Background and aim: Hepatitis C is the main cause of transplantation in the United States (USA) and worldwide, in Mexico it has a prevalence of 0.3-0.5% and represents one of the main causes of liver cirrhosis and alcohol consumption. Treatment has change with the arrival of direct-acting antivirals (DAAs), in particular with pangenotype schemes, reporting sustained viral response (SVR)> 95%. SVR reduces mortality from all causes, the need for liver transplantation, death related to cirrhosis and its complications. Aim: To determine the effect of pangenotype treatment with Glecaprevir / Pibrentasvir in patients with chronic hepatitis C.
Material and methods: Cross-sectional, retrolective, analytical and comparative study. All older subjects diagnosed with chronic hepatitis C, who received glecaprevir-pibrentasvir treatment and who had a viral load result at the end of treatment and APRI and baseline FIB-4 and post-treatment were included. Descriptive statistics and group comparisons were performed with t-Student, to show differences the Wilcoxon test. The project was submitted for approval by the institutional ethics committee.
Results: We analyzed 50 patients, 33 (66%) women, genotype 1b was the most frequent (36%), 41 patients received treatment for 8 weeks (82%), the mean age was 56±13.78 and the median mass index body 26 (23-30). 18% (9) had diabetes mellitus, 2 (4%) patients with chronic kidney disease on hemodialysis. 16% (8) had cirrhosis. SVR 12 was 98%. A significant difference of p<0.05 was shown in the fibrosis markers APRI and FIB-4 when comparing baseline and post-treatment. There were no adverse effects that caused the suspension of the treatment.
Conclusions: Pangenotype treatment with glecaprevir-pibrentasvir is effective in achieving SVR 12 in 98% and improves fibrosis parameters measured with biomarkers as has been shown in previous studies.
Conflicts of interest: The authors have no conflicts of interest to declare.
