Phenotypical characterization of tree nuts and peanut allergies in east Mediterranean children

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"apellidos" => "Karaman" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054620300574?idApp=UINPBA00004N" "url" => "/03010546/0000004800000004/v2_202012180835/S0301054620300574/v2_202012180835/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0301054620300896" "issn" => "03010546" "doi" => "10.1016/j.aller.2020.05.001" "estado" => "S300" "fechaPublicacion" => "2020-07-01" "aid" => "1164" "copyright" => "SEICAP" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "edi" "cita" => "Allergol Immunopathol (Madr). 2020;48:313-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "EDITORIAL" "titulo" => "TREE NUTS ALLERGY: Knowledge, gaps and practical implications" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "313" "paginaFinal" => "315" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Á. Echeverría-Zudaire" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Luis Á." "apellidos" => "Echeverría-Zudaire" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0301054620300896?idApp=UINPBA00004N" "url" => "/03010546/0000004800000004/v2_202012180835/S0301054620300896/v2_202012180835/en/main.assets" ] "en" => array:18 [ "idiomaDefecto" => true "cabecera" => "Original Article" "titulo" => "Phenotypical characterization of tree nuts and peanut allergies in east Mediterranean children" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "316" "paginaFinal" => "322" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Pınar Gur Cetinkaya, Betul Buyuktiryaki, Ozge Soyer, Umit Murat Sahiner, Cansın Sackesen, Bulent Enis Sekerel" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Pınar Gur" "apellidos" => "Cetinkaya" "email" => array:1 [ 0 => "pinar_gur3334@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Betul" "apellidos" => "Buyuktiryaki" "email" => array:1 [ 0 => "betulbuyuktiryaki@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 2 => array:4 [ "nombre" => "Ozge" "apellidos" => "Soyer" "email" => array:1 [ 0 => "ozgeusoyer@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 3 => array:4 [ "nombre" => "Umit Murat" "apellidos" => "Sahiner" "email" => array:1 [ 0 => "umsahner@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] ] ] 4 => array:4 [ "nombre" => "Cansın" "apellidos" => "Sackesen" "email" => array:1 [ 0 => "csackesen@ku.edu.tr" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 5 => array:4 [ "nombre" => "Bulent Enis" "apellidos" => "Sekerel" "email" => array:1 [ 0 => "b_sekerel@yahoo.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Division of Pediatric Allergy and Asthma Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Sıhhiye, Ankara, 06100 Turkey" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Turkey" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1286 "Ancho" => 2177 "Tamanyo" => 122591 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "System involvements in the patients with TNs and PN allergies. aTNs, Tree nuts; PN, Peanut; GIS, Gastrointestinal System; CVS, Cardiovascular System." ] ] ] "textoCompleto" => "IntroductionAllergy to tree nuts (TNs) along with peanut (PN) constitutes a significant risk for severe anaphylactic reactions1 leading to limitations in daily life and creating a major burden on health care.<a class="elsevierStyleCrossRefs" href="#bib0005">2</a> For these reasons, TNs and PN allergies are distinguished among other food allergies in terms of severity.3The prevalence of TNs/PN allergies has doubled in recent decades, especially in childhood.4 On the other hand, the prevalence of TNs/PN allergy is extremely variable and highly dependent on cultural consumption habits and agricultural characteristics of societies. In Turkey, many types of TNs/PN are cultivated and consumed in high quantities, but hazelnut accounts for 75% of the world production.5 However, the data on clinical characteristics, prevalence, risk factors of TNs/PN allergies in Turkey is markedly limited, especially in the pediatric age group.6In this study, we aimed to provide a comprehensive phenotypical characterization of children in the East Mediterranean region with TNs and PN allergy and to reveal the rates of co-sensitization as well as co-allergy between TNs/PN.Methods and materialsPatientsThis research on TNs and PN allergies in childhood (0–18 years old) was conducted at the Division of Pediatric Allergy in Hacettepe University, which is a tertiary referral center for the country, between January 2010 and March 2018. The study was performed in accordance with the protocol approved by the local ethical committee of Hacettepe University (approval identification number is GO 15/649-07).Study designTwo hundred and twenty-seven TNs/PN allergic patients who fulfilled at least one of the two following criteria were enrolled in the study.<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">1)Presence of specific IgE (sIgE) to at least one type of TNs or PN (≥0.35kU/L) or positive skin-prick test (SPT) (≥3mm) along with at least one of the three following criteria:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010">aA consistent (at least two occasions) and clear-cut history of at least one TN and/or PN related symptoms after the ingestion of the causative TNs/PN (n=115).</li><li class="elsevierStyleListItem" id="lsti0015">bPositive open food challenge (OFC) tests with causative TNs/PN (n=31).</li><li class="elsevierStyleListItem" id="lsti0020">cAnaphylaxis with at least one TN and/or PN within the last 12 months (n=41).</li></ul></li><li class="elsevierStyleListItem" id="lsti0025">2)sIgE levels and/or SPT wheal diameters of TNs/PN indicating clinical reactivity with >95% accuracy (n=155).</li></ul>Patients were further analyzed for co-sensitization and co-allergy,14 and grouped as multiple TNs/PN sensitization (SPT was ≥3mm and sIgE value was ≥0.35Ku/L, but these two parameters were below the cut-off values that predict clinical reactivity with >95% accuracy) and multiple TNs/PN allergy (allergy to more than one type of TNs with or without PN).15 Multiple TNs/PN allergy was diagnosed according to the four given criteria above.All data were collected by the questioning caregivers and reviewing of file records for current age, gender, age of onset of the TNs/PN allergy, initial and subsequent reactions to TNs/PN, family history of atopy, laboratory parameters such as total laboratory parameters including immunoglobulin E (IgE) and sIgE values, eosinophil and basophil counts. The diagnosis of “food allergies other than TNs/PN”, AD, asthma, and AR was met according to international guidelines.16–19 Likewise, reactions during consumption of TNs/PN were defined and categorized based on World Allergy Organization Anaphylaxis Guidelines.20Study interventionsSkin prick test was done with walnut, hazelnut, almond, cashew nut, pistachio, and peanut (®Stallergenes, SA, Antony, France) for each participant; SPT with pollens (grass, weed, and tree) (®Stallergenes, SA, Antony, France) were applied on upper backs or volar face of the forearms of the children older than two years. For patients younger than two years, SPT with other food allergens (cow’s milk, egg white, soy, wheat, sesame, lentil, chickpea) (®Stallergenes, SA, Antony, France) were performed on the upper backs of the subjects.Specific IgE for TNs, PN, and total IgE were measured by the Immuno-CAP method in the sera of the patients (Pharmacia & Upjohn, Uppsala, Sweden).The children whose caregivers gave informed consent underwent OFC with TNs and/or PN based on the recommendations in the guidelines.21 Open OFCs were preferred over double-blind, placebo-controlled food challenges due to simplicity in clinical practice.21 OFC tests were discontinued and accepted positive when objective hypersensitivity symptoms occurred.21Statistical analysisStatistical analyses were performed using SPSS Version 22.0 statistical software package (IBM SPSS Statistics Chicago, Ill, USA). Categorical values were not normally distributed; thus, the data are given as median and interquartile ranges (IQR). All data including current age, onset age of the symptoms, eosinophil and basophil counts, total IgE, and sIgE values were given as median and interquartile range due to non-normally distribution, and all statistical comparisons were performed using Mann–Whitney U test on ranks as appropriate. The statistical tests were two-sided, and a p-value≤0.05 was regarded as statistically significant.ResultsA total of 227 children (M/F: 166/61) with a median age of 4.8 (3.2–6.8) years who had TNs and/or PN allergy were enrolled in the study (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The median age of onset of the diagnosis with TNs and PN was 12 (10.0–18.0) months. The earliest age of onset of the diagnosis occurred with walnut 9.0 (6.0–12.0) and hazelnut 9.0 (6.0–12.0).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia>Patients with concomitant allergic disorders including asthma, AR, AD, and food allergies other than TNs/PN constituted 86% (n=195) of the study group. Among these, AD was the most common allergic disorder (n=163, 72%), and this was followed by concomitant food allergy other than TNs/PN by 62.1% (n=141). (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).Of 227 children, 94 (41.4%) had anaphylaxis with at least one type of in the previous history or in OFCs. Of the whole study population, 145 (63.9%) had hazelnut, 124 (54.6%) had pistachio, 96 (42.3%) had cashew nut, 91 (40.1%) had walnut, 50 (22%) had PN, and 24 (10.6%) had the almond allergy. In addition, there was no patient in our study group who had ever consumed pecan, probably due to the dietary habits of our country.Of the study population, five of the patients (2.2%) had only PN allergy, 99 (43.6%) had only one TN allergy, and 123 (54.2%) had more than one TN allergy or at least one TN along with PN allergy. On the other hand, 45 (90%) of the PN allergic patients were also allergic to other TNs.Two hundred and forty-two open OFC tests with TNs/PN were performed, and the most frequent positivity was observed with pistachio, hazelnut, and cashew nut, and the least positivity was seen with almond.System involvements during hypersensitivity reactions due to TNs and PNThe majority of the subjects (98.5%) presented with cutaneous symptoms, and this was followed by the respiratory (35.5%) and gastrointestinal system (GIS) symptoms (28%). The least commonly occurring symptoms were associated with cardiovascular (CVS) [hypotension (n=2), loss of consciousness (n=1)] (2%) and neurological systems [seizure n=1)] (1%).In PN allergies, GIS was the second most commonly involved system during hypersensitivity reaction. In addition, respiratory system and GIS involvement were most frequently observed in patients with the cashew nut allergy (42%) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<elsevierMultimedia ident="fig0005"></elsevierMultimedia>Single vs. multiple TNs/PN sensitizations and allergyOverall, 164 patients (72.2%) based on SPT and 142 patients (62.6%) upon sIgE results were sensitized to at least two types of TNs with or without PN (multiple TNs/PN sensitization). Nevertheless, only 123 subjects (54.2%) had multiple TNs/PN allergy. While the proportion of multiple TNs/PN allergy continuously increased by age (36.5% at two years old, 60.5% at six years old, 83.3% at 10 years old, 50% at 14 years old) up to 10 years, then decreased and stayed on the same level throughout adolescence.In addition, current ages 6–10 years [OR:2.455, 95% CI:1.255-4.852, p=0.009] and family history of atopy [OR: 2.156, 95% CI: 1.182–3.932, p=0.012] were the risk factors for multiple TNs/PN allergies determined in multivariate analysis.Co-sensitization between SPT and sIgE measurements of TNs and PN, and co-allergy between TNs/PNThe strongest co-sensitization correlation coefficient with respect to SPT wheal diameters existed between pistachio and cashew nut (r=0.715, p<0.001) (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2a</a>). While the weakest correlation was observed with TNs, the strongest correlation was seen with almond in PN allergic children (r=0.456, p<0.001). In addition, with regard to sIgE results, the strongest co-sensitization correlation coefficient was observed between pistachio and cashew nut (r=0.869, p<0.001) (<a class="elsevierStyleCrossRef" href="#tbl0015">Table 2b</a>).The co-allergy relationship between all TNs and PN was analyzed (<a class="elsevierStyleCrossRef" href="#tbl0020">Table 3</a>), and patients with the almond allergy had the highest frequency of co-allergy with all other TNs/PN. This was followed by the co-existing allergy with pistachio in cashew nut allergic children (82.3%). Moreover, PN and walnut allergic children were co-allergic to hazelnut in relatively higher ratios (76% for PN, 71.4% for walnut).<elsevierMultimedia ident="tbl0020"></elsevierMultimedia>DiscussionThis study emphasized earlier onset age of the hypersensitivity symptoms with TNs/PN and higher frequency of allergy with hazelnut, pistachio, and cashew nut in Turkish children. The prevalence of multiple TNs/PN allergy increased up to the age of 10 years after which it decreased and then reached a steady level. The strongest co-sensitization and the most frequent co-allergy were determined between pistachio and cashew TNs/PN allergic children. Although almond allergy was the rarest experienced TN allergy in our study population, the most frequent co-allergy was observed in almond allergic children to all other types of TNs/PN.One of the most important outcomes of the current study is the earlier age of onset of the TNs/PN related symptoms in Turkish children. We showed that children experienced the first reactions with TNs/PN at the age of one. In a study,15 TNs/PN related allergic symptoms have been reported by the age of two. Moreover, Sicherer et al. reported that the median age of onset of the reaction with TNs was about 36 months, whereas the age of onset of allergy with PN was 14 months.22 Earlier age of onset of the TNs/PN related symptoms in allergic Turkish children may be the effect of early cutaneous exposure to TNs/PN allergens within household dusts before introduction to complementary foods due to the high consumption of TNs/PN for cultural reasons. Moreover, the age of onset of allergic symptoms with walnut and hazelnut was earlier than the symptoms of other TNs/PN in our study. The underlying reason of an earlier age of onset of the symptoms with those two TNs may be the relatively high cultivation as well as consumption habits of walnut and hazelnut in Turkey.In the current study, allergy to hazelnut, pistachio, and cashew nut was the most commonly observed TNs/PN allergy in children. In the literature, characteristics of allergy to the TNs/PN species are extremely variable.3,23,24 The most common TN allergies are walnut3 and cashew nut3,23 in the United States, but hazelnut and walnut in Spain.25 Remarkably, the presence of pistachio allergy in Turkey has been emphasized, and its prevalence has been reported as 6.7% in food allergic children.6 The possible reason for this higher frequency of pistachio and hazelnut allergies in the current study is that pistachio and hazelnut are grown, exported, and consumed in relatively higher amounts in Turkey compared to other countries.5 In addition, cashew nut shows a higher frequency of co-sensitization and co-allergy with pistachio than the other TNs. Therefore, the wide variety in the allergy prevalence and characteristics of TNs depends on the geographical region and cultural eating habits.26Similar to previous reports,27 skin (98%) was the most frequently involved system upon TNs/PN consumption, and this was followed by respiratory and GIS system in the current study. Likewise, symptoms of respiratory system and GIS have been frequently reported in TNs/PN allergic children following skin involvement.28,29 In a recent study,30 the respiratory system has been associated with severe anaphylaxis in TNs, but not in PN. Likewise, allergic reactions with TNs, especially with cashew nut, were more severe and related to respiratory system more frequently than with PN in our study. Furthermore, we observed that CVS and neurological symptoms were more common with cashew nut, pistachio, and hazelnut. Similarly, CVS symptoms have been prominently reported in cashew nut allergic patients in the literature.28,31 Further precautions should be taken while performing OFC with TNs, especially with cashew nut in clinics. Also, clinicians should make an anaphylaxis emergency plan for patients with TNs/PN allergies, including the prescription of adrenaline auto-injector.Children with TNs/PN allergy can have co-sensitization and co-allergy to other types of TNs/PN.15 The increase of prevalence of both multiple TNs/PN allergy and sensitization by age has been previously reported.15 As distinct from that study,15 multiple TNs/PN allergy increased up to 10 years, then decreased and remained at a stable level after that age in our study. Although the possible reason for the different age pattern of multiple TNs/PN allergy is not clear, this may be due to cultural influences on consumption habits of TNs/PN, development of tolerance by age in a subgroup of those patients, and an increase in the prevalence of TNs/PN allergies in younger generations.The strongest correlation upon both SPT and sIgE results occurred between pistachio and cashew nut because both pistachio and cashew nut belong to the Anacardiaceae botanical family.32 We showed that PN had the strongest correlation with almond. To share common IgE-binding epitopes of major peanut allergen Ara h 2 with almond33 is due in part to this relationship.Although allergy to almond was the least observed TNs allergy in our study population, the most frequent co-allergy occurred in almond allergic children to all other TNs/PN. Therefore, we thought that the occurrence of almond allergy was rare, but the presence of almond allergy might be the sign of the high burden of TNs/PN allergy. In the current study, since almond allergy was the least frequently encountered TNs allergy, beginning with almond to the diet of TNs/PN allergic children may be a safe alternative of TNs. The second most common co-allergy was seen in cashew nut allergic subjects to pistachio (82.3%) and walnut allergic children to hazelnut (71.4%). In one study, all pistachio allergic patients were shown to be allergic to cashew nut.34 In contrast, we identified only 63.7% of pistachio allergic patients as co-allergic to cashew nut. Van der Valk et al.35 demonstrated that only nine of 20 patients (45%) with pistachio allergy exhibited co-allergy to cashew nut similar to our study. Interestingly, our results showed that PN allergic children had 76% co-allergy to hazelnut, but hazelnut allergic patients had only 26.2% co-allergy to PN. Similarly, Masthoff et al. reported the high ratios of co-allergy in PN allergic patients to hazelnut, whereas those with hazelnut allergic patients have a lower ratio of PN allergy by 48%.36 However, the underlying mechanism of this multifaceted relation should be clarified.Allergy to almond is rarely seen among all TNs allergies34; however, almond allergy was found to be 10.6% in the current study. In the USA, almond allergy has been reported from 9% to 15% among TNs allergies,22,37 whereas the prevalence ranged from 22% to 33% in the UK.3 The study by Luyt et al. demonstrated almond sensitization (61.9%) and allergy (7.4%) in higher ratios in South Asian children,38 as shown in the current study. This higher ratio of almond allergy in South Asian children was clarified by them being more likely to have household almond exposure during daily dietary habits.<a class="elsevierStyleCrossRefs" href="#bib0055">38</a> Our results confirm the literature data that prevalence of TN allergy highly differs according to agricultural status, dietary routine of the societies, and therefore household contact of children with TNs/PN.The limitation of this study is that the diagnosis of food allergy was not totally based on DBPCFCs, which is the gold standard for the diagnosis of food allergy. However, the presence of a clear-cut history or positive open OFC, together with positive TNs/PN sIgE and/or SPT, or to have sIgE levels and/or SPT wheal diameters indicating clinical reactivity with >95% accuracy minimize the uncertainty of the diagnosis of TNs/PN allergy. sIgE levels of TNs/PN in Turkish children13 have been found to be lower than children with TNs/PN allergy living in Western countries. However, we accepted Western population data for TNs sIgE cut-off values, which are higher than the levels of our patients, to predict clinical reactivity with >95% accuracy. The most important considerable strength of the current study is to be the first study on the TNs/PN allergy spectrum from the East Mediterranean region. Moreover, a comprehensive overview of cross-reactivity and co-sensitization among TNs/PN has been revealed.In conclusion, TNs/PN allergic children living in the East Mediterranean region have similar characteristics in terms of severity, co-sensitization, concomitant allergies, and co-allergies compared to counterparts living in Western countries. However, earlier age of onset of the symptoms, clinical spectrum, and age pattern of multiple TNs/PN allergy exhibited variabilities, and all these dissimilarities support the role of cultural dietary habits of the societies in the development of TNs/PN allergies. In addition, although almond may be a good choice for the consumption of children with TNs allergy, allergy to almond may be a sign of multiple TNs/PN allergies.This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.All authors approve the final version of the manuscriptAll parents/guardians provided written informed consentThe study was performed in accordance with the protocol approved by the local ethical committee of Hacettepe University (approval identification number is GO 15/649-07)Conflict of interestThe authors have no conflict of interest to declare." "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1437432" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction/Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1312164" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "xpalclavsec1312163" "titulo" => "Abbreviations" ] 3 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 4 => array:3 [ "identificador" => "sec0010" "titulo" => "Methods and materials" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Study design" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Study interventions" ] 3 => array:2 [ "identificador" => "sec0030" "titulo" => "Statistical analysis" ] ] ] 5 => array:3 [ "identificador" => "sec0035" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "System involvements during hypersensitivity reactions due to TNs and PN" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Single vs. multiple TNs/PN sensitizations and allergy" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Co-sensitization between SPT and sIgE measurements of TNs and PN, and co-allergy between TNs/PN" ] ] ] 6 => array:2 [ "identificador" => "sec0055" "titulo" => "Discussion" ] 7 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflict of interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-05-17" "fechaAceptado" => "2019-07-26" "PalabrasClave" => array:1 [ "en" => array:2 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1312164" "palabras" => array:5 [ 0 => "Children" 1 => "Co-allergy" 2 => "Co-sensitization" 3 => "Peanut" 4 => "Tree nuts" ] ] 1 => array:4 [ "clase" => "abr" "titulo" => "Abbreviations" "identificador" => "xpalclavsec1312163" "palabras" => array:10 [ 0 => "AD" 1 => "AR" 2 => "CVS" 3 => "GIS" 4 => "IQR" 5 => "OFC" 6 => "PN" 7 => "sIgE" 8 => "SPT" 9 => "TNs" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Introduction/ObjectivesThe characteristics of tree nuts (TNs) and peanut (PN) allergies vary in different regions of the world. We aim to identify the characteristics of TNs/PN allergies in Turkish children. Patients and MethodsA total of 227 children [4.8 (3.2–6.8) years] with TN and/or PN allergies were included. The phenotypical features of TNs/PN allergic children and the risk factors for multiple TNs/PN allergies were evaluated. ResultsAllergy to TNs/PN developed at a median age of 12.0 (10.0–18.0) months. The most common TNs/PN responsible for food allergies were the hazelnut (63.9%) and the pistachio (54.6%). Of TNs/PN allergic children, 54.2% experienced reactions with at least two types of . Current ages 6–10 years [OR:2.455, 95% CI:1.255-4.852, p=0.009] and family history of atopy [OR:2.156, 95% CI:1.182–3.932, p=0.012] were the risk factors for multiple TNs/PN allergies. Most of the patients with cashew nut and pistachio allergies exhibited co-sensitization and co-allergy to both of these TNs/PN. Although the rarest TNs/PN allergy was seen with almond, the possibility of allergy to other TNs or PN was highly increased in the patients with almond allergy compared to other TNs/PN. ConclusionsChildren with TNs/PN allergy living in an East Mediterranean region differ from the counterparts living in Western countries by an earlier age of onset of the TNs/PN allergy symptoms, increasing possibility to have multiple TNs/PN allergy at older ages, and different spectrum of TN/PN allergies (hazelnut followed by pistachio/cashew) that all indicate the consumption habits which are important determinants of TN/PN allergy development." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Introduction/Objectives" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Patients and Methods" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusions" ] ] ] ] "multimedia" => array:6 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1286 "Ancho" => 2177 "Tamanyo" => 122591 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Figure " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "System involvements in the patients with TNs and PN allergies. aTNs, Tree nuts; PN, Peanut; GIS, Gastrointestinal System; CVS, Cardiovascular System." ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0010" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical and laboratory parameters \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Current age (years)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.8 (3.2–6.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age of the onset of the allergic symptoms to TNs (months)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (10.0–18.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age of the onset of the allergic symptoms to PN (months)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (10.0–18.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients with allergic symptoms following consumption at the time of the diagnosis of TNs/PN allergy (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">115/50.6% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients with AD diagnosed as TNs/PN allergy by performing SPT or sIgE with TNs/PN (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88/38.8% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patients diagnosed as TNs/PN allergy by performing SPT or sIgE with TNs/PN due to symptoms with foods other than TNs/PN (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23/10.1% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gender (M) (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">161/71% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AD (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">163 (72%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AR (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">27 (12%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Asthma (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">82 (36.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Accompanying pollen sensitization (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33 (14.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Anaphylactic reactions after the consumption of any TNs or PN (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">94 (41.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNs/PN Allergy \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hazelnut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">145 (63.9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pistachio (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">124 (54.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cashew nut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96 (42.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Walnut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">91 (40.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Peanut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50 (22.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Almond (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24 (10.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OFC test positivity (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">242 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hazelnut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6/26 (23%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pistachio (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">24/81 (29.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cashew nut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11/50 (22%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Walnut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/22 (9%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Peanut (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/25 (8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Almond (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/38 (2.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Concomitant Food Allergy other than TNs/PN (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">141(62.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Only Cow’s milk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (17.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Only Egg white \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59 (26%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Concomitant cow’s milk and egg white \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55 (24.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Wheat \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.04%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Legumes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0.08%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lentil \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0.08%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sesame/Tahini \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (0.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Family history of atopy (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67 (29.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Family history of food allergy (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (5.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Family history of TNs/PN allergy (n/%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (2.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eosinophil count (/mm3)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">400 (200-675) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Basophil count (/mm3)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0-100) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Total IgE (kU/L)<a class="elsevierStyleCrossRef" href="#tblfn0005">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">211 (73.6-473.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2472544.png" ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tblfn0005" "etiqueta" => "a" "nota" => "Median (Interquartile range-IQR); M, Male; F, Female; TNs, Tree nuts; PN, Peanut; sBT, serum Basal Tryptase, AD, Atopic Dermatitis, AR, Allergic Rhinitis, OFC, Oral Food Challenge." ] ] ] "descripcion" => array:1 [ "en" => "Characterization of the study population (n=227)." ] ] 2 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2a" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0015" "detalle" => "Table 2" "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "SPT, Skin Prick Test." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Walnut</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hazelnut</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pecan</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Almond</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pistachio</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cashew nut</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hazelnut \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.475 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pecan \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.685 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.445 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Almond \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.310 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.120 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.085 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.384 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pistachio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.143 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.049 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.060 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.406 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.278 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.197 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cashew nut \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.243 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.189 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.307 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.235 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.728 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Peanut \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.300 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.214 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.249 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.336 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.065 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0369 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.198 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.007 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2472545.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Correlation between SPT wheal diameters of TNs and PN." ] ] 3 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 2b" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0020" "detalle" => "Table 2" "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "sIgE: specific Immunoglobulin E." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Walnut</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hazelnut</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Almond</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pistachio</th><th class="td-with-role" title="\n \t\t\t\t\ttable-head\n \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cashew nut</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hazelnut \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.692 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Almond \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.611 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.753 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pistachio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.569 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.630 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.688 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cashew nut \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.560 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.605 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.235 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.869 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Peanut \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.562 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.673 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.002 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.756 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.571 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.541 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2472546.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Correlation between sIgE of TNs and PN." ] ] 4 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0025" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; 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Pınar Gur Cetinkayaa, Betul Buyuktiryakia, Ozge Soyera, Umit Murat Sahinera, Cansın Sackesenb, Bulent Enis Sekerela,

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b_sekerel@yahoo.com

Corresponding author.

a Division of Pediatric Allergy and Asthma Unit, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Sıhhiye, Ankara, 06100 Turkey

b Division of Pediatric Allergy, Koc University School of Medicine, Istanbul, Turkey

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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">System involvements in the patients with TNs and PN allergies&#46; <span class="elsevierStyleSup">a</span>TNs&#44; Tree nuts&#59; PN&#44; Peanut&#59; GIS&#44; Gastrointestinal System&#59; CVS&#44; Cardiovascular System&#46;</p>"
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many types of TNs&#47;PN are cultivated and consumed in high quantities&#44; but hazelnut accounts for 75&#37; of the world production&#46;5 However&#44; the data on clinical characteristics&#44; prevalence&#44; risk factors of TNs&#47;PN allergies in Turkey is markedly limited&#44; especially in the pediatric age group&#46;6</p><p id="par0015" class="elsevierStylePara elsevierViewall">In this study&#44; we aimed to provide a comprehensive phenotypical characterization of children in the East Mediterranean region with TNs and PN allergy and to reveal the rates of co-sensitization as well as co-allergy between TNs&#47;PN&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Methods and materials</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Patients</span><p id="par0020" class="elsevierStylePara elsevierViewall">This research on TNs and PN allergies in childhood &#40;0&#8211;18 years old&#41; was conducted at the Division of Pediatric Allergy in Hacettepe University&#44; which is a tertiary referral center for the country&#44; between January 2010 and March 2018&#46; The study was performed in accordance with the protocol approved by the local ethical committee of Hacettepe University &#40;approval identification number is GO 15&#47;649-07&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Study design</span><p id="par0025" class="elsevierStylePara elsevierViewall">Two hundred and twenty-seven TNs&#47;PN allergic patients who fulfilled at least one of the two following criteria were enrolled in the study&#46;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall">Presence of specific IgE &#40;sIgE&#41; to at least one type of TNs or PN &#40;&#8805;0&#46;35<span class="elsevierStyleHsp" style=""></span>kU&#47;L&#41; or positive skin-prick test &#40;SPT&#41; &#40;&#8805;3<span class="elsevierStyleHsp" style=""></span>mm&#41; along with at least one of the three following criteria&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">a</span><p id="par0035" class="elsevierStylePara elsevierViewall">A consistent &#40;at least two occasions&#41; and clear-cut history of at least one TN and&#47;or PN related symptoms after the ingestion of the causative TNs&#47;PN &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>115&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">b</span><p id="par0040" class="elsevierStylePara elsevierViewall">Positive open food challenge &#40;OFC&#41; tests with causative TNs&#47;PN &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>31&#41;&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">c</span><p id="par0045" class="elsevierStylePara elsevierViewall">Anaphylaxis with at least one TN and&#47;or PN within the last 12 months &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>41&#41;&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2&#41;</span><p id="par0050" class="elsevierStylePara elsevierViewall">sIgE levels and&#47;or SPT wheal diameters of TNs&#47;PN indicating clinical reactivity with &#62;95&#37; accuracy &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>155&#41;&#46;</p></li></ul></p><p id="par0055" class="elsevierStylePara elsevierViewall">Patients were further analyzed for co-sensitization and co-allergy&#44;14 and grouped as multiple TNs&#47;PN sensitization &#40;SPT was &#8805;3<span class="elsevierStyleHsp" style=""></span>mm and sIgE value was &#8805;0&#46;35<span class="elsevierStyleHsp" style=""></span>Ku&#47;L&#44; but these two parameters were below the cut-off values that predict clinical reactivity with &#62;95&#37; accuracy&#41; and multiple TNs&#47;PN allergy &#40;allergy to more than one type of TNs with or without PN&#41;&#46;15 Multiple TNs&#47;PN allergy was diagnosed according to the four given criteria above&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">All data were collected by the questioning caregivers and reviewing of file records for current age&#44; gender&#44; age of onset of the TNs&#47;PN allergy&#44; initial and subsequent reactions to TNs&#47;PN&#44; family history of atopy&#44; laboratory parameters such as total laboratory parameters including immunoglobulin E &#40;IgE&#41; and sIgE values&#44; eosinophil and basophil counts&#46; The diagnosis of &#8220;food allergies other than TNs&#47;PN&#8221;&#44; AD&#44; asthma&#44; and AR was met according to international guidelines&#46;16&#8211;19 Likewise&#44; reactions during consumption of TNs&#47;PN were defined and categorized based on World Allergy Organization Anaphylaxis Guidelines&#46;20</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Study interventions</span><p id="par0065" class="elsevierStylePara elsevierViewall">Skin prick test was done with walnut&#44; hazelnut&#44; almond&#44; cashew nut&#44; pistachio&#44; and peanut &#40;&#174;Stallergenes&#44; SA&#44; Antony&#44; France&#41; for each participant&#59; SPT with pollens &#40;grass&#44; weed&#44; and tree&#41; &#40;&#174;Stallergenes&#44; SA&#44; Antony&#44; France&#41; were applied on upper backs or volar face of the forearms of the children older than two years&#46; For patients younger than two years&#44; SPT with other food allergens &#40;cow&#8217;s milk&#44; egg white&#44; soy&#44; wheat&#44; sesame&#44; lentil&#44; chickpea&#41; &#40;&#174;Stallergenes&#44; SA&#44; Antony&#44; France&#41; were performed on the upper backs of the subjects&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Specific IgE for TNs&#44; PN&#44; and total IgE were measured by the Immuno-CAP method in the sera of the patients &#40;Pharmacia &#38; Upjohn&#44; Uppsala&#44; Sweden&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">The children whose caregivers gave informed consent underwent OFC with TNs and&#47;or PN based on the recommendations in the guidelines&#46;21 Open OFCs were preferred over double-blind&#44; placebo-controlled food challenges due to simplicity in clinical practice&#46;21 OFC tests were discontinued and accepted positive when objective hypersensitivity symptoms occurred&#46;21</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Statistical analysis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Statistical analyses were performed using SPSS Version 22&#46;0 statistical software package &#40;IBM SPSS Statistics Chicago&#44; Ill&#44; USA&#41;&#46; Categorical values were not normally distributed&#59; thus&#44; the data are given as median and interquartile ranges &#40;IQR&#41;&#46; All data including current age&#44; onset age of the symptoms&#44; eosinophil and basophil counts&#44; total IgE&#44; and sIgE values were given as median and interquartile range due to non-normally distribution&#44; and all statistical comparisons were performed using Mann&#8211;Whitney <span class="elsevierStyleItalic">U</span> test on ranks as appropriate&#46; The statistical tests were two-sided&#44; and a <span class="elsevierStyleItalic">p-value</span><span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>0&#46;05 was regarded as statistically significant&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Results</span><p id="par0085" class="elsevierStylePara elsevierViewall">A total of 227 children &#40;M&#47;F&#58; 166&#47;61&#41; with a median age of 4&#46;8 &#40;3&#46;2&#8211;6&#46;8&#41; years who had TNs and&#47;or PN allergy were enrolled in the study &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46; The median age of onset of the diagnosis with TNs and PN was 12 &#40;10&#46;0&#8211;18&#46;0&#41; months&#46; The earliest age of onset of the diagnosis occurred with walnut 9&#46;0 &#40;6&#46;0&#8211;12&#46;0&#41; and hazelnut 9&#46;0 &#40;6&#46;0&#8211;12&#46;0&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Patients with concomitant allergic disorders including asthma&#44; AR&#44; AD&#44; and food allergies other than TNs&#47;PN constituted 86&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>195&#41; of the study group&#46; Among these&#44; AD was the most common allergic disorder &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>163&#44; 72&#37;&#41;&#44; and this was followed by concomitant food allergy other than TNs&#47;PN by 62&#46;1&#37; &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>141&#41;&#46; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Of 227 children&#44; 94 &#40;41&#46;4&#37;&#41; had anaphylaxis with at least one type of in the previous history or in OFCs&#46; Of the whole study population&#44; 145 &#40;63&#46;9&#37;&#41; had hazelnut&#44; 124 &#40;54&#46;6&#37;&#41; had pistachio&#44; 96 &#40;42&#46;3&#37;&#41; had cashew nut&#44; 91 &#40;40&#46;1&#37;&#41; had walnut&#44; 50 &#40;22&#37;&#41; had PN&#44; and 24 &#40;10&#46;6&#37;&#41; had the almond allergy&#46; In addition&#44; there was no patient in our study group who had ever consumed pecan&#44; probably due to the dietary habits of our country&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Of the study population&#44; five of the patients &#40;2&#46;2&#37;&#41; had only PN allergy&#44; 99 &#40;43&#46;6&#37;&#41; had only one TN allergy&#44; and 123 &#40;54&#46;2&#37;&#41; had more than one TN allergy or at least one TN along with PN allergy&#46; On the other hand&#44; 45 &#40;90&#37;&#41; of the PN allergic patients were also allergic to other TNs&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Two hundred and forty-two open OFC tests with TNs&#47;PN were performed&#44; and the most frequent positivity was observed with pistachio&#44; hazelnut&#44; and cashew nut&#44; and the least positivity was seen with almond&#46;</p><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">System involvements during hypersensitivity reactions due to TNs and PN</span><p id="par0110" class="elsevierStylePara elsevierViewall">The majority of the subjects &#40;98&#46;5&#37;&#41; presented with cutaneous symptoms&#44; and this was followed by the respiratory &#40;35&#46;5&#37;&#41; and gastrointestinal system &#40;GIS&#41; symptoms &#40;28&#37;&#41;&#46; The least commonly occurring symptoms were associated with cardiovascular &#40;CVS&#41; &#91;hypotension &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2&#41;&#44; loss of consciousness &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#93; &#40;2&#37;&#41; and neurological systems &#91;seizure n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>1&#41;&#93; &#40;1&#37;&#41;&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">In PN allergies&#44; GIS was the second most commonly involved system during hypersensitivity reaction&#46; In addition&#44; respiratory system and GIS involvement were most frequently observed in patients with the cashew nut allergy &#40;42&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Single vs&#46; multiple TNs&#47;PN sensitizations and allergy</span><p id="par0120" class="elsevierStylePara elsevierViewall">Overall&#44; 164 patients &#40;72&#46;2&#37;&#41; based on SPT and 142 patients &#40;62&#46;6&#37;&#41; upon sIgE results were sensitized to at least two types of TNs with or without PN &#40;multiple TNs&#47;PN sensitization&#41;&#46; Nevertheless&#44; only 123 subjects &#40;54&#46;2&#37;&#41; had multiple TNs&#47;PN allergy&#46; While the proportion of multiple TNs&#47;PN allergy continuously increased by age &#40;36&#46;5&#37; at two years old&#44; 60&#46;5&#37; at six years old&#44; 83&#46;3&#37; at 10 years old&#44; 50&#37; at 14 years old&#41; up to 10 years&#44; then decreased and stayed on the same level throughout adolescence&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In addition&#44; current ages 6&#8211;10 years &#91;OR&#58;2&#46;455&#44; 95&#37; CI&#58;1&#46;255-4&#46;852&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#93; and family history of atopy &#91;OR&#58; 2&#46;156&#44; 95&#37; CI&#58; 1&#46;182&#8211;3&#46;932&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#93; were the risk factors for multiple TNs&#47;PN allergies determined in multivariate analysis&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Co-sensitization between SPT and sIgE measurements of TNs and PN&#44; and co-allergy between TNs&#47;PN</span><p id="par0130" class="elsevierStylePara elsevierViewall">The strongest co-sensitization correlation coefficient with respect to SPT wheal diameters existed between pistachio and cashew nut &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;715&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2a</a>&#41;&#46; While the weakest correlation was observed with TNs&#44; the strongest correlation was seen with almond in PN allergic children &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;456&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#46; In addition&#44; with regard to sIgE results&#44; the strongest co-sensitization correlation coefficient was observed between pistachio and cashew nut &#40;r<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;869&#44; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">Table 2b</a>&#41;&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">The co-allergy relationship between all TNs and PN was analyzed &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">Table 3</a>&#41;&#44; and patients with the almond allergy had the highest frequency of co-allergy with all other TNs&#47;PN&#46; This was followed by the co-existing allergy with pistachio in cashew nut allergic children &#40;82&#46;3&#37;&#41;&#46; Moreover&#44; PN and walnut allergic children were co-allergic to hazelnut in relatively higher ratios &#40;76&#37; for PN&#44; 71&#46;4&#37; for walnut&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Discussion</span><p id="par0140" class="elsevierStylePara elsevierViewall">This study emphasized earlier onset age of the hypersensitivity symptoms with TNs&#47;PN and higher frequency of allergy with hazelnut&#44; pistachio&#44; and cashew nut in Turkish children&#46; The prevalence of multiple TNs&#47;PN allergy increased up to the age of 10 years after which it decreased and then reached a steady level&#46; The strongest co-sensitization and the most frequent co-allergy were determined between pistachio and cashew TNs&#47;PN allergic children&#46; Although almond allergy was the rarest experienced TN allergy in our study population&#44; the most frequent co-allergy was observed in almond allergic children to all other types of TNs&#47;PN&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">One of the most important outcomes of the current study is the earlier age of onset of the TNs&#47;PN related symptoms in Turkish children&#46; We showed that children experienced the first reactions with TNs&#47;PN at the age of one&#46; In a study&#44;15 TNs&#47;PN related allergic symptoms have been reported by the age of two&#46; Moreover&#44; Sicherer et al&#46; reported that the median age of onset of the reaction with TNs was about 36 months&#44; whereas the age of onset of allergy with PN was 14 months&#46;22 Earlier age of onset of the TNs&#47;PN related symptoms in allergic Turkish children may be the effect of early cutaneous exposure to TNs&#47;PN allergens within household dusts before introduction to complementary foods due to the high consumption of TNs&#47;PN for cultural reasons&#46; Moreover&#44; the age of onset of allergic symptoms with walnut and hazelnut was earlier than the symptoms of other TNs&#47;PN in our study&#46; The underlying reason of an earlier age of onset of the symptoms with those two TNs may be the relatively high cultivation as well as consumption habits of walnut and hazelnut in Turkey&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">In the current study&#44; allergy to hazelnut&#44; pistachio&#44; and cashew nut was the most commonly observed TNs&#47;PN allergy in children&#46; In the literature&#44; characteristics of allergy to the TNs&#47;PN species are extremely variable&#46;3&#44;23&#44;24 The most common TN allergies are walnut3 and cashew nut3&#44;23 in the United States&#44; but hazelnut and walnut in Spain&#46;25 Remarkably&#44; the presence of pistachio allergy in Turkey has been emphasized&#44; and its prevalence has been reported as 6&#46;7&#37; in food allergic children&#46;6 The possible reason for this higher frequency of pistachio and hazelnut allergies in the current study is that pistachio and hazelnut are grown&#44; exported&#44; and consumed in relatively higher amounts in Turkey compared to other countries&#46;5 In addition&#44; cashew nut shows a higher frequency of co-sensitization and co-allergy with pistachio than the other TNs&#46; Therefore&#44; the wide variety in the allergy prevalence and characteristics of TNs depends on the geographical region and cultural eating habits&#46;26</p><p id="par0155" class="elsevierStylePara elsevierViewall">Similar to previous reports&#44;27 skin &#40;98&#37;&#41; was the most frequently involved system upon TNs&#47;PN consumption&#44; and this was followed by respiratory and GIS system in the current study&#46; Likewise&#44; symptoms of respiratory system and GIS have been frequently reported in TNs&#47;PN allergic children following skin involvement&#46;28&#44;29 In a recent study&#44;30 the respiratory system has been associated with severe anaphylaxis in TNs&#44; but not in PN&#46; Likewise&#44; allergic reactions with TNs&#44; especially with cashew nut&#44; were more severe and related to respiratory system more frequently than with PN in our study&#46; Furthermore&#44; we observed that CVS and neurological symptoms were more common with cashew nut&#44; pistachio&#44; and hazelnut&#46; Similarly&#44; CVS symptoms have been prominently reported in cashew nut allergic patients in the literature&#46;28&#44;31 Further precautions should be taken while performing OFC with TNs&#44; especially with cashew nut in clinics&#46; Also&#44; clinicians should make an anaphylaxis emergency plan for patients with TNs&#47;PN allergies&#44; including the prescription of adrenaline auto-injector&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Children with TNs&#47;PN allergy can have co-sensitization and co-allergy to other types of TNs&#47;PN&#46;15 The increase of prevalence of both multiple TNs&#47;PN allergy and sensitization by age has been previously reported&#46;15 As distinct from that study&#44;15 multiple TNs&#47;PN allergy increased up to 10 years&#44; then decreased and remained at a stable level after that age in our study&#46; Although the possible reason for the different age pattern of multiple TNs&#47;PN allergy is not clear&#44; this may be due to cultural influences on consumption habits of TNs&#47;PN&#44; development of tolerance by age in a subgroup of those patients&#44; and an increase in the prevalence of TNs&#47;PN allergies in younger generations&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">The strongest correlation upon both SPT and sIgE results occurred between pistachio and cashew nut because both pistachio and cashew nut belong to the <span class="elsevierStyleItalic">Anacardiaceae</span> botanical family&#46;32 We showed that PN had the strongest correlation with almond&#46; To share common IgE-binding epitopes of major peanut allergen Ara h 2 with almond33 is due in part to this relationship&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">Although allergy to almond was the least observed TNs allergy in our study population&#44; the most frequent co-allergy occurred in almond allergic children to all other TNs&#47;PN&#46; Therefore&#44; we thought that the occurrence of almond allergy was rare&#44; but the presence of almond allergy might be the sign of the high burden of TNs&#47;PN allergy&#46; In the current study&#44; since almond allergy was the least frequently encountered TNs allergy&#44; beginning with almond to the diet of TNs&#47;PN allergic children may be a safe alternative of TNs&#46; The second most common co-allergy was seen in cashew nut allergic subjects to pistachio &#40;82&#46;3&#37;&#41; and walnut allergic children to hazelnut &#40;71&#46;4&#37;&#41;&#46; In one study&#44; all pistachio allergic patients were shown to be allergic to cashew nut&#46;34 In contrast&#44; we identified only 63&#46;7&#37; of pistachio allergic patients as co-allergic to cashew nut&#46; Van der Valk et al&#46;35 demonstrated that only nine of 20 patients &#40;45&#37;&#41; with pistachio allergy exhibited co-allergy to cashew nut similar to our study&#46; Interestingly&#44; our results showed that PN allergic children had 76&#37; co-allergy to hazelnut&#44; but hazelnut allergic patients had only 26&#46;2&#37; co-allergy to PN&#46; Similarly&#44; Masthoff et al&#46; reported the high ratios of co-allergy in PN allergic patients to hazelnut&#44; whereas those with hazelnut allergic patients have a lower ratio of PN allergy by 48&#37;&#46;36 However&#44; the underlying mechanism of this multifaceted relation should be clarified&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">Allergy to almond is rarely seen among all TNs allergies34&#59; however&#44; almond allergy was found to be 10&#46;6&#37; in the current study&#46; In the USA&#44; almond allergy has been reported from 9&#37; to 15&#37; among TNs allergies&#44;22&#44;37 whereas the prevalence ranged from 22&#37; to 33&#37; in the UK&#46;3 The study by Luyt et al&#46; demonstrated almond sensitization &#40;61&#46;9&#37;&#41; and allergy &#40;7&#46;4&#37;&#41; in higher ratios in South Asian children&#44;38 as shown in the current study&#46; This higher ratio of almond allergy in South Asian children was clarified by them being more likely to have household almond exposure during daily dietary habits&#46;<a class="elsevierStyleCrossRefs" href="#bib0055">38</a> Our results confirm the literature data that prevalence of TN allergy highly differs according to agricultural status&#44; dietary routine of the societies&#44; and therefore household contact of children with TNs&#47;PN&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">The limitation of this study is that the diagnosis of food allergy was not totally based on DBPCFCs&#44; which is the gold standard for the diagnosis of food allergy&#46; However&#44; the presence of a clear-cut history or positive open OFC&#44; together with positive TNs&#47;PN sIgE and&#47;or SPT&#44; or to have sIgE levels and&#47;or SPT wheal diameters indicating clinical reactivity with &#62;95&#37; accuracy minimize the uncertainty of the diagnosis of TNs&#47;PN allergy&#46; sIgE levels of TNs&#47;PN in Turkish children13 have been found to be lower than children with TNs&#47;PN allergy living in Western countries&#46; However&#44; we accepted Western population data for TNs sIgE cut-off values&#44; which are higher than the levels of our patients&#44; to predict clinical reactivity with &#62;95&#37; accuracy&#46; The most important considerable strength of the current study is to be the first study on the TNs&#47;PN allergy spectrum from the East Mediterranean region&#46; Moreover&#44; a comprehensive overview of cross-reactivity and co-sensitization among TNs&#47;PN has been revealed&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">In conclusion&#44; TNs&#47;PN allergic children living in the East Mediterranean region have similar characteristics in terms of severity&#44; co-sensitization&#44; concomitant allergies&#44; and co-allergies compared to counterparts living in Western countries&#46; However&#44; earlier age of onset of the symptoms&#44; clinical spectrum&#44; and age pattern of multiple TNs&#47;PN allergy exhibited variabilities&#44; and all these dissimilarities support the role of cultural dietary habits of the societies in the development of TNs&#47;PN allergies&#46; In addition&#44; although almond may be a good choice for the consumption of children with TNs allergy&#44; allergy to almond may be a sign of multiple TNs&#47;PN allergies&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">This research did not receive any specific grant from funding agencies in the public&#44; commercial&#44; or not-for-profit sectors&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">All authors approve the final version of the manuscript</p><p id="par0200" class="elsevierStylePara elsevierViewall">All parents&#47;guardians provided written informed consent</p><p id="par0205" class="elsevierStylePara elsevierViewall">The study was performed in accordance with the protocol approved by the local ethical committee of Hacettepe University &#40;approval identification number is GO 15&#47;649-07&#41;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflict of interest</span><p id="par0210" class="elsevierStylePara elsevierViewall">The authors have no conflict of interest to declare&#46;</p></span></span>"
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              "titulo" => "System involvements during hypersensitivity reactions due to TNs and PN"
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              "titulo" => "Single vs&#46; multiple TNs&#47;PN sensitizations and allergy"
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            2 => "Co-sensitization"
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        1 => array:4 [
          "clase" => "abr"
          "titulo" => "Abbreviations"
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            1 => "AR"
            2 => "CVS"
            3 => "GIS"
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            7 => "sIgE"
            8 => "SPT"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introduction&#47;Objectives</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The characteristics of tree nuts &#40;TNs&#41; and peanut &#40;PN&#41; allergies vary in different regions of the world&#46; We aim to identify the characteristics of TNs&#47;PN allergies in Turkish children&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Patients and Methods</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A total of 227 children &#91;4&#46;8 &#40;3&#46;2&#8211;6&#46;8&#41; years&#93; with TN and&#47;or PN allergies were included&#46; The phenotypical features of TNs&#47;PN allergic children and the risk factors for multiple TNs&#47;PN allergies were evaluated&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Results</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Allergy to TNs&#47;PN developed at a median age of 12&#46;0 &#40;10&#46;0&#8211;18&#46;0&#41; months&#46; The most common TNs&#47;PN responsible for food allergies were the hazelnut &#40;63&#46;9&#37;&#41; and the pistachio &#40;54&#46;6&#37;&#41;&#46; Of TNs&#47;PN allergic children&#44; 54&#46;2&#37; experienced reactions with at least two types of &#46; Current ages 6&#8211;10 years &#91;OR&#58;2&#46;455&#44; 95&#37; CI&#58;1&#46;255-4&#46;852&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#93; and family history of atopy &#91;OR&#58;2&#46;156&#44; 95&#37; CI&#58;1&#46;182&#8211;3&#46;932&#44; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;012&#93; were the risk factors for multiple TNs&#47;PN allergies&#46; Most of the patients with cashew nut and pistachio allergies exhibited co-sensitization and co-allergy to both of these TNs&#47;PN&#46; Although the rarest TNs&#47;PN allergy was seen with almond&#44; the possibility of allergy to other TNs or PN was highly increased in the patients with almond allergy compared to other TNs&#47;PN&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusions</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Children with TNs&#47;PN allergy living in an East Mediterranean region differ from the counterparts living in Western countries by an earlier age of onset of the TNs&#47;PN allergy symptoms&#44; increasing possibility to have multiple TNs&#47;PN allergy at older ages&#44; and different spectrum of TN&#47;PN allergies &#40;hazelnut followed by pistachio&#47;cashew&#41; that all indicate the consumption habits which are important determinants of TN&#47;PN allergy development&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introduction&#47;Objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Patients and Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Results"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusions"
          ]
        ]
      ]
    ]
    "multimedia" => array:6 [
      0 => array:8 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1286
            "Ancho" => 2177
            "Tamanyo" => 122591
          ]
        ]
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0005"
            "detalle" => "Figure "
            "rol" => "short"
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">System involvements in the patients with TNs and PN allergies&#46; <span class="elsevierStyleSup">a</span>TNs&#44; Tree nuts&#59; PN&#44; Peanut&#59; GIS&#44; Gastrointestinal System&#59; CVS&#44; Cardiovascular System&#46;</p>"
        ]
      ]
      1 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at0010"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Clinical and laboratory parameters&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Current age &#40;years&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;8 &#40;3&#46;2&#8211;6&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age of the onset of the allergic symptoms to TNs &#40;months&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;10&#46;0&#8211;18&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age of the onset of the allergic symptoms to PN &#40;months&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;10&#46;0&#8211;18&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients with allergic symptoms following consumption at the time of the diagnosis of TNs&#47;PN allergy &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115&#47;50&#46;6&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients with AD diagnosed as TNs&#47;PN allergy by performing SPT or sIgE with TNs&#47;PN &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">88&#47;38&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Patients diagnosed as TNs&#47;PN allergy by performing SPT or sIgE with TNs&#47;PN due to symptoms with foods other than TNs&#47;PN &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23&#47;10&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gender &#40;M&#41; &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">161&#47;71&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AD &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">163 &#40;72&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AR &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">27 &#40;12&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Asthma &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">82 &#40;36&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Accompanying pollen sensitization &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;14&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anaphylactic reactions after the consumption of any TNs or PN &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">94 &#40;41&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">TNs&#47;PN Allergy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hazelnut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">145 &#40;63&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pistachio &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124 &#40;54&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cashew nut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;42&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Walnut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;40&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peanut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50 &#40;22&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Almond &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24 &#40;10&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OFC test positivity &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">242&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hazelnut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#47;26 &#40;23&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Pistachio &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">24&#47;81 &#40;29&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Cashew nut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#47;50 &#40;22&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Walnut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;22 &#40;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Peanut &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#47;25 &#40;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Almond &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#47;38 &#40;2&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Concomitant Food Allergy other than TNs&#47;PN &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141&#40;62&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Only Cow&#8217;s milk&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17 &#40;17&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Only Egg white&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59 &#40;26&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Concomitant cow&#8217;s milk and egg white&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;24&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Wheat&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;0&#46;04&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Legumes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;08&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lentil&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;0&#46;08&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sesame&#47;Tahini&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;0&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Family history of atopy &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;29&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Family history of food allergy &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;5&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Family history of TNs&#47;PN allergy &#40;n&#47;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Eosinophil count &#40;&#47;mm3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">400 &#40;200-675&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Basophil count &#40;&#47;mm3&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Total IgE &#40;kU&#47;L&#41;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">211 &#40;73&#46;6-473&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_colgroup " colspan="2" align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">rho&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">rho</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">rho</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hazelnut&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;475&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2472545.png"
              ]
            ]
          ]
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Article information

ISSN: 03010546
Original language: English

DOI:10.1016/j.aller.2019.07.005

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	2	1	3
2024 October	42	19	61
2024 September	53	18	71
2024 August	56	23	79
2024 July	31	20	51
2024 June	24	8	32
2024 May	64	4	68
2024 April	47	20	67
2024 March	59	7	66
2024 February	38	11	49
2024 January	39	6	45
2023 December	44	12	56
2023 November	64	14	78
2023 October	70	11	81
2023 September	54	9	63
2023 August	67	15	82
2023 July	61	7	68
2023 June	61	7	68
2023 May	93	10	103
2023 April	70	3	73
2023 March	38	8	46
2023 February	26	6	32
2023 January	38	5	43
2022 December	40	5	45
2022 November	51	18	69
2022 October	50	8	58
2022 September	47	12	59
2022 August	41	6	47
2022 July	44	8	52
2022 June	45	12	57
2022 May	44	29	73
2022 April	62	7	69
2022 March	81	15	96
2022 February	65	6	71
2022 January	66	8	74
2021 December	57	11	68
2021 November	44	14	58
2021 October	35	29	64
2021 September	26	20	46
2021 August	19	27	46
2021 July	23	13	36
2021 June	16	19	35
2021 May	24	15	39
2021 April	40	14	54
2021 March	42	8	50
2021 February	22	10	32
2021 January	15	9	24
2020 December	2	0	2
2020 October	1	2	3
2020 July	15	3	18
2019 October	0	4	4

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Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications

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Allergologia et Immunopathologia is no longer published on Elsevier since the 2021 year.Transferred to Codon Publications

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