metricas
covid
Buscar en
Annals of Hepatology
Toda la web
Inicio Annals of Hepatology Association between hypothyroidism and non-alcoholic fatty liver disease
Journal Information
Vol. 27. Issue S3.
Abstracts from XVII Mexican Congress of Hepatology
(December 2022)
Share
Share
Download PDF
More article options
Vol. 27. Issue S3.
Abstracts from XVII Mexican Congress of Hepatology
(December 2022)
Open Access
Association between hypothyroidism and non-alcoholic fatty liver disease
Visits
512
J Zuarth-Vázquez1, JP Soriano-Márquez2, A Velázquez-Alemán3, L Moreno-Castañeda1, I López-Méndez4, MH Ramos-Ostos5, M Uribe2, E Juárez-Hernández3
1 Internal Medicine Service. Fundación Clínica Médica Sur. México City. México
2 Gastroenterology and Obesity Service. Fundación Clínica Médica Sur. México City. México
3 Translational Research Unit. Fundación Clínica Médica Sur. México City. México
4 Hepatology and Transplant Service. Fundación Clínica Médica Sur. México City. México
5 Comprehensive Diagnosis and Treatment Center. Fundación Clínica Médica Sur. Mexico City. Mexico
This item has received

Under a Creative Commons license
Article information
Abstract
Full Text
Download PDF
Statistics
Special issue
This article is part of special issue:
Vol. 27. Issue S3

Abstracts from XVII Mexican Congress of Hepatology

More info
Introduction and Objectives

Association between hypothyroidism and non-alcoholic fatty liver disease (NAFLD) is controversial. The aim of the study was to evaluate the association between levels of thyroid stimulating hormone (TSH) and NAFLD.

Material and Methods

This is a cross-sectional study of patients who attended at check-up unit. NAFLD was evaluated by the controlled attenuation parameter (CAP). Also, patients were classified by metabolic dysfunction-associated fatty liver disease (MAFLD) criteria. TSH levels were divided into three different cut-off points (>4.5, >3.1 y >2.5). Associations between THS, NAFLD and MAFLD were evaluated by univariate and multivariate logistic regression analysis.

Results

Three thousand seven hundred forty-one patients were included, 59% (n=2211) were male, mean of age and body mass index were 48 [43-55] years and 25.9 [23.6-28.6] kg/m2.44.5% (n=1664) of patients were diagnosed with NAFLD meanwhile, 1% (n=37) presented significant liver fibrosis. In multivariate analysis, TSH levels did not show an independent association with the presence of NAFLD or MAFLD (Table). According to different cut-off points, patients with high levels of TSH presented similar risks for NAFLD to the general population (presence of metabolic syndrome and high-fat percentage).

Discussion

There is evidence of an association between hypothyroidism and NAFLD. However, liver steatosis is diagnosed by abdominal ultrasound. This is the first study that evaluates steatosis by CAP.

Conclusion

TSH levels are not associated with NAFLD or MAFLD; patients with high TSH levels have the same risk for NAFLD as the general population.

Funding

The resources used in this study were from the hospital without any additional financing

Declaration of interest

The authors declare no potential conflicts of interest.

Full Text

Table. Association between TSH and NAFLD/MAFLD.

  NAFLDMAFLD
Characteristic  UnivariateMultivariateUnivariateMultivariate
  OR (IC 95%)  OR(IC 95%)  OR (IC 95%)  OR (IC 95%) 
Male  2.1 (1.8-2.4)  **      1.5 (1.2-1.82)  **     
MetS  5.1 (4.2-6.1)  **  1.6 (1.2-2.1)  **  3.1 (2.5-3.8)  **  1.6 (1.2-2.1)  ** 
TSH >4.5  1.2 (0.9-1.5)  0.11      1.3 (0.9-1.8)  0.09     
TSH >2.5  1.1 (1.0-1.3)  0.01      1.2 (1.0-1.4)  0.03     
TSH >3.1  1.2 (1.0-1.4)  0.002      1.2 (1.0-1.5)  0.01     
% fat >29.8  2.2 (1.9-2.6)  **  2.2 (1.6-2.9)  **  1.8 (1.5-2.1)  **  2.0 (1.4-2.8)  ** 

** p≤0.001; NAFLD non-alcoholic fatty liver disease; MAFLD metabolic dysfunction-associated fatty liver disease; MetS metabolic syndrome; TSH thyroid stimulating hormone.

Download PDF
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos