P-64 THE ALCOHOL-ASSOCIATED LIVER DISEASE PARADOX IN CHILE: AN ASSESSMENT WITH DATA FROM THE NATIONAL HEALTH SURVEY (ENS 2016-2017)

Introduction

It has been observed people with low-income-level ( <il) have="" greater="" liver="" injury="" due="" to="" alcohol="" consumption="" (ac),="" even="" when="" their="" levels="" are="" lower="" or="" equal="" those="" with="" high-income-level="" (=""> IL). The aim of this study was to evaluate alcohol-associated liver disease (ALD) paradox in Chile. </il)>

Methods

With data from the ENS 2016-17 (N=2,190; age 25-64) we constructed a logit regression model that estimated the effect hazardous AC (AUDIT≥8) on the probability of presenting ALD (GPT≥40 U/L). We focus on the interaction between hazardous AC and IL, controlling for the presence of metabolic syndrome (MS), diabetes mellitus (T2DM), obesity and tobacco.

Results

The average AC was 39g of alcohol per week (13g women <il; 23g="" women=""> IL; 64g men, without differences by IL). In women, hazardous AC only increased ALD among those >IL who presented with obesity or MS in combination with T2DM (+36% obesity+MS+T2DM; p<0.01). In men, hazardous AC only increased ALD among those with </il;>

Conclusion

ALD paradox can be observed in Chile among men, but not among women. The evaluated associated comorbidities increased the effect of hazardous AC on ALD. It is necessary to investigate how the IL determines the patterns of AC and comorbidities. Among men, <il is="" likely="" to="" be="" associated="" with="" more="" harmful="" drinking="" patterns="" and="" a="" greater="" presence="" of="" comorbidities.="" among="" women,=""> IL is likely associated with higher AC and more harmful consumption patterns. </il>