Levels of IGFBP-1, 3 and 7 in human serum induced by alcohol consumption, NAFLD and dual insult

Introduction and Objectives

Alcoholic liver and non-alcoholic liver disease causes liver disease. Dual damage has been gaining great relevance. Insulin growth factor binding proteins (IGFBPs) regulate the signaling pathways of IGF; IGFBP-3 have emerged as promising biomarkers in HGNA; however, in alcohol intake and dual damage has not been previously reported the levels of IGFBPs. To demonstrate the changes in the serum levels of IGFBP-1, 3 and 7 in alcohol consumption, NAFLD and dual insult

Materials and Patients

Prospective, cross-sectional and multicenter study; approved by the research and ethics commission of the UNAM and the General Hospital of Mexico. A clinical history was taken and an informed consent was requested. IGFBP-1, 3 and 7 were evaluated in alcoholism (OH), alcoholic liver disease (cirrhosis (CiOH)), alcoholic hepatitis (AH), NAFLD, dual patients and control group (CT) using multiple suspension arrays. Kruskal-Wallis, Mann-Whitney U test were used for the statistical analysis.

Results

The data showed that alcohol dependence increased the serum levels of IGFBP-1, 3 and 7 (ng/mL) vs. CT, and vs. the other hepatopathies as follows OH>AH>CiOH>HGNA>Dual. Whereas in CiOH the levels of IGFBP-1, 3 and 7 were reduced vs. CT, but a slight increment was observed in AH; however, it never reached similar values to CT. On the other hand, in NAFLD the serum concentrations of all the IGFBPs evaluated were downregulated vs. CT.

Conclusions

The serum levels of IGFBPs were regulated in a differential manner in accordance with the negative liver stimuli, these changes were more evident in alcoholism The dual stimulus showed the clear synergistic effects of alcohol consumption and diet in IGFBP regulation. IGFBPs could be used as biomarkers or targets in the control of different hepatopathies.

Ethical statement

The study was previously approved by the institutional ethics committees of the Hospital General de México (HG/DI/16/107/03/082) and the Universidad Nacional Autónoma de México

(FMD/DI/15/2015), guaranteeing its performance in accordance with the ethical principles described in the 1975 Declaration of Helsinki. A clinical history was taken and an informed consent was requested.

Declaration of interests

None

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.