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Feasibility of Hepatology-Directed Microwave Ablation in Management of Hepatocellular Carcinoma in North America: A Pilot Project
Mohammad S. Ansari*, Tomohiro Tanaka**,
Corresponding author
tomohiro-tanaka@uiowa.edu

Correspondence and reprint request:
, Sandeep T. Laroia***, Shiliang Sun***
* Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
** Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA, USA
*** Division of Vascular and Interventional Radiology, Department of Radiology, University of Iowa Carver College of Medicine, Iowa City, IA, USA
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Introduction</span><p id="p0010" class="elsevierStylePara elsevierViewall">In both transplant and non-transplant settings&#44; the establishment of a multidisciplinary approach for patients with hepatocellular carcinoma &#40;HCC&#41; has been reported to improve outcomes&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">1&#44;2</span></a> In North America&#44; the management of HCC and survival outcomes is affected by having access to multidisciplinary tumor boards and specialists&#46; The role of Hepatologists in active management of HCC is usually limited&#44; however is associated with up to 30&#37; reduction in mortality&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> We theorize that access to Interventional Radiology for care in tumor management may be limited to large tertiary-care facilities and academic institutions&#44; whereas Hepatologists are more readily available in the community setting&#46; We therefore conducted this pilot study to investigate the feasibility of Hepatology-directed microwave ablation &#40;MWA&#41; of HCC tumors in collaboration with Interventional Radiology at an academic liver transplant &#40;LT&#41; center in North America&#46;</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Material and Methods</span><p id="p0015" class="elsevierStylePara elsevierViewall">We reviewed a prospective cohort of consecutive HCC cases receiving MWA for tumor treatment administered by a Hepatologist Dr&#46; Tomohiro Tanaka &#40;TT&#41;&#44; who is also the primary Hepatologist involved in the care of these patients at the University of Iowa - Division of Gastroenterology&#47;Hepatology and Organ Transplant Center&#46; TT has completed a fellowship in Gastroenterology&#47;Hepatology at a high volume liver cancer center in Japan&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a> This training included comprehensive hands-on teaching of tumor ablative techniques for liver cancers&#44; under the direct supervision of experienced attending Hepatologists&#46; Upon completion of the 3-year fellowship&#44; TT had successfully completed over 120 ablations and was certified for independent practice in performing the procedures&#46; At the onset of this project in January 2017&#44; TT had over 10 years of experience practicing as a Hepatologist&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">This project was conducted in collaboration with the Division of Interventional Radiology at the University of Iowa&#44; where professional charges were divided equally amongst the two services depending on the primary practitioner&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">The HCC diagnosis was confirmed by multiphase magnetic resonance imaging &#40;MRI&#41; or computed tomography &#40;CT&#41;&#46; Board-certified radiologists diagnosed HCC on the basis of Liver Imaging Reporting and Data System &#40;LI-RADS&#41;&#46; Prior to the procedure&#44; all patients with LI-RADS 4 or 5 were reviewed at our Multidisciplinary Hepatobiliary Tumor Board&#46;</p><p id="p0030" class="elsevierStylePara elsevierViewall">MWA was performed from January 2017 to April 2018 under general anesthesia&#44; using either Emprint Ablation System with Thermosphere Technology &#40;Covidien&#44; Boulder&#44; CO&#41; or Solero Microwave Tissue Ablation System &#40;AngioDynamics&#44; Latham&#44; NY&#41;&#59; both were used under real-time ultrasound guidance&#46;</p><p id="p0035" class="elsevierStylePara elsevierViewall">Follow-up was performed with multiphase MRI or CT following ablation&#46; Time to initial imaging varied between 4 and 6 weeks&#46; MRI or CT was obtained every 3 months to evaluate disease progression in those with an initial complete response &#40;CR&#41;&#44; or earlier in those without&#46; Response was evaluated by modified response evaluation criteria in solid tumor &#40;mRECIST&#41; criteria&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a> This project was approved by the institutional review board &#40;&#35;201708797&#41;&#46;</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025">Outcomes</span><p id="p0040" class="elsevierStylePara elsevierViewall">During the study period&#44; the Hepatologist conducted 14 cases of MWA for HCC &#40;<a class="elsevierStyleCrossRef" href="#t0010">Table 1</a>&#41;&#46; The first 5 cases were by Emprint system and the following 8 were by Solero system&#46; Median follow up period was 3&#46;1 &#40;1&#46;2 - 13&#46;4&#41; months post-treatment&#46; 13 patients had solitary lesions which were between 11-44 mm &#40;median 20&#46;5 mm&#41; in diameter&#44; with 1 patient having 2 smaller sub-centimeter nodules &#40;LI-RADS4&#41; that were not amenable to treatment&#46; BCLC stages were 0-A for all 14 patients&#46; CLIP scores were between 0 and 3&#44; with a median of 1&#46; No patients experienced adverse events related to the procedures&#46; All of the 14 underwent at least one &#40;range&#44; 1-4&#41; follow up CT or MRI with 13 &#40;93&#37;&#41; achieving complete remission &#40;CR&#41; and 1&#44; who initially had largest tumor size of 44 mm&#44; achieving partial response &#40;PR&#41;&#46; The 1 patient with PR was not indicated for TACE due to non-tumor portal vein thrombosis&#44; and was alive at the end of the study period&#46; Only 1 patient died&#44; from primary lung cancer which was diagnosed 8 months following the MWA for HCC&#44; and no further liver lesions amenable to intervention were observed throughout the follow-up period&#46; All other 12 patients were alive without local or distant recurrence at the end of the study period&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030">Discussion</span><p id="p0045" class="elsevierStylePara