P-116 PREGNANCY AFTER LIVER TRANSPLANTATION: OUTCOMES IN PERU

Introduction

Pregnancy after liver transplantation has favorable results, but maternal and graft risk, optimal immunosuppression (IS), and fetal outcomes are described.

Objective

To show our outcomes of pregnancy after liver transplantation

Materials and Methods

This is a case series study. We conducted a retrospective review of liver transplant recipients who had received prenatal care at Guillermo Almenara Hospital between Mach 2001 and February 2021

Results

During the study period, 286 patients underwent liver transplantation. There were 45 women (15 %) in childbearing age (15-45 years old), and 7 (15%) of them became pregnant during the study period.

There was a total of 7 pregnancies. The mean age of patients at the time of transplant was 31.7 +- 4.5 years, and the mean interval between transplant and conception were 16.6 (IQR 38, 25 % <11.6 meses). There were 5 live births (71.4%), 1 spontaneous miscarriage (14 %), and one fetal death at 22 weeks. Median gestational age at delivery was 34.8+-4.21 weeks (range, 29–39), and the median birthweight was 2483 g (range, 1350–3060 g). Prematurity occurred in 3 (60 %) neonates, and 3 (60 %) neonates were adequate birth weight. Apgar scores were ≥7 in 100 %.

All the pregnant has an immunosuppressive regimen base in tacrolimus. One pregnant with chronic rejection had a newborn with good evolution.

Conclusions

The Pregnancy after liver transplantation had a favorable outcome in most of our cases, but there are still serious risks to the mother and the fetus. The Evaluation and follow-up must involve a multidisciplinary team.