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Inicio Annals of Hepatology Evaluation of IL-12 and CXCL-10 in patients with hepatitis C, non-alcoholic fatt...
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Vol. 27. Issue S3.
Abstracts from XVII Mexican Congress of Hepatology
(December 2022)
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Vol. 27. Issue S3.
Abstracts from XVII Mexican Congress of Hepatology
(December 2022)
Open Access
Evaluation of IL-12 and CXCL-10 in patients with hepatitis C, non-alcoholic fatty liver disease and liver damage for alcohol consumption
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M Hernandez-Santillan1, M Martínez-Castillo1, Z Medina-Ávila1, M Lemus-Peña1, D Montes de Oca-Ángeles1, A Hernández-Barragan1, JL Pérez-Hernández2, F Higuera-De la Tijera2, D Santana-Vargas2, P Cordero-Pérez3, L Muñoz-Espinoza3, J Córdova-Gallardo4, D Kershenobich1,5, G Gutiérrez-Reyes1
1 Liver, Pancreas and Motility laboratory. Unit of Research in Experimental Medicine. School of Medicine. UNAM. Mexico City. Mexico
2 Department of Gastroenterology. General Hospital of México “Dr. Eduardo Liceaga.” México City. México
3 Universitary Hospital “Dr. José Eluterio González”. School of Medicine. UANL. Nuevo Leon. México City. México
4 General Hospital “Dr. Manuel Gea González”. México City. México
5 National Institute of Medical Sciences and Nutrition “Salvador Zubirán.” México City. México
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Vol. 27. Issue S3

Abstracts from XVII Mexican Congress of Hepatology

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Introduction and Objectives

To Compare serum levels of IL-12 and CXCL-10 in different etiologies of liver disease.

Materials and methods

A cross-sectional and multicenter study was carried out, including subjects with alcoholism according to criteria WHO, without (OH) and with liver injury (cirrhosis, CiOH) and (Alcoholic Hepatitis, HA); non-alcoholic fatty liver (NAFLD) and chronic Hepatitis C (CHC), diagnosed by clinical, biochemical data. They were compared with subjects control (CT). For determination of IL-12 and CXCL-10 with Multiplex®-MERCK©. Statistical analysis by SPSS V.22 using U de Mann Whitney, p<0.05; values expressed as mean ± standard error.

Results

Included 20 subjects with NAFLD, 78 CHC, 14 HA, 20 CiOH, 15 OH y 60 CT. IL-12 was found elevated in OH, HA, CHC vs. CT in OH vs. HCc y HGNA (p≤0.05). CXCL-10 was found elevated in CiOH, HA and CHC vs. CT(p≤0.050).

Discussion

The IL-12 showed elevated levels in subjects with alcohol consumption and CHC vs. CT that activates other cell types involved in inflammation. CXCL-10 is induced by IFN-γ, was found elevated in CiOH, HA and CHC, exerting their biological effects through CXCR3, including activation of peripheral immune cells and apoptosis. The ratio of IL-12/CXCL-10 in OH increased 4.6 times, ratifying the participation in chronic and continual inflammatory response by alcohol consumption.

Conclusions

IL-12 and CXCL-10 have an important role in alcohol-induced liver disease, confirming their contribution to inflammation, being evident CXCL-10 in advanced stages of the disease, by stimulating and favoring the migration of immune cells to the damage sites.

Funding

This work was partially financed by CONACyT SALUD-2016-272579 and PAPIIT- UNAM TA200515.

Declaration of interest

The authors declare no potential conflicts of interest.

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