Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients

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Renner, David Wong, Hemant Shah, Jordan Feld, Harry L.A. Janssen, Morris Sherman" "autores" => array:12 [ 0 => array:2 [ "nombre" => "Mayur" "apellidos" => "Brahmania" ] 1 => array:2 [ "nombre" => "Osman" "apellidos" => "Ahmed" ] 2 => array:2 [ "nombre" => "Melissa" "apellidos" => "Kelley" ] 3 => array:2 [ "nombre" => "Matthew" "apellidos" => "Kowgier" ] 4 => array:2 [ "nombre" => "Korosh" "apellidos" => "Khalili" ] 5 => array:2 [ "nombre" => "Rob" "apellidos" => "Beecroft" ] 6 => array:2 [ "nombre" => "Eberhard L." "apellidos" => "Renner" ] 7 => array:2 [ "nombre" => "David" "apellidos" => "Wong" ] 8 => array:2 [ "nombre" => "Hemant" "apellidos" => "Shah" ] 9 => array:2 [ "nombre" => "Jordan" "apellidos" => "Feld" ] 10 => array:2 [ "nombre" => "Harry L.A." "apellidos" => "Janssen" ] 11 => array:2 [ "nombre" => "Morris" "apellidos" => "Sherman" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119304363?idApp=UINPBA00004N" "url" => "/16652681/0000001600000005/v1_201905301208/S1665268119304363/v1_201905301208/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "titulo" => "Validation of the Simplified Criteria for the Diagnosis of Autoimmune Hepatitis in Chilean-Hispanic Patients" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "772" "paginaFinal" => "779" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Roberto Candia, Blanca Norero, Carlos Agüero, Luis Díaz, Juan Pablo Ortega, Rodrigo Wolff, Cristian Hernández-Rocha, Ignacio Duarte, Alejandro Soza, Carlos Benítez, Marco Arrese" "autores" => array:11 [ 0 => array:4 [ "nombre" => "Roberto" "apellidos" => "Candia" "email" => array:1 [ 0 => "rcandiab@med.puc.cl" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Blanca" "apellidos" => "Norero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Carlos" "apellidos" => "Agüero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Luis" "apellidos" => "Díaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Juan Pablo" "apellidos" => "Ortega" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "Rodrigo" "apellidos" => "Wolff" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff2" ] ] ] 6 => array:3 [ "nombre" => "Cristian" "apellidos" => "Hernández-Rocha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 7 => array:3 [ "nombre" => "Ignacio" "apellidos" => "Duarte" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "**" "identificador" => "aff2" ] ] ] 8 => array:3 [ "nombre" => "Alejandro" "apellidos" => "Soza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 9 => array:3 [ "nombre" => "Carlos" "apellidos" => "Benítez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] 10 => array:3 [ "nombre" => "Marco" "apellidos" => "Arrese" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile" "etiqueta" => "*" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile" "etiqueta" => "**" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence and reprint request:" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 815 "Ancho" => 985 "Tamanyo" => 75921 ] ] "descripcion" => array:1 [ "en" => "Distribution of patients according to the score obtained with the simplified criteria for the diagnosis of AIH. AIH: autoimmune hepatitis. n: amount of patients." ] ] ] "textoCompleto" => "IntroductionAutoimmune hepatitis (AIH) is a progressive inflammatory liver disease of unknown origin and is a frequent cause of liver transplantation.<a class="elsevierStyleCrossRefs" href="#bib0010">1-6</a> This disease is characterized by the presence of autoantibodies, high levels of gam-maglobulins, interphase hepatitis on biopsy examination and being more frequent in women (sex ratio 3.6:1).<a class="elsevierStyleCrossRefs" href="#bib0010">1,7</a> AIH has been described in all ethnic groups around the world. Epidemiologic data from Caucasian population estimate a prevalence ranging from 11 to 24/100,000 inhabit-ants,<a class="elsevierStyleCrossRefs" href="#bib0045">8-10</a> while in Asiatic population the prevalence appears to be lower (4-5/100,000 inhabitants).<a class="elsevierStyleCrossRefs" href="#bib0060">11,12</a> In Latin America the information is scarce.The diagnosis of AIH is challenging for many reasons. First, there is not a specific laboratory test to make the diagnosis with certainty.<a class="elsevierStyleCrossRef" href="#bib0010">1</a> Second, clinical presentation is variable and includes a wide spectrum of conditions: asymptomatic patients, acute and chronic hepatitis, fulminant liver failure and cirrosis.<a class="elsevierStyleCrossRefs" href="#bib0010">1,7</a> Finally, its clinical behavior varies among different races. For instance, AIH is more frequently diagnosed at cirrhosis stage in Afro-American and Hispanic patients than in Caucasian population; similarly a worst long-term survival has been described in Asian patients.<a class="elsevierStyleCrossRefs" href="#bib0070">13,14</a>In this context, an international panel published a descriptive diagnostic scoring system for AIH in 1993 and then a revised version in 1999.<a class="elsevierStyleCrossRefs" href="#bib0080">15,16</a> This criteria is composed by 13 items scored between -5 to +3 points and has been validated in many populations,<a class="elsevierStyleCrossRefs" href="#bib0090">17-20</a> however, its application in clinical practice is complicated. To resolve this issue the International Autoimmune Hepatitis Group proposed a simplified scoring system.<a class="elsevierStyleCrossRef" href="#bib0110">21</a> These new criteria include only 4 variables and the score varies between 0 and 8 points, with sensitivity and specificity of 88% and 97% at a cutoff of 6 points, respectively. Considering its advantages in clinical application, this simplified score has been validated in Caucasian, Chinese and Japanese population,<a class="elsevierStyleCrossRefs" href="#bib0115">22-28</a> showing a high performance. In Hispanic Latin-American population the available evidence is limited.<a class="elsevierStyleCrossRef" href="#bib0150">29</a> Considering this, the main aim of our study is to validate the simplified criteria for the diagnosis of AIH in a cohort of adult Hispanic patients from Chile.Material and MethodsPatients and diagnostic criteriaAll patients undergoing percutaneous liver biopsy in a Chilean university hospital from January 2007 to January 2013 were evaluated. In our center (Hospital Clínico Pon-tificia Universidad Católica de Chile; Santiago, Chile) the liver biopsy is obtained using the Menghini technique<a class="elsevierStyleCrossRefs" href="#bib0155">30,31</a> after abdominal ultrasound visualization. We selected a retrospective cohort according to the following inclusion criteria:<ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010">•Adults ( ≥18 years old).</li><li class="elsevierStyleListItem" id="u0015">•Complete clinical follow-up and laboratory data for at least 12 months after biopsy.</li><li class="elsevierStyleListItem" id="u0020">•Patient's last name or mother's maiden name from Hispanic origin.</li></ul>We excluded patients with the following characteristics:<ul class="elsevierStyleList" id="l0015"><li class="elsevierStyleListItem" id="u0025">•Previous immunosuppressive therapy.</li><li class="elsevierStyleListItem" id="u0030">•Being a liver transplant recipient.</li><li class="elsevierStyleListItem" id="u0035">•Incomplete laboratory data (inability to calculate the simplified criteria of AIH or to establish definitive diagnosis).</li><li class="elsevierStyleListItem" id="u0040">•Tissue sample that does not allow a suitable interpretation by pathologist (insufficient sample, advanced cirrhosis).</li></ul>In patients with 2 or more liver biopsies (i.e. patients under histological follow-up to evaluate the progression of a known liver disease) we only included the first biopsy. Clinical records were reviewed to obtain medical history, age, gender, comorbidities, autoimmune serology, levels of immunoglobulin, hepatitis B surface antigen (HBsAg), hepatitis B anti-core antibodies (anticore-HBV), hepatitis C serology (anti-HCV), histology, therapy and clinical evolution. If data were incomplete or confusing, we contacted the treating gastroenterologist in order to obtain further details.The study was approved by the Institutional Review Board Ethics Committee for Human Studies of the Pon-tificia Universidad Católica de Chile (Project number: 14-449).Determination of definitive diagnosis (gold standard)AIH does not have a diagnostic gold standard, for that reason in our study the definitive diagnosis was established according to clinical follow-up, as it has been proposed by previous studies and QUADAS-2.<a class="elsevierStyleCrossRefs" href="#bib0165">32,33</a> We considered a follow-up of at least 12 months as an appropriate minimum time to determine the final diagnosis of the liver disease. The definitive diagnosis was established by the treating gastroenterologist, as it was described in the medical record. Two authors (BN and RC) retrospectively reviewed all medical records and confirmed the diagnosis. We contacted the treating gastroenterologist in case of discrepancies, which were resolved by consensus. The definitive diagnostic was established according to criteria described below:<ul class="elsevierStyleList" id="l0020"><li class="elsevierStyleListItem" id="u0045">•For the diagnosis of AIH we took in consideration clinical characteristics and laboratory tests similar to the revised criteria proposed by the International Autoimmune Hepatitis Group (IAIHG):<a class="elsevierStyleCrossRef" href="#bib0085">16</a> female gender; acute hepatitis or persistent abnormal liver tests for more than 2 months and negative viral serology: anti-HAV (hepatitis A virus) IgM, anti-HCV, anti-core-HBV IgM and HBsAg (-); serum IgG levels over the upper limit of normal level; a positive test for antinuclear antibody (ANA) and/or anti-smooth muscle antibody (SMA); daily alcoholic intake < 20 g; a liver biopsy showing moderate or severe peripor-tal or periseptal hepatitis with lymphocytic piecemeal necrosis. The most important factor to establish the gold standard was the clinical course of the disease during the follow-up (at least 12 months). We did not calculate the revised diagnostic score proposed by IAIHG in 1999, because the most important criterion was clinical follow-up. Similarly to original stud-ies,<a class="elsevierStyleCrossRefs" href="#bib0085">16,21</a> patients with overlap syndrome were included as AIH.</li><li class="elsevierStyleListItem" id="u0050">•The diagnosis of non-alcoholic steatohepatitis (NASH) was established according to the following criteria:<ul class="elsevierStyleList" id="l0025"><li class="elsevierStyleListItem" id="o0010">a.Persistent abnormal liver tests for more than 2 months.</li><li class="elsevierStyleListItem" id="o0015">b.Liver biopsy compatible with NASH.</li><li class="elsevierStyleListItem" id="o0020">c.Daily alcohol consumption of < 20 g.</li><li class="elsevierStyleListItem" id="o0025">d.Appropriate exclusion of other liver diseases.<a class="elsevierStyleCrossRef" href="#bib0175">34</a></li></ul></li><li class="elsevierStyleListItem" id="u0055">•Chronic hepatitis C was considered the definitive diagnosis when a positive HCV antibody test and quantifiable HCV RNA in serum were positive and liver biopsy was compatible with the diagnosis of chronic hepatitis C.<a class="elsevierStyleCrossRef" href="#bib0180">35</a></li><li class="elsevierStyleListItem" id="u0060">•Chronic hepatitis B was defined as:<ul class="elsevierStyleList" id="l0030"><li class="elsevierStyleListItem" id="o0030">a.HBsAg (+) for > 6 months.</li><li class="elsevierStyleListItem" id="o0035">b.Persistent or intermittent elevation in alanine ami- notransferase levels.</li><li class="elsevierStyleListItem" id="o0040">c.Liver biopsy compatible with the diagnosis of chronic hepatitis B.<a class="elsevierStyleCrossRef" href="#bib0185">36</a></li></ul></li><li class="elsevierStyleListItem" id="u0065">•The diagnosis of primary biliary cholangitis (PBC) was established when two of the following three crite ria were met:<ul class="elsevierStyleList" id="l0035"><li class="elsevierStyleListItem" id="o0045">a.Biochemical evidence of cholestasis based mainly on alkaline phosphatase elevation.</li><li class="elsevierStyleListItem" id="o0050">b.Presence of anti-mitochondrial antibody.</li><li class="elsevierStyleListItem" id="o0055">c.Histological evidence of non-suppurative destruc tive cholangitis and destruction of interlobular bile ducts.<a class="elsevierStyleCrossRef" href="#bib0190">37</a></li></ul></li><li class="elsevierStyleListItem" id="u0070">•The diagnosis of drug-induced liver injury (DILI) was established by the treating gastroenterologist. The fac tors taken in consideration were:<ul class="elsevierStyleList" id="l0040"><li class="elsevierStyleListItem" id="o0060">a.A history of ingestion of drugs (including homeo pathic medicines) within 6 months of onset of ill ness.</li><li class="elsevierStyleListItem" id="o0065">b.Negative viral serology: anti-HAV IgM, anti-HCV, anticore-HBV IgM and HBsAg (-).</li><li class="elsevierStyleListItem" id="o0070">c.Daily alcoholic intake < 20 g.</li><li class="elsevierStyleListItem" id="o0075">d.Appropriate exclusion of other liver diseases.</li><li class="elsevierStyleListItem" id="o0080">e.Total or partial resolution of abnormal liver tests with the withdrawal of the drug.</li><li class="elsevierStyleListItem" id="o0085">f.If the patient used corticoids, these were suspend ed before one year of follow-up without recur rence of hepatitis.</li></ul></li><li class="elsevierStyleListItem" id="u0075">•Self-limited hepatitis and/or cholestasis was de fined as:<ul class="elsevierStyleList" id="l0045"><li class="elsevierStyleListItem" id="o0090">a.Acute hepatitis or persistent abnormal liver tests for more than 2 months and negative viral serology: anti-HAV IgM, anti-HCV, anticore-HBV IgM and HBsAg (-).</li><li class="elsevierStyleListItem" id="o0095">b.Non-diagnostic or unspecific liver biopsy.</li><li class="elsevierStyleListItem" id="o0100">c.Daily alcohol consumption of < 20 g.</li><li class="elsevierStyleListItem" id="o0105">d.Appropriate exclusion of other liver diseases.</li><li class="elsevierStyleListItem" id="o0110">e.Spontaneous resolution of abnormal liver tests dur ing the follow-up.</li></ul></li><li class="elsevierStyleListItem" id="u0080">•Overlap syndrome was considered the definitive diag nosis when the patient simultaneously met the criteria for PBC or primary sclerosing cholangitis and AIH.<a class="elsevierStyleCrossRef" href="#bib0195">38</a> An adequate response to double therapy (immunosup- pressive treatment plus ursodeoxycholic acid) was considered a supporting factor for this diagnosis.</li></ul>Simplified diagnostic criteria of AIHWe applied the simplified criteria for the diagnosis of AIH according to the original study to all included pa-tients.<a class="elsevierStyleCrossRef" href="#bib0110">21</a> These criteria include 4 variables and the score varies between 0 and 8 points. The variables used were the following:<ul class="elsevierStyleList" id="l0050"><li class="elsevierStyleListItem" id="u0085">•Autoimmune serology. ANA, SMA, liver-kidney mi-crosomal antibodies (LKM). If ANA/SMA ≥ 1:40, we assigned 1 point; if ANA/SMA ≥ 1:80 or LKM ≥ 1:40, we assigned 2 points. For this variable the maximum score was 2 points. In our center soluble liver/liver-pancreas antibodies is not available.</li><li class="elsevierStyleListItem" id="u0090">•Immunoglobulin G levels. If levels > upper normal limit, we assigned 1 point; if levels > 1.1 times the upper normal limit, we assigned 2 points. For this variable the maximum score was 2 points.</li><li class="elsevierStyleListItem" id="u0095">•Liver histology (evidence of hepatitis was a necessary condition). If the findings were compatible, we assigned 1 point; if the findings were typical, we assigned 2 points. For this variable the maximum score was 2 points. Liver histology was evaluated by the local pathologists, who were not blinded to the patient's history.</li><li class="elsevierStyleListItem" id="u0100">•Viral hepatitis status. If there was not viral hepatitis evidence, we assigned 2 points.</li></ul>Each medical record was evaluated by two authors to calculate the simplified criteria. The discrepancies were resolved by consensus.Statistical analysisContinuous data were described using mean and standard deviation (SD) or median and interquartile range (25 and 75 percentiles) (IQR), according to data distribution. Nominal data were described using percentages. A multi-variate logistic regression model was conducted to establish if age or gender are independently associated to AIH after adjustment by the simplified diagnostic criteria. Odds ratio (OR) and 95% confidence interval (CI) were used to report these results. Additionally, we calculated sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and likelihood ratio (LR) of the simplified diagnostic criteria of AIH with diagnostic cutoffs 5, 6 and 7 points. The global diagnostic accuracy was assessed by the area under the receiver operating characteristic curve (AUROC). Statistical analysis was performed with SAS software version 9.4 (SAS Institute, Cary, NC). A p value of < 0.05 was considered statistically significant.ResultsGeneral characteristicsA total of 481 patients were evaluated, 294 met the inclusion criteria. The main causes of exclusion were cirrhosis and liver transplanted patients. Two hundred eighteen patients (74.15%) were female, the mean age was 48.5 years (SD: 12.3), the median follow-up 33 months (IQR: 18-51) (<a class="elsevierStyleCrossRef" href="#t0010">Table 1</a>). The distribution of patients according to the score obtained in the simplified diagnostic criteria of AIH and the definitive diagnosis is detailed in <a class="elsevierStyleCrossRef" href="#f0010">figure 1</a>.<elsevierMultimedia ident="t0010"></elsevierMultimedia><elsevierMultimedia ident="f0010"></elsevierMultimedia>The most frequent liver disease detected was NASH (96 patients, 32.65%). AIH was the second diagnosis most frequent (66 patients, 22.45%). Other liver diseases detected were PBC (40 patients, 13.61%), hepatitis C (31 patients, 10.54%), DILI (9 patients, 3.06%), hepatitis B (8 patients, 2.72%), hemochromatosis (6 patients, 2.04%) and self-limited hepatitis or cholestasis of unknown origin (16 patients, 5.44%). Sixteen female patients (5.44%) had overlap syndrome. General characteristics of patients and the simplified score for AIH according to the main causes of liver disease are described in <a class="elsevierStyleCrossRef" href="#t0015">tables 2</a>.<elsevierMultimedia ident="t0015"></elsevierMultimedia>In the multivariable analysis female gender was strongly associated to the diagnosis of AIH (OR: 13.9, 95% CI: 1.9-100.6, p = 0.009), after adjustment by age (OR: 0.98, 95% CI: 0.94-1.03, p = 0.5) and the simplified diagnostic criteria (OR: 8.6, 95% CI: 4.5-16.6, p < 0.001).Diagnostic accuracy of simplified criteria of AIHIn our cohort the AUROC of the simplified criteria for the diagnosis of AIH was 0.976 (<a class="elsevierStyleCrossRef" href="#f0015">Figure 2</a>). The sensitivity, specificity, PPV, NPV and LR were calculated using diagnostic criteria of ≥ 5, ≥ 6 and ≥ 7 points (<a class="elsevierStyleCrossRef" href="#t0020">Table 3</a>).<elsevierMultimedia ident="f0015"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia>When a cutoff ≥ 6 points is considered diagnostic of AIH, the performance of the simplified criteria looks suitable, with sensitivity and specificity of 86.4% and 98.7%, respectively, and LR (+) of 65.6. Using ≥ 7 points as diagnostic criteria, the sensitivity decreases to 54.6%, but specificity and LR (+) increase to 99.6% and 124.3, respectively. Using ≥ 5 points as diagnostic criteria, the sensitivity was 93.9%, but specificity, PPV and LR (+) decrease to 90.4%, 73.8% and 9.7, respectively. For more details, PPV, NPV and LR (-) (<a class="elsevierStyleCrossRef" href="#t0020">Table 3</a>).Description of false negative and false positive patientsUsing a cutoff ≥ 6 as diagnostic criteria, 12 patients were misclassified:<ul class="elsevierStyleList" id="l0055"><li class="elsevierStyleListItem" id="u0105">•False negatives. Nine patients had score ≤ 6 and the clinical follow-up was compatible with AIH. Five patients had 5 points in the simplified diagnostic score, 6 had seronegative AIH and 5 had normal IgG levels. Despite this, all false negative were female, had successful response to corticosteroids or immunosup-pressive therapy and biopsy was suggestive or compatible with AIH.</li><li class="elsevierStyleListItem" id="u0110">•False positives. Three patients had score ≥ 6 but the clinical follow-up was not compatible with AIH. One patient (male gender) obtained 6 points in the simplified score, but he had acquired immune deficiency syndrome (AIDS) and the biopsy was compatible with a granulomatous hepatitis. The other male patient had 7 points in the simplified score and the histological evaluation suggested an overlap syndrome (PBC plus AIH), however, he had an excellent response to urso-deoxycholic acid (UDCA). Considering that this patient never received immunosuppressive therapy, the definitive diagnosis was established as PBC. The third patient (female gender) had 6 points in the simplified score, however, her hepatitis was detected in relation to use of nitrofurantoin. The patient suspended the drug and received a short course of corticoids with an excellent response. After 5 years of follow up she is asymptomatic and has normal liver tests, for that reason the definitive diagnosis was DILI.</li></ul>DiscussionIn our retrospective cohort of Chilean-Hispanic patients, the simplified score of AIH had a high global diagnostic accuracy with an AUROC of 0.976. According to our data, the most suitable cutoff is ≥ 6 points, with sensitivity 86.4%, specificity 98.7% and predictive values over 95%. These findings are similar to the original study and other validation articles.<a class="elsevierStyleCrossRefs" href="#bib0110">21-28</a> Despite this, our data had a lower performance than previous studies using cutoff ≥ 7 points.<a class="elsevierStyleCrossRefs" href="#bib0110">21-28</a> The global accuracy of these criteria could be put in practice using a dynamic approach: Considering the LR (+) of 65 and specificity over 98% at cutoff ≥ 6 points and LR (+) of 124 and specificity over 99% at cutoff ≥ 7 points, patients with 6, 7 and 8 points could confidently start with immunosuppressive therapy. On the other hand, considering the LR (-) < 0.1 and sensibility of 93.9% at cutoff ≥ 5, AIH could be safely ruled out in patients with less than 5 points, especially if they are male. A challenging scenario is a patient with 5 points: in our cohort 20% of patients with 5 points had AIH (<a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>). Considering that at the same age and simplified diagnostic score the OR of having AIH is almost 14 times higher in female than male patients, our suggestion is to consider immunosuppressive therapy as a suitable strategy if the patient is a woman with no other obvious diagnostic alternative.According to our literature review, this is the first validation study of the simplified criteria for the diagnosis of AIH focused in Hispanic patients. This point matters, because this ethnic group has been under-represented in previous studies.<a class="elsevierStyleCrossRefs" href="#bib0110">21-28</a> Although our study was only conducted on Chilean patients, the genetic background of this population is similar to other Hispanic populations, especially those with low African heritage.<a class="elsevierStyleCrossRefs" href="#bib0200">39-44</a> Considering this, we feel that our data could be extrapolated to other Latin-American countries, except Brazil and some countries from Central-America, where the African genetic background is > 5%.<a class="elsevierStyleCrossRef" href="#bib0230">45</a>The main limitation of our study is related to its retrospective design. On one hand, there is risk of measurement bias secondary to mistakes of data collection; on the other hand, the calculation of simplified score of AIH was not blinded to our gold standard, because the definitive diagnosis was always available in the medical record. To address these limitations and reduce the risk of bias, all data and the calculation of the simplified score of AIH were obtained by one author and afterwards reviewed independently by a second author. All discrepancies were resolved by consensus.Our research study has strengths. The previous validation studies have used as gold standard the diagnostic criteria revised by IAIHG in 1999.<a class="elsevierStyleCrossRef" href="#bib0085">16</a> Considering that both diagnostic criteria have similar items (auto-antibodies, viral serology, immunoglobulins levels), it is highly probable a biased overestimation of the diagnostic accuracy of simplified criteria. In our opinion the definitive diagnosis of AIH established with long-term follow-up is a more suitable gold standard. This situation could explain the differences observed among our data and previous studies, specifically our lower sensibility and NPV at cutoff ≥ 7 points. Other strength of our study is the spectrum of patients included in our cohort. Some validation studies mainly included as controls patients with PBC, NASH or viral hepatitis,<a class="elsevierStyleCrossRefs" href="#bib0110">21,23,26</a> all of them with a clinical presentation easily differentiable from AIH without sophisticated diagnostic tools. This situation usually overestimates the diagnostic accuracy of the new test through spectrum bias.<a class="elsevierStyleCrossRef" href="#bib0170">33</a> A diagnostic tool for AIH is useful in clinical practice when it is able to resolve more challenging scenarios, as DILI, self-limited hepatitis/cholestasis of unknown origin and other immunological conditions. In our cohort approximately 10% of patients met these conditions, decreasing the risk of spectrum bias.In summary, this study supports that simplified criteria for the diagnosis of AIH have a high diagnostic accuracy in Chilean-Hispanic population. The female gender is strongly associated to AIH and could help in difficult cases. Further studies with a prospective design and using as gold-standard long-term follow-up are necessary to confirm these observations.Abbreviations<ul class="elsevierStyleList" id="l0060"><li class="elsevierStyleListItem" id="u0115">•AIDS: acquired immune deficiency syndrome.</li><li class="elsevierStyleListItem" id="u0120">•AIH: autoimmune hepatitis.</li><li class="elsevierStyleListItem" id="u0125">•ANA: antinuclear antibody.</li><li class="elsevierStyleListItem" id="u0130">•Anticore-HBV: hepatitis B anti-core antibodies.</li><li class="elsevierStyleListItem" id="u0135">•Anti-HCV: hepatitis C serology.</li><li class="elsevierStyleListItem" id="u0140">•AUROC: area under the receiver operating characteristic curve.</li><li class="elsevierStyleListItem" id="u0145">•DILI: Drug-induced liver injury.</li><li class="elsevierStyleListItem" id="u0150">•HAV: hepatitis A virus.</li><li class="elsevierStyleListItem" id="u0155">•HBsAg: hepatitis B surface antigen.</li><li class="elsevierStyleListItem" id="u0160">•HBV: hepatitis B virus.</li><li class="elsevierStyleListItem" id="u0165">•HCV: hepatitis C virus.</li><li class="elsevierStyleListItem" id="u0170">•IAIHG: International Autoimmune Hepatitis Group.</li><li class="elsevierStyleListItem" id="u0175">•IQR: interquartile range.</li><li class="elsevierStyleListItem" id="u0180">•LKM: liver-kidney microsomal antibodies.</li><li class="elsevierStyleListItem" id="u0185">•LR: likelihood ratio.</li><li class="elsevierStyleListItem" id="u0190">•NASH: non-alcoholic steatohepatitis.</li><li class="elsevierStyleListItem" id="u0195">•NPV: negative predictive value.</li><li class="elsevierStyleListItem" id="u0200">•PBC: primary biliary cholangitis.</li><li class="elsevierStyleListItem" id="u0205">•PPV: positive predictive value.</li><li class="elsevierStyleListItem" id="u0210">•SD: standard deviation.</li><li class="elsevierStyleListItem" id="u0215">•SMA: anti-smooth muscle antibody.</li><li class="elsevierStyleListItem" id="u0220">•UDCA: ursodeoxycholic acid.</li></ul>Conflicts of InterestThe authors of this article do not have conflicts of interest.This article was not funded." "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1197557" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abs0010" "titulo" => "Introduction and aim" ] 1 => array:2 [ "identificador" => "abs0015" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abs0020" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abs0025" "titulo" => "Conclusion" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1116243" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "s0010" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "s0015" "titulo" => "Material and Methods" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "s0020" "titulo" => "Patients and diagnostic criteria" ] 1 => array:2 [ "identificador" => "s0025" "titulo" => "Determination of definitive diagnosis (gold standard)" ] 2 => array:2 [ "identificador" => "s0030" "titulo" => "Simplified diagnostic criteria of AIH" ] 3 => array:2 [ "identificador" => "s0035" "titulo" => "Statistical analysis" ] ] ] 4 => array:3 [ "identificador" => "s0040" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "s0045" "titulo" => "General characteristics" ] 1 => array:2 [ "identificador" => "s0050" "titulo" => "Diagnostic accuracy of simplified criteria of AIH" ] 2 => array:2 [ "identificador" => "s0055" "titulo" => "Description of false negative and false positive patients" ] ] ] 5 => array:2 [ "identificador" => "s0060" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "s0065" "titulo" => "Abbreviations" ] 7 => array:2 [ "identificador" => "s0070" "titulo" => "Conflicts of Interest" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-10-04" "fechaAceptado" => "2017-02-11" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1116243" "palabras" => array:5 [ 0 => "Diagnostic criteria" 1 => "AUROC" 2 => "AIH" 3 => "Hepatitis" 4 => "Hispanic population" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "Introduction and aimIn 2008 the International autoimmune hepatitis (AIH) Group proposed the simplified diagnostic criteria for this disease. The original cohort study was performed in 11 international centers, but validation studies are scarce in Latin-America. The aim of this study is validate these criteria in Hispanic patients. Material and methodsA retrospective cohort of patients undergoing percutaneous liver biopsy and follow-up of at least 12 months was recruited from a Chilean University hospital. Patients with previous immunosuppressive therapy and liver transplant recipients were excluded. The diagnostic accuracy was analyzed using as gold standard the clinical course during long-term follow-up. Sensitivity, specificity, positive and negative predictive values (PPV and NPV) and area under the ROC curve (AUROC) were calculated. ResultsFour hundred eighty one patients were evaluated, 294 were included. 218 (74.15%) were female, mean age 48.5 (± 12.3) years, mean follow-up 34 (± 18) months. 66 patients had AIH or overlap syndrome (22.45%), 96 (32.65%) non-alcoholic steatohepatitis, 40 (13.61%) primary biliary cholangitis, 31 (10.54%) hepatitis C, 8 (2.72%) hepatitis B, 53 (18.02%) other etiologies. The AUROC for AIH simplified criteria was 0.976. Using a cutoff ≥ 6 and ≥ 7 points, the sensitivity was 86.4% and 54.6%; specificity, 98.7% and 99.6%; PPV, 95% and 97.3%; and NPV, 96.2% and 88.6%, respectively. ConclusionSimplified criteria for the diagnosis of AIH have a high accuracy in our Chilean-Hispanic cohort. The female gender is strongly associated to AIH and could help in difficult cases. Further studies with a prospective design are necessary to confirm these observations." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abs0010" "titulo" => "Introduction and aim" ] 1 => array:2 [ "identificador" => "abs0015" "titulo" => "Material and methods" ] 2 => array:2 [ "identificador" => "abs0020" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abs0025" "titulo" => "Conclusion" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 815 "Ancho" => 985 "Tamanyo" => 75921 ] ] "descripcion" => array:1 [ "en" => "Distribution of patients according to the score obtained with the simplified criteria for the diagnosis of AIH. AIH: autoimmune hepatitis. n: amount of patients." ] ] 1 => array:7 [ "identificador" => "f0015" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 916 "Ancho" => 932 "Tamanyo" => 45529 ] ] "descripcion" => array:1 [ "en" => "ROC curve for AIH simplified score in Hispanic patients. The AUROC was 0.976. AUROC: area under the receiver operating characteristic curve." ] ] 2 => array:7 [ "identificador" => "t0010" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total, n (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">294 (100%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">218 (74.15%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years), mean, SD. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.5 ± 12.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Follow up (months) median, (IQR). \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">33 (18-51) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnosis, n (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NASH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96 (32.65%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Autoimmune hepatitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">66 (22.45%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Primary biliary cholangitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">40 (13.61%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis C virus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 (10.54%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DILI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (3.06%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis B virus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (2.72%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemochromatosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (2.04%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sarcoidosis/Granulomatous hepatitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (1.02%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Coeliac disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (1.02%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Amyloidosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0.68%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Primary sclerosing cholangitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (0.68%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Alcoholic hepatitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.34%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Self-limited hepatitis and/or cholestasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (5.44%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Others \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (3.74%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Simplified score for diagnosis of AIH, median (IQR). \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2-5) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045117.png" ] ] ] ] "descripcion" => array:1 [ "en" => "General characteristics of included patients." ] ] 3 => array:7 [ "identificador" => "t0015" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "NASH: non-alcoholic steatohepatitis. DILI: drug-induced liver injury. SD: standard deviation, IQR: interquartile range." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age,yearsMean (SD) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex, female n (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Follow-up,monthsMedian (IQR) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Simplified score of AIH, points Median (IQR) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Autoimmune hepatitis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46.2 (12.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62 (93.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 (20-56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (6-8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NASH \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.8 (12.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">68 (70.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">34 (18-53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (2-4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Primary biliary cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52.2 (10.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (92.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">30 (17-45) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 (2-5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis C virus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.8 (11.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (54.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (15-49) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0-1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">DILI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 9 (13.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 (23-50) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2-4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hepatitis B virus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.5 (8.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (12.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21 (14-49) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0-1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hemochromatosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.5 (11.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0 (0%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (30-47) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 (2-2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Self-limited hepatitis or cholestasis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.7 (15.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12 (75%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31 (19-52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (2-4) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045115.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Characteristics of included patients according to main diagnoses." ] ] 4 => array:7 [ "identificador" => "t0020" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "PPV: positive predictive value. NPV: negative predictive value. LR: likelihood ratio." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Diagnostic cutoff \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">≥ 5 points \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">≥ 6 points \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">≥ 7 points \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sensibility (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">93.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">86.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Specificity (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">98.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">99.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PPV (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">95 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">97.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">NPV (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">98.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">96.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88.6 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LR+ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">124.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LR- \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.06 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.45 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045116.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Diagnostic accuracy of AIH simplified score in Hispanic patients." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0010" "bibliografiaReferencia" => array:45 [ 0 => array:3 [ "identificador" => "bib0010" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of autoimmune hepatitis" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "American Association for the Study of Liver Diseases" "etal" => false "autores" => array:7 [ 0 => "Manns M.P." 1 => "Czaja A.J." 2 => "Gorham J.D." 3 => "Krawitt E.L." 4 => "Mieli-Vergani G." 5 => "Vergani D." 6 => "Vierling J.M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.23584" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2010" "volumen" => "51" "paginaInicial" => "2193" "paginaFinal" => "2213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20513004" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0015" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoimmune liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Czaja A.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MOG.0b013e3282f57268" "Revista" => array:6 [ "tituloSerie" => "Current Opinion in Gastroenterology" "fecha" => "2008" "volumen" => "24" "paginaInicial" => "298" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18408457" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0020" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current therapy for autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Montano Loza A.J." 1 => "Czaja A.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/s41512-018-0038-1" "Revista" => array:6 [ "tituloSerie" => "Nature Clinical Practice Gastroenterology & Hepatology" "fecha" => "2007" "volumen" => "4" "paginaInicial" => "202" "paginaFinal" => "214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31093568" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0025" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Cattan P." 1 => "Berney T." 2 => "Conti F." 3 => "Calmus Y." 4 => "Homberg J.C." 5 => "Houssin D." 6 => "Soubrane O." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00147-001-0376-7" "Revista" => array:6 [ "tituloSerie" => "Transplant International" "fecha" => "2002" "volumen" => "15" "paginaInicial" => "34" "paginaFinal" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11875611" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0030" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver transplantation for autoimmune hepatitis: a long-term pathologic study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Ayata G." 1 => "Gordon F.D." 2 => "Lewis W.D." 3 => "Pomfret E." 4 => "Pomposelli J.J." 5 => "Jenkins R.L." 6 => "Khettry U." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/jhep.2000.9077" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2000" "volumen" => "32" "paginaInicial" => "185" "paginaFinal" => "192" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10915722" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0035" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cryptogenic cirrhosis: clinicopatho-logic findings at and after liver transplantation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Ayata G." 1 => "Gordon F.D." 2 => "Lewis W.D." 3 => "Pomfret E." 4 => "Pomposelli J.J." 5 => "Jenkins R.L." 6 => "Khettry U." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/hupa.2002.129419" "Revista" => array:6 [ "tituloSerie" => "Human Pathology" "fecha" => "2002" "volumen" => "33" "paginaInicial" => "1098" "paginaFinal" => "1104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12454814" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0040" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of autoimmune hepatitis and comparison of two diagnostic criteria in Korea: a nationwide, multicenter study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Kim B.H." 1 => "Kim Y.J." 2 => "Jeong S.H." 3 => "Tak W.Y." 4 => "Ahn S.H." 5 => "Lee Y.J." 6 => "Jung E.U." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00535-019-01594-6" "Revista" => array:6 [ "tituloSerie" => "J Gastroenterol & Hepatol" "fecha" => "2013" "volumen" => "28" "paginaInicial" => "128" "paginaFinal" => "134" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31134334" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0045" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidence and prevalence of primary biliary cirrhosis, primary sclerosing cholangitis, and autoimmune hepatitis in a Norwegian population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Boberg K.M." 1 => "Aadland E." 2 => "Jahnsen J." 3 => "Raknerud N." 4 => "Stiris M." 5 => "Bell H." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Scandinavian J Gastroenterol" "fecha" => "1998" "volumen" => "33" "paginaInicial" => "99" "paginaFinal" => "103" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0050" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and the initial presentation of autoimmune hepatitis in Sweden: a nationwide study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Werner M." 1 => "Prytz H." 2 => "Ohlsson B." 3 => "Almer S." 4 => "Bjornsson E." 5 => "Bergquist A." 6 => "Wallerstedt S." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scandinavian J Gastroenterol" "fecha" => "2008" "volumen" => "43" "paginaInicial" => "1232" "paginaFinal" => "1240" "itemHostRev" => array:3 [ "pii" => "S0140673616315938" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0055" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Population-based epidemiology study of autoimmune hepatitis: a disease of older women?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Ngu J.H." 1 => "Bechly K." 2 => "Chapman B.A." 3 => "Burt M.J." 4 => "Barclay M.L." 5 => "Gearry R.B." 6 => "Stedman C.A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Gastro-enterol Hepatol" "fecha" => "2010" "volumen" => "25" "paginaInicial" => "1681" "paginaFinal" => "1686" "itemHostRev" => array:3 [ "pii" => "S0140673615003104" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0060" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoimmune hepatitis in Singapore: a rare syndrome affecting middle-aged women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Lee Y.M." 1 => "Teo E.K." 2 => "Ng T.M." 3 => "Khor C." 4 => "Fock K.M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00535-019-01594-6" "Revista" => array:6 [ "tituloSerie" => "J Gastroenterol & Hepatol" "fecha" => "2001" "volumen" => "16" "paginaInicial" => "1384" "paginaFinal" => "1389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31134334" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0065" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profiles of autoimmune hepatitis in Brunei Darussalam" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Jalihal A." 1 => "Telisinghe P.U." 2 => "Chong V.H." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jgh.14680" "Revista" => array:7 [ "tituloSerie" => "Hepatobiliary & Pancreatic Diseases International" "fecha" => "2009" "volumen" => "8" "paginaInicial" => "602" "paginaFinal" => "607" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31141835" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673613616128" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0070" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of race/ethnicity on the clinical epidemiology of autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Wong R.J." 1 => "Gish R." 2 => "Frederick T." 3 => "Bzowej N." 4 => "Frenette C." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/MCG.0b013e318228b781" "Revista" => array:6 [ "tituloSerie" => "J Clin Gastroenterol" "fecha" => "2012" "volumen" => "46" "paginaInicial" => "155" "paginaFinal" => "161" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21814143" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0075" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoimmune hepatitis in diverse ethnic populations and geographical regions" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Czaja A.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/17474124.2019.1621165" "Revista" => array:6 [ "tituloSerie" => "Expert Rev Gastroenterol & Hepatol" "fecha" => "2013" "volumen" => "7" "paginaInicial" => "365" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31132887" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0080" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Meeting report: International Autoimmune Hepatitis Group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Johnson P.J." 1 => "McFarlane I.G." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "1993" "volumen" => "18" "paginaInicial" => "998" "paginaFinal" => "1005" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8406375" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0085" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "International Autoimmune Hepatitis Group Report: review of criteria for diagnosis of autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Alvarez F." 1 => "Berg P.A." 2 => "Bianchi F.B." 3 => "Bianchi L." 4 => "Burroughs A.K." 5 => "Cancado E.L." 6 => "Chapman R.W." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "1999" "volumen" => "31" "paginaInicial" => "929" "paginaFinal" => "938" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10580593" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0090" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Present status of autoimmune hepatitis in Japan--correlating the characteristics with international criteria in an area with a high rate of HCV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Toda G." 1 => "Zeniya M." 2 => "Watanabe F." 3 => "Imawari M." 4 => "Kiyosawa K." 5 => "Nishioka M." 6 => "Tsuji T." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Japanese National Study Group of Autoimmune Hepatitis. J Hepatol" "fecha" => "1997" "volumen" => "26" "paginaInicial" => "1207" "paginaFinal" => "1212" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0095" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of scoring system for diagnosis of autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Czaja A." 1 => "Carpenter H.A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dig Dis Sci" "fecha" => "1996" "volumen" => "41" "paginaInicial" => "305" "paginaFinal" => "314" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8601374" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0100" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impact of international autoimmune hepatitis group scoring system in definition of autoimmune hepatitis. An Italian experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Bianchi F.B." 1 => "Cassani F." 2 => "Lenzi M." 3 => "Ballardini G." 4 => "Muratori L." 5 => "Gi-ostra F." 6 => "Zauli D." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dig Dis Sci" "fecha" => "1996" "volumen" => "41" "paginaInicial" => "166" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8565751" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0105" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The international autoimmune hepatitis score in chronic hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Dickson R.C." 1 => "Gaffey M.J." 2 => "Ishitani M.B." 3 => "Roarty T.P." 4 => "Driscoll C.J." 5 => "Caldwell S.H." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Viral Hepat" "fecha" => "1997" "volumen" => "4" "paginaInicial" => "121" "paginaFinal" => "128" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9097268" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0110" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Simplified criteria for the diagnosis of autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Hennes E.M." 1 => "Zeniya M." 2 => "Czaja A.J." 3 => "Pares A." 4 => "Dalekos G.N." 5 => "Krawitt E.L." 6 => "Bittencourt P.L." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.22322" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2008" "volumen" => "48" "paginaInicial" => "169" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18537184" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0115" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Performance parameters of the diagnostic scoring systems for autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Czaja A.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.22513" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2008" "volumen" => "48" "paginaInicial" => "1540" "paginaFinal" => "1548" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18924244" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0120" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of simplified diagnostic criteria for autoimmune hepatitis in Italian patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Muratori P." 1 => "Granito A." 2 => "Pappas G." 3 => "Muratori L." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.22825" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2009" "volumen" => "49" "paginaInicial" => "1782" "paginaFinal" => "1783" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19402135" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0125" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of autoimmune hepatitis diagnosed based on simplified criteria of the International Autoimmune Hepatitis Group" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Miyake Y." 1 => "Iwasaki Y." 2 => "Kobashi H." 3 => "Yasunaka T." 4 => "Ikeda F." 5 => "Takaki A." 6 => "Yamamoto K." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.saa.2019.05.010" "Revista" => array:6 [ "tituloSerie" => "Digestive & Liver Disease" "fecha" => "2010" "volumen" => "42" "paginaInicial" => "210" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31141767" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0130" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Qiu D." 1 => "Wang Q." 2 => "Wang H." 3 => "Xie Q." 4 => "Zang G." 5 => "Jiang H." 6 => "Tu C." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2010.06.032" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2011" "volumen" => "54" "paginaInicial" => "340" "paginaFinal" => "347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21056494" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0135" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group (IAIHG) criteria in acute and chronic liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Yeoman A.D." 1 => "Westbrook R.H." 2 => "Al-Chalabi T." 3 => "Carey I." 4 => "Heaton N.D." 5 => "Portmann B.C." 6 => "Heneghan M.A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hepatolo-gy" "fecha" => "2009" "volumen" => "50" "paginaInicial" => "538" "paginaFinal" => "545" "itemHostRev" => array:3 [ "pii" => "S1473309917303018" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0140" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group criteria in acute-onset autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Fujiwara K." 1 => "Yasui S." 2 => "Tawada A." 3 => "Fukuda Y." 4 => "Nakano M." 5 => "Yoko-suka O." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1478-3231.2011.02524.x" "Revista" => array:7 [ "tituloSerie" => "Liver International" "fecha" => "2011" "volumen" => "31" "paginaInicial" => "1013" "paginaFinal" => "1020" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21733091" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1473309918300665" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0145" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of simplified score with the revised original score for the diagnosis of autoimmune hepatitis: a new or a complementary diagnostic score?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Gatselis N.K." 1 => "Zachou K." 2 => "Papamichalis P." 3 => "Koukoulis G.K." 4 => "Gabe-ta S." 5 => "Dalekos G.N." 6 => "Rigopoulou E.I." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.dld.2010.03.005" "Revista" => array:7 [ "tituloSerie" => "Dig Liver Dis" "fecha" => "2010" "volumen" => "42" "paginaInicial" => "807" "paginaFinal" => "812" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20399157" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1473309918300641" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0150" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aplicación del modelo diagnóstico del grupo internacional para la hepatitis autoinmune (GIHA) en una población de pacientes de Medellín, Colombia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Londoño M.C." 1 => "Gonzalez L." 2 => "Chavarriaga J." 3 => "Múnera V." 4 => "Ramos F." 5 => "Suárez L." 6 => "Marin J.I." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Rev Colomb Gastroenterol" "fecha" => "2003" "volumen" => "18" "paginaInicial" => "16" "paginaFinal" => "19" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0155" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "One-second biopsy of the liver--problems of its clinical application" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Menghini G." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM197009102831107" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1970" "volumen" => "283" "paginaInicial" => "582" "paginaFinal" => "585" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4915875" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0160" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "One-second needle biopsy of the liver" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Menghini G." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gastro-enterology" "fecha" => "1958" "volumen" => "35" "paginaInicial" => "190" "paginaFinal" => "199" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0165" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED)" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "PIOPED Investigators" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "JAMA" "fecha" => "1990" "volumen" => "263" "paginaInicial" => "2753" "paginaFinal" => "2759" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2332918" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1473309917304474" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0170" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Whiting P.F." 1 => "Rutjes A.W." 2 => "Westwood M.E." 3 => "Mallett S." 4 => "Deeks J.J." 5 => "Reitsma J.B." 6 => "Leeflang M.M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.7326/0003-4819-155-8-201110180-00009" "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2011" "volumen" => "155" "paginaInicial" => "529" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22007046" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0175" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "American Gastroenterological Association medical position statement: nonalcoholic fatty liver disease" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Gastroenterolo-gy" "fecha" => "2002" "volumen" => "123" "paginaInicial" => "1702" "paginaFinal" => "1704" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0180" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis, management, and treatment of hepatitis C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Strader D.B." 1 => "Wright T." 2 => "Thomas D.L." 3 => "Seeff L.B." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.20119" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2004" "volumen" => "39" "paginaInicial" => "1147" "paginaFinal" => "1171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15057920" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0185" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic hepatitis B" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Lok A.S." 1 => "McMahon B.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.21513" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "507" "paginaFinal" => "539" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17256718" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0190" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of primary biliary cirrhosis. The American Association for the Study of Liver Diseases practice guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Heathcote E.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/he.2000.5984" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "2000" "volumen" => "31" "paginaInicial" => "1005" "paginaFinal" => "1013" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10733559" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0195" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency and nature of the variant syndromes of autoimmune liver disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Czaja A.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.510280210" "Revista" => array:6 [ "tituloSerie" => "Hepatology" "fecha" => "1998" "volumen" => "28" "paginaInicial" => "360" "paginaFinal" => "365" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9695997" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0200" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequency of the hypervariable DNA loci D18S849, D3S1744, D12S1090 and D1S80 in a mixed ancestry population of Chilean blood donors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Acuna M." 1 => "Jorquera H." 2 => "Cifuentes L." 3 => "Armanet L." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genet Mol Res" "fecha" => "2002" "volumen" => "1" "paginaInicial" => "139" "paginaFinal" => "146" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14963840" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0205" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene geography of Chile: Regional distribution of American, European and African genetic contributions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Fuentes M." 1 => "Pulgar I." 2 => "Gallo C." 3 => "Bortolini M.C." 4 => "Canizales-Quinter-os S." 5 => "Bedoya G." 6 => "Gonzalez-Jose R." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4067/S0034-98872014000300001" "Revista" => array:6 [ "tituloSerie" => "Rev Med Chil" "fecha" => "2014" "volumen" => "142" "paginaInicial" => "281" "paginaFinal" => "289" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25052264" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0210" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Heterogeneity in genetic admixture across different regions of Argentina" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Avena S." 1 => "Via M." 2 => "Ziv E." 3 => "Perez-Stable E.J." 4 => "Gignoux C.R." 5 => "Dejean C." 6 => "Huntsman S." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0034695" "Revista" => array:5 [ "tituloSerie" => "PLoS One" "fecha" => "2012" "volumen" => "7" "paginaInicial" => "e34695" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22506044" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0215" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inferring continental ancestry of argentineans from Autosomal, Y-chromosomal and mitochondrial DNA" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Corach D." 1 => "Lao O." 2 => "Bobillo C." 3 => "van Der G.K." 4 => "Zuniga S." 5 => "Vermeu-len M." 6 => "van D.K." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1469-1809.2009.00556.x" "Revista" => array:6 [ "tituloSerie" => "Ann Hum Genet" "fecha" => "2010" "volumen" => "74" "paginaInicial" => "65" "paginaFinal" => "76" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20059473" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0220" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Geographic patterns of genome admixture in Latin American Mestizos" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Wang S." 1 => "Ray N." 2 => "Rojas W." 3 => "Parra M.V." 4 => "Bedoya G." 5 => "Gallo C." 6 => "Po-letti G." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pgen.1000037" "Revista" => array:5 [ "tituloSerie" => "PLoS Genet" "fecha" => "2008" "volumen" => "4" "paginaInicial" => "e1000037" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18369456" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0225" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Silva-Zolezzi I." 1 => "Hidalgo-Miranda A." 2 => "Estrada-Gil J." 3 => "Fernandez-Lopez J.C." 4 => "Uribe-Figueroa L." 5 => "Contreras A." 6 => "Balam-Ortiz E." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1073/pnas.0903045106" "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci U S A" "fecha" => "2009" "volumen" => "106" "paginaInicial" => "8611" "paginaFinal" => "8616" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19433783" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0230" "etiqueta" => "45." 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Roberto Candia

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rcandiab@med.puc.cl

Correspondence and reprint request:

, Blanca Norero*, Carlos Agüero*, Luis Díaz*, Juan Pablo Ortega*, Rodrigo Wolff**, Cristian Hernández-Rocha*, Ignacio Duarte**, Alejandro Soza*, Carlos Benítez*, Marco Arrese*

* Departamento de Gastroenterología, Facultad de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile

** Departamento de Anatomía Patológica, Facultad de Medicina, Pontificia Universidad Católica de Chile. Santiago, Chile

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behavior varies among different races&#46; For instance&#44; AIH is more frequently diagnosed at cirrhosis stage in Afro-American and Hispanic patients than in Caucasian population&#59; similarly a worst long-term survival has been described in Asian patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">13&#44;14</span></a></p><p id="p0020" class="elsevierStylePara elsevierViewall">In this context&#44; an international panel published a descriptive diagnostic scoring system for AIH in 1993 and then a revised version in 1999&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">15&#44;16</span></a> This criteria is composed by 13 items scored between -5 to &#43;3 points and has been validated in many populations&#44;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">17-20</span></a> however&#44; its application in clinical practice is complicated&#46; To resolve this issue the International Autoimmune Hepatitis Group proposed a simplified scoring system&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">21</span></a> These new criteria include only 4 variables and the score varies between 0 and 8 points&#44; with sensitivity and specificity of 88&#37; and 97&#37; at a cutoff of 6 points&#44; respectively&#46; Considering its advantages in clinical application&#44; this simplified score has been validated in Caucasian&#44; Chinese and Japanese population&#44;<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">22-28</span></a> showing a high performance&#46; In Hispanic Latin-American population the available evidence is limited&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">29</span></a> Considering this&#44; the main aim of our study is to validate the simplified criteria for the diagnosis of AIH in a cohort of adult Hispanic patients from Chile&#46;</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Material and Methods</span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Patients and diagnostic criteria</span><p id="p0025" class="elsevierStylePara elsevierViewall">All patients undergoing percutaneous liver biopsy in a Chilean university hospital from January 2007 to January 2013 were evaluated&#46; In our center &#40;Hospital Cl&#237;nico Pon-tificia Universidad Cat&#243;lica de Chile&#59; Santiago&#44; Chile&#41; the liver biopsy is obtained using the Menghini technique<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">30&#44;31</span></a> after abdominal ultrasound visualization&#46; We selected a retrospective cohort according to the following inclusion criteria&#58;<ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">&#8226;</span><p id="p0030" class="elsevierStylePara elsevierViewall">Adults &#40; &#8805;18 years old&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">&#8226;</span><p id="p0035" class="elsevierStylePara elsevierViewall">Complete clinical follow-up and laboratory data for at least 12 months after biopsy&#46;</p></li><li class="elsevierStyleListItem" id="u0020"><span class="elsevierStyleLabel">&#8226;</span><p id="p0040" class="elsevierStylePara elsevierViewall">Patient&#39;s last name or mother&#39;s maiden name from Hispanic origin&#46;</p></li></ul></p><p id="p0045" class="elsevierStylePara elsevierViewall">We excluded patients with the following characteristics&#58;<ul class="elsevierStyleList" id="l0015"><li class="elsevierStyleListItem" id="u0025"><span class="elsevierStyleLabel">&#8226;</span><p id="p0050" class="elsevierStylePara elsevierViewall">Previous immunosuppressive therapy&#46;</p></li><li class="elsevierStyleListItem" id="u0030"><span class="elsevierStyleLabel">&#8226;</span><p id="p0055" class="elsevierStylePara elsevierViewall">Being a liver transplant recipient&#46;</p></li><li class="elsevierStyleListItem" id="u0035"><span class="elsevierStyleLabel">&#8226;</span><p id="p0060" class="elsevierStylePara elsevierViewall">Incomplete laboratory data &#40;inability to calculate the simplified criteria of AIH or to establish definitive diagnosis&#41;&#46;</p></li><li class="elsevierStyleListItem" id="u0040"><span class="elsevierStyleLabel">&#8226;</span><p id="p0065" class="elsevierStylePara elsevierViewall">Tissue sample that does not allow a suitable interpretation by pathologist &#40;insufficient sample&#44; advanced cirrhosis&#41;&#46;</p></li></ul></p><p id="p0070" class="elsevierStylePara elsevierViewall">In patients with 2 or more liver biopsies &#40;i&#46;e&#46; patients under histological follow-up to evaluate the progression of a known liver disease&#41; we only included the first biopsy&#46; Clinical records were reviewed to obtain medical history&#44; age&#44; gender&#44; comorbidities&#44; autoimmune serology&#44; levels of immunoglobulin&#44; hepatitis B surface antigen &#40;HBsAg&#41;&#44; hepatitis B anti-core antibodies &#40;anticore-HBV&#41;&#44; hepatitis C serology &#40;anti-HCV&#41;&#44; histology&#44; therapy and clinical evolution&#46; If data were incomplete or confusing&#44; we contacted the treating gastroenterologist in order to obtain further details&#46;</p><p id="p0075" class="elsevierStylePara elsevierViewall">The study was approved by the Institutional Review Board Ethics Committee for Human Studies of the Pon-tificia Universidad Cat&#243;lica de Chile &#40;Project number&#58; 14-449&#41;&#46;</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0055">Determination of definitive diagnosis &#40;gold standard&#41;</span><p id="p0080" class="elsevierStylePara elsevierViewall">AIH does not have a diagnostic gold standard&#44; for that reason in our study the definitive diagnosis was established according to clinical follow-up&#44; as it has been proposed by previous studies and QUADAS-2&#46;<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">32&#44;33</span></a> We considered a follow-up of at least 12 months as an appropriate minimum time to determine the final diagnosis of the liver disease&#46; The definitive diagnosis was established by the treating gastroenterologist&#44; as it was described in the medical record&#46; Two authors &#40;BN and RC&#41; retrospectively reviewed all medical records and confirmed the diagnosis&#46; We contacted the treating gastroenterologist in case of discrepancies&#44; which were resolved by consensus&#46; The definitive diagnostic was established according to criteria described below&#58;<ul class="elsevierStyleList" id="l0020"><li class="elsevierStyleListItem" id="u0045"><span class="elsevierStyleLabel">&#8226;</span><p id="p0085" class="elsevierStylePara elsevierViewall">For the diagnosis of AIH we took in consideration clinical characteristics and laboratory tests similar to the revised criteria proposed by the International Autoimmune Hepatitis Group &#40;IAIHG&#41;&#58;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">16</span></a> female gender&#59; acute hepatitis or persistent abnormal liver tests for more than 2 months and negative viral serology&#58; anti-HAV &#40;hepatitis A virus&#41; IgM&#44; anti-HCV&#44; anti-core-HBV IgM and HBsAg &#40;-&#41;&#59; serum IgG levels over the upper limit of normal level&#59; a positive test for antinuclear antibody &#40;ANA&#41; and&#47;or anti-smooth muscle antibody &#40;SMA&#41;&#59; daily alcoholic intake &#60; 20 g&#59; a liver biopsy showing moderate or severe peripor-tal or periseptal hepatitis with lymphocytic piecemeal necrosis&#46; The most important factor to establish the gold standard was the clinical course of the disease during the follow-up &#40;at least 12 months&#41;&#46; We did not calculate the revised diagnostic score proposed by IAIHG in 1999&#44; because the most important criterion was clinical follow-up&#46; Similarly to original stud-ies&#44;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">16&#44;21</span></a> patients with overlap syndrome were included as AIH&#46;</p></li><li class="elsevierStyleListItem" id="u0050"><span class="elsevierStyleLabel">&#8226;</span><p id="p0090" class="elsevierStylePara elsevierViewall">The diagnosis of non-alcoholic steatohepatitis &#40;NASH&#41; was established according to the following criteria&#58;<ul class="elsevierStyleList" id="l0025"><li class="elsevierStyleListItem" id="o0010"><span class="elsevierStyleLabel">a&#46;</span><p id="p0095" class="elsevierStylePara elsevierViewall">Persistent abnormal liver tests for more than 2 months&#46;</p></li><li class="elsevierStyleListItem" id="o0015"><span class="elsevierStyleLabel">b&#46;</span><p id="p0100" class="elsevierStylePara elsevierViewall">Liver biopsy compatible with NASH&#46;</p></li><li class="elsevierStyleListItem" id="o0020"><span class="elsevierStyleLabel">c&#46;</span><p id="p0105" class="elsevierStylePara elsevierViewall">Daily alcohol consumption of &#60; 20 g&#46;</p></li><li class="elsevierStyleListItem" id="o0025"><span class="elsevierStyleLabel">d&#46;</span><p id="p0110" class="elsevierStylePara elsevierViewall">Appropriate exclusion of other liver diseases&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">34</span></a></p></li></ul></p></li><li class="elsevierStyleListItem" id="u0055"><span class="elsevierStyleLabel">&#8226;</span><p id="p0115" class="elsevierStylePara elsevierViewall">Chronic hepatitis C was considered the definitive diagnosis when a positive HCV antibody test and quantifiable HCV RNA in serum were positive and liver biopsy was compatible with the diagnosis of chronic hepatitis C&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">35</span></a></p></li><li class="elsevierStyleListItem" id="u0060"><span class="elsevierStyleLabel">&#8226;</span><p id="p0120" class="elsevierStylePara elsevierViewall">Chronic hepatitis B was defined as&#58;<ul class="elsevierStyleList" id="l0030"><li class="elsevierStyleListItem" id="o0030"><span class="elsevierStyleLabel">a&#46;</span><p id="p0125" class="elsevierStylePara elsevierViewall">HBsAg &#40;&#43;&#41; for &#62; 6 months&#46;</p></li><li class="elsevierStyleListItem" id="o0035"><span class="elsevierStyleLabel">b&#46;</span><p id="p0130" class="elsevierStylePara elsevierViewall">Persistent or intermittent elevation in alanine ami- notransferase levels&#46;</p></li><li class="elsevierStyleListItem" id="o0040"><span class="elsevierStyleLabel">c&#46;</span><p id="p0135" class="elsevierStylePara elsevierViewall">Liver biopsy compatible with the diagnosis of chronic hepatitis B&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">36</span></a></p></li></ul></p></li><li class="elsevierStyleListItem" id="u0065"><span class="elsevierStyleLabel">&#8226;</span><p id="p0140" class="elsevierStylePara elsevierViewall">The diagnosis of primary biliary cholangitis &#40;PBC&#41; was established when two of the following three crite ria were met&#58;<ul class="elsevierStyleList" id="l0035"><li class="elsevierStyleListItem" id="o0045"><span class="elsevierStyleLabel">a&#46;</span><p id="p0145" class="elsevierStylePara elsevierViewall">Biochemical evidence of cholestasis based mainly on alkaline phosphatase elevation&#46;</p></li><li class="elsevierStyleListItem" id="o0050"><span class="elsevierStyleLabel">b&#46;</span><p id="p0150" class="elsevierStylePara elsevierViewall">Presence of anti-mitochondrial antibody&#46;</p></li><li class="elsevierStyleListItem" id="o0055"><span class="elsevierStyleLabel">c&#46;</span><p id="p0155" class="elsevierStylePara elsevierViewall">Histological evidence of non-suppurative destruc tive cholangitis and destruction of interlobular bile ducts&#46;<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">37</span></a></p></li></ul></p></li><li class="elsevierStyleListItem" id="u0070"><span class="elsevierStyleLabel">&#8226;</span><p id="p0160" class="elsevierStylePara elsevierViewall">The diagnosis of drug-induced liver injury &#40;DILI&#41; was established by the treating gastroenterologist&#46; The fac tors taken in consideration were&#58;<ul class="elsevierStyleList" id="l0040"><li class="elsevierStyleListItem" id="o0060"><span class="elsevierStyleLabel">a&#46;</span><p id="p0165" class="elsevierStylePara elsevierViewall">A history of ingestion of drugs &#40;including homeo pathic medicines&#41; within 6 months of onset of ill ness&#46;</p></li><li class="elsevierStyleListItem" id="o0065"><span class="elsevierStyleLabel">b&#46;</span><p id="p0170" class="elsevierStylePara elsevierViewall">Negative viral serology&#58; anti-HAV IgM&#44; anti-HCV&#44; anticore-HBV IgM and HBsAg &#40;-&#41;&#46;</p></li><li class="elsevierStyleListItem" id="o0070"><span class="elsevierStyleLabel">c&#46;</span><p id="p0175" class="elsevierStylePara elsevierViewall">Daily alcoholic intake &#60; 20 g&#46;</p></li><li class="elsevierStyleListItem" id="o0075"><span class="elsevierStyleLabel">d&#46;</span><p id="p0180" class="elsevierStylePara elsevierViewall">Appropriate exclusion of other liver diseases&#46;</p></li><li class="elsevierStyleListItem" id="o0080"><span class="elsevierStyleLabel">e&#46;</span><p id="p0185" class="elsevierStylePara elsevierViewall">Total or partial resolution of abnormal liver tests with the withdrawal of the drug&#46;</p></li><li class="elsevierStyleListItem" id="o0085"><span class="elsevierStyleLabel">f&#46;</span><p id="p0190" class="elsevierStylePara elsevierViewall">If the patient used corticoids&#44; these were suspend ed before one year of follow-up without recur rence of hepatitis&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="u0075"><span class="elsevierStyleLabel">&#8226;</span><p id="p0195" class="elsevierStylePara elsevierViewall">Self-limited hepatitis and&#47;or cholestasis was de fined as&#58;<ul class="elsevierStyleList" id="l0045"><li class="elsevierStyleListItem" id="o0090"><span class="elsevierStyleLabel">a&#46;</span><p id="p0200" class="elsevierStylePara elsevierViewall">Acute hepatitis or persistent abnormal liver tests for more than 2 months and negative viral serology&#58; anti-HAV IgM&#44; anti-HCV&#44; anticore-HBV IgM and HBsAg &#40;-&#41;&#46;</p></li><li class="elsevierStyleListItem" id="o0095"><span class="elsevierStyleLabel">b&#46;</span><p id="p0205" class="elsevierStylePara elsevierViewall">Non-diagnostic or unspecific liver biopsy&#46;</p></li><li class="elsevierStyleListItem" id="o0100"><span class="elsevierStyleLabel">c&#46;</span><p id="p0210" class="elsevierStylePara elsevierViewall">Daily alcohol consumption of &#60; 20 g&#46;</p></li><li class="elsevierStyleListItem" id="o0105"><span class="elsevierStyleLabel">d&#46;</span><p id="p0215" class="elsevierStylePara elsevierViewall">Appropriate exclusion of other liver diseases&#46;</p></li><li class="elsevierStyleListItem" id="o0110"><span class="elsevierStyleLabel">e&#46;</span><p id="p0220" class="elsevierStylePara elsevierViewall">Spontaneous resolution of abnormal liver tests dur ing the follow-up&#46;</p></li></ul></p></li><li class="elsevierStyleListItem" id="u0080"><span class="elsevierStyleLabel">&#8226;</span><p id="p0225" class="elsevierStylePara elsevierViewall">Overlap syndrome was considered the definitive diag nosis when the patient simultaneously met the criteria for PBC or primary sclerosing cholangitis and AIH&#46;<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">38</span></a> An adequate response to double therapy &#40;immunosup- pressive treatment plus ursodeoxycholic acid&#41; was considered a supporting factor for this diagnosis&#46;</p></li></ul></p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0060">Simplified diagnostic criteria of AIH</span><p id="p0230" class="elsevierStylePara elsevierViewall">We applied the simplified criteria for the diagnosis of AIH according to the original study to all included pa-tients&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">21</span></a> These criteria include 4 variables and the score varies between 0 and 8 points&#46; The variables used were the following&#58;<ul class="elsevierStyleList" id="l0050"><li class="elsevierStyleListItem" id="u0085"><span class="elsevierStyleLabel">&#8226;</span><p id="p0235" class="elsevierStylePara elsevierViewall">Autoimmune serology&#46; ANA&#44; SMA&#44; liver-kidney mi-crosomal antibodies &#40;LKM&#41;&#46; If ANA&#47;SMA &#8805; 1&#58;40&#44; we assigned 1 point&#59; if ANA&#47;SMA &#8805; 1&#58;80 or LKM &#8805; 1&#58;40&#44; we assigned 2 points&#46; For this variable the maximum score was 2 points&#46; In our center soluble liver&#47;liver-pancreas antibodies is not available&#46;</p></li><li class="elsevierStyleListItem" id="u0090"><span class="elsevierStyleLabel">&#8226;</span><p id="p0240" class="elsevierStylePara elsevierViewall">Immunoglobulin G levels&#46; If levels &#62; upper normal limit&#44; we assigned 1 point&#59; if levels &#62; 1&#46;1 times the upper normal limit&#44; we assigned 2 points&#46; For this variable the maximum score was 2 points&#46;</p></li><li class="elsevierStyleListItem" id="u0095"><span class="elsevierStyleLabel">&#8226;</span><p id="p0245" class="elsevierStylePara elsevierViewall">Liver histology &#40;evidence of hepatitis was a necessary condition&#41;&#46; If the findings were compatible&#44; we assigned 1 point&#59; if the findings were typical&#44; we assigned 2 points&#46; For this variable the maximum score was 2 points&#46; Liver histology was evaluated by the local pathologists&#44; who were not blinded to the patient&#39;s history&#46;</p></li><li class="elsevierStyleListItem" id="u0100"><span class="elsevierStyleLabel">&#8226;</span><p id="p0250" class="elsevierStylePara elsevierViewall">Viral hepatitis status&#46; If there was not viral hepatitis evidence&#44; we assigned 2 points&#46;</p></li></ul></p><p id="p0255" class="elsevierStylePara elsevierViewall">Each medical record was evaluated by two authors to calculate the simplified criteria&#46; The discrepancies were resolved by consensus&#46;</p></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Statistical analysis</span><p id="p0260" class="elsevierStylePara elsevierViewall">Continuous data were described using mean and standard deviation &#40;SD&#41; or median and interquartile range &#40;25 and 75 percentiles&#41; &#40;IQR&#41;&#44; according to data distribution&#46; Nominal data were described using percentages&#46; A multi-variate logistic regression model was conducted to establish if age or gender are independently associated to AIH after adjustment by the simplified diagnostic criteria&#46; Odds ratio &#40;OR&#41; and 95&#37; confidence interval &#40;CI&#41; were used to report these results&#46; Additionally&#44; we calculated sensitivity&#44; specificity&#44; positive predictive value &#40;PPV&#41;&#44; negative predictive value &#40;NPV&#41; and likelihood ratio &#40;LR&#41; of the simplified diagnostic criteria of AIH with diagnostic cutoffs 5&#44; 6 and 7 points&#46; The global diagnostic accuracy was assessed by the area under the receiver operating characteristic curve &#40;AUROC&#41;&#46; Statistical analysis was performed with SAS software version 9&#46;4 &#40;SAS Institute&#44; Cary&#44; NC&#41;&#46; A p value of &#60; 0&#46;05 was considered statistically significant&#46;</p></span></span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Results</span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">General characteristics</span><p id="p0265" class="elsevierStylePara elsevierViewall">A total of 481 patients were evaluated&#44; 294 met the inclusion criteria&#46; The main causes of exclusion were cirrhosis and liver transplanted patients&#46; Two hundred eighteen patients &#40;74&#46;15&#37;&#41; were female&#44; the mean age was 48&#46;5 years &#40;SD&#58; 12&#46;3&#41;&#44; the median follow-up 33 months &#40;IQR&#58; 18-51&#41; &#40;<a class="elsevierStyleCrossRef" href="#t0010">Table 1</a>&#41;&#46; The distribution of patients according to the score obtained in the simplified diagnostic criteria of AIH and the definitive diagnosis is detailed in <a class="elsevierStyleCrossRef" href="#f0010">figure 1</a>&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0270" class="elsevierStylePara elsevierViewall">The most frequent liver disease detected was NASH &#40;96 patients&#44; 32&#46;65&#37;&#41;&#46; AIH was the second diagnosis most frequent &#40;66 patients&#44; 22&#46;45&#37;&#41;&#46; Other liver diseases detected were PBC &#40;40 patients&#44; 13&#46;61&#37;&#41;&#44; hepatitis C &#40;31 patients&#44; 10&#46;54&#37;&#41;&#44; DILI &#40;9 patients&#44; 3&#46;06&#37;&#41;&#44; hepatitis B &#40;8 patients&#44; 2&#46;72&#37;&#41;&#44; hemochromatosis &#40;6 patients&#44; 2&#46;04&#37;&#41; and self-limited hepatitis or cholestasis of unknown origin &#40;16 patients&#44; 5&#46;44&#37;&#41;&#46; Sixteen female patients &#40;5&#46;44&#37;&#41; had overlap syndrome&#46; General characteristics of patients and the simplified score for AIH according to the main causes of liver disease are described in <a class="elsevierStyleCrossRef" href="#t0015">tables 2</a>&#46;</p><elsevierMultimedia ident="t0015"></elsevierMultimedia><p id="p0275" class="elsevierStylePara elsevierViewall">In the multivariable analysis female gender was strongly associated to the diagnosis of AIH &#40;OR&#58; 13&#46;9&#44; 95&#37; CI&#58; 1&#46;9-100&#46;6&#44; p &#61; 0&#46;009&#41;&#44; after adjustment by age &#40;OR&#58; 0&#46;98&#44; 95&#37; CI&#58; 0&#46;94-1&#46;03&#44; p &#61; 0&#46;5&#41; and the simplified diagnostic criteria &#40;OR&#58; 8&#46;6&#44; 95&#37; CI&#58; 4&#46;5-16&#46;6&#44; p &#60; 0&#46;001&#41;&#46;</p></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Diagnostic accuracy of simplified criteria of AIH</span><p id="p0280" class="elsevierStylePara elsevierViewall">In our cohort the AUROC of the simplified criteria for the diagnosis of AIH was 0&#46;976 &#40;<a class="elsevierStyleCrossRef" href="#f0015">Figure 2</a>&#41;&#46; The sensitivity&#44; specificity&#44; PPV&#44; NPV and LR were calculated using diagnostic criteria of &#8805; 5&#44; &#8805; 6 and &#8805; 7 points &#40;<a class="elsevierStyleCrossRef" href="#t0020">Table 3</a>&#41;&#46;</p><elsevierMultimedia ident="f0015"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0285" class="elsevierStylePara elsevierViewall">When a cutoff &#8805; 6 points is considered diagnostic of AIH&#44; the performance of the simplified criteria looks suitable&#44; with sensitivity and specificity of 86&#46;4&#37; and 98&#46;7&#37;&#44; respectively&#44; and LR &#40;&#43;&#41; of 65&#46;6&#46; Using &#8805; 7 points as diagnostic criteria&#44; the sensitivity decreases to 54&#46;6&#37;&#44; but specificity and LR &#40;&#43;&#41; increase to 99&#46;6&#37; and 124&#46;3&#44; respectively&#46; Using &#8805; 5 points as diagnostic criteria&#44; the sensitivity was 93&#46;9&#37;&#44; but specificity&#44; PPV and LR &#40;&#43;&#41; decrease to 90&#46;4&#37;&#44; 73&#46;8&#37; and 9&#46;7&#44; respectively&#46; For more details&#44; PPV&#44; NPV and LR &#40;-&#41; &#40;<a class="elsevierStyleCrossRef" href="#t0020">Table 3</a>&#41;&#46;</p></span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Description of false negative and false positive patients</span><p id="p0290" class="elsevierStylePara elsevierViewall">Using a cutoff &#8805; 6 as diagnostic criteria&#44; 12 patients were misclassified&#58;<ul class="elsevierStyleList" id="l0055"><li class="elsevierStyleListItem" id="u0105"><span class="elsevierStyleLabel">&#8226;</span><p id="p0295" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">False negatives&#46;</span> Nine patients had score &#8804; 6 and the clinical follow-up was compatible with AIH&#46; Five patients had 5 points in the simplified diagnostic score&#44; 6 had seronegative AIH