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Inicio Annals of Hepatology P-66 COULD PROTEIN CONTENT OF URINARY EXTRACELLULAR VESICLES BE USEFUL TO DETECT...
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Vol. 24. Issue S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(September 2021)
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Vol. 24. Issue S1.
Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)
(September 2021)
Open Access
P-66 COULD PROTEIN CONTENT OF URINARY EXTRACELLULAR VESICLES BE USEFUL TO DETECT CIRRHOSIS IN ALCOHOLIC LIVER DISEASE?
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E. Gonzalez1, M. Azkargorta2, C. Garcia-Vallicrosa1, J. Prieto-Elordui3, F. Elortza2, S. Blanco-Sampascual3, J.M. Falcon-Perez1,4,5
1 Exosomes Laboratory, Center for Cooperative Research in Biosciences (CIC Biogune), Basque Research and Technology Alliance (BRTA), Derio, Spain
2 Proteomics Platform. Center for Cooperative Research in Biosciences (CIC Biogune), Basque Research and Technology Alliance (BRTA), Derio, Spain
3 Servicio de Aparato Digestivo, Hospital Universitario de Basurto, Bilbao Vizcaya, España
4 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain
5 Ikerbasque Basque Foundation for Science Bilbao Spain
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Vol. 24. Issue S1

Abstracts of the 2021 Annual meeting of the ALEH (Asociación Latinoamericana para el Estudio del Hígado)

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Introduction

Alcohol abuse has a high impact on the mortality and morbidity related to a great number of diseases and is responsible for the development of alcoholic liver disease (ALD). It remains challenging to detect and evaluate its severity, which is crucial for prognosis.

Objective

In this work, we studied if urinary EVs (uEVs) could serve in diagnose and evaluate cirrhosis in ALD.

Methods

uEVs characterization by cryo-electron microscopy (Cryo-EM), Nanoparticle Tracking Analysis (NTA) and Western blotting (WB) was performed in a cohort of 21 controls and 21 cirrhotic patients. Then, proteomics of urinary EVs (uEVs) was carried out in a second cohort of 6 controls and 8 patients in order to identify new putative biomarkers for cirrhosis in ALD.

Results

uEVs concentration, size and composition were altered in cirrhotic patients. A total of 1304 proteins were identified in uEVs, and 90 of them were found to be altered in cirrhotic patients.

Conclusions

uEVs could be considered as a tool and a supplier of new biomarkers for ALD, whose application would be especially relevant in chronic patients. Yet, further research is necessary to obtain more relevant result in clinical terms.

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