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Vol. 19. Issue S1.
Abstracts of the 2020 Annual meeting of the Mexican Association of Hepatology (AMH) – XV Congreso Nacional de Hepatología (23-25 de julio)
Pages 13-14 (September 2020)
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Vol. 19. Issue S1.
Abstracts of the 2020 Annual meeting of the Mexican Association of Hepatology (AMH) – XV Congreso Nacional de Hepatología (23-25 de julio)
Pages 13-14 (September 2020)
28
Open Access
Hepatocelullar carcinoma is a major risk factor for the development of portal ven thrombosis in cirrhotic patients
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C.A. Espinoza1,2, F. Higuera de la Tijera1,2, J.A. Meléndez-Andrade1,2, A. Servín-Caamaño1,2
1 Gastroenterology, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico
2 Internal Medicine, Hospital General de México “Dr. Eduardo Liceaga”, Mexico City, Mexico
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Table 1. Adjusted multivariate logistic regression model exploring risk factors for PVT in patients with cirrhosis.
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Background and aim: Portal vein thrombosis (PVT) is a rare complication in cirrhotic patients specially in advanced stages, multiple series demonstrated 5-20% prevalence in cirrhotic patients.

Aim: To identify risk factors for the development of PVT in cirrhotic patients.

Material and methods: Research Design: Case-control study. Procedure: We searched medical records from inpatients during 2019 with the diagnosis of PVT; cirrhotic patients with PVT were used as cases and paired in a 1:2 ratio with cirrhotic patients without PVT. Qualitative variables were depicted as frequencies and percentage, numeric variables as mean and standard deviation. X2, fisher's exact, student's t and Mann-Whitney's U were used to compare groups accordingly. Logistic regression was used to examine risk factors. P value <0.05 was considered statistically significant.

Results: Out of 1371 records, 40 patients with PVT were found (2.92%); 30 of them with cirrhosis were paired with 60 non-PVT cirrhotic patients. 53 (58.9%) were male; mean age: 56,2±13,9 years. According to Child-Pugh: 49 (54,4%) A, 22 (24,4%) B and 19 (21,1%) C. Fifteen (16,7%) had hepatocellular carcinoma (HCC). PVT was more prevalent in women than men (17/37 vs. 13/53 [45.9 vs. 24.5%]; OR=2.6, IC95%: 1.1-6.4; P=0.03). Patients with HCC had a higher prevalence of PVT against those without HCC (11/15 vs. 19/75 [73.3 vs. 25.3%]; OR=8.1, IC95%: 2.3-28.5; P=0.001). Decompensated cirrhosis patients had a higher rate of PVT than compensated patients (19/41 vs. 11/49 [46.3 vs. 22.4%]; OR=2.9, IC95%: 1.2-7.4; P=0.02). Adjusted multivariate logistic regression model is shown in Table 1.

Table 1.

Adjusted multivariate logistic regression model exploring risk factors for PVT in patients with cirrhosis.

Variables  P  OR  95%CI
      Lower  Upper 
Female  0.06  2.690  0.951  7.606 
Hepatocellular carcinoma  0.005  7.722  1.876  31.783 
Child-Pugh B  0.86  1.114  0.325  3.820 
Child-Pugh C  0.07  3.184  0.889  11.400 
Constant  0.000  0.165     

Conclusions: PVT is more frequent in women and decompensated cirrhosis, the presence of HCC in cirrhotic patients is the main prothrombotic factor.

Conflicts of interest: The authors have no conflicts of interest to declare.

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