and 5 had normal IgG levels&#46; Despite this&#44; all false negative were female&#44; had successful response to corticosteroids or immunosup-pressive therapy and biopsy was suggestive or compatible with AIH&#46;</p></li><li class="elsevierStyleListItem" id="u0110"><span class="elsevierStyleLabel">&#8226;</span><p id="p0300" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">False positives&#46;</span> Three patients had score &#8805; 6 but the clinical follow-up was not compatible with AIH&#46; One patient &#40;male gender&#41; obtained 6 points in the simplified score&#44; but he had acquired immune deficiency syndrome &#40;AIDS&#41; and the biopsy was compatible with a granulomatous hepatitis&#46; The other male patient had 7 points in the simplified score and the histological evaluation suggested an overlap syndrome &#40;PBC plus AIH&#41;&#44; however&#44; he had an excellent response to urso-deoxycholic acid &#40;UDCA&#41;&#46; Considering that this patient never received immunosuppressive therapy&#44; the definitive diagnosis was established as PBC&#46; The third patient &#40;female gender&#41; had 6 points in the simplified score&#44; however&#44; her hepatitis was detected in relation to use of nitrofurantoin&#46; The patient suspended the drug and received a short course of corticoids with an excellent response&#46; After 5 years of follow up she is asymptomatic and has normal liver tests&#44; for that reason the definitive diagnosis was DILI&#46;</p></li></ul></p></span></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Discussion</span><p id="p0305" class="elsevierStylePara elsevierViewall">In our retrospective cohort of Chilean-Hispanic patients&#44; the simplified score of AIH had a high global diagnostic accuracy with an AUROC of 0&#46;976&#46; According to our data&#44; the most suitable cutoff is &#8805; 6 points&#44; with sensitivity 86&#46;4&#37;&#44; specificity 98&#46;7&#37; and predictive values over 95&#37;&#46; These findings are similar to the original study and other validation articles&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">21-28</span></a> Despite this&#44; our data had a lower performance than previous studies using cutoff &#8805; 7 points&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">21-28</span></a> The global accuracy of these criteria could be put in practice using a dynamic approach&#58; Considering the LR &#40;&#43;&#41; of 65 and specificity over 98&#37; at cutoff &#8805; 6 points and LR &#40;&#43;&#41; of 124 and specificity over 99&#37; at cutoff &#8805; 7 points&#44; patients with 6&#44; 7 and 8 points could confidently start with immunosuppressive therapy&#46; On the other hand&#44; considering the LR &#40;-&#41; &#60; 0&#46;1 and sensibility of 93&#46;9&#37; at cutoff &#8805; 5&#44; AIH could be safely ruled out in patients with less than 5 points&#44; especially if they are male&#46; A challenging scenario is a patient with 5 points&#58; in our cohort 20&#37; of patients with 5 points had AIH &#40;<a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>&#41;&#46; Considering that at the same age and simplified diagnostic score the OR of having AIH is almost 14 times higher in female than male patients&#44; our suggestion is to consider immunosuppressive therapy as a suitable strategy if the patient is a woman with no other obvious diagnostic alternative&#46;</p><p id="p0310" class="elsevierStylePara elsevierViewall">According to our literature review&#44; this is the first validation study of the simplified criteria for the diagnosis of AIH focused in Hispanic patients&#46; This point matters&#44; because this ethnic group has been under-represented in previous studies&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">21-28</span></a> Although our study was only conducted on Chilean patients&#44; the genetic background of this population is similar to other Hispanic populations&#44; especially those with low African heritage&#46;<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">39-44</span></a> Considering this&#44; we feel that our data could be extrapolated to other Latin-American countries&#44; except Brazil and some countries from Central-America&#44; where the African genetic background is &#62; 5&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">45</span></a></p><p id="p0315" class="elsevierStylePara elsevierViewall">The main limitation of our study is related to its retrospective design&#46; On one hand&#44; there is risk of measurement bias secondary to mistakes of data collection&#59; on the other hand&#44; the calculation of simplified score of AIH was not blinded to our gold standard&#44; because the definitive diagnosis was always available in the medical record&#46; To address these limitations and reduce the risk of bias&#44; all data and the calculation of the simplified score of AIH were obtained by one author and afterwards reviewed independently by a second author&#46; All discrepancies were resolved by consensus&#46;</p><p id="p0320" class="elsevierStylePara elsevierViewall">Our research study has strengths&#46; The previous validation studies have used as gold standard the diagnostic criteria revised by IAIHG in 1999&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">16</span></a> Considering that both diagnostic criteria have similar items &#40;auto-antibodies&#44; viral serology&#44; immunoglobulins levels&#41;&#44; it is highly probable a biased overestimation of the diagnostic accuracy of simplified criteria&#46; In our opinion the definitive diagnosis of AIH established with long-term follow-up is a more suitable gold standard&#46; This situation could explain the differences observed among our data and previous studies&#44; specifically our lower sensibility and NPV at cutoff &#8805; 7 points&#46; Other strength of our study is the spectrum of patients included in our cohort&#46; Some validation studies mainly included as controls patients with PBC&#44; NASH or viral hepatitis&#44;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">21&#44;23&#44;26</span></a> all of them with a clinical presentation easily differentiable from AIH without sophisticated diagnostic tools&#46; This situation usually overestimates the diagnostic accuracy of the new test through spectrum bias&#46;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">33</span></a> A diagnostic tool for AIH is useful in clinical practice when it is able to resolve more challenging scenarios&#44; as DILI&#44; self-limited hepatitis&#47;cholestasis of unknown origin and other immunological conditions&#46; In our cohort approximately 10&#37; of patients met these conditions&#44; decreasing the risk of spectrum bias&#46;</p><p id="p0325" class="elsevierStylePara elsevierViewall">In summary&#44; this study supports that simplified criteria for the diagnosis of AIH have a high diagnostic accuracy in Chilean-Hispanic population&#46; The female gender is strongly associated to AIH and could help in difficult cases&#46; Further studies with a prospective design and using as gold-standard long-term follow-up are necessary to confirm these observations&#46;</p></span><span id="s0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Abbreviations</span><p id="p0330" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0060"><li class="elsevierStyleListItem" id="u0115"><span class="elsevierStyleLabel">&#8226;</span><p id="p0335" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AIDS&#58;</span> acquired immune deficiency syndrome&#46;</p></li><li class="elsevierStyleListItem" id="u0120"><span class="elsevierStyleLabel">&#8226;</span><p id="p0340" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AIH&#58;</span> autoimmune hepatitis&#46;</p></li><li class="elsevierStyleListItem" id="u0125"><span class="elsevierStyleLabel">&#8226;</span><p id="p0345" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ANA&#58;</span> antinuclear antibody&#46;</p></li><li class="elsevierStyleListItem" id="u0130"><span class="elsevierStyleLabel">&#8226;</span><p id="p0350" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Anticore-HBV&#58;</span> hepatitis B anti-core antibodies&#46;</p></li><li class="elsevierStyleListItem" id="u0135"><span class="elsevierStyleLabel">&#8226;</span><p id="p0355" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Anti-HCV&#58;</span> hepatitis C serology&#46;</p></li><li class="elsevierStyleListItem" id="u0140"><span class="elsevierStyleLabel">&#8226;</span><p id="p0360" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AUROC&#58;</span> area under the receiver operating characteristic curve&#46;</p></li><li class="elsevierStyleListItem" id="u0145"><span class="elsevierStyleLabel">&#8226;</span><p id="p0365" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">DILI&#58;</span> Drug-induced liver injury&#46;</p></li><li class="elsevierStyleListItem" id="u0150"><span class="elsevierStyleLabel">&#8226;</span><p id="p0370" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HAV&#58;</span> hepatitis A virus&#46;</p></li><li class="elsevierStyleListItem" id="u0155"><span class="elsevierStyleLabel">&#8226;</span><p id="p0375" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HBsAg&#58;</span> hepatitis B surface antigen&#46;</p></li><li class="elsevierStyleListItem" id="u0160"><span class="elsevierStyleLabel">&#8226;</span><p id="p0380" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HBV&#58;</span> hepatitis B virus&#46;</p></li><li class="elsevierStyleListItem" id="u0165"><span class="elsevierStyleLabel">&#8226;</span><p id="p0385" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HCV&#58;</span> hepatitis C virus&#46;</p></li><li class="elsevierStyleListItem" id="u0170"><span class="elsevierStyleLabel">&#8226;</span><p id="p0390" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">IAIHG&#58;</span> International Autoimmune Hepatitis Group&#46;</p></li><li class="elsevierStyleListItem" id="u0175"><span class="elsevierStyleLabel">&#8226;</span><p id="p0395" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">IQR&#58;</span> interquartile range&#46;</p></li><li class="elsevierStyleListItem" id="u0180"><span class="elsevierStyleLabel">&#8226;</span><p id="p0400" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">LKM&#58;</span> liver-kidney microsomal antibodies&#46;</p></li><li class="elsevierStyleListItem" id="u0185"><span class="elsevierStyleLabel">&#8226;</span><p id="p0405" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">LR&#58;</span> likelihood ratio&#46;</p></li><li class="elsevierStyleListItem" id="u0190"><span class="elsevierStyleLabel">&#8226;</span><p id="p0410" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">NASH&#58;</span> non-alcoholic steatohepatitis&#46;</p></li><li class="elsevierStyleListItem" id="u0195"><span class="elsevierStyleLabel">&#8226;</span><p id="p0415" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">NPV&#58;</span> negative predictive value&#46;</p></li><li class="elsevierStyleListItem" id="u0200"><span class="elsevierStyleLabel">&#8226;</span><p id="p0420" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PBC&#58;</span> primary biliary cholangitis&#46;</p></li><li class="elsevierStyleListItem" id="u0205"><span class="elsevierStyleLabel">&#8226;</span><p id="p0425" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PPV&#58;</span> positive predictive value&#46;</p></li><li class="elsevierStyleListItem" id="u0210"><span class="elsevierStyleLabel">&#8226;</span><p id="p0430" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SD&#58;</span> standard deviation&#46;</p></li><li class="elsevierStyleListItem" id="u0215"><span class="elsevierStyleLabel">&#8226;</span><p id="p0435" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SMA&#58;</span> anti-smooth muscle antibody&#46;</p></li><li class="elsevierStyleListItem" id="u0220"><span class="elsevierStyleLabel">&#8226;</span><p id="p0440" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">UDCA&#58;</span> ursodeoxycholic acid&#46;</p></li></ul></p></span><span id="s0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0100">Conflicts of Interest</span><p id="p0445" class="elsevierStylePara elsevierViewall">The authors of this article do not have conflicts of interest&#46;</p><p id="p0450" class="elsevierStylePara elsevierViewall">This article was not funded&#46;</p></span></span>"
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          "identificador" => "xres1197557"
          "titulo" => "Abstract"
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              "titulo" => "Introduction and aim"
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          "titulo" => "Keywords"
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        2 => array:2 [
          "identificador" => "s0010"
          "titulo" => "Introduction"
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          "titulo" => "Material and Methods"
          "secciones" => array:4 [
            0 => array:2 [
              "identificador" => "s0020"
              "titulo" => "Patients and diagnostic criteria"
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            1 => array:2 [
              "identificador" => "s0025"
              "titulo" => "Determination of definitive diagnosis &#40;gold standard&#41;"
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            2 => array:2 [
              "identificador" => "s0030"
              "titulo" => "Simplified diagnostic criteria of AIH"
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              "titulo" => "Statistical analysis"
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          "titulo" => "Results"
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            0 => array:2 [
              "identificador" => "s0045"
              "titulo" => "General characteristics"
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            1 => array:2 [
              "identificador" => "s0050"
              "titulo" => "Diagnostic accuracy of simplified criteria of AIH"
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            2 => array:2 [
              "identificador" => "s0055"
              "titulo" => "Description of false negative and false positive patients"
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          "titulo" => "Discussion"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-10-04"
    "fechaAceptado" => "2017-02-11"
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          "clase" => "keyword"
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          "palabras" => array:5 [
            0 => "Diagnostic criteria"
            1 => "AUROC"
            2 => "AIH"
            3 => "Hepatitis"
            4 => "Hispanic population"
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    "resumen" => array:1 [
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        "titulo" => "Abstract"
        "resumen" => "<span id="abs0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015"><span class="elsevierStyleBold">Introduction and aim</span></span><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">In 2008 the International autoimmune hepatitis &#40;AIH&#41; Group proposed the simplified diagnostic criteria for this disease&#46; The original cohort study was performed in 11 international centers&#44; but validation studies are scarce in Latin-America&#46; The aim of this study is validate these criteria in Hispanic patients&#46;</p></span> <span id="abs0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020"><span class="elsevierStyleBold">Material and methods</span></span><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">A retrospective cohort of patients undergoing percutaneous liver biopsy and follow-up of at least 12 months was recruited from a Chilean University hospital&#46; Patients with previous immunosuppressive therapy and liver transplant recipients were excluded&#46; The diagnostic accuracy was analyzed using as gold standard the clinical course during long-term follow-up&#46; Sensitivity&#44; specificity&#44; positive and negative predictive values &#40;PPV and NPV&#41; and area under the ROC curve &#40;AUROC&#41; were calculated&#46;</p></span> <span id="abs0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025"><span class="elsevierStyleBold">Results</span></span><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Four hundred eighty one patients were evaluated&#44; 294 were included&#46; 218 &#40;74&#46;15&#37;&#41; were female&#44; mean age 48&#46;5 &#40;&#177; 12&#46;3&#41; years&#44; mean follow-up 34 &#40;&#177; 18&#41; months&#46; 66 patients had AIH or overlap syndrome &#40;22&#46;45&#37;&#41;&#44; 96 &#40;32&#46;65&#37;&#41; non-alcoholic steatohepatitis&#44; 40 &#40;13&#46;61&#37;&#41; primary biliary cholangitis&#44; 31 &#40;10&#46;54&#37;&#41; hepatitis C&#44; 8 &#40;2&#46;72&#37;&#41; hepatitis B&#44; 53 &#40;18&#46;02&#37;&#41; other etiologies&#46; The AUROC for AIH simplified criteria was 0&#46;976&#46; Using a cutoff &#8805; 6 and &#8805; 7 points&#44; the sensitivity was 86&#46;4&#37; and 54&#46;6&#37;&#59; specificity&#44; 98&#46;7&#37; and 99&#46;6&#37;&#59; PPV&#44; 95&#37; and 97&#46;3&#37;&#59; and NPV&#44; 96&#46;2&#37; and 88&#46;6&#37;&#44; respectively&#46;</p></span> <span id="abs0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030"><span class="elsevierStyleBold">Conclusion</span></span><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">Simplified criteria for the diagnosis of AIH have a high accuracy in our Chilean-Hispanic cohort&#46; The female gender is strongly associated to AIH and could help in difficult cases&#46; Further studies with a prospective design are necessary to confirm these observations&#46;</p></span>"
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          "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Distribution of patients according to the score obtained with the simplified criteria for the diagnosis of AIH&#46; AIH&#58; autoimmune hepatitis&#46; n&#58; amount of patients&#46;</p>"
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          "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">ROC curve for AIH simplified score in Hispanic patients&#46; The AUROC was 0&#46;976&#46; AUROC&#58; area under the receiver operating characteristic curve&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">294 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">218 &#40;74&#46;15&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&#44; mean&#44; SD&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">48&#46;5 &#177; 12&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Follow up &#40;months&#41; median&#44; &#40;IQR&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">33 &#40;18-51&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Diagnosis&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NASH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96 &#40;32&#46;65&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Autoimmune hepatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;22&#46;45&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Primary biliary cholangitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;13&#46;61&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis C virus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;10&#46;54&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DILI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;3&#46;06&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis B virus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;2&#46;72&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemochromatosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;2&#46;04&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sarcoidosis&#47;Granulomatous hepatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#46;02&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Coeliac disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;1&#46;02&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Amyloidosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;68&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Primary sclerosing cholangitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;0&#46;68&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Alcoholic hepatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;34&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Self-limited hepatitis and&#47;or cholestasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;5&#46;44&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Others&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;3&#46;74&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Simplified score for diagnosis of AIH&#44; median &#40;IQR&#41;&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab2045117.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">General characteristics of included patients&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "t0015"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">NASH&#58; non-alcoholic steatohepatitis&#46; DILI&#58; drug-induced liver injury&#46; SD&#58; standard deviation&#44; IQR&#58; interquartile range&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age&#44;yearsMean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&#44; female n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Follow-up&#44;monthsMedian &#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Simplified score of AIH&#44; points Median &#40;IQR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Autoimmune hepatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;2 &#40;12&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">62 &#40;93&#46;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;20-56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;6-8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">NASH&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;8 &#40;12&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;70&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34 &#40;18-53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2-4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Primary biliary cirrhosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#46;2 &#40;10&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;92&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;17-45&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;2-5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis C virus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;8 &#40;11&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;54&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;15-49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DILI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 9 &#40;13&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;23-50&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;2-4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hepatitis B virus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&#46;5 &#40;8&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;12&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21 &#40;14-49&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0-1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hemochromatosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;5 &#40;11&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37 &#40;30-47&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;2-2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Self-limited hepatitis or cholestasis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#46;7 &#40;15&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;75&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
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                            4 => "Mieli-Vergani G&#46;"
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                      "titulo" => "Population-based epidemiology study of autoimmune hepatitis&#58; a disease of older women&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Ngu J&#46;H&#46;"
                            1 => "Bechly K&#46;"
                            2 => "Chapman B&#46;A&#46;"
                            3 => "Burt M&#46;J&#46;"
                            4 => "Barclay M&#46;L&#46;"
                            5 => "Gearry R&#46;B&#46;"
                            6 => "Stedman C&#46;A&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gastro-enterol Hepatol"
                        "fecha" => "2010"
                        "volumen" => "25"
                        "paginaInicial" => "1681"
                        "paginaFinal" => "1686"
                        "itemHostRev" => array:3 [
                          "pii" => "S0140673615003104"
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                          "issn" => "01406736"
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            10 => array:3 [
              "identificador" => "bib0060"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autoimmune hepatitis in Singapore&#58; a rare syndrome affecting middle-aged women"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Lee Y&#46;M&#46;"
                            1 => "Teo E&#46;K&#46;"
                            2 => "Ng T&#46;M&#46;"
                            3 => "Khor C&#46;"
                            4 => "Fock K&#46;M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00535-019-01594-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Gastroenterol &#38; Hepatol"
                        "fecha" => "2001"
                        "volumen" => "16"
                        "paginaInicial" => "1384"
                        "paginaFinal" => "1389"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31134334"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            11 => array:3 [
              "identificador" => "bib0065"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profiles of autoimmune hepatitis in Brunei Darussalam"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Jalihal A&#46;"
                            1 => "Telisinghe P&#46;U&#46;"
                            2 => "Chong V&#46;H&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jgh.14680"
                      "Revista" => array:7 [
                        "tituloSerie" => "Hepatobiliary &#38; Pancreatic Diseases International"
                        "fecha" => "2009"
                        "volumen" => "8"
                        "paginaInicial" => "602"
                        "paginaFinal" => "607"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31141835"
                            "web" => "Medline"
                          ]
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                          "pii" => "S0140673613616128"
                          "estado" => "S300"
                          "issn" => "01406736"
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              ]
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            12 => array:3 [
              "identificador" => "bib0070"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The impact of race&#47;ethnicity on the clinical epidemiology of autoimmune hepatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Wong R&#46;J&#46;"
                            1 => "Gish R&#46;"
                            2 => "Frederick T&#46;"
                            3 => "Bzowej N&#46;"
                            4 => "Frenette C&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/MCG.0b013e318228b781"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Gastroenterol"
                        "fecha" => "2012"
                        "volumen" => "46"
                        "paginaInicial" => "155"
                        "paginaFinal" => "161"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21814143"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Autoimmune hepatitis in diverse ethnic populations and geographical regions"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Czaja A&#46;J&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17474124.2019.1621165"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Gastroenterol &#38; Hepatol"
                        "fecha" => "2013"
                        "volumen" => "7"
                        "paginaInicial" => "365"
                        "paginaFinal" => "385"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31132887"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0080"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meeting report&#58; International Autoimmune Hepatitis Group"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Johnson P&#46;J&#46;"
                            1 => "McFarlane I&#46;G&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
                        "fecha" => "1993"
                        "volumen" => "18"
                        "paginaInicial" => "998"
                        "paginaFinal" => "1005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8406375"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            15 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International Autoimmune Hepatitis Group Report&#58; review of criteria for diagnosis of autoimmune hepatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Alvarez F&#46;"
                            1 => "Berg P&#46;A&#46;"
                            2 => "Bianchi F&#46;B&#46;"
                            3 => "Bianchi L&#46;"
                            4 => "Burroughs A&#46;K&#46;"
                            5 => "Cancado E&#46;L&#46;"
                            6 => "Chapman R&#46;W&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "1999"
                        "volumen" => "31"
                        "paginaInicial" => "929"
                        "paginaFinal" => "938"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10580593"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0090"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Present status of autoimmune hepatitis in Japan--correlating the characteristics with international criteria in an area with a high rate of HCV infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Toda G&#46;"
                            1 => "Zeniya M&#46;"
                            2 => "Watanabe F&#46;"
                            3 => "Imawari M&#46;"
                            4 => "Kiyosawa K&#46;"
                            5 => "Nishioka M&#46;"
                            6 => "Tsuji T&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Japanese National Study Group of Autoimmune Hepatitis&#46; J Hepatol"
                        "fecha" => "1997"
                        "volumen" => "26"
                        "paginaInicial" => "1207"
                        "paginaFinal" => "1212"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Validation of scoring system for diagnosis of autoimmune hepatitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "Czaja A&#46;"
                            1 => "Carpenter H&#46;A&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1996"
                        "volumen" => "41"
                        "paginaInicial" => "305"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8601374"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0100"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of international autoimmune hepatitis group scoring system in definition of autoimmune hepatitis&#46; An Italian experience"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "Bianchi F&#46;B&#46;"
                            1 => "Cassani F&#46;"
                            2 => "Lenzi M&#46;"
                            3 => "Ballardini G&#46;"
                            4 => "Muratori L&#46;"
                            5 => "Gi-ostra F&#46;"
                            6 => "Zauli D&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Dig Dis Sci"
                        "fecha" => "1996"
                        "volumen" => "41"
                        "paginaInicial" => "166"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8565751"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0105"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The international autoimmune hepatitis score in chronic hepatitis C"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "Dickson R&#46;C&#46;"
                            1 => "Gaffey M&#46;J&#46;"
                            2 => "Ishitani M&#46;B&#46;"
                            3 => "Roarty T&#46;P&#46;"
                            4 => "Driscoll C&#46;J&#46;"
                            5 => "Caldwell S&#46;H&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Viral Hepat"
                        "fecha" => "1997"
                        "volumen" => "4"
                        "paginaInicial" => "121"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9097268"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            20 => array:3 [
              "identificador" => "bib0110"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Simplified criteria for the diagnosis of autoimmune hepatitis"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Hennes E&#46;M&#46;"
                            1 => "Zeniya M&#46;"
                            2 => "Czaja A&#46;J&#46;"
                            3 => "Pares A&#46;"
                            4 => "Dalekos G&#46;N&#46;"
                            5 => "Krawitt E&#46;L&#46;"
                            6 => "Bittencourt P&#46;L&#46;"
                          ]
                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
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                        "tituloSerie" => "Hepatology"
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                        "paginaInicial" => "169"
                        "paginaFinal" => "176"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18537184"
                            "web" => "Medline"
                          ]
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              ]
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              "identificador" => "bib0115"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Performance parameters of the diagnostic scoring systems for autoimmune hepatitis"
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                        "paginaInicial" => "1540"
                        "paginaFinal" => "1548"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18924244"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Validation of simplified diagnostic criteria for autoimmune hepatitis in Italian patients"
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                          "autores" => array:4 [
                            0 => "Muratori P&#46;"
                            1 => "Granito A&#46;"
                            2 => "Pappas G&#46;"
                            3 => "Muratori L&#46;"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.22825"
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatology"
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                        "volumen" => "49"
                        "paginaInicial" => "1782"
                        "paginaFinal" => "1783"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19402135"
                            "web" => "Medline"
                          ]
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            23 => array:3 [
              "identificador" => "bib0125"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Clinical features of autoimmune hepatitis diagnosed based on simplified criteria of the International Autoimmune Hepatitis Group"
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                            0 => "Miyake Y&#46;"
                            1 => "Iwasaki Y&#46;"
                            2 => "Kobashi H&#46;"
                            3 => "Yasunaka T&#46;"
                            4 => "Ikeda F&#46;"
                            5 => "Takaki A&#46;"
                            6 => "Yamamoto K&#46;"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.saa.2019.05.010"
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                        "tituloSerie" => "Digestive &#38; Liver Disease"
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                        "paginaInicial" => "210"
                        "paginaFinal" => "215"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31141767"
                            "web" => "Medline"
                          ]
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                ]
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              "identificador" => "bib0130"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Validation of the simplified criteria for diagnosis of autoimmune hepatitis in Chinese patients"
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                            3 => "Xie Q&#46;"
                            4 => "Zang G&#46;"
                            5 => "Jiang H&#46;"
                            6 => "Tu C&#46;"
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                        ]
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2010.06.032"
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                        "tituloSerie" => "J Hepatol"
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                        "paginaInicial" => "340"
                        "paginaFinal" => "347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21056494"
                            "web" => "Medline"
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              "identificador" => "bib0135"
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                0 => array:2 [
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                      "titulo" => "Diagnostic value and utility of the simplified International Autoimmune Hepatitis Group &#40;IAIHG&#41; criteria in acute and chronic liver disease"
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                        0 => array:2 [
                          "etal" => false
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                            1 => "Westbrook R&#46;H&#46;"
                            2 => "Al-Chalabi T&#46;"
                            3 => "Carey I&#46;"
                            4 => "Heaton N&#46;D&#46;"
                            5 => "Portmann B&#46;C&#46;"
                            6 => "Heneghan M&#46;A&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Hepatolo-gy"
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                        "paginaFinal" => "545"
                        "itemHostRev" => array:3 [
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              "identificador" => "bib0140"
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                0 => array:2 [
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                          "etal" => false
                          "autores" => array:6 [
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                            1 => "Yasui S&#46;"
                            2 => "Tawada A&#46;"
                            3 => "Fukuda Y&#46;"
                            4 => "Nakano M&#46;"
                            5 => "Yoko-suka O&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1478-3231.2011.02524.x"
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                        "tituloSerie" => "Liver International"
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                        "paginaInicial" => "1013"
                        "paginaFinal" => "1020"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21733091"
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                          "etal" => false
                          "autores" => array:7 [
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                            2 => "Papamichalis P&#46;"
                            3 => "Koukoulis G&#46;K&#46;"
                            4 => "Gabe-ta S&#46;"
                            5 => "Dalekos G&#46;N&#46;"
                            6 => "Rigopoulou E&#46;I&#46;"
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                        "tituloSerie" => "Dig Liver Dis"
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                        "volumen" => "42"
                        "paginaInicial" => "807"
                        "paginaFinal" => "812"
                        "link" => array:1 [
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                      "titulo" => "Aplicaci&#243;n del modelo diagn&#243;stico del grupo internacional para la hepatitis autoinmune &#40;GIHA&#41; en una poblaci&#243;n de pacientes de Medell&#237;n&#44; Colombia"
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                          "autores" => array:7 [
                            0 => "Londo&#241;o M&#46;C&#46;"
                            1 => "Gonzalez L&#46;"
                            2 => "Chavarriaga J&#46;"
                            3 => "M&#250;nera V&#46;"
                            4 => "Ramos F&#46;"
                            5 => "Su&#225;rez L&#46;"
                            6 => "Marin J&#46;I&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Colomb Gastroenterol"
                        "fecha" => "2003"
                        "volumen" => "18"
                        "paginaInicial" => "16"
                        "paginaFinal" => "19"
                      ]
                    ]
                  ]
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                      "titulo" => "One-second biopsy of the liver--problems of its clinical application"
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                          "autores" => array:1 [
                            0 => "Menghini G&#46;"
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                      "doi" => "10.1056/NEJM197009102831107"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1970"
                        "volumen" => "283"
                        "paginaInicial" => "582"
                        "paginaFinal" => "585"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4915875"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0160"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "One-second needle biopsy of the liver"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Menghini G&#46;"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gastro-enterology"
                        "fecha" => "1958"
                        "volumen" => "35"
                        "paginaInicial" => "190"
                        "paginaFinal" => "199"
                      ]
                    ]
                  ]
                ]
              ]
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            31 => array:3 [
              "identificador" => "bib0165"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Value of the ventilation&#47;perfusion scan in acute pulmonary embolism&#46; Results of the prospective investigation of pulmonary embolism diagnosis &#40;PIOPED&#41;"
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                        0 => array:2 [
                          "colaboracion" => "PIOPED Investigators"
                          "etal" => false
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                    ]
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                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "JAMA"
                        "fecha" => "1990"
                        "volumen" => "263"
                        "paginaInicial" => "2753"
                        "paginaFinal" => "2759"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2332918"
                            "web" => "Medline"
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              "identificador" => "bib0170"
              "etiqueta" => "33&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "QUADAS-2&#58; a revised tool for the quality assessment of diagnostic accuracy studies"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:7 [
                            0 => "Whiting P&#46;F&#46;"
                            1 => "Rutjes A&#46;W&#46;"
                            2 => "Westwood M&#46;E&#46;"
                            3 => "Mallett S&#46;"
                            4 => "Deeks J&#46;J&#46;"
                            5 => "Reitsma J&#46;B&#46;"
                            6 => "Leeflang M&#46;M&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.7326/0003-4819-155-8-201110180-00009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "2011"
                        "volumen" => "155"
                        "paginaInicial" => "529"
                        "paginaFinal" => "536"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22007046"
                            "web" => "Medline"
                          ]
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                      ]
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                ]
              ]
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            33 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
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                          "colaboracion" => "American Gastroenterological Association medical position statement&#58; nonalcoholic fatty liver disease"
                          "etal" => false
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Gastroenterolo-gy"
                        "fecha" => "2002"
                        "volumen" => "123"
                        "paginaInicial" => "1702"
                        "paginaFinal" => "1704"
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            34 => array:3 [
              "identificador" => "bib0180"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Diagnosis&#44; management&#44; and treatment of hepatitis C"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "Strader D&#46;B&#46;"
                            1 => "Wright T&#46;"
                            2 => "Thomas D&#46;L&#46;"
                            3 => "Seeff L&#46;B&#46;"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1002/hep.20119"
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                        "tituloSerie" => "Hepatology"
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                        "paginaInicial" => "1147"
                        "paginaFinal" => "1171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15057920"
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                    0 => array:2 [
                      "titulo" => "Chronic hepatitis B"
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                            0 => "Lok A&#46;S&#46;"
                            1 => "McMahon B&#46;J&#46;"
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                    0 => array:2 [
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                        "tituloSerie" => "Hepatology"
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                        "volumen" => "45"
                        "paginaInicial" => "507"
                        "paginaFinal" => "539"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17256718"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Management of primary biliary cirrhosis&#46; The American Association for the Study of Liver Diseases practice guidelines"
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                          "autores" => array:1 [
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                    0 => array:2 [
                      "doi" => "10.1053/he.2000.5984"
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                        "tituloSerie" => "Hepatology"
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                        "volumen" => "31"
                        "paginaInicial" => "1005"
                        "paginaFinal" => "1013"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10733559"
                            "web" => "Medline"
                          ]
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            37 => array:3 [
              "identificador" => "bib0195"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Frequency and nature of the variant syndromes of autoimmune liver disease"
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                            0 => "Czaja A&#46;J&#46;"
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                    0 => array:2 [
                      "doi" => "10.1002/hep.510280210"
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                        "tituloSerie" => "Hepatology"
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                        "volumen" => "28"
                        "paginaInicial" => "360"
                        "paginaFinal" => "365"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9695997"
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                            2 => "Cifuentes L&#46;"
                            3 => "Armanet L&#46;"
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                      "Revista" => array:6 [
                        "tituloSerie" => "Genet Mol Res"
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                        "volumen" => "1"
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                        "paginaFinal" => "146"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14963840"
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                            2 => "Gallo C&#46;"
                            3 => "Bortolini M&#46;C&#46;"
                            4 => "Canizales-Quinter-os S&#46;"
                            5 => "Bedoya G&#46;"
                            6 => "Gonzalez-Jose R&#46;"
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                  "host" => array:1 [
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                        "tituloSerie" => "Rev Med Chil"
                        "fecha" => "2014"
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                        "paginaInicial" => "281"
                        "paginaFinal" => "289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25052264"
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                            4 => "Gignoux C&#46;R&#46;"
                            5 => "Dejean C&#46;"
                            6 => "Huntsman S&#46;"
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                        "tituloSerie" => "PLoS One"
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                            6 => "van D&#46;K&#46;"
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                        "tituloSerie" => "Ann Hum Genet"
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                        "paginaFinal" => "76"
                        "link" => array:1 [
                          0 => array:2 [
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                            4 => "Bedoya G&#46;"
                            5 => "Gallo C&#46;"
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                        "paginaInicial" => "e1000037"
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                        "tituloSerie" => "Proc Natl Acad Sci U S A"
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                        "paginaFinal" => "8616"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24073242"
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]

Article information

ISSN: 16652681
Original language: English

DOI:10.5604/01.3001.0010.2787

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Year/Month	Html	Pdf	Total

2024 November	12	0	12
2024 October	62	11	73
2024 September	82	27	109
2024 August	55	14	69
2024 July	54	16	70
2024 June	47	5	52
2024 May	57	8	65
2024 April	58	8	66
2024 March	64	10	74
2024 February	74	17	91
2024 January	97	25	122
2023 December	62	25	87
2023 November	53	15	68
2023 October	60	18	78
2023 September	65	4	69
2023 August	50	9	59
2023 July	42	13	55
2023 June	44	6	50
2023 May	78	9	87
2023 April	104	5	109
2023 March	70	4	74
2023 February	39	19	58
2023 January	45	11	56
2022 December	48	8	56
2022 November	39	8	47
2022 October	56	12	68
2022 September	39	11	50
2022 August	57	14	71
2022 July	41	11	52
2022 June	41	10	51
2022 May	40	21	61
2022 April	30	9	39
2022 March	31	21	52
2022 February	33	12	45
2022 January	43	22	65
2021 December	45	11	56
2021 November	34	25	59
2021 October	24	27	51
2021 September	14	19	33
2021 August	19	17	36
2021 July	14	10	24
2021 June	17	10	27
2021 May	21	7	28
2021 April	79	10	89
2021 March	38	8	46
2021 February	14	7	21
2021 January	21	7	28
2020 December	19	12	31
2020 November	16	14	30
2020 October	6	4	10
2020 September	16	9	25
2020 August	19	5	24
2020 July	12	7	19
2020 June	8	2	10
2020 May	19	6	25
2020 April	15	1	16
2020 March	13	0	13
2020 February	18	5	23
2020 January	13	4	17
2019 December	9	3	12
2019 November	8	3	11
2019 October	9	2	11
2019 September	6	2	8
2019 August	3	1	4
2019 July	10	10	20
2019 June	6	15	21
2019 May	2	4	6

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