elsevierViewall">Hepatocellular carcinoma &#40;HCC&#41; is the fifth most common cancer and the second most frequent cause of cancer-related death worldwide&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">6</span></a> Liver resection&#44; thermal ablation&#44; and liver transplantation are potentially curative treatments&#44; with 5-year survival up to 70&#37;&#44; with thermal ablative techniques being used for treatment of non-resectable HCC&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">6</span></a> No conclusive studies have been done comparing MWA to radiofrequency ablation &#40;RFA&#41;&#44; however likely advantages include shorter ablation time&#44; less pain&#44; and less heat sink effect&#46; MW energy produces faster heating and higher temperatures&#44; which results in better demarcated and larger area of necrosis as compared with RFA&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">6</span></a> thus MWA was chosen for this project&#46;</p><p id="p0050" class="elsevierStylePara elsevierViewall">The treatment of HCC is particularly complex&#44; and thus often involves both tumor-specific &#40;size&#44; number&#44; and portal vein thrombosis&#41; and liver disease-specific &#40;cirrhosis&#44; portal hypertension and&#47;or coagulopathy&#41; considerations&#46; Therefore&#44; the delivery of care to patients with HCC is best conducted with a multidisciplinary approach&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">2&#44;3</span></a> Although multiple studies have shown that multispecialty involvement in regards to treatment of HCC has overall improved survival benefit and patient outcomes&#44; this is often limited by geographical limitations in access to facilities and specialists and may delay initiation of treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">1&#44;2</span></a> In the United States&#44; thermal ablation has been traditionally conducted by trained Radiologists rather than Hepatologists&#46; In contrast&#44; in other parts of the world such as East Asia&#44; Hepatologists have been trained in ultrasound-guided locolesional therapy&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">7</span></a> There are no studies comparing Hepatology-directed thermal ablation therapy to Radiology-directed procedures&#46; We believe that allowing trained Hepatologists to play a pivotal and direct role in HCC treatment using ultrasound-guided MWA in collaboration with Radiologists is a new and innovative strategy to the comprehensive multidisciplinary team approach&#44; with improved early access to treatment and improved patient survival and satisfaction&#46;</p><p id="p0055" class="elsevierStylePara elsevierViewall">The limitations of the pilot study include the relatively small number of patients enrolled thus far without a control arm&#46; In addition&#44; 1 out of the 14 patients died from primary lung cancer in addition to primary liver cancer&#46; It is unlikely that the liver tumor treated was a metastatic lesion given negative chest imaging immediately before the initial diagnosis of HCC&#44; however this has to be taken into consideration&#46; The current training curriculum in North America for Gastrotenterology&#47;Hepatology fellows typically does not include learning image-guided procedures for liver tumors including thermal ablative techniques&#44; which may be an important future consideration for training programs&#46;</p><p id="p0060" class="elsevierStylePara elsevierViewall">Overall&#44; Hepatology-directed thermal ablative management of HCC may be an innovative strategy to improving the patient access and treatment rates&#44; decrease dropouts in LT waitlist&#44; and ultimately allow for improved overall survival with a comprehensive multidisciplinary team approach&#46; Further studies with large number of patients including a control arm and longer follow up period is required to draw more robust conclusions&#46;</p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0035">Abbreviations</span><p id="p0065" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">&#8226;</span><p id="p0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">CR</span>&#58; complete response&#46;</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">&#8226;</span><p id="p0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">CT</span>&#58; computed tomography&#46;</p></li><li class="elsevierStyleListItem" id="u0020"><span class="elsevierStyleLabel">&#8226;</span><p id="p0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HCC</span>&#58; hepatocellular carcinoma&#46;</p></li><li class="elsevierStyleListItem" id="u0025"><span class="elsevierStyleLabel">&#8226;</span><p id="p0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">LI-RADS</span>&#58; liver imaging reporting and data system&#46;</p></li><li class="elsevierStyleListItem" id="u0030"><span class="elsevierStyleLabel">&#8226;</span><p id="p0090" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">mRECIST</span>&#58; modified response evaluation criteria in solid tumor&#46;</p></li><li class="elsevierStyleListItem" id="u0035"><span class="elsevierStyleLabel">&#8226;</span><p id="p0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">MRI</span>&#58; magnetic resonance imaging&#46;</p></li><li class="elsevierStyleListItem" id="u0040"><span class="elsevierStyleLabel">&#8226;</span><p id="p0100" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">MWA</span>&#58; microwave ablation&#46;</p></li><li class="elsevierStyleListItem" id="u0045"><span class="elsevierStyleLabel">&#8226;</span><p id="p0105" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PR</span>&#58; partial response&#46;</p></li><li class="elsevierStyleListItem" id="u0050"><span class="elsevierStyleLabel">&#8226;</span><p id="p0110" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">RFA</span>&#58; radiofrequency ablation&#46;</p></li></ul></p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Conflict of Interest</span><p id="p0115" class="elsevierStylePara elsevierViewall">The authors declares that there is no conflict of interest regarding the publication of this article&#46;</p></span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Funding</span><p id="p0120" class="elsevierStylePara elsevierViewall">This study is not funded&#46;</p></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Author Contributions</span><p id="p0125" class="elsevierStylePara elsevierViewall">MSA &#40;acquisition of data&#59; drafting of the manuscript&#41;&#44; TT &#40;study concept and design&#59; analysis and interpretation of data&#59; critical revision of the manuscript&#41;&#44; STL and SS &#40;study concept and design&#59; supervision of the study&#41;&#46;</p></span></span>"
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        "resumen" => "<span id="abs0010" class="elsevierStyleSection elsevierViewall"><p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">In North America&#44; the role of Hepatologists in treatment of hepatocellular carcinoma is limited&#46; We conducted a pilot project wherein a Hepatologist participated directly in microwave ablation of HCC at an academic center in the United States &#40;n &#61; 14&#41;&#46; The pilot project shows promising outcomes&#44; with complete remission rate of 93&#37;&#46;</p></span>"
      ]
    ]
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      0 => array:8 [
        "identificador" => "t0010"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "fuente" => "<span class="elsevierStyleItalic">Unless otherwise indicated&#44; numbers are shown as median &#40;range&#41;&#46;</span>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Age 60 &#40;35-73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">Gender&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">&#40;n &#61; 12&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">F&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#40;n &#61; 2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">MELD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;6-22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Child-Pugh&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6-A &#40;5-9&#44; A-B&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BCLC&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A &#40;0-A&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CLIP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AFP &#40;ng &#47; mL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;70 &#40;2-69&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tumor number&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1-3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tumor size &#40;largest diameter&#44; cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;9 &#40;0&#46;7-4&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61; 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">S8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">mRECIST at First CT &#47; MRI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61; 13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">mRECIST at Last CT &#47; MRI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">CR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n &#61; 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Follow up period &#40;m&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;4 &#40;1&#46;2 - 14&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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        "descripcion" => array:1 [
          "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Profile of patients with HCC undergoing MWA&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bs0010"
          "bibliografiaReferencia" => array:7 [
            0 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "1&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multidisciplinary approach for HCC patients&#58; hepatology for the oncologists&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Barone C&#46;"
                            1 => "Koeberle D&#46;"
                            2 => "Metselaar H&#46;"
                            3 => "Parisi G&#46;"
                            4 => "Sansonno D&#46;"
                            5 => "Spinzi G&#46;"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdt053"
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                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2013"
                        "volumen" => "24"
                        "numero" => "Suppl 2"
                        "paginaInicial" => "ii15"
                        "paginaFinal" => "23"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23715939"
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              "identificador" => "bib0015"
              "etiqueta" => "2&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multidisciplinary clinic in the management of hepatocellular carcinoma&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "Soares K&#46;C&#46;"
                            1 => "Cosgrove D&#46;C&#46;"
                            2 => "Herman J&#46;M&#46;"
                            3 => "Pawlik T&#46;M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1245/s10434-013-3419-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Surg Oncol"
                        "fecha" => "2014"
                        "volumen" => "21"
                        "paginaInicial" => "1059"
                        "paginaFinal" => "1061"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24318097"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                ]
              ]
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              "etiqueta" => "3&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Association of Provider Specialty and Multidisciplinary Care With Hepatocellular Carcinoma Treatment and Mortality&#46;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Serper M&#46;"
                            1 => "Taddei T&#46;H&#46;"
                            2 => "Mehta R&#46;"
                            3 => "D&#39;Addeo K&#46;"
                            4 => "Dai F&#46;"
                            5 => "Aytaman A&#46;"
                            6 => "Baytarian M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2017.02.040"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2017"
                        "volumen" => "152"
                        "paginaInicial" => "1954"
                        "paginaFinal" => "1964"
                        "link" => array:1 [
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Article information
ISSN: 16652681
Original language: English
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