P- 48 EFFECT OF THE COMBINATION OF ORLISTAT AND L-CARNITINE ON THE QUALITY OF LIFE (SF.36) IN 16 OVERWEIGTH PATIENTS

Carmona, Miguel Yael; Vera, Saúl André; Higuera, María De Fatima; Delgado, Livan; Camacho, Santiago

doi:10.1016/j.aohep.2023.101235

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To our knowledge, the effect of this combination on the quality of life of overweight patients has not been determined. We aimed to evaluate the effects on the quality of life of patients who took the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment. Materials and MethodsWe evaluated the quality of life (Short Form-36) in 16 patients [41.81±8.26 (37.77-45.86) years, 81% women] undergoing pharmacotherapy of the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment. Data express mean SD and 95%IC or percentages as correspond. We use paired Student t Test, two tails with an alpha=0.05. ResultsFigure. Patients lowered their weight in about 5%. Patients show improvement on body pain, general health, vitality and in both Mental [45.68±6.51 (42.49-48.86) vs. 49.88±3.21 (48.31-51.46), p=0.02] and Physical [59.4±8.92 (55.03-63.77) vs. 63.36±9.64 (58.63-68.08), p=0.01) summaries. ConclusionsThese results suggest a beneficial effect of the combination of Orlistat and l-carnitine on the treatment of overweight." 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ISSN: 1665-2681

Annals of Hepatology (AoH) is an international, open access journal published bi-monthly with funds from the Fundación Clínica Médica Sur. It is the official journal of the Mexican Association of Hepatology (AMH), the Latin American Association for the Study of the Liver (ALEH), the Canadian Association for the Study of the Liver (CASL) and the Czech Society of Hepatology (CSH). AoH publishes editorials, opinions, concise reviews, original articles, brief reports, letters to the editor, news from affiliated associations, clinical practice guidelines and summaries of congresses in the field of Hepatology.

Topics covered by AoH include alcoholic liver disease, autoimmune hepatitis, biliary diseases, drug-induced liver injury, genetic liver diseases, NAFLD/NASH and viral hepatitis (HAV, HBV, HCV, HDV, HEV). Our journal seeks to publish articles on basic clinical care and translational research focused on preventing rather than treating the complications of end-stage liver disease.

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Orlistat is a drug widely used in overweight/obese patients, while the combination with l-carnitine could offer an improvement in these patients. To our knowledge, the effect of this combination on the quality of life of overweight patients has not been determined. We aimed to evaluate the effects on the quality of life of patients who took the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment.

Materials and Methods

We evaluated the quality of life (Short Form-36) in 16 patients [41.81±8.26 (37.77-45.86) years, 81% women] undergoing pharmacotherapy of the combination of orlistat and l-carnitine at 4 and 8 weeks of treatment. Data express mean SD and 95%IC or percentages as correspond. We use paired Student t Test, two tails with an alpha=0.05.

Results

Figure. Patients lowered their weight in about 5%. Patients show improvement on body pain, general health, vitality and in both Mental [45.68±6.51 (42.49-48.86) vs. 49.88±3.21 (48.31-51.46), p=0.02] and Physical [59.4±8.92 (55.03-63.77) vs. 63.36±9.64 (58.63-68.08), p=0.01) summaries.

Conclusions

These results suggest a beneficial effect of the combination of Orlistat and l-carnitine on the treatment of overweight.

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