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Assessing risk factors of acute kidney injury after liver transplantation
Fu Shan Xue
Corresponding author
xuefushan@aliyun.com
fushan.xue@gmail.com

Correspondence and reprint request:
, Chao Sun, Gao Pu Liu, Rui-Ping Li
Department of Anesthesiology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0005">To the Editor&#58;</span><p id="p0005" class="elsevierStylePara elsevierViewall">We read with interest the recent article by Barreto&#44; <span class="elsevierStyleItalic">et al&#46;</span><a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>evaluating the risk factors for acute kidney injury &#40;AKI&#41; and 30-day mortality after liver transplantation &#40;LT&#41; in a single-center retrospective cohort study&#46; They showed that viral hepatitis&#44; longer warm ischemia time and high levels of serum lactate were risk factors for AKI&#46; Given AKI is associated with significantly increased short- and long-term morbidity and mortality after LT&#44; their findings have potentially clinical implications&#46; In our view&#44; however&#44; a limitation of this study design is that some important perioperative factors affecting postoperative AKI are not included in multivariable regression analyses evaluating variables that are independently associated with development of postoperative AKI after LT&#46;</p><p id="p0010" class="elsevierStylePara elsevierViewall">First&#44; preoperative albumin levels&#44; body mass index and race were not provided&#46; It has been shown that preoperative hypoalbuminemia is highly common among patients undergoing LT and is independently associated with postoperative AKI&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Furthermore&#44; increased body mass index and non-Caucasian race have been shown as independent risk factors of AKI following LT&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="p0015" class="elsevierStylePara elsevierViewall">Second&#44; this study only provided incidences of intraoperative bleeding and blood transfusion&#44; but not volumes of intraoperative blood loss and blood transfusion&#46; Actually&#44; both vast blood loss &#40;for example&#44; &#62; 60 mL&#47;kg&#41; and more than five blood transfusions in the intraoperative period has been shown as the independent risk factors of postoperative AKI in the patients undergoing LT&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Furthermore&#44; intraoperative hemodynamic instability&#44; use of vasopressor and urine output were not included in the adjusted confounders for postoperative AKI&#46; The available evidence suggests that intraoperative hypotension&#44; use of noradrenaline and low urine output &#40;for example&#44; &#60; 60 mL&#47;h&#41; are independently associated with increased risk of AKI following LT&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> In addition&#44; it was also unclear whether hydroxyethyl starch was used for intravascular volume resuscitation in the perioperative period&#46; It has been shown that compared with patients receiving 5&#37; albumin&#44; patients receiving hydroxyethyl starch have an increased risk of AKI following liver transplantation&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="p0020" class="elsevierStylePara elsevierViewall">Third&#44; we were not provided with postoperative complications&#46; It has been shown that hypotension&#44; hypoalbuminemia&#44; postreperfusion syndrome&#44; hepatic allograft dysfunction&#44; reoperation&#44; sepsis and surgical complications in the early postoperative period are significantly associated with occurrence of AKI after LT&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#44;<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">7</span></a><span class="elsevierStyleSup">&#8211;</span><a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> Thus&#44; we argue that not taking the above perioperative factors into account would have tampered with the inferences of the multivariable regression analyses for the risk factors of AKI following LT in this study&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">Finally&#44; in this study&#44; AKI was defined according to the Acute Kidney Injury Network criteria as an increase more than two times in serum creatinine &#40;stage 2 or 3 AKI&#41; in the first 72 h after surgery&#46; Furthermore&#44; AKI was diagnosed only based on serum creatinine component of the Acute Kidney Injury Network criteria since data on urinary output was not available for all patients&#46; However&#44; the Acute Kidney Injury Network criteria require to use a 48 h time window&#44; and a 24-h urine output collection is a better alternative to estimate glomerular filtration rate than serum creatinine&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> We are concerned that these factors would have confused incidence of postoperative AKI reported in this study&#46; In addition&#44; we would like to know why this study did not included stage 1 AKI&#44; although it is more common than stage 2 or 3 AKI in the patients undergoing LT&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p></span><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0010">Acknowledgement</span><p id="p0030" class="elsevierStylePara elsevierViewall">All authors have no financial support and potential conflicts of interest for this work&#46;</p></span></span>"
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ISSN: 16652681
Original language: English
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es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos