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HbA1c Levels as a Parameter of Glycemic Control in Patients with Liver Diseases
Leonardo de Lucca Schiavon
Corresponding author
leo-jf@uol.com.br

Correspondence and reprint request:
, Janaína Luz Narciso-Schiavon
Department of Internal Medicine, Division of Gastroenterology, Federal University of Santa Catarina. Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="p0010" class="elsevierStylePara elsevierViewall">Dear editor&#58;</p><p id="p0015" class="elsevierStylePara elsevierViewall">We read with interest the recent study by Stine&#44; <span class="elsevierStyleItalic">et al</span>&#46; In the article&#44; DAA therapy for chronic hepatitis C showed no effect on glycemic control of diabetic patients as assessed by HbA1c levels&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">1</span></a> Although the authors highlighted some limitations of the study in the discussion section&#44; we would like to comment on HbA1c as a marker of glycemic control&#46;</p><p id="p0020" class="elsevierStylePara elsevierViewall">Several factors might result in falsely high or low HbA1c levels&#59; some of those are common in patients with liver diseases&#46; Falsely high HbA1c levels were related to severe hyperbilirubinemia<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a> and alcoholism&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">3</span></a> On the other hand&#44; HbA1c values are decreased in patients with liver cirrhosis and are not an accurate parameter for glycemic control in those patients&#44; especially in the setting of a more advanced liver disease&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a> Cacciatore&#44; <span class="elsevierStyleItalic">et al&#46;</span> when comparing cirrhotics with nondiabetic subjects with chronic hepatitis without cirrhosis and healthy controls showed that HbA1c levels were not different between groups&#44; even though glucose intolerance and diabetes were present 15&#37; and 27&#37; of the cirrhotics&#44; respectively&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a> Nomura&#44; <span class="elsevierStyleItalic">et al&#46;</span> also observed similar HbA1c levels between patients with cirrhosis and nondiabetic controls&#44; even though blood glucose was significantly higher in cirrhotics as compared to controls&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">6</span></a> More recently&#44; a study included 200 patients with decompensated cirrhosis evaluated for liver transplant with HbA1c measurement and three glucose levels available for estimating HbA1c based on blood glucose&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">7</span></a> In this study&#44; a difference &#62; 0&#46;5&#37; between &#8220;measured HbA1c&#8221; and &#8220;calculated HbA1c&#8221; was observed in 47&#37; of patients and HbA1c was &#60; 5&#37; in 49&#37; of the cases&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">7</span></a> The reasons for that are not completely understood&#44; but a possible explanation is the shortened erythrocyte life span and anemia frequent observed in patients with cirrhosis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">8</span></a></p><p id="p0025" class="elsevierStylePara elsevierViewall">In the study by Stine&#44; <span class="elsevierStyleItalic">et al&#46;</span>&#44;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">1</span></a> the inclusion of a limited number of patients&#44; the majority of them cirrhotics&#44; along with the potential impact of ribavirin use on HbA1c levels might have significantly influenced HbA1c measurement&#46; Although HbA1c levels are known to be influenced by liver cirrhosis for decades&#44; it continues to be used in several hepatology and liver transplant centers worldwide&#46; One reason for that is the limited number of tools available for glycemic control in this specific group&#46; Alternative tests such as fructosamine&#44; glycated albumin and 1&#44;5-Anhydro-glucitol are also affected by liver cirrhosis and cannot be routinely recommended&#46; To date&#44; the best option for diagnosing diabetes in patients with liver cirrhosis is the oral glucose tolerance test&#44; as fasting blood glucose and HbA1c levels may be normal despite diabetes&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a> For monitoring diabetes&#44; self-blood glucose monitoring and continuous glucose monitoring are suitable options&#44; especially for those with more advanced liver disease in whom HbA1c is not a reliable parameter of glycemic control&#46;</p><p id="p0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; clinicians should be aware of the limitations of HbA1c as a parameter of glycemic control in patients with chronic liver diseases&#44; especially liver cirrhosis&#46; Future studies investigating new options for glycemic monitoring in those patients are urgently required&#46;</p><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0010">Abbreviations</span><p id="p0035" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">&#8226;</span><p id="p0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">DAA&#58;</span> Direct antiviral agents&#46;</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">&#8226;</span><p id="p0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HbA1c&#58;</span> Glycated hemoglobin&#46;</p></li></ul></p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015">Statement of Interests</span><p id="p0050" class="elsevierStylePara elsevierViewall">Authors&#8217; declaration of personal interests&#58; nothing to report&#46;</p></span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020">Declaration of Funding Interests</span><p id="p0055" class="elsevierStylePara elsevierViewall">Nothing to report&#46;</p></span></span>"
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Article information
ISSN: 16652681
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos