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      "titulo" => "The Presence and Severity of Nonalcoholic Steatohepatitis Is Associated with Specific Changes in Circulating Bile Acids"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0005">A New Stage in Annals of Hepatology</span><p id="p0005" class="elsevierStylePara elsevierViewall">As science and technology advance&#44; new challenges emerge to be faced and solved&#46; <span class="elsevierStyleItalic">Annals of Hepatology</span> was born 16 years ago as a necessity for Mexican and Latin American academic doctors and scientists interested in the field of Hepatology&#46;</p><p id="p0010" class="elsevierStylePara elsevierViewall">Many of us&#44; as M&#46;D&#46; and Ph&#46;D&#46; students&#44; remember the gratifying annual meeting held by Dr&#46; Hans Popper and a group of devotees of liver pathologies in Chicago&#46; These meetings were later enhanced by Madam Sheila Sherlock in the clinical area&#44; transforming them into integrative basic and clinical study sessions of liver diseases&#46; Basic and clinical research &#40;also known as translational&#41; as well as teaching and tutor counseling&#44; have been the basilar points in resolving the leading etiologies of liver diseases&#46;</p><p id="p0015" class="elsevierStylePara elsevierViewall">At that time&#44; the study and the understanding of liver diseases were focused on alcoholism&#46; They started with topics that included mechanisms of liver fibrosis&#44; biliary disease&#44; clinical complications of cirrhosis such as encephalopathy&#44; esophageal varices&#44; and ascites&#44; ending with hepatorenal syndrome&#46; Subsecuently&#44; new topics were incorporated&#44; such as viral hepatitis &#40;B and C&#41;&#44; which attracted the attention of hepatologists throughout the globe&#46; In a relatively short period&#44; research highlighted the role of viral genotypes in chronic liver disease and the cell cycle of the virus&#44; paving the way to novel and more effective antiviral drugs&#46; At the same time&#44; the obesity epidemic has risen to a significant health problem in westernized countries mainly due to changes in lifestyle &#40;diet&#44; physical activity&#44; and mental health&#41; generating a disease now known as nonalcoholic steatohepatitis or NASH&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">As clinical and basic sciences advance&#44; it has become more evident that discrepancies exist in the leading causes of liver disease between the developed and less developed countries worldwide&#46; In this scenario&#44; <span class="elsevierStyleItalic">Annals of Hepatology</span> raised interest not only of the Mexican and Latin American hepatologists but also of other colleagues around the world&#46; This global interest&#44; together with the sponsorship of Medica Sur Clinical Foundation and the hard work of Doctors Misael Uribe and Editor-in-Chief Nahum M&#233;ndez-S&#225;nchez gained <span class="elsevierStyleItalic">Annals of Hepatology</span> the impact factor of 2&#46;2 in 2014&#46; <span class="elsevierStyleItalic">Annals of Hepatology</span> is also the official journal of the Mexican Association of Liver Disease&#44; the Latin American Association for Hepatology and the Canadian Association of the Study of Liver Disease&#46; Therefore&#44; the challenge and commitment of <span class="elsevierStyleItalic">Annals of Hepatology</span> are to respond to the academic and clinical community interested in the study of the liver&#44; to improve its quality and become one of the best publishing options&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">In the past 16 years&#44; major changes have occurred in hepatology&#44; transforming the paradigm of common and deadly liver diseases such as hepatitis C&#44; or developing new concepts such as acute-on-chronic liver failure&#46; In addition&#44; new technologies have contributed to the sharing of knowledge &#40;e&#46;g&#46; BioRxiv&#41;&#59; new metrics to assess the impact of research in the scientific community &#40;e&#46;g&#46; Altimetric&#41;&#44; and new channels to discuss and debate about science &#40;e&#46;g&#46; PUBPEER&#41;&#46; Finally&#44; complex statistical analysis and basic research techniques are common nowadays&#46;</p><p id="p0030" class="elsevierStylePara elsevierViewall">Considering this new outlook&#44; <span class="elsevierStyleItalic">Annals of Hepatology</span> will launch a new strategy by re-constructing the editorial team and organization of the journal with the Editor-in-Chief and Associate Editors to efficiently select and review the medical and scientific quality of the submitted manuscripts&#46; Special attention will be given to expedite the review process of the manuscripts&#46; April 1&#44; 2018&#44; is the inaugural date of this new organizational structure&#44; and the upcoming strategy will be defined in the following numbers&#46; Our goal is that <span class="elsevierStyleItalic">Annals of Hepatology</span> will rank amoung the best publishing options - not only in Latin America&#44; but also worldwide - for the academic communities involved in the study of the liver with the shared purpose of resolving liver disease&#46;</p></span></span>"
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