IL-23 and IL-17&#44; which altogether limits the ability of our investigation to reach a consolidated answer to the questions considering the precise role of the above-mentioned gene variants in both the cytokines&#8217; production and JSLE pathogenesis&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">To conclude&#44; the results of the current investigation suggested rs7517847 variant of <span class="elsevierStyleItalic">IL23R</span> as a novel susceptibility gene in JSLE&#46; However&#44; as this gene is not yet widely evaluated in JSLE patients&#44; we are unable to incisively accept or reject the definite role of this gene in the pathogenesis of JSLE&#46; Further multi-center studies enrolling larger sample sizes of different ethnicities are required to confirm this finding&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Funding</span><p id="par0060" class="elsevierStylePara elsevierViewall">This study was supported by a grant from <span class="elsevierStyleGrantSponsor" id="gs0005">Tehran University of Medical Sciences</span> &#40;<span class="elsevierStyleGrantNumber" refid="gs0005">95-03-154-32285</span>&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Conflict of interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">It should be noted that there is no ethical problem &#40;approved by the research ethics committee of Tehran University of Medical Sciences&#41; or conflict of interest in our research&#46; There was no honorarium&#44; grant&#44; or other form of payment to authors to produce the manuscript&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
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        0 => array:3 [
          "identificador" => "xres1427785"
          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "abst0005"
              "titulo" => "Introduction and objectives"
            ]
            1 => array:2 [
              "identificador" => "abst0010"
              "titulo" => "Materials and methods"
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            2 => array:2 [
              "identificador" => "abst0015"
              "titulo" => "Results"
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            3 => array:2 [
              "identificador" => "abst0020"
              "titulo" => "Conclusion"
            ]
          ]
        ]
        1 => array:2 [
          "identificador" => "xpalclavsec1304207"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        3 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Materials and methods"
        ]
        4 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Results"
        ]
        5 => array:2 [
          "identificador" => "sec0020"
          "titulo" => "Discussion"
        ]
        6 => array:2 [
          "identificador" => "sec0025"
          "titulo" => "Funding"
        ]
        7 => array:2 [
          "identificador" => "sec0030"
          "titulo" => "Conflict of interest"
        ]
        8 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2019-02-24"
    "fechaAceptado" => "2019-05-22"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1304207"
          "palabras" => array:4 [
            0 => "Interleukin-23 receptor"
            1 => "Single nucleotide polymorphism"
            2 => "Systemic lupus erythematosus"
            3 => "Children"
          ]
        ]
      ]
    ]
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    "resumen" => array:1 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction and objectives</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Considering the possible roles of interleukin-23 receptor &#40;IL-23R&#41; gene in the pathogenesis of juvenile systemic lupus erythematosus &#40;JSLE&#41;&#44; the objective of this study was to elucidate whether polymorphisms of the <span class="elsevierStyleItalic">IL23R</span> are associated with susceptibility to JSLE in an Iranian population&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Materials and methods</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A case-control study on 62 patients with JSLE and 78 healthy controls was performed to investigate the associations of four single nucleotide polymorphisms &#40;SNPs&#41; in <span class="elsevierStyleItalic">IL-23R</span> gene&#44; namely&#44; rs7517847&#44; rs10489629&#44; rs11209026&#44; and rs1343151&#44; with susceptibility to JSLE&#44; using real-time polymerase chain reaction Taqman genotyping technique&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Analysis of allele and genotype frequency of four selected SNPs revealed statistically significant positive association between homozygous variant of rs7517847 &#40;TT&#41; &#40;P&#44; 0&#46;02&#41; and T allele at the same position &#40;P&#44; 0&#46;01&#41; with JSLE vulnerability&#46; There was no significant association between other evaluated SNPs and JSLE susceptibility&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusion</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">These findings suggest that particular <span class="elsevierStyleItalic">IL-23R</span> gene variants could affect individual susceptibility to JSLE&#46;</p></span>"
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            "titulo" => "Results"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Gene location&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">67681669&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">G&#47;T&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">rs7517847&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Intron&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">67688349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">C&#47;T&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">rs10489629&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Exon&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">67705958&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">A&#47;G&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">rs11209026&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">rs1343151&nbsp;\t\t\t\t\t\t\n
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Details of IL-23R gene single nucleotide polymorphisms &#40;SNPs&#41;&#44; gene polymorphisms&#44; positions and locations&#44; assessed in the present investigation&#46;</p>"
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          "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">JSLE&#58; Juvenile systemic lupus erythematosus&#59; OR&#58; odds ratio&#59; CI&#58; confidence interval&#46;</p>"
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                  <table border="0" frame="\n
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">SNP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alleles&#47;genotypes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">JSLE &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>62&#41; N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>78&#41; N &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">P</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OR &#40;95&#37; CI&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle"><span class="elsevierStyleItalic">IL-23R</span> Rs7517847<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a></td><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">T</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">106 &#40;88&#46;3&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">118 &#40;75&#46;6&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;01</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">2&#46;43 &#40;1&#46;25-4&#46;74&#41;</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">G</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">14 &#40;11&#46;7&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">38 &#40;24&#46;4&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;01</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">0&#46;41 &#40;0&#46;21-0&#46;79&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">TT</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">46 &#40;76&#46;7&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">44 &#40;56&#46;4&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle"><span class="elsevierStyleItalic">IL-23R</span> Rs10489629</td><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">93 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle"><span class="elsevierStyleItalic">IL-23R</span> Rs11209026</td><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;95 &#40;0&#46;27-3&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">GA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;7&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;82 &#40;0&#46;22-3&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AA&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;1&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle"><span class="elsevierStyleItalic">IL-23R</span> Rs1343151</td><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">G&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">102 &#40;82&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">106 &#40;67&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
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                        "volumen" => "2018"
                        "link" => array:1 [
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                        "volumen" => "2"
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                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22346244"
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                            1 => "S&#46; Harsini"
                            2 => "A&#46; Rezaei"
                            3 => "M&#46; Sadr"
                            4 => "S&#46; Zoghi"
                            5 => "M&#46;H&#46; Moradinejad"
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                      ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.aller.2015.10.005"
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                        "paginaInicial" => "303"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27040810"
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                    0 => array:2 [
                      "titulo" => "Polymorphisms of genes encoding interleukin-4 and its receptor in Iranian patients with juvenile idiopathic arthritis"
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                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Ziaee"
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                            3 => "M&#46; Maddah"
                            4 => "S&#46; Zoghi"
                            5 => "M&#46; Sadr"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10067-016-3224-y"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Rheumatol"
                        "fecha" => "2016"
                        "volumen" => "35"
                        "paginaInicial" => "1943"
                        "paginaFinal" => "1948"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26951255"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor necrosis factor-alpha single nucleotide polymorphisms in juvenile systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "F&#46; Tahghighi"
                            1 => "V&#46; Ziaee"
                            2 => "M&#46;H&#46; Moradinejad"
                            3 => "A&#46; Rezaei"
                            4 => "S&#46; Harsini"
                            5 => "S&#46; Soltani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.humimm.2015.06.011"
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                        "tituloSerie" => "Human Immunol"
                        "fecha" => "2015"
                        "volumen" => "76"
                        "paginaInicial" => "533"
                        "paginaFinal" => "536"
                      ]
                    ]
                  ]
                ]
              ]
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            15 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between interleukin-10&#44; transforming growth factor-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Rezaei"
                            1 => "V&#46; Ziaee"
                            2 => "F&#46;T&#46; Sharabian"
                            3 => "S&#46; Harsini"
                            4 => "M&#46; Mahmoudi"
                            5 => "S&#46; Soltani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10067-015-2877-2"
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                        "tituloSerie" => "Clin Rheumatol"
                        "fecha" => "2015"
                        "volumen" => "34"
                        "paginaInicial" => "1059"
                        "paginaFinal" => "1064"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25633651"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-4 single nucleotide polymorphisms in juvenile systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Mahmoudi"
                            1 => "F&#46; Tahghighi"
                            2 => "V&#46; Ziaee"
                            3 => "S&#46; Harsini"
                            4 => "A&#46; Rezaei"
                            5 => "S&#46; Soltani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/iji.12152"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Immunogenet"
                        "fecha" => "2014"
                        "volumen" => "41"
                        "paginaInicial" => "512"
                        "paginaFinal" => "517"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25320043"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-6&#44; interleukin-1 gene cluster and interleukin-1 receptor polymorphisms in Iranian patients with juvenile systemic lupus erythematosus"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46; Ziaee"
                            1 => "F&#46; Tahghighi"
                            2 => "M&#46;H&#46; Moradinejad"
                            3 => "S&#46; Harsini"
                            4 => "M&#46; Mahmoudi"
                            5 => "A&#46; Rezaei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1684/ecn.2014.0352"
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur Cytokine Network"
                        "fecha" => "2014"
                        "volumen" => "25"
                        "paginaInicial" => "35"
                        "paginaFinal" => "40"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-23 drives a pathogenic T cell population that induces autoimmune inflammation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;L&#46; Langrish"
                            1 => "Y&#46; Chen"
                            2 => "W&#46;M&#46; Blumenschein"
                            3 => "J&#46; Mattson"
                            4 => "B&#46; Basham"
                            5 => "J&#46;D&#46; Sedgwick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1084/jem.20041257"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Exp Med"
                        "fecha" => "2005"
                        "volumen" => "201"
                        "paginaInicial" => "233"
                        "paginaFinal" => "240"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15657292"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Novel p19 protein engages IL-12p40 to form a cytokine&#44; IL-23&#44; with biological activities similar as well as distinct from IL-12"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Oppmann"
                            1 => "R&#46; Lesley"
                            2 => "B&#46; Blom"
                            3 => "J&#46;C&#46; Timans"
                            4 => "Y&#46; Xu"
                            5 => "B&#46; Hunte"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s1074-7613(00)00070-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunity"
                        "fecha" => "2000"
                        "volumen" => "13"
                        "paginaInicial" => "715"
                        "paginaFinal" => "725"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11114383"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of IL-23R gene rs7517847 T&#62; G SNP and susceptibility to systemic lupus erythematosus&#58; a systematic review and meta-analysis"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Imani"
                            1 => "R&#46; Rezaei"
                            2 => "A&#46; Poorsheikhani"
                            3 => "S&#46; Alizadeh"
                            4 => "M&#46; Mahmoudi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatol Res"
                        "fecha" => "2018"
                        "volumen" => "3"
                        "paginaInicial" => "13"
                        "paginaFinal" => "20"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Analysis of interleukin&#8208;23 receptor &#40;IL23R&#41; gene polymorphisms in systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Sanchez"
                            1 => "B&#46; Rueda"
                            2 => "J&#46; Callejas"
                            3 => "J&#46; Sabio"
                            4 => "N&#46; Ortego&#8208;Centeno"
                            5 => "J&#46; Jimenez&#8208;Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1399-0039.2007.00881.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Tissue Antigens"
                        "fecha" => "2007"
                        "volumen" => "70"
                        "paginaInicial" => "233"
                        "paginaFinal" => "237"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17661912"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0115"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Understanding the IL-23&#8211;IL-17 immune pathway"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "B&#46;S&#46; McKenzie"
                            1 => "R&#46;A&#46; Kastelein"
                            2 => "D&#46;J&#46; Cua"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Trend Immunol"
                        "fecha" => "2006"
                        "volumen" => "27"
                        "paginaInicial" => "17"
                        "paginaFinal" => "23"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "IL-17 and Th17 Cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46; Korn"
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                            2 => "M&#46; Oukka"
                            3 => "V&#46;K&#46; Kuchroo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Rev Immunol"
                        "fecha" => "2009"
                        "volumen" => "27"
                        "paginaInicial" => "485"
                        "paginaFinal" => "517"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The IL-12 family of heterodimeric cytokines&#58; new players in the regulation of T cell responses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G&#46; Trinchieri"
                            1 => "S&#46; Pflanz"
                            2 => "R&#46;A&#46; Kastelein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s1074-7613(03)00296-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunity"
                        "fecha" => "2003"
                        "volumen" => "19"
                        "paginaInicial" => "641"
                        "paginaFinal" => "644"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14614851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis&#58; genetic associations and immune system changes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Liu"
                            1 => "J&#46; Krueger"
                            2 => "A&#46; Bowcock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/sj.gene.6364351"
                      "Revista" => array:5 [
                        "tituloSerie" => "Genes Immunity"
                        "fecha" => "2007"
                        "volumen" => "8"
                        "paginaInicial" => "1"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17093502"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0135"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The association between interleukin-23 receptor gene polymorphisms and systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Li"
                            1 => "W&#46;-B&#46; Liang"
                            2 => "C&#46; Li"
                            3 => "L&#46;-B&#46; Gao"
                            4 => "B&#46; Zhou"
                            5 => "Y&#46;-Y&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/dna.2009.0913"
                      "Revista" => array:6 [
                        "tituloSerie" => "DNA Cell Biol"
                        "fecha" => "2010"
                        "volumen" => "29"
                        "paginaInicial" => "79"
                        "paginaFinal" => "82"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19895338"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;-S&#46; Kim"
                            1 => "I&#46; Kim"
                            2 => "J&#46;O&#46; Kim"
                            3 => "J&#46;S&#46; Bae"
                            4 => "H&#46;D&#46; Shin"
                            5 => "S&#46;-C&#46; Bae"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00296-009-0893-8"
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                        "tituloSerie" => "Rheumatol Int"
                        "fecha" => "2009"
                        "volumen" => "30"
                        "paginaInicial" => "33"
                        "paginaFinal" => "38"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19306001"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Safrany"
                            1 => "R&#46; Hobor"
                            2 => "L&#46; Jakab"
                            3 => "T&#46; Tarr"
                            4 => "V&#46; Csongei"
                            5 => "L&#46; Jaromi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00011-009-0089-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2010"
                        "volumen" => "59"
                        "paginaInicial" => "159"
                        "paginaFinal" => "164"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19757086"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
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                            2 => "Q&#46;L&#46; Ye"
                            3 => "J&#46; Wang"
                            4 => "H&#46; Cen"
                            5 => "R&#46; Li"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Inflamm Res"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "791"
                        "paginaFinal" => "795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23754344"
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                          "pii" => "S0735109716324032"
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                          "issn" => "07351097"
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                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The interleukin 23 receptor gene does not confer risk to systemic sclerosis and is not associated with systemic sclerosis disease phenotype"
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                            2 => "O&#46; Torres"
                            3 => "C&#46; Simeon"
                            4 => "N&#46; Ortego-Centeno"
                            5 => "M&#46;M&#46; Schrijvenaars"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2008.096719"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheumat Dis"
                        "fecha" => "2009"
                        "volumen" => "68"
                        "paginaInicial" => "253"
                        "paginaFinal" => "256"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18713787"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Functional variants of interleukin-23 receptor gene confer risk for rheumatoid arthritis but not for systemic sclerosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "B&#46; Farago"
                            1 => "L&#46; Magyari"
                            2 => "E&#46; Safrany"
                            3 => "V&#46; Csongei"
                            4 => "L&#46; Jaromi"
                            5 => "K&#46; Horvatovich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1136/ard.2007.072819"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Rheumat Dis"
                        "fecha" => "2008"
                        "volumen" => "67"
                        "paginaInicial" => "248"
                        "paginaFinal" => "250"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17606463"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A genome-wide association study identifies IL23R as an inflammatory bowel disease gene"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;H&#46; Duerr"
                            1 => "K&#46;D&#46; Taylor"
                            2 => "S&#46;R&#46; Brant"
                            3 => "J&#46;D&#46; Rioux"
                            4 => "M&#46;S&#46; Silverberg"
                            5 => "M&#46;J&#46; Daly"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1126/science.1135245"
                      "Revista" => array:5 [
                        "tituloSerie" => "Science &#40;NY&#41;"
                        "fecha" => "2006"
                        "volumen" => "314"
                        "paginaInicial" => "1461"
                        "paginaFinal" => "1463"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;J&#46; Cua"
                            1 => "J&#46; Sherlock"
                            2 => "Y&#46; Chen"
                            3 => "C&#46;A&#46; Murphy"
                            4 => "B&#46; Joyce"
                            5 => "B&#46; Seymour"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nature01355"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nature"
                        "fecha" => "2003"
                        "volumen" => "421"
                        "paginaInicial" => "744"
                        "paginaFinal" => "748"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12610626"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0175"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of interleukin 23 receptor gene polymorphisms &#40;rs10489629&#44; rs7517847&#41; with rheumatoid arthritis in European population&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Zhai"
                            1 => "K&#46; Xu"
                            2 => "F&#46; Huang"
                            3 => "H&#46; Peng"
                            4 => "C&#46;C&#46; Feng"
                            5 => "K&#46;K&#46; Zhu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11033-012-1768-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mol Biol Rep"
                        "fecha" => "2012"
                        "volumen" => "39"
                        "paginaInicial" => "8987"
                        "paginaFinal" => "8994"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22718508"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association between the interleukin 23 receptor and ankylosing spondylitis is confirmed by a new UK case-control study and meta-analysis of published series"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Karaderi"
                            1 => "D&#46; Harvey"
                            2 => "C&#46; Farrar"
                            3 => "L&#46;H&#46; Appleton"
                            4 => "M&#46;A&#46; Stone"
                            5 => "R&#46;D&#46; Sturrock"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/ken501"
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#44; England&#41;"
                        "fecha" => "2009"
                        "volumen" => "48"
                        "paginaInicial" => "386"
                        "paginaFinal" => "389"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Cargill"
                            1 => "S&#46;J&#46; Schrodi"
                            2 => "M&#46; Chang"
                            3 => "V&#46;E&#46; Garcia"
                            4 => "R&#46; Brandon"
                            5 => "K&#46;P&#46; Callis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/511051"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Human Genet"
                        "fecha" => "2007"
                        "volumen" => "80"
                        "paginaInicial" => "273"
                        "paginaFinal" => "290"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interleukin 12 &#40;IL12B&#41;&#44; interleukin 12 receptor &#40;IL12RB1&#41; and interleukin 23 &#40;IL23A&#41; gene polymorphism in systemic lupus erythematosus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46; Sanchez"
                            1 => "S&#46; Morales"
                            2 => "L&#46; Paco"
                            3 => "M&#46;A&#46; Lopez-Nevot"
                            4 => "C&#46; Hidalgo"
                            5 => "J&#46; Jimenez-Alonso"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/rheumatology/keh697"
                      "Revista" => array:5 [
                        "tituloSerie" => "Rheumatology &#40;Oxford&#44; England&#41;"
                        "fecha" => "2005"
                        "volumen" => "44"
                        "paginaInicial" => "1136"
                        "paginaFinal" => "1139"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0195"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The type I interferon system in systemic lupus erythematosus"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "L&#46; Ronnblom"
                            1 => "M&#46;L&#46; Eloranta"
                            2 => "G&#46;V&#46; Alm"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/art.21571"
                      "Revista" => array:6 [
                        "tituloSerie" => "Arthritis Rheumatism"
                        "fecha" => "2006"
                        "volumen" => "54"
                        "paginaInicial" => "408"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16447217"
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                ]
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Article information

ISSN: 03010546
Original language: English

DOI:10.1016/j.aller.2019.05.007

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Year/Month	Html	Pdf	Total

2024 November	6	2	8
2024 October	32	4	36
2024 September	30	9	39
2024 August	50	18	68
2024 July	24	12	36
2024 June	19	5	24
2024 May	23	5	28
2024 April	36	6	42
2024 March	41	14	55
2024 February	38	13	51
2024 January	44	25	69
2023 December	53	29	82
2023 November	40	18	58
2023 October	63	38	101
2023 September	41	23	64
2023 August	45	23	68
2023 July	45	31	76
2023 June	44	20	64
2023 May	78	34	112
2023 April	62	31	93
2023 March	46	28	74
2023 February	29	24	53
2023 January	17	50	67
2022 December	19	19	38
2022 November	17	7	24
2022 October	29	7	36
2022 September	19	10	29
2022 August	23	9	32
2022 July	14	10	24
2022 June	15	11	26
2022 May	18	15	33
2022 April	23	14	37
2022 March	26	11	37
2022 February	38	6	44
2022 January	49	9	58
2021 December	34	19	53
2021 November	27	8	35
2021 October	41	16	57
2021 September	32	15	47
2021 August	28	10	38
2021 July	36	6	42
2021 June	24	13	37
2021 May	23	7	30
2021 April	33	21	54
2021 March	10	11	21
2021 February	13	7	20
2021 January	12	2	14
2020 July	0	1	1
2020 March	2	0	2
2020 January	2	0	2

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Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications

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Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications

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