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Inicio Annals of Hepatology P-118 HEPATOCELLULAR CARCINOMA. AN EXPERIENCE IN A TRANSPLANT CENTER IN COLOMBIA
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Vol. 28. Issue S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(March 2023)
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Vol. 28. Issue S1.
Abstracts of the 2022 Annual Meeting of the ALEH
(March 2023)
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P-118 HEPATOCELLULAR CARCINOMA. AN EXPERIENCE IN A TRANSPLANT CENTER IN COLOMBIA
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Adriana Varón1, José Leonardo Pérez2, Cristina Torres1, Juan Manuel Pérez3, José Gabriel Caviedes3, Diego Piñeros3, Gilberto Mejía4, Jairo Rivera4, Ciro Murcia4, Geovanny Hernández1, Martin Garzón1, Oscar Beltrán1
1 Hepatology Department, LaCardio, Cardioinfantil Foundation. Bogotá, Colombia
2 Gastroenterology Department, LaCardio, Cardioinfantil Foundation. Bogotá, Colombia
3 Interventional Radiology Department, LaCardio, Cardioinfantil Foundation. Bogotá, Colombia
4 Liver Transplant Department, LaCardio, Cardioinfantil Foundation. Bogotá, Colombia
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Vol. 28. Issue S1

Abstracts of the 2022 Annual Meeting of the ALEH

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Introduction and Objectives

Hepatocellular carcinoma (HCC) is the sixth most frequent type of cancer and the fourth cause of death related to cancer worldwide. Remarkably, HCC is the most common type of liver cancer. According to the International Agency for Research on Cancer (IARC), the incidence of liver cancer in Colombia was 2%, with a 4% mortality in 2020. This study aimed to describe the clinical characteristics of patients with HCC at a liver transplant center in Colombia in the period 2015 to 2020.

Materials and Methods

Descriptive study of consecutive patients with HCC. We developed an HCC registry from our outpatient Clinic in which we reported clinical status, imaging, and therapeutic management. The continuous variables were described as the mean and standard deviation, and nominal variables were evaluated based on frequencies and percentages. All analyses were done in Statistical Package for the Social Sciences (SPPS) v. 21.0.

Results

In total, 131 HCC patients were included, 76 men and 37 women, with an average age of 65 years. Of these patients, 40% were classified as CHILD PUGH (CP) - A, 42% were CP-B and in less proportion, 16.7% were CP-C. The etiology of the cirrhosis was diverse; most cases had a history of alcoholism (34%) and a past medical history of B and C viral infection (23.6%). The radiological characteristics of patients with HCC are shown in table 1. Therapeutic interventions assessed were radiofrequency ablation (ARF 61.6%), microwave ablation (AMO, 7.53%), transarterial chemoembolization (TACE, 30.8%) and liver transplant after ablative treatment (20.5%). Different outcomes analyzed were complete responses for ARF (52.2%), AMO (72.7%) and TACE (4.4%).

Conclusions

In our historical cohort, liver function allowed the achievement of curative therapeutic interventions (ARF/AMO) with a complete response in more than 50% of patients intervened and 20% of patients taken for a liver transplant. Our results highlight the importance of premature detection of high-risk patients and early therapeutic interventions in this population of patients.

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Table. Radiological characteristics of patients with HCC

Liver lesions (HCC)location of liver lesions
Number of lesions  n (%)  Hepatic segment  n (%) 
  • 1 lesion

 
63 (70)  Segment II  4 (6,2) 
  • 2 lesions

 
12 (13,3)  Segment III  2 (3,0) 
  • 3 lesions

 
10 (11,1)  Segment IV  15 (22,7) 
  • 4 lesions

 
2 (2,2)  Segment V  6 (9,1) 
  • 5 lesions

 
2 (2,2)  Segment VI  10 (15,2) 
  • 6 lesions

 
1 (1,1)  Segment VII  16 (24,2) 
    Segment VIII  13 (19,7) 
LIRADS    Radiological performance   
LIRADS 4*  17 (19,3)  Arterial enhancement  65 (72,2) 
LIRADS 5  71 (80,7)  Contrast wash  62 (68,9) 
    Pseudocapsule formation  40 (44,4) 
    Restriction  13 (14,4) 

* confirmed with histopathology

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